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MHC class II-positive microglia in human brain: association with Alzheimer lesions
Perlmutter LS, Scott SA, Barrón E, Chui HC.. Journal of neuroscience research, 1992-12-01
Topic: Amyloid, tau and blood-test diagnosis
Cells of the mononuclear phagocytic system (MPS) present foreign antigen on their cell surfaces bound to major histocompatibility complex (MHC) class II molecules. Previous studies of normal human brain samples reported MHC class II expression primarily by perivascular MPS cells and white matter microglial cells. Marked increases in MHC class II-expressing microglia have been shown in many neuropathologic disorders, including Alzheimer's disease (AD).
Key findings
- Previous studies of normal human brain samples reported MHC class II expression primarily by perivascular MPS cells and white matter microglial cells.
- Marked increases in MHC class II-expressing microglia have been shown in many neuropathologic disorders, including Alzheimer's disease (AD).
- A close morphologic association between these cells and Alzheimer senile plaque beta-amyloid has been demonstrated.
- The present study used a mixed aldehyde fixative to enhance the localization of MHC class II-expressing MPS cells in non-AD and AD brain.
Why it matters
This study describes increased MHC class II-expressing microglia in Alzheimer's disease and a close physical association between these cells and senile plaque beta-amyloid. It is a descriptive tissue study and does not test any treatment or prevention.
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroscience research) |
| Journal's citation record | 2 / 4 | Journal of Neuroscience Research: journal h-index 222 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1992 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 231 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.4 citations a year over 36 year(s) since 1992 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Helena Chang Chui: h-index 93 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Southern California: institution h-index 1,521 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 1484388) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Perlmutter, L. S., Scott, S. A., Barrón, E., & Chui, H. C. (1992). MHC class II-positive microglia in human brain: association with Alzheimer lesions. Journal of neuroscience research. https://doi.org/10.1002/jnr.490330407
Vancouver
Perlmutter LS, Scott SA, Barrón E, Chui HC. MHC class II-positive microglia in human brain: association with Alzheimer lesions. Journal of neuroscience research. 1992. doi:10.1002/jnr.490330407. PMID: 1484388.
BibTeX
@article{perlmutter1992-1484388,
author = {Perlmutter, L. S. and Scott, S. A. and Barrón, E. and Chui, H. C.},
title = {{MHC class II-positive microglia in human brain: association with Alzheimer lesions}},
journal = {Journal of neuroscience research},
year = {1992},
doi = {10.1002/jnr.490330407},
pmid = {1484388},
url = {https://doi.org/10.1002/jnr.490330407}
}
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