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Home › Research › Topic

Plasma and spinal-fluid biomarkers

1,573 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 1,573 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Region-specific hierarchy between atrophy, hypometabolism, and β-amyloid (Aβ) load in Alzheimer's disease dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-11-01 Brain scans and imaging

    Gray matter atrophy, glucose hypometabolism, and β-amyloid Aβ deposition are well-described hallmarks of Alzheimer's disease, but their relationships are poorly understood.

  2. The clinical features of pathologically confirmed vascular parkinsonism

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurology, neurosurgery, and psychiatry 2012-10-01 Digital health tools

    In comparison with other Parkinsonian syndromes the patients were older and had an extremely low frequency of visual hallucinations compared with Parkinson's disease.

  3. Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biomarkers in medicine 2012-08-01 Getting a diagnosis

    Early diagnosis of neurodegenerative disorders such as Alzheimer's (AD) or Parkinson's disease (PD) is needed to slow down or halt the disease at the earliest stage.

  4. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2012-03-30 Brain scans and imaging

    This paper introduces neurite orientation dispersion and density imaging (NODDI), a practical diffusion MRI technique for estimating the microstructural complexity of dendrites and axons in vivo on clinical MRI scanners.

  5. Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2012-01-01 Biomarkers

    Tau proteins and amyloid-β (Aβ) peptides are the current recognized cerebrospinal fluid (CSF) biomarkers used as an aid in the diagnosis of Alzheimer's disease (AD).

  6. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of lipid research 2011-12-27 Biomarkers

    We performed unbiased analysis of steroid-related compounds to identify novel Alzheimer's disease (AD) plasma biomarkers using liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy.

  7. PET imaging of brain amyloid in dementia: a review

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. International journal of geriatric psychiatry 2010-12-28 Treatments

    PIB-PET imaging is a sensitive and specific marker for underlying Aβ amyloid deposition and represents an important investigative tool for examining the relationship between amyloid burden, clinical symptoms and structural and functional changes in dementia.

  8. Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2010-09-13 Brain scans and imaging

    Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism.

  9. MRI quantification of non-Gaussian water diffusion by kurtosis analysis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NMR in biomedicine 2010-08-01 Brain scans and imaging

    Quantification of non-Gaussianity for water diffusion in brain by means of diffusional kurtosis imaging (DKI) is reviewed.

  10. Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2010-06-08 Brain scans and imaging

    Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes.

  11. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2010-01-01 Biomarkers

    The study of Alzheimer's disease (AD) pathogenesis requires the use of animal models that develop some amount of amyloid pathology in the brain.

  12. Total and phosphorylated tau protein as biological markers of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental gerontology 2009-10-22 Biomarkers

    Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts.

  13. AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 2009-10-01 Genetics

    There is an urgent need for Alzheimer's disease (AD) biomarkers-especially in the context of clinical trials.

  14. Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. ACS nano 2009-09-01 Drug development

    Alzheimer's disease (AD) is a progressive mental disorder disease, which affects 26.6 million people worldwide and estimated increments can be 100 millions by 2050.

  15. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of Pathology 2008-09-18 Genetics

    The brains of Alzheimer's disease sufferers are characterized by amyloid plaques and neurofibrillary tangles.

  16. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2007-06-01 Brain scans and imaging

    The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD).

  17. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2007-03-19 Brain scans and imaging

    In Alzheimer's disease (AD), brain lesions are marked by severe neuronal loss and retinal degeneration was previously mentioned in affected patients.

  18. CSF neurofilament proteins in the differential diagnosis of dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurology, neurosurgery, and psychiatry 2007-02-21 Biomarkers

    In the diagnostic workup of relatively young dementia patients, CSF NFL levels may play a role in the discrimination between FTLD and EAD, especially in combination with Abeta42 and p-tau181 analysis.

  19. Alzheimer's disease in Down syndrome: neurobiology and risk

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Mental retardation and developmental disabilities research reviews 2007-01-01 Down syndrome and Alzheimer's

    Down syndrome (DS) is characterized by increased mortality rates, both during early and later stages of life, and age-specific mortality risk remains higher in adults with DS compared with the overall population of people with mental retardation and with typically developing populations.

  20. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006-11-01 Genetics

    Amyloid beta-peptide (Abeta) clearance from the central nervous system (CNS) maintains its low levels in brain.

  21. Elevation in plasma Abeta42 in geriatric depression: a pilot study

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemical research 2006-03-01 Biomarkers

    Elevated plasma amyloid beta 1-42 (Abeta42) level has been linked to increased risk for incident AD in cognitively-intact elderly.

  22. Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature protocols 2006-01-01 Treatments

    In the current protocol, we describe the Congo red staining method and a method for separately quantifying vascular and parenchymal amyloid deposits in brain tissue sections.

  23. Measurement of thirteen biological markers in CSF of patients with Alzheimer's disease and other dementias

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Dementia and geriatric cognitive disorders 2005-10-21 Biomarkers

    Cerebrospinal fluid (CSF) biological markers may be of valuable help in the diagnosis of dementia.

  24. Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Chemical Society 2005-02-01 Tau biomarkers

    A nanoscale optical biosensor based on localized surface plasmon resonance (LSPR) spectroscopy has been developed to monitor the interaction between the antigen, amyloid-beta derived diffusible ligands (ADDLs), and specific anti-ADDL antibodies.

  25. Imaging iron stores in the brain using magnetic resonance imaging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Magnetic resonance imaging 2005-01-01 Brain scans and imaging

    For the last century, there has been great physiological interest in brain iron and its role in brain function and disease.

From across this topic

10 of the 1,573 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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