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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. 100 years of Lewy pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neurology 2012-11-27 Brain tissue and pathology

    In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot.

  2. Structures of human acetylcholinesterase in complex with pharmacologically important ligands

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of medicinal chemistry 2012-11-12 Treatments

    Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs.

  3. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of medicinal chemistry 2012-10-08 Down syndrome and Alzheimer's

    DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's disease and Down syndrome.

  4. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012-10-04 Biomarkers

    The accumulation of aggregated amyloid-β (Aβ) in amyloid plaques is a neuropathological hallmark of Alzheimer's disease (AD).

  5. Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2012-09-04 Biomarkers

    Alzheimer's disease (AD) is characterized by the presence of toxic protein aggregates or plaques composed of the amyloid β (Aβ) peptide.

  6. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Science translational medicine 2012-09-01 Tau biomarkers

    Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of Alzheimer's disease (AD).

  7. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Future medicinal chemistry 2012-09-01 Drug development

    Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia, affecting more than 5.4 million people in the USA.

  8. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. British journal of pharmacology 2012-09-01 Treatments

    β-amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying Alzheimer's disease (AD), although there is presently lively debate regarding the relative roles of particular species/forms of this peptide.

  9. Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. ACS chemical neuroscience 2012-08-28 Down syndrome and Alzheimer's

    With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020, dementia is currently a leading unmet medical need and costly burden on public health.

  10. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2012-08-06 Risk genes beyond APOE

    In light of the rising prevalence of Alzheimer's disease (AD), new strategies to prevent, halt, and reverse this condition are needed urgently.

  11. Biochemistry and cell biology of tau protein in neurofibrillary degeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cold Spring Harbor perspectives in medicine 2012-07-01 Disease mechanisms

    Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms.

  12. Mitochondrial dysfunction in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of pharmacology and experimental therapeutics 2012-06-13 Disease mechanisms

    Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes.

  13. Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cold Spring Harbor perspectives in medicine 2012-06-01 Treatments

    Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving memory and cognition is an invariant and defining feature of Alzheimer disease.

  14. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2012-05-01 Drug development

    Recent data indicate that Tau immunotherapy may be relevant for interfering with neurofibrillary degeneration in Alzheimer disease and related disorders referred to as Tauopathies.

  15. Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 2012-04-14 Biomarkers

    Alzheimer's disease (AD) is the most frequent cause of dementia.

  16. A human stem cell model of early Alzheimer's disease pathology in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Science translational medicine 2012-02-15 Down syndrome and Alzheimer's

    Human cellular models of Alzheimer's disease (AD) pathogenesis would enable the investigation of candidate pathogenic mechanisms in AD and the testing and developing of new therapeutic strategies.

  17. Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2012-01-01 Treatments

    The amyloid-β lowering capacity of anti-Aβ antibodies has been demonstrated in transgenic models of Alzheimer's disease (AD) and in AD patients.

  18. Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2012-01-01 Treatments

    Curcumin, a natural polyphenolic pigment present in the spice turmeric (Curcuma longa), is known to possess a pleiotropic activity such as antioxidant, anti-inflammatory, and anti-amyloid-β activities.

  19. Neurological phenotypes for Down syndrome across the life span

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in brain research 2012-01-01 Digital health tools

    This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging.

  20. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature structural & molecular biology 2011-12-18 Genetics

    In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease.

  21. Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2011-12-08 Biomarkers

    The β-amyloid peptide (Aβ) is directly related to neurotoxicity in Alzheimer disease (AD).

  22. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2011-09-30 Biomarkers

    The amyloid β-peptide (Aβ), strongly implicated in the pathogenesis of Alzheimer's disease (AD), is produced from the amyloid β-protein precursor (APP) through consecutive proteolysis by β- and γ-secretases.

  23. Modeling familial Alzheimer's disease with induced pluripotent stem cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human Molecular Genetics 2011-09-07 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most common form of age-related dementia, characterized by progressive memory loss and cognitive disturbance.

  24. Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2011-09-01 Risk factors

    Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the inducible nitric oxide synthase (NOS2) resulting in increased NO production.

  25. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-08-25 Disease mechanisms

    Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in Alzheimer's disease (AD).

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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