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Home › Research › Topics › mitochondrial

mitochondrial

275 studies tagged mitochondrial, dated 1989-01-01 to 2026-10-23. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Pantethine and Neurodegeneration: A Coenzyme A-Centered Framework Linking Metabolism, Neuroinflammation, and Mitochondrial Dysfunction 2026-10-23
  2. BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function 2026-10-20
  3. Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster 2026-10-19

Studies

275 studies carry this tag.

Date range

1989 to 2026

Top journals

  • The Journal of neuroscience : the official journal of the Society for Neuroscience 9
  • Free radical biology & medicine 8
  • Redox biology 8
  • Proceedings of the National Academy of Sciences of the United States of America 7
  • Biochimica et biophysica acta 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Oxidative stress, protein modification and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research bulletin 2016-06-15 Genetics

    Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly population with complex etiology.

  2. Aging and Neurodegeneration: A Tangle of Models and Mechanisms

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Aging and disease 2016-03-15 Disease mechanisms

    The research on aging and age-related diseases, especially the neurodegenerative diseases, is on the fast track.

  3. Role of oxidative stress in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biomedical reports 2016-03-15 Brain tissue and pathology

    Alzheimer's disease (AD) is the most common cause of disability in individuals aged >65 years worldwide.

  4. Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. ACS Nano 2016-02-04 Disease mechanisms

    Mitochondrial oxidative stress is a key pathologic factor in neurodegenerative diseases, including Alzheimer's disease.

  5. The Role of Oxidative Stress in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Experimental neurobiology 2015-10-12 Disease mechanisms

    Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system.

  6. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of toxicology 2015-09-07 Disease mechanisms

    The depletion of zinc may enhance DNA damage by impairing DNA repair mechanisms.

  7. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015-08-07 Disease mechanisms

    Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for the energy production.

  8. NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2015-06-06 Risk factors

    Exposure to environmental toxins such as pesticides is implicated in increasing Alzheimer's disease risk.

  9. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Oxidative medicine and cellular longevity 2015-03-05 Disease mechanisms

    Neuroinflammation and mitochondrial dysfunction are common features of chronic neurodegenerative diseases of the central nervous system.

  10. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer’s disease or vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Clinical Chemistry and Laboratory Medicine (CCLM) 2015-01-01 Mild cognitive impairment

    A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer’s disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI).

  11. Disturbed mitochondrial dynamics and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neurology 2014-12-09 Risk genes beyond APOE

    Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic process, with mitochondrial segments fusing and breaking apart continuously.

  12. Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pineal research 2014-12-09 Biomarkers

    Melatonin acts as a pleiotropic agent in various age-related neurodegenerative diseases.

  13. Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell biochemistry and biophysics 2014-11 Disease mechanisms

    The autophagic process is the only known mechanism for mitochondrial turnover and it has been speculated that dysfunction of autophagy may result in mitochondrial error and cellular stress.

  14. Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2014-11-01 Disease mechanisms

    In recent years there has been enormous interest in researching oxidative stress.

  15. The role of iron in brain ageing and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Lancet. Neurology 2014-10-01 Vascular contributions

    In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters.

  16. Free radicals: properties, sources, targets, and their implication in various diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Indian journal of clinical biochemistry : IJCB 2014-07-15 Risk factors

    Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases.

  17. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Global advances in health and medicine 2014-05-01 Brain scans and imaging

    Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA), a US Food and Drug Administration-approved hydrophilic bile acid for the treatment of certain cholestatic liver diseases.

  18. Role of early life exposure and environment on neurodegeneration: implications on brain disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Translational neurodegeneration 2014-04-29 Risk factors

    Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively and varying molecular mechanisms have been proposed for onset of such diseases.

  19. The role of lipid peroxidation in neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical biochemistry and nutrition 2014-04-09 Down syndrome and Alzheimer's

    There has been much evidence demonstrating the involvement of oxidative stress in the pathology of neurological disorders.

  20. SIRT1 in neurodevelopment and brain senescence

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-02-01 Risk factors

    Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.

  21. Mitochondrial biogenesis: pharmacological approaches

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current pharmaceutical design 2014-01-01 Drug development

    Whereas a modest expression of this transcriptional co-activator results in positive effects, a moderate to substantial overexpession may have deleterious consequences.

  22. Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Free radical biology & medicine 2013-12-16 Drug development

    Glycogen synthase kinase (GSK)-3β is a multifunctional protein that has been implicated in the pathological characteristics of Alzheimer's disease (AD), including the heightened levels of neurofibrillary tangles, amyloid-beta (Aβ), and neurodegeneration.

  23. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2013-11-01 Disease mechanisms

    Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being detected peripherally as well as associated with the vulnerable regions of the brain affected in disease.

  24. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2013-09-23 Risk genes beyond APOE

    Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade hypothesis.

  25. Oxidative stress and the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Oxidative medicine and cellular longevity 2013-07-25 Disease mechanisms

    Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia in the elderly.

  26. Oxidative stress, mitochondrial damage and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neural regeneration research 2013-07-01 Disease mechanisms

    Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

  27. Excitotoxicity: bridge to various triggers in neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of pharmacology 2012-10-30 Risk factors

    Glutamate is one of the most prominent neurotransmitter in the body, present in over 50% of nervous tissue and plays an important role in neuronal excitation.

  28. Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Free radical biology & medicine 2012-10-05 Genetics

    Lipid peroxidation involves a cascade of reactions in which production of free radicals occurs selectively in the lipid components of cellular membranes.

  29. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 2012-09-18 Disease mechanisms

    Mitochondrial dysfunctions cause numerous human disorders.

  30. Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicology 2012-09-18 Risk factors

    It has recently been reported that iron oxide nanoparticles (Fe(3)O(4)-NPs, 30 nm) have the ability to translocate directly from the olfactory nerve to the brain.

  31. Astrocyte Senescence as a Component of Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS ONE 2012-09-12 Disease mechanisms

    Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging process that predispose the brain to the development of AD are largely unknown.

  32. Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicity research 2012-06-28 Brain scans and imaging

    The pineal product melatonin has remarkable antioxidant properties.

  33. Mitochondrial dysfunction in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of pharmacology and experimental therapeutics 2012-06-13 Disease mechanisms

    Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes.

  34. Mitochondria, oxidative stress and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the neurological sciences 2012-06-04 Disease mechanisms

    Mitochondria are involved in ATP supply to cells through oxidative phosphorylation (OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in apoptosis.

  35. The ketogenic diet as a treatment paradigm for diverse neurological disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in pharmacology 2012-04-09 Risk factors

    Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis.

  36. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemical research 2012-03-30 Biomarkers

    Oxidative stress and mitochondrial damage are implicated in the evolution of neurodegenerative diseases.

  37. Oxidative stress and human health

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Advances in Bioscience and Biotechnology 2012-01-01 Brain scans and imaging

    Redox degenerative reactions of the biological system inevitably produce reactive oxygen species (ROS) and their derivatives.

  38. Zinc and human health: an update

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of toxicology 2011-11-10 Genetics

    The importance of micronutrients in health and nutrition is undisputable, and among them, zinc is an essential element whose significance to health is increasingly appreciated and whose deficiency may play an important role in the appearance of diseases.

  39. Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2011-09-01 Risk factors

    Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the inducible nitric oxide synthase (NOS2) resulting in increased NO production.

  40. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-08-25 Disease mechanisms

    Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in Alzheimer's disease (AD).

  41. Exercise training increases mitochondrial biogenesis in the brain

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of applied physiology (Bethesda, Md. : 1985) 2011-08-04 Prevention trials

    Increased muscle mitochondria are largely responsible for the increased resistance to fatigue and health benefits ascribed to exercise training.

  42. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular aspects of medicine 2011-08-01 Disease mechanisms

    For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging.

  43. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell death and differentiation 2011-05-20 Treatments

    The pathological processes of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases engender synaptic and neuronal cell damage.

  44. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-03-31 Disease mechanisms

    The purpose of our study was to better understand the relationship between mitochondrial structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the progression of Alzheimer's disease (AD).

  45. Advances in metal-induced oxidative stress and human disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Toxicology 2011-03-23 Risk factors

    Detailed studies in the past two decades have shown that redox active metals like iron (Fe), copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions and possess the ability to produce reactive radicals such as superoxide anion radical and nitric oxide in biological systems.

  46. The redox basis of epigenetic modifications: from mechanisms to functional consequences

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Antioxidants & redox signaling 2011-02-05 Genetics

    Epigenetic modifications represent mechanisms by which cells may effectively translate multiple signaling inputs into phenotypic outputs.

  47. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2010-10-11 Risk genes beyond APOE

    Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer's disease (AD).

  48. Metals, oxidative stress and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular and cellular biochemistry 2010-08-22 Inflammation and the immune system

    Biochemical analysis of amyloid plaques revealed that the main constituent is fibrillar aggregates of a 39-42 residue peptide referred to as the amyloid-β protein (Aβ).

  49. Selective neuronal vulnerability to oxidative stress in the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in aging neuroscience 2010-03-30 Disease mechanisms

    Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia.

  50. AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2010-01-15 Disease mechanisms

    Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-beta (Abeta) peptide deposition into cerebral amyloid plaques.

From across this tag

9 of the 275 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts