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TREM2 ectodomain and its soluble form in Alzheimer's disease
Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z.. Journal of neuroinflammation, 2020-07-07
Topic: Brain proteins, microglia and lab models
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia. It mediates multiple pathophysiological processes in various diseases. Recently, TREM2 has been found to play a role in the development of Alzheimer's disease (AD).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yang, J., Fu, Z., Zhang, X., Xiong, M., Meng, L., & Zhang, Z. (2020). TREM2 ectodomain and its soluble form in Alzheimer's disease. Journal of neuroinflammation. https://doi.org/10.1186/s12974-020-01878-2
Vancouver
Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z. TREM2 ectodomain and its soluble form in Alzheimer's disease. Journal of neuroinflammation. 2020. doi:10.1186/s12974-020-01878-2. PMID: 32635934.
BibTeX
@article{yang2020-32635934,
author = {Yang, J. and Fu, Z. and Zhang, X. and Xiong, M. and Meng, L. and Zhang, Z.},
title = {{TREM2 ectodomain and its soluble form in Alzheimer's disease}},
journal = {Journal of neuroinflammation},
year = {2020},
doi = {10.1186/s12974-020-01878-2},
pmid = {32635934},
url = {https://doi.org/10.1186/s12974-020-01878-2}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- It mediates multiple pathophysiological processes in various diseases.
- Recently, TREM2 has been found to play a role in the development of Alzheimer's disease (AD).
- TREM2 is a transmembrane protein that is specifically expressed on microglia in the brain.
- It contains a long ectodomain that directly interacts with the extracellular environment to regulate microglial function.
Why it matters
This review describes TREM2 as a microglial receptor with a long ectodomain that interacts with the extracellular environment and has been found to play a role in Alzheimer's disease. It reports no treatment, cure, or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | 2 / 4 | Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 115 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.4 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 4.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 56 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Zhentao Zhang: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Renmin Hospital of Wuhan University: institution h-index 427 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32635934) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s12974-020-01878-2
- PubMed: 32635934
- Original source →
- Free full text: Journal of Neuroinflammation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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