Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Gaps in Vascular Evaluation Before Major Lower-Extremity Amputation Among Medicare Beneficiaries With Chronic Limb-Threatening Ischemia

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-04-28 Costs and economics

    Among 10,666 patients (mean age 76.6 years; 35% female; 70% White, 21% Black), phenotype distribution was: A, 9.4%; B, 7.1%; C, 50.7%; D, 32.7%.

  2. A Simulation-Based Discrete Choice Experiment Framework for Alzheimer’s Disease-Modifying Therapy Implementation: Methodology and Interactive Decision Support Tool

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-04-14 Treatments

    Under calibrated simulation parameters, slowing of cognitive decline emerged as the most important attribute (relative importance 25.7%), followed by annual cost (17.6%), ARIA risk (15.4%), and travel to treatment centre (13.0%).

  3. PREFER-DMT: A Discrete Choice Experiment Framework for Eliciting Stakeholder Preferences on Disease-Modifying Therapy Implementation in European Healthcare Systems

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-04-14 Treatments

    Simulation-based validation demonstrates the framework’s analytical capability.

  4. Effectiveness of a Socially Implemented Cognitive Decline Prevention Program: A Retrospective Observational Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-04-09 Health systems and care delivery

    The multifactorial interventions implemented in community settings showed no effect on dementia onset or health outcomes.

  5. Pharmacotherapy for Depression in Long-Term Care: A Real-World EHR Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-03-16 Health systems and care delivery

    Overall, 81.7% of residents diagnosed with depression had ≥1 pharmacological depression treatment order.

  6. Assessing the risk of early-onset dementia within 5 years of cancer diagnosis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-02-15 Digital health tools

    EOD incidence peaked at 4-5% among beneficiaries with and without cancer.

  7. Incidence of dementia after a recent cancer diagnosis among people with HIV

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-02-15 Digital health tools

    Dementia risk may be increased among people with HIV with certain cancers, including AIDS-defining cancers.

  8. Comparison of quality of sepsis care among patients with vs. without acute mental health crises

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-02-11 Clinical safety

    Previous research has shown patients with mental health issues receive worse quality of diabetes and cardiac care and have poorer outcomes compared with those without mental health issues.

  9. Preventive and Need-Driven Use of Dental Services among Community-Dwelling Older People with Long-Term Care Needs

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-30 Health systems and care delivery

    Oral health is a key component of quality of life among older adults, yet maintaining preventive dental care becomes increasingly difficult for those with long-term care (LTC) needs.

  10. How does palliative care fit into national health spending? A secondary analysis of trends in long-term healthcare expenditure in the United Kingdom

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-24 Health systems and care delivery

    Real-terms UK government spending on health-related long-term care grew by £6.4 billion (22.9%) between 2013 and 2022, from £27.9 to £34.3 billion.

  11. Wearable devices may facilitate the measurement and treatment of specific BPSD, as well as reduce caregiver burden.

  12. Prevalence and outcomes of recorded dementia vary by data source: a population cohort study of 133,407 older adults

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-09 Clinical safety

    Dementia is variably recorded across routine datasets, and the setting in which dementia is first recorded identifies groups with markedly different prognosis.

  13. The Societal Cost of Alzheimer’s Disease depends on the Diagnosis Timing

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2026-01-08 Costs and economics

    Earlier diagnosis increases total expenditures but improves care and cost allocation.

  14. Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive Impairment

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2025-12-29 Digital health tools

    The mean age was 66.8 years and 21% had CI.

  15. Antidepressant Use at the Threshold: using electronic health records to characterise people prescribed antidepressants around the time of dementia diagnosis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv 2025-12-17 Digital health tools

    The high incidence of new prescribing, as well as the lack of deprescribing, points to unmet needs and a role for more proactive medication review.

  16. Longitudinal Pain Management Patterns and Risk of Adverse Outcomes in Older Adults: Insights from Group-Based Multi-Trajectory Modeling

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Authorea Preprints 2024-12-28 Costs and economics

    These findings highlight that extensive long-term utilization of pain management strategies in older adults is associated with increased risks of adverse outcomes, particularly hospitalizations and incident dementia, especially among fit older adults, emphasizing the need for careful monitoring and personalized approaches to pain management in older populations, balancing effective pain control with minimization of potential long-term risks.

  17. The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. medRxiv : the preprint server for health sciences 2024-06-03 Disparities

    AADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement.

  18. Chronic Pain Among Adults - United States, 2019-2021

    ⚠ Report — not peer-reviewed alzhub usefulness score 16 out of 100. MMWR. Morbidity and mortality weekly report 2023-04-14 Risk factors

    Chronic pain (i.e., pain lasting ≥3 months) is a debilitating condition that affects daily work and life activities for many adults in the United States and has been linked with depression (1), Alzheimer disease and related dementias (2), higher suicide risk (3), and substance use and misuse (4).

  19. The Potential Public Health Relevance of Social Isolation and Loneliness: Prevalence, Epidemiology, and Risk Factors

    ⚠ Report — not peer-reviewed alzhub usefulness score 16 out of 100. Public Policy & Aging Report 2017-01-01 Risk factors

    News headlines from many nations, including the United States, Germany, Australia, and the United Kingdom, suggest that we are facing a loneliness epidemic (http://www.campaigntoendloneliness.org/loneliness-research, http://www.spiegel.de/international/germany/germany-faces-epidemic-of-lonely-and-isolated-seniors-a-876635.html, https://startsat60.com/health/new-survey-reveals-australias-loneliness-epidemic, http://www.huffingtonpost.com.au/tania-de-jong/loneliness-is-the-global-epidemic-of-our-times), leading to the important question of whether there is evidence to support such a claim and, if so, whether we are facing a public health crisis.

  20. Two hundred and sixty participants were randomised (173 intervention, 87 TAU).

  21. REMCARE: reminiscence groups for people with dementia and their family caregivers – effectiveness and cost-effectiveness pragmatic multicentre randomised trial

    ⚠ Report — not peer-reviewed alzhub usefulness score 16 out of 100. Health Technology Assessment 2012-12-01 Costs and economics

    The intention-to-treat analysis identified no differences in outcome between the intervention and control conditions on primary or secondary outcomes [self-reported quality of life in Alzheimer's disease: mean difference 0.07, standard error (SE) 0.65; F = 0.48; p = 0.53].

  22. Physical illness and depression in older adults : a handbook of theory, research, and practice

    ⚠ Report — not peer-reviewed alzhub usefulness score 13 out of 100. 2000-01-01 End-of-life care

    Foreword. Preface C.R. Snyder. 1. Physical Illness and Depression in Older Adults: An Introduction D.R.

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