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Home › Research › Topics › oxidative

oxidative

275 studies tagged oxidative, dated 1989-01-01 to 2026-10-23. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Pantethine and Neurodegeneration: A Coenzyme A-Centered Framework Linking Metabolism, Neuroinflammation, and Mitochondrial Dysfunction 2026-10-23
  2. BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function 2026-10-20
  3. Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster 2026-10-19

Studies

275 studies carry this tag.

Date range

1989 to 2026

Top journals

  • The Journal of neuroscience : the official journal of the Society for Neuroscience 9
  • Free radical biology & medicine 8
  • Redox biology 8
  • Proceedings of the National Academy of Sciences of the United States of America 7
  • Biochimica et biophysica acta 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Pantethine and Neurodegeneration: A Coenzyme A-Centered Framework Linking Metabolism, Neuroinflammation, and Mitochondrial Dysfunction

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-10-23 Inflammation and the immune system

    Neurodegenerative diseases are a growing global health burden associated with aging and characterized by progressive neuronal dysfunction, metabolic failure, mitochondrial impairment, oxidative stress, and chronic neuroinflammation.

  2. BNIP3L/NIX-mediated mitophagy limits Alzheimer’s disease pathology and preserves neuronal function

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-20 Disease mechanisms

    Defective mitophagy is emerging as a key contributor to Alzheimer’s disease (AD), but the neuronal pathways governing mitochondrial clearance and their contribution to disease progression remain poorly understood.

  3. Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-19 Disease mechanisms

    Mitochondrial dysfunction is a shared biological thread between terrestrial Alzheimer’s disease (AD) and in the unique stress environment of spaceflight, making mitochondrial pathophysiology a compelling target for comparative investigation.

  4. Constraint Based Metabolic Modeling Identifies Robust Biomarkers and Therapeutic Target Combinations in Alzheimer Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-15 Prevention and risk

    Alzheimer’s disease (AD) involves widespread metabolic, mitochondrial, inflammatory, and redox dysfunction.

  5. PDE4D inhibition activates cAMP-PKA signaling to preserve mitochondrial homeostasis and prevent neuronal necroptosis in Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-12 Disease mechanisms

    Alzheimer’s disease involves progressive necroptosis of neurons, and the associated cognitive deficits can be mitigated by inhibiting cAMP-degrading phosphodiesterase 4D (PDE4D).

  6. MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-09 TREM2 and immune genetics

    These data further support the use of the LOAD2.Mthfr 677C>T mouse model to study aspects of ADRD such as cerebrovascular compromise.

  7. Spermine inhibits ferroptosis in vascular dementia rats by intervening Nrf2/SLC7A11/GPX4 expression in chondriosome

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-09 Vascular contributions

    Spermine exerts neuroprotective effects in VaD by inhibiting TRPM2-mediated oxidative stress and activating the Nrf2/SLC7A11/GPX4 pathway, thereby suppressing ferroptosis.

  8. Neuroprotective Role of Vitamin D Against LPS-Induced Cognitive Deficits in Rats: Targeting Hippocampal PERK-ATF4-CHOP-Mediated ER Stress and Calcium Dyshomeostasis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-08 Biomarkers

    Although endoplasmic reticulum (ER) stress and maladaptive unfolded protein response (UPR) are increasingly implicated in Alzheimer’s disease (AD), the influence of vitamin D (VitD) on these mechanisms remains unclear.

  9. Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-06 Risk genes beyond APOE

    Traumatic brain injury (TBI) is a risk factor for Alzheimer’s disease (AD), and both conditions are associated with impaired glucose metabolism and mitochondrial dysfunction.

  10. Apigenin Improves Healthspan and Protects Against Alzheimer’s Disease-Associated Proteotoxicity in C. elegans

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-29 Disease mechanisms

    Apigenin is an abundant, bioactive phytochemical with reported therapeutic potential and neuroprotective effects in a variety of age-related disease models.

  11. Mitochondrial DNA copy number in neurodegenerative diseases: a global meta-analysis of 156 comparisons across 76 studies

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-29 How common it is

    Consequently, changes in mitochondrial DNA copy number (mtDNA-CN), the number of mtDNA genomes per cell or tissue sample, are associated with diseases ranging from cancer and obesity to psoriasis and all-cause mortality.

  12. Low-dose lithium prevents age-dependent metabolic stress–driven alzheimer’s disease–like pathology through restoration of the NAMPT–NAD⁺–SIRT1–AMPK–TFEB metabolic resilience network

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-08-26 Drug development

    These findings identify an age-dependent breakdown of the metabolic resilience network formed by NAMPT, NAD⁺, SIRT1, and AMPK as a key mechanistic driver of metabolic stress-induced early AD-like pathology.

  13. Autophagy Stimulation by Intermittent Fasting and Its Potential Neuroprotective Role in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-08-24 Risk factors

    Alzheimer’s disease (AD) is characterised by progressive accumulation of misfolded proteins and failure of cellular clearance pathways, particularly the autophagy–lysosomal system.

  14. High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-08-19 Risk factors

    Transactive response DNA-binding protein 43 (TDP-43) aggregation and loss of function are hallmark features of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) among other neurodegenerative diseases.

  15. Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Medical gas research 2026-08-03 Disease mechanisms

    Cardiovascular disease and cognitive loss have a neurocardiac basis.

  16. Senescence in Aging and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging and disease 2025-11-25 Disease mechanisms

    Cellular senescence, once considered a protective mechanism against oncogenesis, is now recognized as a key driver of aging and age-related diseases, including Alzheimer's disease (AD).

  17. AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. CNS neuroscience & therapeutics 2025-11-01 Drug development

    The AMPK/SIRT1/PGC-1α pathway represents a cornerstone target at the intersection of metabolism, aging, and disease.

  18. Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia (New York, N. Y.) 2025-10-07 Biomarkers

    As expected, males had higher lean mass and VO2peak than females (p = 0.01), but groups did not differ in body mass index (p = 0.51).

  19. Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroendocrinology 2025-10-03 Drug development

    While mitochondria provide critical energy resources, mitochondrial dysfunction can lead to both metabolic and neurodegenerative disorders.

  20. Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Redox biology 2025-09-17 Inflammation and the immune system

    Microglia play a significant role in the development and progression of Alzheimer's disease (AD).

  21. SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025-07-29 Disease mechanisms

    SUMOylation, a reversible post-translational modification, regulates various mitochondrial processes, including biogenesis, dynamics, mitophagy, and the mitochondrial unfolded protein response.

  22. The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2025-03-27 Biomarkers

    Traumatic brain injury (TBI) is a major risk factor for neurodegenerative diseases, including Alzheimer's disease (AD), yet the mechanistic link remains unclear.

  23. Cerebral ischemic injury impairs autophagy and exacerbates cognitive impairment in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. International immunopharmacology 2024-11-12 Disease mechanisms

    Autophagy plays a pivotal role in the pathogenesis and progression of Alzheimer's disease (AD).

  24. A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Redox biology 2024-11-06 Drug development

    Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by memory loss, speech and motor defects, personality changes, and psychological disorders.

  25. Oxidative stress-mediated neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Naunyn-Schmiedeberg's archives of pharmacology 2024-06-04 Inflammation and the immune system

    Reactive oxygen species (ROS) are metabolic by-products that constitute an indispensable component of physiological processes, albeit their heightened presence may proffer substantial perils to biological entities.

  26. Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. International journal of molecular medicine 2024-04-05 Inflammation and the immune system

    Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders.

  27. Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2024-01-18 Drug development

    Considering these results, combination of mitochondria-targeted compounds with other anti-amyloid beta or anti-tau therapies hold promise as neuroprotective drugs for the prevention and/or treatment of AD.

  28. Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of cellular biochemistry 2024-01-17 Drug development

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective cure.

  29. Oxidative stress in Alzheimer's disease: current knowledge of signaling pathways and therapeutics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular biology reports 2024-01-02 Treatments

    Alzheimer's disease's pathophysiology is still a conundrum.

  30. Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2023-12-14 Treatments

    Amyloid beta (Aβ) deposition within the brain vasculature is an early hallmark of Alzheimer's disease (AD), which triggers loss of brain vascular smooth muscle cells (BVSMCs) in cerebral arteries, via poorly understood mechanisms, altering cerebral blood flow, brain waste clearance, and promoting cognitive impairment.

  31. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of toxicology 2023-08-19 Risk factors

    Increased levels of ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result in a harmful condition termed oxidative stress ("bad stress").

  32. Mitochondria: It is all about energy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in physiology 2023-04-25 Disease mechanisms

    Mitochondria play a key role in both health and disease.

  33. Therapeutic targeting of mitochondria-proteostasis axis by antioxidant polysaccharides in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Advances in protein chemistry and structural biology 2023-03-21 Disease mechanisms

    Aging is a major risk factor for many age-associated disorders, including neurodegenerative diseases.

  34. Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cell and developmental biology 2023-03-10 Disease mechanisms

    The disturbance in mitochondrial functions and homeostasis are the major features of neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis, and Alzheimer's disease, along with protein misfolding.

  35. Molecular mechanisms of ferroptosis and their involvement in brain diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Pharmacology & therapeutics 2023-03-08 Drug development

    Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion, nicotinamide adenine dinucleotide phosphate oxidation and lipid peroxidation.

  36. Vitamin D and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Heliyon 2023-01-12 Prevention and risk

    Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present.

  37. Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Redox biology 2023-01-10 Disease mechanisms

    Oxidative stress, a state of disrupted redox signaling, reactive oxygen species (ROS) overproduction, and oxidative cell damage, accompanies numerous brain pathologies, including aging-related dementia and Alzheimer's disease, the most common neurodegenerative disorder of the elderly population.

  38. Essential metals in health and disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Chemico-biological interactions 2022-09-22 Risk factors

    In total, twenty elements appear to be essential for the correct functioning of the human body, half of which are metals and half are non-metals.

  39. An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. International journal of molecular sciences 2022-05-25 Inflammation and the immune system

    Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders.

  40. A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2022-05-20 Genetics

    Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments.

  41. Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Ageing research reviews 2022-04-05 Disease mechanisms

    As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering to their families and causes a heavy socioeconomic burden to society.

  42. Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of immunology research 2022-03-23 Risk factors

    Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) and other toxic substances.

  43. The interplay between oxidative stress and autophagy: focus on the development of neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Behavioral and brain functions : BBF 2022-01-29 Disease mechanisms

    Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter.

  44. Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in physiology 2022-01-11 Disease mechanisms

    Astrocytes play key roles in the regulation of brain energy metabolism, which has a major impact on brain functions, including memory, neuroprotection, resistance to oxidative stress and homeostatic tone.

  45. Mitophagy in aging and longevity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. IUBMB life 2021-12-10 Disease mechanisms

    The clearance of damaged or unwanted mitochondria by autophagy (also known as mitophagy) is a mitochondrial quality control mechanism postulated to play an essential role in cellular homeostasis, metabolism, and development and confers protection against a wide range of diseases.

  46. Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Annals of medicine 2021-12 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system.

  47. NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2021-09-14 Inflammation and the immune system

    Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder.

  48. Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Toxics 2021-08-27 Risk factors

    Environmental exposure to neurotoxic metals and metalloids such as arsenic, cadmium, lead, mercury, or manganese is a global health concern affecting millions of people worldwide.

  49. Emerging roles of oxidative stress in brain aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging 2021-07-25 Prevention trials

    Reactive oxygen species (ROS) are metabolic byproducts that are necessary for physiological function but can be toxic at high levels.

  50. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature reviews. Drug discovery 2021-06-30 Disease mechanisms

    Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer.

From across this tag

9 of the 275 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts