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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Autophagy and apoptosis dysfunction in neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2013-11-06 Disease mechanisms

    Autophagy and apoptosis are basic physiologic processes contributing to the maintenance of cellular homeostasis.

  2. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2013-10-07 Biomarkers

    Age-related cognitive decline is accompanied by an increase of neuronal apoptosis and a dysregulation of neuroplasticity-related molecules such as brain-derived neurotrophic factor and neurotoxic factors including beta amyloid (Aβ) peptide.

  3. Psychosis in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2013-10-06 Genetics

    Psychotic symptoms, delusions and hallucinations, occur in approximately 50% of individuals with Alzheimer's disease (AD) (AD with psychosis [AD + P]).

  4. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2013-09-26 Drug development

    Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and many other disorders collectively termed tauopathies. trans-cellular propagation of tau pathology, mediated by extracellular tau aggregates, may underlie pathogenesis of these conditions.

  5. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2013-09-01 Disease mechanisms

    Soluble amyloid-β oligomers (Aβo) trigger Alzheimer's disease (AD) pathophysiology and bind with high affinity to cellular prion protein (PrP(C)).

  6. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013-07-15 Brain scans and imaging

    (18)F-labeled THK-5105 and THK-5117 are promising candidates as PET tau imaging radiotracers.

  7. Antisense reduction of tau in adult mice protects against seizures

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013-07-01 Drug development

    Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hyperexcitability.

  8. Distinct α-synuclein strains differentially promote tau inclusions in neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 2013-07-01 Brain tissue and pathology

    Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease and Lewy bodies composed of α-synuclein in Parkinson's disease.

  9. Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of molecular biology 2013-06-25 Biomarkers

    Amyloid β (Aβ) peptides are a primary component of fibrils and oligomers implicated in the etiology of Alzheimer's disease (AD).

  10. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2013-06-17 Risk factors

    Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer's disease (AD).

  11. Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Chemical Society 2013-06-04 Genetics

    The top-down approach to proteomics offers compelling advantages due to the potential to provide complete characterization of protein sequence and post-translational modifications.

  12. Ascending monoaminergic systems alterations in Alzheimer's disease. translating basic science into clinical care

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience and biobehavioral reviews 2013-05-24 Genetics

    Extensive neuropathological studies have established a compelling link between abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems and the pathophysiology of Alzheimer's disease (AD).

  13. Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2013-04-30 Down syndrome and Alzheimer's

    In addition to intellectual disability, individuals with Down syndrome (DS) exhibit dementia by the third or fourth decade of life, due to the early onset of neuropathological changes typical of Alzheimer's disease (AD).

  14. Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2013-04-29 Biomarkers

    Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most common cause of elderly dementia.

  15. Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2013-04-26 Biomarkers

    The "amyloid-β (Aβ) hypothesis" posits that accumulating Aβ peptides (Aβs) produced by neurons cause Alzheimer's disease (AD).

  16. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2013-04-18 Down syndrome and Alzheimer's

    DS is the most frequent genetic cause of intellectual disability characterized by the anomalous presence of three copies of chromosome 21.

  17. The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in pharmacological sciences 2013-04-10 Treatments

    Soluble Aβ oligomers are now widely recognized as key pathogenic structures in Alzheimer's disease.

  18. Alpha‐synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Movement Disorders 2013-03-01 Brain tissue and pathology

    The variant was not observed in public databases or identified in unrelated subjects.

  19. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell stem cell 2013-02-21 Risk genes beyond APOE

    Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear.

  20. Wnt/β-catenin signalling: from plasma membrane to nucleus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Biochemical journal 2013-02-01 Genetics

    Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue homoeostasis in adults.

  21. GDNF, NGF and BDNF as therapeutic options for neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology & therapeutics 2013-01-21 Vascular contributions

    Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain.

  22. The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2013-01-01 Drug development

    The aim of this study was to investigate the effect of liraglutide on Alzheimer-like learning and memory impairment in mice, which were intracerebroventricularly (i.c.v.) injected with streptozotocin (STZ).

  23. Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of psychiatry & neuroscience : JPN 2013-01-01 Treatments

    Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and postmortem by neuritic plaques containing amyloid ß peptide and neurofibrillary tangles containing phospho-tau protein.

  24. GSK3 and tau: two convergence points in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2013-01-01 Drug development

    Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed serine/threonine kinase that plays a key role in the pathogenesis of Alzheimer's disease (AD).

  25. Maturation of autophagosomes and endosomes: a key role for Rab7

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2012-12-05 Brain scans and imaging

    Macroautophagy is an important route in cellular maintenance, in the breakdown and reuse of intracellular materials.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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