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Home › Research › Topics › amyloid-beta

amyloid-beta

1,365 studies tagged amyloid-beta, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,365 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 68
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

375 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-04-01 Risk genes beyond APOE

    Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology.

  2. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. European journal of pharmacology 2004-04-01 Risk genes beyond APOE

    Nosologically, Alzheimer disease is not a single disorder in spite of a common clinical phenotype.

  3. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2004-03-01 Biomarkers

    These data support distinct processes in the initiation and progression of AD pathology within the temporal cortex: Deposition of Abeta reaches a "ceiling" early in the disease process, whereas NFT formation, synaptic loss, and gliosis continue throughout the course of the illness.

  4. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2004-03-01 How common it is

    Longitudinal clinicopathologic cohort study.

  5. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Archives of neurology 2004-03-01 Treatments

    This study questions the effect of statins on the processing of amyloid precursor protein in humans.

  6. Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Current protein & peptide science 2004-02-01 Risk genes beyond APOE

    The binding of amyloid beta peptides (Abeta) to plasma membranes appears to be a promising point of intervention in the events leading to the development of Alzheimer's disease (AD).

  7. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2004-02-01 Risk genes beyond APOE

    Amyloid precursor protein (APP), ADAM 10, and beta-site-APP cleaving enzyme (BACE) alterations were evaluated in platelets of 31 patients with Alzheimer disease (AD) and 15 age-matched controls.

  8. Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Advances in experimental medicine and biology 2004-01-01 Risk genes beyond APOE

    Alzheimer disease is not a single disorder.

  9. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2003-12-01 Risk genes beyond APOE

    Converging evidence suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD) reflects an imbalance between the production and degradation of this self-aggregating peptide.

  10. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2003-12-01 Risk genes beyond APOE

    Epidemiological studies of Alzheimer patients from a wide variety of ethnic and socioeconomic backgrounds have identified education and occupation as environmental factors that can affect the risk of developing disease.

  11. Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2003-11-01 Biomarkers

    Previously, we found that amyloid beta-protein (Abeta)1-42 exhibits neurotoxicity, while Abeta1-40 serves as an antioxidant molecule by quenching metal ions and inhibiting metal-mediated oxygen radical generation.

  12. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cancer research 2003-11-01 Risk genes beyond APOE

    Abnormal cleavage of amyloid precursor protein (APP) in the central nervous system has been linked to the development of Alzheimer's disease.

  13. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain pathology (Zurich, Switzerland) 2003-10-01 Risk genes beyond APOE

    Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls.

  14. Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2003-10-01 Biomarkers

    Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease.

  15. Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2003-09-25 Risk factors

    We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD).

  16. Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurological research 2003-09-01 Risk genes beyond APOE

    Cerebral amyloid angiopathy (CAA) is a feature of ageing and Alzheimer's disease (AD); it is also associated with intracerebral hemorrhage and stroke.

  17. Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Experimental neurology 2003-09-01 Genetics

    One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates.

  18. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2003-09-01 Biomarkers

    Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia.

  19. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2003-07-01 Risk genes beyond APOE

    Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD).

  20. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology 2003-07-01 Genetics

    Serum hypercholesterolemia may be an early risk factor for the development of AD amyloid pathology.

  21. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Neuron 2003-07-01 Laboratory science

    Researchers derived a triple-transgenic model to study the interaction between Abeta and tau and their effect on synaptic function.

  22. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Archives of neurology 2003-06-01 Genetics

    Inheritance of the APOE epsilon4 allele is associated with increased risk of late posttraumatic seizures.

  23. Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neurochemistry 2003-06-01 Risk genes beyond APOE

    Vaccination against human beta-amyloid peptide (A beta) has been shown to remove the amyloid burden produced in transgenic mice overexpressing the mutated human amyloid precursor protein (APP) gene.

  24. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain research 2003-05-01 Down syndrome and Alzheimer's

    beta-Amyloid(1-42) (A beta 42), a major component of amyloid plaques, accumulates within pyramidal neurons in the brains of individuals with Alzheimer's disease (AD) and Down syndrome.

  25. Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Archives of internal medicine 2003-05-01 Genetics

    In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD.

  26. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The British journal of nutrition 2003-04-01 Cognitive tests and assessment

    Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status.

  27. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. FEBS letters 2003-04-01 Risk genes beyond APOE

    Presenilin 1 (PS1) is a key factor for beta-amyloid (Ab) formation in Alzheimer disease (AD).

  28. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature medicine 2003-03-17 Brain tissue and pathology

    Amyloid-beta peptide (Abeta) has a key role in the pathogenesis of Alzheimer disease (AD).

  29. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2003-02-01 Genetics

    Apolipoprotein E epsilon4 led to increased risk of AD among white subjects but not black subjects.

  30. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Journal of cell biology 2003-01-06 Risk genes beyond APOE

    Formation of senile plaques containing the beta-amyloid peptide (A beta) derived from the amyloid precursor protein (APP) is an invariant feature of Alzheimer's disease (AD).

  31. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The European journal of neuroscience 2003-01-01 Risk genes beyond APOE

    Heterozygous APP23 mice, expressing human amyloid-precursor protein with the Swedish double mutation and control littermates, were subjected to behavioral and neuromotor tasks at the age of 6-8 weeks, 3 and 6 months.

  32. Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuromolecular medicine 2003-01-01 Risk genes beyond APOE

    Studies of amyloid precursor protein transgenic mice suggest that immune responses to amyloid beta peptide (Abeta) may be instrumental in the removal of plaques from the brain, but the initial clinical trial of an Abeta vaccine in patients with Alzheimer s disease (AD) was halted as the result of serious neurological complications in some patients.

  33. Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1)

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. The Journal of biological chemistry 2002-12-07 Risk genes beyond APOE

    BACE1 is a membrane-bound aspartic protease that cleaves the amyloid precursor protein (APP) at the beta-secretase site, a critical step in the Alzheimer disease pathogenesis.

  34. alpha- and beta-secretase: profound changes in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biochemical and biophysical research communications 2002-12-01 Risk genes beyond APOE

    The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of beta-amyloid (Abeta) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme beta-secretase.

  35. Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuropathology and experimental neurology 2002-12-01 Risk genes beyond APOE

    Brain trauma has been shown to be a risk factor for developing Alzheimer disease (AD), and AD-like plaques containing amyloid-beta (Abeta) peptides have been found in the brain shortly following trauma.

  36. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2002-12-01 Genetics

    The most frequent human apolipoprotein (apo) E isoforms, E3 and E4, differentially affect Alzheimer's disease (AD) risk (E4 > E3) and age of onset (E4 < E3).

  37. Serum insulin-like growth factor I regulates brain amyloid-beta levels

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature medicine 2002-11-04 Caregiving

    Levels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-beta (Abeta), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain.

  38. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurochemistry international 2002-11-01 Mild cognitive impairment

    Over the past several years, experiments with synthetic amyloid-beta peptide (Abeta) and animal models have strongly suggested that pathogenesis of Alzheimer's disease (AD) involves soluble assemblies of Abeta peptides (Trends Neurosci. 24 (2001) 219).

  39. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature medicine 2002-10-15 Risk genes beyond APOE

    To characterize antibodies produced in humans in response to Abeta42 vaccination, we carried out immunohistochemical examinations of the brains of both transgenic mice and human patients with beta-amyloid pathology.

  40. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Progress in neurobiology 2002-10-01 Brain tissue and pathology

    Alzheimer's disease (AD) is the most common form of degenerative dementia and is characterized by progressive impairment in cognitive function during mid- to late-adult life.

  41. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Archives of neurology 2002-09-01 Risk genes beyond APOE

    Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-beta protein (Abeta).

  42. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Annals of internal medicine 2002-08-01 Genetics

    The association between the apoE epsilon4 allele and Alzheimer disease does not seem to be mediated by vascular factors.

  43. Differential distribution of laminins in Alzheimer disease and normal human brain tissue

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of neuroscience research 2002-07-01 Biomarkers

    Immunocytochemistry, Western blotting, and RT-PCR were used to identify the isoforms of laminin expressed in the Alzheimer disease, but not in normal human brain tissue.

  44. Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Experimental gerontology 2002-07-01 Risk genes beyond APOE

    Active immunization with the human amyloid peptide (Abeta42) or passive immunization with anti-Abeta42 antibodies protects mice that express a mutant human amyloid precursor protein (APP) transgene from cerebral amyloid deposits.

  45. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of lipid research 2002-07-01 Risk genes beyond APOE

    Cholesterol is implicated to play a role in Alzheimer disease pathology.

  46. The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2002-07-01 Risk genes beyond APOE

    Aging of the brain has been demonstrated to be the main risk factor for late-onset sporadic AD what is in contrast to early-onset familial AD in which mutations predominate the pathology.

  47. The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Archives of neurology 2002-07-01 Genetics

    The presence of epsilon 4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95% confidence interval, 1.27-2.89).

  48. Phases of Aβ-deposition in the human brain and its relevance for the development of AD

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2002-06-25 Brain tissue and pathology

    In the first of five phases in the evolution of beta-amyloidosis Abeta deposits are found exclusively in the neocortex.

  49. Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2002-06-01 Disease mechanisms

    Alzheimer's disease (AD) brain is characterized by excess deposition of amyloid beta-peptide (Abeta), particularly the 42-amino acid peptide [Abeta(1-42)] and by extensive oxidative stress.

  50. Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Journal of neurochemistry 2002-05-01 Inflammation and the immune system

    Human lumbar CSF patterns of Abeta peptides were analysed by urea-based beta-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot).

From across this tag

10 of the 1,363 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts