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Newest in this topic

  1. Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
  2. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
  3. Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01

Studies

492 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Neurology 38
  • Biological psychiatry 36
  • NeuroImage 32
  • The American journal of psychiatry 22
  • Proceedings of the National Academy of Sciences of the United States of America 20

148 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neuropsychologia 2004-01-01 Hippocampus size on brain scans

    Poor memory ability and small hippocampal volume measurements in magnetic resonance images co-occur in neurological patients.

  2. Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-01-01 Mild cognitive impairment

    Lesions in the hippocampus (HC), the entorhinal cortex (EC), and the prefrontal cortex (PFC) are associated with impairment of episodic memory; reduced HC volume is linked to memory declines in dementia; and decline in EC volume predicts progression from mild cognitive impairment to dementia.

  3. Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The European journal of neuroscience 2004-01-01 Hippocampus size on brain scans

    Acute stress suppresses new cell birth in the hippocampus in several species.

  4. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of general psychiatry 2003-12-01 Hippocampus size on brain scans

    These results suggest that BD is associated with decreased volumes of medial temporal lobe structures, with greater effect sizes in the amygdala than in the hippocampus.

  5. The aging hippocampus: cognitive, biochemical and structural findings

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cerebral cortex (New York, N.Y. : 1991) 2003-12-01 Hippocampus size on brain scans

    Aging is often accompanied by learning and memory problems, many of which resemble deficits associated with hippocampal damage.

  6. Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2003-11-01 Hippocampus size on brain scans

    These findings indicate that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner.

  7. Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. NeuroImage 2003-10-01 Hippocampus size on brain scans

    Rates of hippocampal volume loss have been shown to distinguish subjects with dementia of the Alzheimer type (DAT) from nondemented controls.

  8. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Biological psychiatry 2003-10-01 Hippocampus size on brain scans

    These findings suggest that long-term treatment with paroxetine is associated with improvement of verbal declarative memory deficits and an increase in hippocampal volume in PTSD.

  9. A longitudinal study of brain morphometrics using quantitative magnetic resonance imaging and difference image analysis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. NeuroImage 2003-09-01 Hippocampus size on brain scans

    Serial quantitative magnetic resonance imaging (MRI) allows the detection of subtle volumetric changes in brain volume.

  10. Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology 2003-08-22 Hippocampus size on brain scans

    Our recently published data on children investigated within 5 days of a PFC showed that children investigated by MRI within 48 h of a PFC had large hippocampal volumes and prolongation of T2 relaxation time.

  11. Untreated depression and hippocampal volume loss

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 2003-08-01 Hippocampus size on brain scans

    Antidepressants may have a neuroprotective effect during depression.

  12. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-07-09 Hippocampus size on brain scans

    MRI studies using the manual tracing method have shown a smaller-than-normal hippocampal volume in patients with posttraumatic stress disorder (PTSD).

  13. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 2003-05-01 Hippocampus size on brain scans

    These results are consistent with deficits in hippocampal function and structure in abuse-related PTSD.

  14. Temporal lobe regions engaged during normal speech comprehension

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2003-05-01 Digital health tools

    Processing of speech is obligatory. Thus, during normal speech comprehension, the listener is aware of the overall meaning of the speaker's utterance without the need to direct attention to individual linguistic and paralinguistic (intonational, prosodic, etc.) features contained within the speech signal.

  15. Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Psychiatry research 2003-04-01 Hippocampus size on brain scans

    Borderline personality disorder (BPD) is a common disorder associated with emotional dysregulation and other symptoms that have been hypothesized to be related to dysfunction of limbic brain areas including hippocampus and amygdala.

  16. Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2003-03-01 Hippocampus size on brain scans

    Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred.

  17. PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 2003-03-01 Hippocampus size on brain scans

    These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci.

  18. Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of Alzheimer's disease : JAD 2003-02-01 Mild cognitive impairment

    Several recent studies indicate that activity of cholinergic enzymes in the cortex of people with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) are preserved.

  19. Course of illness, hippocampal function, and hippocampal volume in major depression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-01-24 Hippocampus size on brain scans

    Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes.

  20. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-01-24 Hippocampus size on brain scans

    High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease.

  21. High-dimensional mapping of the hippocampus in depression

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The American journal of psychiatry 2003-01-01 Hippocampus size on brain scans

    Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume.

  22. Homocysteine and brain atrophy on MRI of non-demented elderly

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2003-01-01 Hippocampus size on brain scans

    Patients with Alzheimer's disease have higher plasma homocysteine levels than controls, but it is uncertain whether higher plasma homocysteine levels are involved in the early pathogenesis of the disease.

  23. Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of child and adolescent psychopharmacology 2003-01-01 Hippocampus size on brain scans

    These results suggest that alterations in amygdala:hippocampal volume ratios in pediatric MDD may more reflect severity of associated anxiety than depression.

  24. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2003-01-01 Hippocampus size on brain scans

    The consistency of MRI measurements obtained across sites, and the consistency between the multisite milameline data and that obtained in prior single-site studies, demonstrate the technical feasibility of using structural MRI measures as a surrogate endpoint of disease progression in therapeutic trials.

  25. Navigation expertise and the human hippocampus: a structural brain imaging analysis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Hippocampus 2003-01-01 Hippocampus size on brain scans

    Grey matter volume in the posterior hippocampus of London taxi drivers is greater than in age-matched controls, and the size of this increase correlates positively with time spent taxi driving (E.A.

  26. Childhood trauma associated with smaller hippocampal volume in women with major depression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 2002-12-01 Hippocampus size on brain scans

    A smaller hippocampal volume in adult women with major depressive disorder was observed exclusively in those who had a history of severe and prolonged physical and/or sexual abuse in childhood.

  27. Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 2002-12-01 Hippocampus size on brain scans

    Schizophrenia is associated with structural deformities of the hippocampus, which suggest a disturbance of the connections between the hippocampus and the frontal cortex.

  28. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature neuroscience 2002-11-01 Hippocampus size on brain scans

    In animals, exposure to severe stress can damage the hippocampus.

  29. Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of magnetic resonance imaging : JMRI 2002-09-01 Hippocampus size on brain scans

    Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in studies of aging and dementia.

  30. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The American journal of psychiatry 2002-09-01 Hippocampus size on brain scans

    These findings suggest that in patients with schizophrenia spectrum disorders, hippocampal volume is influenced in part by schizophrenia susceptibility genes and an interaction of these genes with fetal hypoxia.

  31. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of general psychiatry 2002-09-01 Hippocampus size on brain scans

    Compared with controls, relatives, particularly from multiplex families, had significantly smaller left hippocampi.

  32. Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2002-09-01 Hippocampus size on brain scans

    Hippocampal volume may index disease severity and predict progression in AD.

  33. Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of psychiatry 2002-08-01 Hippocampus size on brain scans

    These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness.

  34. Neuroimaging findings in post-traumatic stress disorder. Systematic review

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. The British journal of psychiatry : the journal of mental science 2002-08-01 Hippocampus size on brain scans

    Evidence from neuroimaging studies has suggested areas of the brain that may be damaged by psychological trauma.

  35. Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2002-07-01 Hippocampus size on brain scans

    Our results replicate previous findings of reduced hippocampal volume in PTSD but also suggest independent, generalized, white matter atrophy.

  36. The hippocampus and depression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European psychiatry : the journal of the Association of European Psychiatrists 2002-07-01 Hippocampus size on brain scans

    The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies.

  37. Hippocampal neurons in schizophrenia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2002-05-01 Hippocampus size on brain scans

    The hippocampus is crucial for normal brain function, especially for the encoding and retrieval of multimodal sensory information.

  38. Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 2002-05-01 Brain scans and imaging

    Postmortem MRI scans were obtained for the first 56 participants of the Nun Study who were scanned.

  39. Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Annals of neurology 2002-05-01 Hippocampus size on brain scans

    This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years.

  40. Stress and depression: possible links to neuron death in the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Bipolar disorders 2002-04-01 Hippocampus size on brain scans

    Recent intriguing reports have shown an association between major depression and selective and persistent loss of hippocampal volume, prompting considerable speculation as to its underlying causes.

  41. Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2002-02-26 Hippocampus size on brain scans

    Longitudinally oriented axon collaterals of CA3 pyramidal cells may be critical for integrating distributed information in the hippocampus.

  42. Effects of chronic epilepsy on intellectual functions

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Progress in brain research 2002-01-01 Hippocampus size on brain scans

    Intractable epilepsy is related to various transient and chronic brain electric and neurochemical disturbances.

  43. Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 2002-01-01 Hippocampus size on brain scans

    The results confirmed the correlation between hippocampal volumes and neuron cell counts.

  44. The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Progress in brain research 2002-01-01 Hippocampus size on brain scans

    The purpose of this study is to explore the possibility of progressive neuropsychological decline in chronic temporal lobe epilepsy (TLE) and determine how this vulnerability may be associated with the neurodevelopmental impact of the disorder. 53 patients with TLE and 62 healthy controls underwent quantitative MRI volumetric imaging of total brain tissue and hippocampal volumes as well as assessment of intelligence and memory function.

  45. Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2001-12-01 Hippocampus size on brain scans

    Frontal lobe abnormalities may occur as a result of PTSD in children or, alternatively, be a risk factor for the development of the syndrome in this age group.

  46. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biological psychiatry 2001-12-01 Hippocampus size on brain scans

    N-acetyl asparate and creatine reductions imply that there are hippocampal abnormalities in posttraumatic stress disorder.

  47. Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurology 2001-12-01 Hippocampus size on brain scans

    The presence of a single APOE-epsilon4 allele is associated with an increased rate of hippocampal volume loss in healthy women in their sixth decade of life that is not related to any detectable memory changes.

  48. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The European journal of neuroscience 2001-11-01 Hippocampus size on brain scans

    In major depression, decreased hippocampal volume has been attributed to hypercortisolemia, a frequent sign of the disorder, because in animals an excess of corticosteroids has led to dendritic atrophy, astrogliosis and loss of neurons in this brain region.

  49. Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2001-11-01 Hippocampus size on brain scans

    Epilepsy is a common outcome of traumatic brain injury (TBI), but the mechanisms of posttraumatic epileptogenesis are poorly understood.

  50. Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Psychiatry research 2001-11-01 Hippocampus size on brain scans

    The present study measured prefrontal cortical gray and white matter volume in chronic, male schizophrenic subjects who were characterized by a higher proportion of mixed or negative symptoms than previous patients that we have evaluated.

From across this tag

10 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts