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Home › Research › Topics › mitochondrial

mitochondrial

275 studies tagged mitochondrial, dated 1989-01-01 to 2026-10-23. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Pantethine and Neurodegeneration: A Coenzyme A-Centered Framework Linking Metabolism, Neuroinflammation, and Mitochondrial Dysfunction 2026-10-23
  2. BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function 2026-10-20
  3. Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster 2026-10-19

Studies

275 studies carry this tag.

Date range

1989 to 2026

Top journals

  • The Journal of neuroscience : the official journal of the Society for Neuroscience 9
  • Free radical biology & medicine 8
  • Redox biology 8
  • Proceedings of the National Academy of Sciences of the United States of America 7
  • Biochimica et biophysica acta 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biochemical pharmacology 2021-04-22 Drug development

    The glucagon-like peptide-1 (GLP-1) was shown to have neuroprotective effects in Alzheimer's disease (AD).

  2. NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Redox biology 2021-03-19 Disease mechanisms

    Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD).

  3. Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Science advances 2021-02-12 Down syndrome and Alzheimer's

    Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD).

  4. The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Ageing research reviews 2021-02-08 Disease mechanisms

    While the elderly segment of the population continues growing in importance, neurodegenerative diseases increase exponentially.

  5. Ferroptosis: mechanisms and links with diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Signal transduction and targeted therapy 2021-02-03 Disease mechanisms

    Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death.

  6. Mitochondrial unfolded protein response: An emerging pathway in human diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Free radical biology & medicine 2020-12-21 Disease mechanisms

    Mitochondrial unfolded protein response (UPRmt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins and proteases are initiated to maintain proteostasis in mitochondria.

  7. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta neuropathologica communications 2020-11-09 Brain scans and imaging

    Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD).

  8. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature reviews. Drug discovery 2020-07-24 Disease mechanisms

    The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm.

  9. Multifunctional roles of zinc in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurotoxicology 2020-07-24 Drug development

    Zinc is the second abundant trace element in the human central nervous system (CNS).

  10. Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cell death and differentiation 2020-07-23 Disease mechanisms

    Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis and induces neuropathological changes, such as impaired neuronal integrity, neurodegeneration, and cognitive impairment.

  11. Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Antioxidants (Basel, Switzerland) 2020-07-22 Down syndrome and Alzheimer's

    Oxidative stress develops as a response to injury and reflects a breach in the cell's antioxidant capacity.

  12. Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biochimica et biophysica acta. Molecular basis of disease 2020-05-30 Risk factors

    Alzheimer's disease (AD) often coexists with other aging-associated diseases including obesity, diabetes, hypertension, and cardiovascular diseases.

  13. Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2020-05-29 Disease mechanisms

    Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain.

  14. Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental science and pollution research international 2020-05-01 Risk factors

    Organophosphorus pesticides (OPs) are widely used for controlling pests worldwide.

  15. Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Experimental neurology 2020-04-25 Disease mechanisms

    Alzheimer's disease (AD) is a progressive brain disorder characterized by memory loss and the accumulation of two insoluble protein aggregates, tau neurofibrillary tangles and beta-amyloid plaques.

  16. Sex differences in the response to oxidative and proteolytic stress

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Redox biology 2020-03-09 Disease mechanisms

    Sex differences in diseases involving oxidative and proteolytic stress are common, including greater ischemic heart disease, Parkinson disease and stroke in men, and greater Alzheimer disease in women.

  17. Cellular Senescence in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular neuroscience 2020-02-11 Down syndrome and Alzheimer's

    Cellular senescence is a homeostatic biological process characterized by a permanent state of cell cycle arrest that can contribute to the decline of the regenerative potential and function of tissues.

  18. Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in neuroscience 2020-01-29 Disease mechanisms

    Although the basis of Alzheimer's disease (AD) etiology remains unknown, oxidative stress (OS) has been recognized as a prodromal factor associated to its progression.

  19. Alzheimer's Disease and Parkinson's Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of the American College of Nutrition 2019-12-12 Risk factors

    These innovations can be benchmarked on firm understanding of nutrigenomics and the personalized management of individuals at risk.

  20. Systemic and central nervous system metabolic alterations in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Alzheimer's research & therapy 2019-11-28 Biomarkers

    The observed metabolic alterations were associated with core pathological processes of AD to investigate their relation with amyloid pathology and tau-related neurodegeneration.

  21. Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Oxidative medicine and cellular longevity 2019-11-11 Risk factors

    Reactive species produced in the cell during normal cellular metabolism can chemically react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing their oxidative modifications leading to alterations in their compositions and potential damage to their cellular activities.

  22. Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. PLoS ONE 2019-11-07 Risk factors

    Succinate dehydrogenase (SDH) inhibitors (SDHIs) are used worldwide to limit the proliferation of molds on plants and plant products.

  23. NAD + in Brain Aging and Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell metabolism 2019-10-01 Disease mechanisms

    NAD + is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival.

  24. Ageing as a risk factor for neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature reviews. Neurology 2019-09-09 Disease mechanisms

    Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD).

  25. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2019-09-09 Genetics

    Mitochondria vary in morphology and function in different tissues; however, little is known about their molecular diversity among cell types.

  26. Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": implications for retinal structure and eye functions

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Canadian journal of physiology and pharmacology 2019-08-01 Brain scans and imaging

    Homocysteine (Hcy), a sulfur-containing nonproteinogenic amino acid, is generated as a metabolic intermediate.

  27. Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecules (Basel, Switzerland) 2019-04-22 Disease mechanisms

    Oxidative stress is proposed as a regulatory element in ageing and various neurological disorders.

  28. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2019-02-11 Inflammation and the immune system

    Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer's disease (AD).

  29. NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Redox biology 2018-11-28 Vascular contributions

    Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling.

  30. Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2018-11-27 Biomarkers

    Cognitive decline and memory impairment induced by oxidative brain damage are the critical pathological hallmarks of Alzheimer's disease (AD).

  31. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Chemical reviews 2018-08-10 Disparities

    Neurodegenerative diseases pose a substantial socioeconomic burden on society.

  32. Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2018-06-08 Risk factors

    The incidences of presbycusis and dementia are high among geriatric diseases.

  33. NAD + supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2018-02-05 Disease mechanisms

    Emerging findings suggest that compromised cellular bioenergetics and DNA repair contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining pathology is unclear.

  34. Mitochondria and Mitochondrial Cascades in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2018-01-01 Disease mechanisms

    Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ from those of non-AD individuals.

  35. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature 2017-12-06 Disease mechanisms

    Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-β peptide.

  36. Oxidative stress and the amyloid beta peptide in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Redox biology 2017-10-18 Disease mechanisms

    Oxidative stress is known to play an important role in the pathogenesis of a number of diseases.

  37. Resveratrol for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Annals of the New York Academy of Sciences 2017-08-16 Clinical trials

    The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's disease (AD).

  38. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Oxidative medicine and cellular longevity 2017-07-12 Disease mechanisms

    Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative disorders.

  39. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Redox Biology 2017-07-04 Genetics

    Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease.

  40. Targeting Free Radicals in Oxidative Stress-Related Human Diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Trends in pharmacological sciences 2017-05-24 Disease mechanisms

    Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological mechanisms, (ii) an inverse correlation between their incidences, and (iii) oxidative stress being a common denominator of both diseases.

  41. Brain metabolism in health, aging, and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The EMBO journal 2017-04-24 Disease mechanisms

    Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing activity in neuronal circuits, and from environmental energetic stressors such as food deprivation and physical exertion.

  42. Parkinson's Disease: From Pathogenesis to Pharmacogenomics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2017-03-04 Risk factors

    Parkinson's disease (PD) is the second most important age-related neurodegenerative disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from 41 per 100,000 in the fourth decade of life to over 1900 per 100,000 in people over 80 years of age.

  43. Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Trends in neurosciences 2017-02-09 Disease mechanisms

    Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (Aβ) and Tau pathologies.

  44. Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Progress in molecular biology and translational science 2017-02-04 Risk factors

    Alzheimer's disease (AD) is characterized by cognitive dysfunction and progressive neurodegeneration.

  45. Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Redox biology 2017-02-01 Inflammation and the immune system

    Synaptic loss and neuron death are the underlying cause of neurodegenerative diseases such as Alzheimer's disease (AD); however, the modalities of cell death in those diseases remain unclear.

  46. Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Disease mechanisms

    Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure.

  47. Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Free radical biology & medicine 2016-11-29 Prevention trials

    An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses.

  48. Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurological research 2016-11-03 Risk factors

    Reactive species play an important role in physiological functions.

  49. Oxidative Stress and the Central Nervous System

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The Journal of pharmacology and experimental therapeutics 2016-10-17 Risk factors

    Biochemical integrity of the brain is vital for normal functioning of the central nervous system (CNS).

  50. Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biochimica et biophysica acta. Molecular basis of disease 2016-06-21 Risk factors

    Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes, obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases (NDDs).

From across this tag

7 of the 275 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts