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Home › Research › Topics › r47h

r47h

363 studies tagged r47h, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

363 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta pharmaceutica Sinica. B 2021-10-22 TREM2 and immune genetics

    The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown.

  2. Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Frontiers in aging neuroscience 2021-10-11 TREM2 and immune genetics

    Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking.

  3. Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Cell reports 2021-10-01 TREM2 and immune genetics

    Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms.

  4. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. The Journal of experimental medicine 2021-08-23 TREM2 and immune genetics

    Upon demyelinating injury, microglia orchestrate a regenerative response that promotes myelin repair, thereby restoring rapid signal propagation and protecting axons from further damage.

  5. Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-07-01 TREM2 and immune genetics

    Heterozygous genetic variants within the TREM2 gene show a strong association with increased Alzheimer's disease (AD) risk.

  6. TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature communications 2021-04-16 TREM2 and immune genetics

    Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9).

  7. Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neuron 2021-03-05 TREM2 and immune genetics

    Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk.

  8. African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neurology. Genetics 2021-03-04 Tau biomarkers

    The primary cohort included 91 AAs and 868 NHWs.

  9. Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Diabetes 2021-02-24 TREM2 and immune genetics

    Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content.

  10. Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Frontiers in immunology 2021-02-17 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane receptor of the immunoglobulin superfamily and a crucial signaling hub for multiple pathological pathways that mediate immunity.

  11. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Frontiers in immunology 2021-02-03 TREM2 and immune genetics

    Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD).

  12. TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Journal of clinical investigation 2021-02-01 TREM2 and immune genetics

    Sepsis is a leading cause of death in critical illness, and its pathophysiology varies depending on preexisting medical conditions.

  13. TREM2, microglia, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Mechanisms of ageing and development 2021-01-28 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS).

  14. TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Molecular immunology 2021-01-15 TREM2 and immune genetics

    Alzheimer's disease (AD) is characterized by the accumulation in the brain of extracellular amyloid β (Aβ) plaques as well as intraneuronal inclusions (neurofibrillary tangles) consisting of total tau and phosphorylated tau.

  15. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neuroinflammation 2021-01-09 TREM2 and immune genetics

    By engaging membrane-bound TREM2, the selected antibody was shown to promote their cellular proliferation, uptake of oligomeric beta amyloid/apoptotic neurons, and activation in a Syk and Akt dependent manner.

  16. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-01-01 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ).

  17. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Journal of biological chemistry 2021-01-01 TREM2 and immune genetics

    TREM2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting lipids and Aβ and inducing an innate immune response.

  18. Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Redox biology 2020-12-28 TREM2 and immune genetics

    Periodontitis is the sixth most prevalent diseases around the globe, which is closely related to many systemic diseases and affects general health.

  19. Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-12-12 TREM2 and immune genetics

    Herein, we demonstrate that endogenous Tyrobp transcription is specifically increased in recruited microglia.

  20. Function of TREM1 and TREM2 in Liver-Related Diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cells 2020-12-07 TREM2 and immune genetics

    TREM1 and TREM2 are members of the triggering receptors expressed on myeloid cells (TREM) family.

  21. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's research & therapy 2020-11-16 TREM2 and immune genetics

    TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer's disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state.

  22. Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2020-11-02 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively expressed by microglia in the brain, modulates microglial immune homeostasis.

  23. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Human molecular genetics 2020-11-01 TREM2 and immune genetics

    Genome-wide association studies have reported that, amongst other microglial genes, variants in TREM2 can profoundly increase the incidence of developing Alzheimer's disease (AD).

  24. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2020-10-28 TREM2 and immune genetics

    The Trem2 variant R47H, confers substantially elevated risk of developing late onset Alzheimer's disease, while NHD-linked Trem2 variants like Y38C, are associated with development of early onset dementia with white matter pathology.

  25. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Nature communications 2020-10-23 TREM2 and immune genetics

    The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has accelerated research into the role of microglia in AD.

  26. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Aging 2020-10-16 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) has been shown with a neuroprotective function against inflammation and neuronal injury in Alzheimer's disease (AD).

  27. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Experimental neurology 2020-10-13 TREM2 and immune genetics

    Overactivated microglia and neuroinflammation are considered to play a crucial role in the progression of Alzheimer's disease (AD).

  28. A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature communications 2020-10-08 TREM2 and immune genetics

    Identifying factors underlying resistance to immune checkpoint therapy (ICT) is still challenging.

  29. Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-10-08 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) is an immune receptor expressed on microglia that also can become soluble (sTREM2).

  30. Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Molecular neurodegeneration 2020-10-08 TREM2 and immune genetics

    The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD).

  31. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. The Journal of experimental medicine 2020-09-01 TREM2 and immune genetics

    TREM2 is a receptor for lipids expressed in microglia.

  32. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Journal of clinical investigation 2020-09-01 TREM2 and immune genetics

    Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau.

  33. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Acta neuropathologica 2020-08-25 TREM2 and immune genetics

    Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD).

  34. Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Journal of neuroinflammation 2020-08-14 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin.

  35. Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Cell 2020-08-11 TREM2 and immune genetics

    Cell function and activity are regulated through integration of signaling, epigenetic, transcriptional, and metabolic pathways.

  36. TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Cell 2020-08-11 TREM2 and immune genetics

    Checkpoint immunotherapy unleashes T cell control of tumors, but is undermined by immunosuppressive myeloid cells.

  37. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Acta neuropathologica 2020-08-09 TREM2 and immune genetics

    Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms.

  38. A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of neuroinflammation 2020-07-25 TREM2 and immune genetics

    Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid.

  39. Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Molecular neurodegeneration 2020-07-23 TREM2 and immune genetics

    Alzheimer's Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors.

  40. TREM2 ectodomain and its soluble form in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neuroinflammation 2020-07-07 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia.

  41. Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. eLife 2020-06-24 TREM2 and immune genetics

    To study the mechanisms by which the p.R47H variant of the microglia gene and Alzheimer's disease (AD) risk factor TREM2 increases dementia risk, we created Trem2 R47H KI rats.

  42. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Nature neuroscience 2020-06-08 TREM2 and immune genetics

    Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (TREM2) and, more recently, in PLCG2, a phospholipase-encoding gene expressed in microglia.

  43. The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Cell 2020-06-01 TREM2 and immune genetics

    Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical conditions in the Western world.

  44. TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of neuroinflammation 2020-05-28 TREM2 and immune genetics

    Neuroinflammation is an important host defense response to secondary brain injury after intracerebral hemorrhage (ICH).

  45. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Genes & diseases 2020-05-21 TREM2 and immune genetics

    Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) share several common pathophysiological features.

  46. TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PLoS pathogens 2020-05-13 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) serves as an anti-inflammatory receptor, negatively regulating the innate immune response.

  47. Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Molecular neurodegeneration 2020-04-10 TREM2 and immune genetics

    Loss of function of triggering receptor expressed on myeloid cell 2 (TREM2), a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer's disease (AD).

  48. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Acta neuropathologica 2020-03-12 TREM2 and immune genetics

    A rare coding variant (rs72824905, p.P522R) conferring protection against Alzheimer's disease (AD) was identified in the gene encoding the enzyme phospholipase-C-γ2 (PLCG2) that is highly expressed in microglia.

  49. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. EMBO molecular medicine 2020-03-10 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for the transition of homeostatic microglia to a disease-associated microglial state.

  50. Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Brain : a journal of neurology 2020-03-01 TREM2 and immune genetics

    Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease and affects 1% of the population above 60 years old.

From across this tag

8 of the 363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts