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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurodegeneration 2021-01-31 Treatments

    We identify Clu as an astrocyte-derived synaptogenic and anti-amyloid factor; the combination of these activities may influence the progression of late-onset AD.

  2. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of biological chemistry 2021-01-12 Biomarkers

    Production of amyloid β-protein (Aβ) is carried out by the membrane-embedded γ-secretase complex.

  3. Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. International Journal of Biological Sciences 2021-01-01 Inflammation and the immune system

    Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins in AD has been extensively studied.

  4. Current Clinical Applications of In Vivo Gene Therapy with AAVs

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular therapy : the journal of the American Society of Gene Therapy 2020-12-10 Brain scans and imaging

    Hereditary diseases are caused by mutations in genes, and more than 7,000 rare diseases affect over 30 million Americans.

  5. Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2020-09-08 Treatments

    The repeated failures of amyloid-targeting therapies have challenged our narrow understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging investigations into the underlying mechanisms of disease.

  6. Structures of α-synuclein filaments from multiple system atrophy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature 2020-05-27 Brain tissue and pathology

    Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human neurodegenerative diseases 1 .

  7. Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuro-degenerative diseases 2019-07-02 Tau biomarkers

    CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET.

  8. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Science (New York, N.Y.) 2019-01-24 Tau biomarkers

    The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD).

  9. A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of labelled compounds & radiopharmaceuticals 2018-12-19 Brain scans and imaging

    [18 F]MK-6240 (6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective PET radiotracer for the in vivo imaging of neurofibrillary tangles (NFTs). [18 F]MK-6240 was synthesized in one step from its bis-Boc protected precursor N-[(tert-butoxy)carbonyl]-N-(6-nitro-3-[1H-pyrrolo[2,3-c]pyridin-1-yl]isoquinolin-5-yl) carbamate in DMSO using [18 F] fluoride with TEA HCO3 with step-wise heating up to 150°C, resulting in an isolated radiochemical yield of 9.8% ± 1.8% (n = 3) calculated from the end of bombardment (5.2% ± 1.0% calculated from the end of synthesis).

  10. Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (New York, N. Y.) 2018-10-14 Drug development

    The antibody C10.2 bound specifically to pS396-tau with an IC50 of 104 pM and detected preferentially hyperphosphorylated tau aggregates from AD brain with an IC50 of 1.2 nM.

  11. Mechanism of NMDA receptor channel block by MK-801 and memantine

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature 2018-04-18 Treatments

    The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 .

  12. Roles of tau protein in health and disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2017-04-06 Disease mechanisms

    Tau is well established as a microtubule-associated protein in neurons.

  13. Pathogenic PS1 phosphorylation at Ser367

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. eLife 2017-01-30 Biomarkers

    The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its 'phosphorylated' and 'dephosphorylated' states.

  14. Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-09-28 Brain scans and imaging

    3H-PIB, 3H-florbetaben, 3H-AZD2184, and BTA-1 shared a high- and a varying low-affinity binding site in the frontal cortex of sporadic AD.

  15. Sampling the conformational space of the catalytic subunit of human γ-secretase

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. eLife 2015-12-01 Risk genes beyond APOE

    Human γ-secretase is an intra-membrane protease that cleaves many different substrates.

  16. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2015-07-21 Down syndrome and Alzheimer's

    β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated in Alzheimer's disease (AD).

  17. A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell Reports 2014-10-24 Disease mechanisms

    Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity.

  18. PICALM modulates autophagy activity and tau accumulation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature communications 2014-09-22 Genetics

    Genome-wide association studies have identified several loci associated with Alzheimer's disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly protein).

  19. Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2013-08-11 Disease mechanisms

    Expression of long-lasting synaptic plasticity and long-term memory requires protein synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α-subunit (eIF2α).

  20. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta Neuropathologica 2013-04-18 Brain tissue and pathology

    In neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases, deposits of aggregated disease-specific proteins are found.

  21. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2013-03-24 Disease mechanisms

    We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice.

  22. Structural and functional characterization of two alpha-synuclein strains

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature communications 2013-01-01 Brain tissue and pathology

    α-Synuclein aggregation is implicated in a variety of diseases including Parkinson's disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy.

  23. Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2012-07-22 Disease mechanisms

    Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer's disease pathophysiology.

  24. Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2011-10-28 Drug development

    In sporadic Alzheimer's disease (AD), neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau.

  25. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature Communications 2011-08-23 Brain tissue and pathology

    A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study.

From across this topic

9 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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