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Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease
Torres-Mendoza BMG, Ortiz GG, Sánchez-Romero L, Delgado-Lara DLC, García Martínez MT, Mireles-Ramírez MA, Cruz Serrano JA, Pacheco Moisés FP.. Nutricion hospitalaria, 2022-12-01
Topic: Amyloid, tau and blood-test diagnosis
carbonyl groups in proteins and hydroperoxides in plasma have similar values in both treatment groups at the beginning of the study. At six and 12 months of treatment, these values decreased significantly in the fish oil group, while in the placebo group no changes were observed in both oxidative stress markers. Catalase activity increased significantly at six and twelve months after treatment in patients treated with fish oil. While the superoxide dismutase activity was not modified in both study groups. patients who consume omega 3 polyunsaturated fatty acids at a stable dose of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) show decreased oxidation of proteins and lipids in plasma. In addition, an increase in catalase activity was detected. Thus, the presented data warrants further studies evaluating the antioxidant effect of omega 3 polyunsaturated fatty acids.
Key findings
- carbonyl groups in proteins and hydroperoxides in plasma have similar values in both treatment groups at the beginning of the study.
- At six and 12 months of treatment, these values decreased significantly in the fish oil group, while in the placebo group no changes were observed in both oxidative stress markers.
- Catalase activity increased significantly at six and twelve months after treatment in patients treated with fish oil.
- While the superoxide dismutase activity was not modified in both study groups. patients who consume omega 3 polyunsaturated fatty acids at a stable dose of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) show decreased oxidation of proteins and lipids in plasma.
- In addition, an increase in catalase activity was detected.
Why it matters
In patients with probable Alzheimer's disease, fish oil taken for six and 12 months reduced markers of oxidative stress in plasma and increased catalase activity, while superoxide dismutase activity did not change. The authors state that further studies are needed to evaluate the antioxidant effect of omega-3 fatty acids.
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Study details
- Evidence strengthHigh
How this study scored 50/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size and effect reported because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 48 of the 96 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nutricion hospitalaria) |
| Journal's citation record | 0 / 4 | Nutrición Hospitalaria: journal h-index 43 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 1 / 6 | Cited 0.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author José Antonio Cruz Serrano holds only 6 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 0 / 3 | Mexican Social Security Institute: institution h-index 266 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36327127) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 48 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 48 of the 96 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Torres-Mendoza, B. M. G., Ortiz, G. G., Sánchez-Romero, L., Delgado-Lara, D. L. C., García Martínez, M. T., Mireles-Ramírez, M. A., et al. (2022). Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease. Nutricion hospitalaria. https://doi.org/10.20960/nh.04153
Vancouver
Torres-Mendoza BMG, Ortiz GG, Sánchez-Romero L, Delgado-Lara DLC, García Martínez MT, Mireles-Ramírez MA, et al. Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease. Nutricion hospitalaria. 2022. doi:10.20960/nh.04153. PMID: 36327127.
BibTeX
@article{torresmendoza2022-36327127,
author = {Torres-Mendoza, B. M. G. and Ortiz, G. G. and Sánchez-Romero, L. and Delgado-Lara, D. L. C. and García Martínez, M. T. and Mireles-Ramírez, M. A. and Cruz Serrano, J. A. and Pacheco Moisés, F. P.},
title = {{Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease}},
journal = {Nutricion hospitalaria},
year = {2022},
doi = {10.20960/nh.04153},
pmid = {36327127},
url = {https://doi.org/10.20960/nh.04153}
}
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