% alzhub.org topic: amyloid-beta
% Source: https://alzhub.org/topic/amyloid-beta
% 1346 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{cruz2026-42892741,
  author  = {Cruz, L. A. and Liu, S. and Miskimen, K. L. and Cooke Bailey, J. N. and Kinzy, T. and Song, Y. E. and Laux, R. A. and Miron, P. and others},
  title   = {{Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study}},
  journal = {Annals of human genetics},
  year    = {2026},
  doi     = {10.1111/ahg.70063},
  pmid    = {42892741},
  url     = {https://doi.org/10.1111/ahg.70063}
}

@article{mukherjee2026-09be60d1,
  author  = {Mukherjee, S. and Barthélemy, N. R. and Atri, T. and Li, Y. and Yen, D. and He, Y. and Coyle, R. and Ovod, V. and others},
  title   = {{Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.22.26363432},
  url     = {https://doi.org/10.64898/2026.09.22.26363432}
}

@article{caro2026-dd11f0ff,
  author  = {Caro, Ilana and Sargurupremraj, Muralidharan and Yang, Chengran and Akinleye, Callistus A. and Trégouët, David‐Alexandre and Akinyemi, Rufus and Shigemizu, Daichi and Coker, Motunrayo Mojoyin and others},
  title   = {{Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries}},
  journal = {Neurology Genetics},
  year    = {2026},
  doi     = {10.1212/nxg.0000000000200425},
  url     = {https://doi.org/10.1212/nxg.0000000000200425}
}

@article{zhou2026-7b25efbc,
  author  = {Zhou, S. and Borkowski, K. and Liang, N. and Beach, T. G. and Serrano, G. and Kim, K. and Newman, J. W. and Maezawa and others},
  title   = {{Distinct lipid mediator profiles in brain and liver tissues in Alzheimer's disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.22.26363708},
  url     = {https://doi.org/10.64898/2026.09.22.26363708}
}

@article{steinruecke2026-b4f40344,
  author  = {Steinruecke, M. and Baillie, J. K. and Jiwaji, Z.},
  title   = {{Integrated genomic meta-analysis identifies cell-type-specific signatures and targets in early Alzheimer's disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.21.26362150},
  url     = {https://doi.org/10.64898/2026.09.21.26362150}
}

@article{morgan2026-42a583d1,
  author  = {Morgan, K. and Thomas, A. and Brookes, K. J.},
  title   = {{Genetic Associations with Alzheimer's, Lewy Body and Vascular Neuropathology Reveal Shared and Distinct Biological Pathways}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.16.26362814},
  url     = {https://doi.org/10.64898/2026.09.16.26362814}
}

@article{zhao2026-a7c7238d,
  author  = {Zhao, T. and Hoffman, M. M. and Wu, G. and Belzil, V. V.},
  title   = {{Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.17.26363319},
  url     = {https://doi.org/10.64898/2026.09.17.26363319}
}

@article{liu2026-cab8ac54,
  author  = {Liu, Y. and Song, Y. E. and Wang, W. and Lynn, A. and Miskimen, K. and Fuzzell, S. L. and Hochstetler, S. D. and Laux and others},
  title   = {{Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.17.26363309},
  url     = {https://doi.org/10.64898/2026.09.17.26363309}
}

@article{leguen2026-c49638e3,
  author  = {Le Guen, Y. and Pena-Tauber, A. and Catoia Pulgrossi, R. and Park, J. and Orias, H. and Greicius, M. D.},
  title   = {{Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and related dementias and Parkinson's disease and related disorders}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.03.03.26347540},
  url     = {https://doi.org/10.64898/2026.03.03.26347540}
}

@article{costa2026-7fcc0d53,
  author  = {Costa, A. P. and Karim, H. T. and Farinas, M. F. and Geissinger, M. M. and Zeng, X. and Tudorascu, D. L. and Butters, M. A. and Karikari and others},
  title   = {{Proteomic markers linking anxiety phenotypes to Alzheimers disease risk: a multi-analyte proteomic analysis}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.16.26363134},
  url     = {https://doi.org/10.64898/2026.09.16.26363134}
}

@article{luo2026-0e28a66d,
  author  = {Luo, Xinyu and Gao, Li-Yan and Huang, Liang-Yu and Zhang, Xiaohui and Tan, Chen‐Chen and Tan, Lan and Xu, Wei},
  title   = {{The interplay of PICALM with APOE ε4 on Alzheimer’s disease: clues from two longitudinal cohorts and proteomic studies}},
  journal = {Translational Psychiatry},
  year    = {2026},
  doi     = {10.1038/s41398-026-04453-0},
  url     = {https://doi.org/10.1038/s41398-026-04453-0}
}

@article{thomassen2026-42736378,
  author  = {Thomassen, J. Q. and Leonard, H. and Ulms, B. and Grenier-Boley, B. and Heikkinen, S. and Garcia-González, P. and Castillo-Morales, A. and Kikuchi, M. and Gim, J. and Cao, H. and Küçükali, F. and Amin, N. and others},
  title   = {{APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease}},
  journal = {Nature genetics},
  year    = {2026},
  doi     = {10.1038/s41588-026-02713-9},
  pmid    = {42736378},
  url     = {https://doi.org/10.1038/s41588-026-02713-9}
}

@article{suwanlikit2026-fc2d0c77,
  author  = {Suwanlikit, Y. and Crofts, S. J. C. and Moodie, J. E. and Marioni, R. and Robertson, N. A. and Tan, S. H. and Vivithanaporn, P. and Bastin and others},
  title   = {{Clonal Haematopoiesis Tracks Alzheimer's-like Cortical Atrophy in Community-Dwelling Older Adults}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.10.26362681},
  url     = {https://doi.org/10.64898/2026.09.10.26362681}
}

@article{nakai2026-ba303595,
  author  = {Nakai, T. and Koseki, T. and Watanabe, H. and Yamada, S.},
  title   = {{Drug-Drug Interaction Signals Between Anti-Amyloid-β Antibodies and Antithrombotic Drugs for Amyloid-Related Imaging Abnormalities and Intracranial Hemorrhage: A FAERS Disproportionality Analysis}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362402},
  url     = {https://doi.org/10.64898/2026.09.08.26362402}
}

@article{javidnia2026-df90200c,
  author  = {Javidnia, S. and Karhunen, V. and Woolf, B. and Burgess, S. and Proitsi, P. and Velayudhan, L. and Bhattacharyya, S.},
  title   = {{Endocannabinoid System Genes in Dementia: A Systematic Mendelian Randomization Study of Functional Variants and Tissue-Specific Expression Across Clinical, Molecular, and Neuroimaging Phenotypes}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362514},
  url     = {https://doi.org/10.64898/2026.09.08.26362514}
}

@article{ward2026-c1a7a162,
  author  = {Ward, E. L. and Nelson, P. T. and Katsumata, Y. and Fardo, D. W. and Jicha, G. A. and {Alzheimer's Disease Neuroimaging Initiative,} and Miller, J. B.},
  title   = {{Rare extreme polygenic risk scores strongly indicate Alzheimer's disease risk}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362504},
  url     = {https://doi.org/10.64898/2026.09.08.26362504}
}

@article{cheng2026-ba023161,
  author  = {Cheng, Z. and Judaprawira, S. and Perez, J. and Goldstein, A.},
  title   = {{Sex-aware Cross-tissue Regulatory Transformer Identified Sexually Dimorphic Alzheimer's Disease Risk Loci and Causal Cellular Circuit}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362488},
  url     = {https://doi.org/10.64898/2026.09.08.26362488}
}

@article{rahman2026-260cf6f2,
  author  = {Rahman, M. R. and Xia, Y. and Raniga, P. and Fazlollahi, A. and Islam, T. and Dhruva, A. and Ong, J.-S. and MacGregor and others},
  title   = {{Shared genetic architecture between brain iron deposition and Alzheimer's disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.07.26362470},
  url     = {https://doi.org/10.64898/2026.09.07.26362470}
}

@article{boeriu2026-52d13682,
  author  = {Boeriu, A. I. and Gu, T. and Fulton-Howard, B. and Lucero, E. M. and Garg, P. and Sharp, A. and Shortt, J. A. and Gignoux and others},
  title   = {{Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.03.23.26349095},
  url     = {https://doi.org/10.64898/2026.03.23.26349095}
}

@article{lee2026-42761308,
  author  = {Lee, Seungmin and Ju, In Gyoung and Lee, Minji and Kim, Jin Hee and Choi, Yujin and Baek, Chanmi and Kim, Chan and Moon, Kyuho and others},
  title   = {{Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models}},
  journal = {Frontiers in Pharmacology},
  year    = {2026},
  doi     = {10.3389/fphar.2026.1898356},
  pmid    = {42761308},
  url     = {https://doi.org/10.3389/fphar.2026.1898356}
}

@article{kapadia2026-42681024,
  author  = {Kapadia, Akshay and Schuhmann, Fabian and Daşkın, Ezgi and Walter, Jochen and Lindahl, Isabell and Rahmani, Neda and Morrema, Tjado H. J. and Rozemüller, Annemieke J.M. and others},
  title   = {{Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease}},
  journal = {The EMBO Journal},
  year    = {2026},
  doi     = {10.1038/s44318-026-00899-6},
  pmid    = {42681024},
  url     = {https://doi.org/10.1038/s44318-026-00899-6}
}

@article{sarkis2026-42673553,
  author  = {Sarkis, Rani A. and Yang, Hyun‐Sik and Liu, Lei and Lam, Alice D. and Pavlova, Milena and Lemus, Hernan Nicolás and Kozhemiako, Nataliia and Hankerson, Alexis and others},
  title   = {{Association Between Alzheimer Pathology, Sleep, and Cognition in Patients With Late-Onset Unexplained Epilepsy}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218476},
  pmid    = {42673553},
  url     = {https://doi.org/10.1212/wnl.0000000000218476}
}

@article{raikes2026-16df6f75,
  author  = {Raikes, A. C. and Garza, M. and Tirambulo, C. V. G. and Murrell, A. N. and Brinton, R. D.},
  title   = {{Meta-analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.04.07.26350339},
  url     = {https://doi.org/10.64898/2026.04.07.26350339}
}

@article{zheng2026-e4fc5f6b,
  author  = {Zheng, C. and Shivakumar, M. and Shen, L. and Kim, D.},
  title   = {{Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.24.26361271},
  url     = {https://doi.org/10.64898/2026.08.24.26361271}
}

@article{alvarezsirvent2026-5023ac4e,
  author  = {Alvarez Sirvent, D. and Luimes, M. C. and Tesi, N. and Rohde, S. K. and Salazar, A. N. and Bijker, L. J. and van Schoor, N. M. and Tijms and others},
  title   = {{Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.24.26361177},
  url     = {https://doi.org/10.64898/2026.08.24.26361177}
}

@article{quenez2026-42648288,
  author  = {Quenez, O. and Schramm, C. and Cassinari, K. and Nicolas, A. and Groeneveld, J. and Huguet, G. and Grenier-Boley, B. and Hulsman, M. and Walters, G. B. and de Rojas, I. and Rovelet-Lecrux, A. and Feuillette, S. and others},
  title   = {{Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk}},
  journal = {American Journal of Human Genetics},
  year    = {2026},
  doi     = {10.1016/j.ajhg.2026.07.013},
  pmid    = {42648288},
  url     = {https://doi.org/10.1016/j.ajhg.2026.07.013}
}

@article{cunha2026-6c8e9111,
  author  = {Cunha, C. and Pielies Avelli, M. and J. Romero-Lado, M. and Sanz Martinez, R. and R. Belanich, J. and R. Jones, T. and Claussnitzer, M. and Loos, J. F. and others},
  title   = {{Genetic architecture of Alzheimer's disease is enriched in peripheral immune and metabolic programs}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.02.09.26344392},
  url     = {https://doi.org/10.64898/2026.02.09.26344392}
}

@article{wu2026-42700370,
  author  = {Wu, Fengjuan and Wang, Manxia},
  title   = {{Entorhinal cortex astrocytes in early Alzheimer disease: Human evidence, cross-species circuit rationale, and translational boundaries}},
  journal = {Journal of Neuropathology \& Experimental Neurology},
  year    = {2026},
  doi     = {10.1093/jnen/nlag098},
  pmid    = {42700370},
  url     = {https://doi.org/10.1093/jnen/nlag098}
}

@article{salazar2026-28f7dc41,
  author  = {Salazar, A. and Tesi, N. and Knoop, L. and van Schoor, N. M. and Huisman, M. and Tijms, B. and Vijverberg, E. G. B. and der Lee, van and others},
  title   = {{Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and preserved cognition at extreme age}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.1101/2025.02.02.25321330},
  url     = {https://doi.org/10.1101/2025.02.02.25321330}
}

@article{cunha2026-beffb111,
  author  = {Cunha, C. and Garcia-Urena, M. and Martinez, R. and Romero-Lado, M. J. and Fernandez, M. V. and Andreassen, O. A. and Sims, R. and Tsolaki and others},
  title   = {{Genomics link obesity and type 2 diabetes to Alzheimers disease to unveil novel biological insights}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.02.10.26344393},
  url     = {https://doi.org/10.64898/2026.02.10.26344393}
}

@article{tesi2026-d8615865,
  author  = {Tesi, N. and Salazar, A. and Bouland, G. and Alvarez, D. and Zhang, Y. and Knoop, L. and van Schoor, N. M. and Huisman and others},
  title   = {{Long-read sequencing reveals hidden structural complexity within Alzheimers disease-associated GWAS loci}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.03.16.26348487},
  url     = {https://doi.org/10.64898/2026.03.16.26348487}
}

@article{millar2026-71693abf,
  author  = {Millar, Peter R and Doering, Stephanie and Adeyemo, Babatunde and Jindal, Saurabh and McKay, Nicole Sarah and Strain, Jeremy F. and Wisch, Julie K. and An, Gordon Zhaoqi and others},
  title   = {{Network connectivity and amyloid-β align with tau in atypical Alzheimer disease subtypes}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02143-z},
  url     = {https://doi.org/10.1186/s13195-026-02143-z}
}

@article{christensen2026-93b65e21,
  author  = {Christensen, Amy and Valencia‐Olvera, Ana Carolina and Xeros, Helena and Nguyen, Elizabeth T. and Lopez, Marlene and Javaheri, Rojan and Tai, Leon M. and LaDu, Mary Jo and others},
  title   = {{Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD mice}},
  journal = {Biology of Sex Differences},
  year    = {2026},
  doi     = {10.1186/s13293-026-00967-w},
  url     = {https://doi.org/10.1186/s13293-026-00967-w}
}

@article{perfetto2026-42556583,
  author  = {Perfetto, Sofia E. and Ruthirakuhan, Myuri T. and Wong, Yuen Yan and Ryoo, Si Won and Huang, Celine H.L. and Fan, Fan and Chenoweth, Meghan J. and Nestor, Sean M. and others},
  title   = {{Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities}},
  journal = {Journal of Affective Disorders},
  year    = {2026},
  doi     = {10.1016/j.jad.2026.122353},
  pmid    = {42556583},
  url     = {https://doi.org/10.1016/j.jad.2026.122353}
}

@article{penatauber2026-42548036,
  author  = {Peña‐Tauber, Andrés and Arriaza, Ricardo Hernández and Reil, Dylan and Muntaner, Manon and Park, Junyoung and Grenier‐Boley, Benjamin and Hulsman, Marc and Amouyel, Philippe and others},
  title   = {{Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk}},
  journal = {Annals of Neurology},
  year    = {2026},
  doi     = {10.1002/ana.78303},
  pmid    = {42548036},
  url     = {https://doi.org/10.1002/ana.78303}
}

@article{dodd2026-40766450,
  author  = {Dodd, Roger B. and Enomoto, Masahiro and Zhou, Ye and Satoh, Kanayo and Zhang, Yalun and Chen, Fusheng and Acheson, Beatrice and Ghaffari, Deniz and others},
  title   = {{CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk}},
  journal = {Nature Communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-75140-3},
  pmid    = {40766450},
  url     = {https://doi.org/10.1038/s41467-026-75140-3}
}

@article{paez2026-42447420,
  author  = {Paez, A. and Piñol-Ripoll, G. and Carnes-Vendrell, A. and Dakterzada, F. and Barbé, F. and Zetterberg, H. and Dang-Vu, T. T.},
  title   = {{Orexin, Sleep, and Cognition in Alzheimer Disease: Non-REM Oscillatory Activity and Neural Resilience}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218307},
  pmid    = {42447420},
  url     = {https://doi.org/10.1212/wnl.0000000000218307}
}

@article{dodd2026-c8ae3fc8,
  author  = {Dodd, Roger B. and Enomoto, Masahiro and Zhou, Ye and Satoh, Kanayo and Zhang, Yalun and Chen, Fusheng and Acheson, Beatrice and Ghaffari, Deniz and others},
  title   = {{CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk}},
  journal = {DOAJ (DOAJ: Directory of Open Access Journals)},
  year    = {2026},
  doi     = {10.1038/s41467-026-75140-3},
  url     = {https://doi.org/10.1038/s41467-026-75140-3}
}

@article{chmiel2026-42439628,
  author  = {Chmiel, James and Gawełczyk, Wiktor and Soczyńska, Julia and Leszek, Jerzy},
  title   = {{Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?}},
  journal = {Cells},
  year    = {2026},
  doi     = {10.3390/cells15131151},
  pmid    = {42439628},
  url     = {https://doi.org/10.3390/cells15131151}
}

@article{masdeu2026-cc666680,
  author  = {Masdeu, Joseph and Finn, Quentin and Schulz, Paul and Pascual, Belén},
  title   = {{β-amyloid PET Signal Reduction in Regions with ARIA-E Following Anti-amyloid Therapy for Alzheimer Disease (P1-12.010)}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000215645},
  url     = {https://doi.org/10.1212/wnl.0000000000215645}
}

@article{totuk2026-42246690,
  author  = {Totuk, O.},
  title   = {{CHMP2B p.Ala30Ser Variant in Biomarker-Confirmed Early-Onset Alzheimer Disease: A Potential Endolysosomal Disease Modifier}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2026},
  doi     = {10.1097/wad.0000000000000737},
  pmid    = {42246690},
  url     = {https://doi.org/10.1097/wad.0000000000000737}
}

@article{dilworthanderson2026-8139bdf8,
  author  = {Dilworth‐Anderson, Peggye and Steingrimsson, Jon and Smith, Karen and Glavin, Emily and Hanna, Lucy and Weber, Christopher J. and Rabinovici, Gil D. and Gareen, Ilana and others},
  title   = {{Differences in amyloid PET positivity based on ethnoracial group and social determinants of health: The new IDEAS study}},
  journal = {Carolina Digital Repository (University of North Carolina at Chapel Hill)},
  year    = {2026},
  doi     = {10.17615/agh3-gz31},
  url     = {https://doi.org/10.17615/agh3-gz31}
}

@article{kim2026-42234953,
  author  = {Kim, Daeeun and McInerney, Katelyn and Dagli, Chaitali S. and Armstrong, Nicole D. and Cushman, Mary and Bennett, Aleena and Blue, Elizabeth E. and Sofer, Tamar and others},
  title   = {{Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population}},
  journal = {Neurology},
  year    = {2026},
  doi     = {10.1212/wnl.0000000000218163},
  pmid    = {42234953},
  url     = {https://doi.org/10.1212/wnl.0000000000218163}
}

@article{wang2026-42278544,
  author  = {Wang, Xingyu and Rong, Zhouting and Xue, Feng},
  title   = {{Multi-Dimensional Transcriptomics Reveals the Prominent Role of Neuroinflammation in Alzheimer’s Disease}},
  journal = {International Journal of Molecular Sciences},
  year    = {2026},
  doi     = {10.3390/ijms27115020},
  pmid    = {42278544},
  url     = {https://doi.org/10.3390/ijms27115020}
}

@article{angaritarodriguez2026-42311824,
  author  = {Angarita-Rodríguez, Andrea and Vargas-López, Viviana and Pinzón, Andres and Sandoval-Hernandez, Adrián and Kang, Kai and Li, Leping and Papin, Jason and Puentes-Rozo, Pedro and others},
  title   = {{Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression}},
  journal = {Frontiers in Bioinformatics},
  year    = {2026},
  doi     = {10.3389/fbinf.2026.1816121},
  pmid    = {42311824},
  url     = {https://doi.org/10.3389/fbinf.2026.1816121}
}

@article{ziqun2026-46a316ba,
  author  = {Ziqun, LI Bingnan ZHOU},
  title   = {{Single-cell atlas reveals pathological amplification of aging programs and proteostasis collapse in microglia of Alzheimer′s disease mice}},
  journal = {DOAJ (DOAJ: Directory of Open Access Journals)},
  year    = {2026},
  doi     = {10.16352/j.issn.1001-6325.2026.06.0791},
  url     = {https://doi.org/10.16352/j.issn.1001-6325.2026.06.0791}
}

@article{windon2026-4e49a7d2,
  author  = {Windon, Charles and Whitmer, Rachel A and Hillner, Bruce E. and Steingrimsson, Jon and Blazhenets, Ganna and Gatsonis, Constantine and Possin, Katherine L. and Miller, Bruce L. and others},
  title   = {{Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals}},
  journal = {Carolina Digital Repository (University of North Carolina at Chapel Hill)},
  year    = {2026},
  doi     = {10.17615/0g36-z486},
  url     = {https://doi.org/10.17615/0g36-z486}
}

@article{thakur2026-521df110,
  author  = {Thakur, Shalini and Venkateshwarlu, G. and Choudhary, Priyanka and Nikita, Nikita and Kumar, Vipan and Thakur, Nandani},
  title   = {{Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons and Converging Insights from Alternative Hypothesis}},
  journal = {International Journal of Drug Delivery Technology},
  year    = {2026},
  doi     = {10.25258/ijddt.16.32s.128},
  url     = {https://doi.org/10.25258/ijddt.16.32s.128}
}

@article{mazur2026-52694e77,
  author  = {Mazur, Karol and Smoleń, Agata},
  title   = {{Advanced glycation end-products in the pathogenesis of Alzheimer’s disease: a review}},
  journal = {Psychiatria i Psychologia Kliniczna},
  year    = {2026},
  doi     = {10.15557/pipk.2026.0011},
  url     = {https://doi.org/10.15557/pipk.2026.0011}
}

@article{singh2026-42162487,
  author  = {Singh, Alpana and Denkinger, Marisa N. and Leuzy, Antoine and Dieckhoff, Kari and Liu, Jame and Marques, Tainá M. and Monuki, Edwin S. and Stark, Craig and others},
  title   = {{A plasma protein signature for cerebral amyloid angiopathy}},
  journal = {Acta Neuropathologica},
  year    = {2026},
  doi     = {10.1007/s00401-026-03030-5},
  pmid    = {42162487},
  url     = {https://doi.org/10.1007/s00401-026-03030-5}
}

@article{pablo2026-42145634,
  author  = {Pablo, Aguilar-Dominguez and Carmen-Maria, Colceriu and Monroe, Holland Thomas and Lockhart Samuel, N. and Masdeu Joseph, C. and Tramujas, Vasconcellos Neumann Lycia and Snyder Heather, M. and Baker Laura, D. and others},
  title   = {{Association of neighborhood deprivation with Alzheimer's Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status}},
  journal = {medRxiv : the preprint server for health sciences},
  year    = {2026},
  doi     = {10.64898/2026.05.05.26352370},
  pmid    = {42145634},
  url     = {https://doi.org/10.64898/2026.05.05.26352370}
}

@article{gao2026-42152315,
  author  = {Gao, Xueying and Wang, Lingling},
  title   = {{Associations of gut bacterial classes Clostridia and Deltaproteobacteria with type 2 diabetes and Alzheimer’s disease: A two-sample Mendelian randomization study}},
  journal = {Medicine},
  year    = {2026},
  doi     = {10.1097/md.0000000000048685},
  pmid    = {42152315},
  url     = {https://doi.org/10.1097/md.0000000000048685}
}

@article{lu2026-42141098,
  author  = {Lu, L. and Pichet Binette, A. and Hristovska, I. and Janelidze, S. and Smets, B. and Cumplido-Mayoral, I. and Vasanthakumar, A. and Milkovich, B. and An, L. and Ossenkoppele, R. and Krish, V. and others},
  title   = {{Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease}},
  journal = {Nature Aging},
  year    = {2026},
  doi     = {10.1038/s43587-026-01123-0},
  pmid    = {42141098},
  url     = {https://doi.org/10.1038/s43587-026-01123-0}
}

@article{karim2026-42163597,
  author  = {Karim, Ayesha and Alturise, Fahad and Alkhalifah, Tamim and Khan, Yaser Daanial},
  title   = {{predALZ: An Ensemble Learning Framework for Identifying Genetic Biomarkers in Familial Alzheimer’s Disease}},
  journal = {Current Drug Targets},
  year    = {2026},
  doi     = {10.2174/0113894501408301251214192633},
  pmid    = {42163597},
  url     = {https://doi.org/10.2174/0113894501408301251214192633}
}

@article{kishor2026-42152645,
  author  = {Kishor, Komal and Arora, Anish and Yashika and Yadav, Sachin and Singh, Amandeep},
  title   = {{Extracellular Vesicles in Alzheimer’s Disease: Mechanisms, Immunotherapy Links, and Clinical Translation}},
  journal = {Current Pharmaceutical Design},
  year    = {2026},
  doi     = {10.2174/0113816128464813260512100753},
  pmid    = {42152645},
  url     = {https://doi.org/10.2174/0113816128464813260512100753}
}

@article{tarawneh2026-42098850,
  author  = {Tarawneh, Rawan M. and Moulder, Krista L. and Topouza, Danai Georgia and Kar, Amrita Ghosh and Qian, Heng and Pankratz, V. Shane and Timsina, Jigyasha and Franklin, Erin E. and others},
  title   = {{Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02043-2},
  pmid    = {42098850},
  url     = {https://doi.org/10.1186/s13195-026-02043-2}
}

@article{bolton2026-42200449,
  author  = {Bolton, Corey J. and Dilworth‐Anderson, Peggye and Steingrimsson, Jon and Thangarajah, Maryanne and Hanna, Lucy and Gatsonis, Constantine and Windon, Charles and Carrillo, María C. and others},
  title   = {{Differences in amyloid PET positivity based on ethnoracial group and social determinants of health: The new IDEAS study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71406},
  pmid    = {42200449},
  url     = {https://doi.org/10.1002/alz.71406}
}

@article{sun2026-42066773,
  author  = {Sun, X. and Mews, M. and Wheeler, N. R. and Benchek, P. and Gu, T. and Gomez, L. and Ray, N. and Reitz, C. and Naj, A. C. and Below, J. E. and Tosto, G. and Cornejo-Olivas, M. and others},
  title   = {{Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease}},
  journal = {American Journal of Human Genetics},
  year    = {2026},
  doi     = {10.1016/j.ajhg.2026.04.007},
  pmid    = {42066773},
  url     = {https://doi.org/10.1016/j.ajhg.2026.04.007}
}

@article{misra2026-42131707,
  author  = {Misra, Arpita and Wang, Yi and Taheri, M. Reza and Chiang, Gloria Chia-Yi and Cho, Junghun},
  title   = {{Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias}},
  journal = {Frontiers in Neuroscience},
  year    = {2026},
  doi     = {10.3389/fnins.2026.1754415},
  pmid    = {42131707},
  url     = {https://doi.org/10.3389/fnins.2026.1754415}
}

@article{yang2026-41984497,
  author  = {Yang, YoungSoon and Kwak, Yong Tae},
  title   = {{Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-β oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1177/13872877261441816},
  pmid    = {41984497},
  url     = {https://doi.org/10.1177/13872877261441816}
}

@article{yu2026-41961648,
  author  = {Yu, Zhong and Hao, Lu and Zhang, Haofuzi},
  title   = {{Mendelian randomization study of genetic interactions between Alzheimer disease and celiac disease}},
  journal = {Medicine},
  year    = {2026},
  doi     = {10.1097/md.0000000000048320},
  pmid    = {41961648},
  url     = {https://doi.org/10.1097/md.0000000000048320}
}

@article{wang2026-41980911,
  author  = {Wang, Meng and Buthut, Maria and Meinhardt, Jenny and Otto, Carolin and Gallaccio, Gerardina and Fernández‐Zapata, Camila and Teves, Matteo and Samol, Claudia and others},
  title   = {{Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71359},
  pmid    = {41980911},
  url     = {https://doi.org/10.1002/alz.71359}
}

@article{raya2026-41729539,
  author  = {Raya, Maison Abu and Suemoto, Claudia Kimie and Paes, Vitor Ribeiro and Leite, Renata Elaine Paraizo and Pasqualucci, Carlos Augusto and Naslavsky, Michel Satya and Rodriguez, Roberta Diehl and Nitrini, Ricardo and others},
  title   = {{Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample}},
  journal = {JAMA neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2026.0054},
  pmid    = {41729539},
  url     = {https://doi.org/10.1001/jamaneurol.2026.0054}
}

@article{grill2026-41910973,
  author  = {Grill, Joshua D. and RAMAN, REMA and Wang, Shunran and Ernstrom, Karin B. and Andrews, Patricia and Appleby, Brian Stephen and Bhangu, Jaspreet S. and Dhadda, Shobha and others},
  title   = {{Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.3845},
  pmid    = {41910973},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.3845}
}

@article{caro2026-41906765,
  author  = {Caro, Daniela Diaz and Rodriguez, Sophia and Uhlmann, Wendy R. and Goldman, Jill S. and McCain, Sarah and Wetmore, John Brandon and Caban, Maria L. and Chung, Wendy K. and others},
  title   = {{Exploring immediate responses to APOE ε 4/ε4 genotype and Alzheimer's disease risk disclosure in Latinos}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1177/13872877261435633},
  pmid    = {41906765},
  url     = {https://doi.org/10.1177/13872877261435633}
}

@article{khurshid2026-41857676,
  author  = {Khurshid, Zainab and Tong, Tong and Olayinka, Oluwatosin A and Farrell, John Joseph and Zhu, Congcong and {Alzheimer's Disease Sequencing Project} and Martin, Eden R. and Bush, William S. and others},
  title   = {{Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-02005-8},
  pmid    = {41857676},
  url     = {https://doi.org/10.1186/s13195-026-02005-8}
}

@article{norgren2026-41854609,
  author  = {Norgren, Jakob and Carballo‐Casla, Adrián and Grande, Giulia and Börjesson‐Hanson, Anne and Xu, Hong and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia},
  title   = {{Meat Consumption and Cognitive Health by APOE Genotype}},
  journal = {JAMA Network Open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2026.6489},
  pmid    = {41854609},
  url     = {https://doi.org/10.1001/jamanetworkopen.2026.6489}
}

@article{ahn2026-41890209,
  author  = {Ahn, Young Hyeon and Kang, Jin Gu and Choi, DaHyeon and 김대진 and Yang, Chan-Mo and Lee, S. H. and Lee, Sae Hwan and Jung, Young Hyun and others},
  title   = {{Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2026.1773977},
  pmid    = {41890209},
  url     = {https://doi.org/10.3389/fnagi.2026.1773977}
}

@article{vejdanijahromi2026-41781178,
  author  = {Vejdani-Jahromi, Maryam and Calle, Esteban and Ganem, Odette and Rohatgi, Saurabh and Farzaneh, Hana and Griffin, Harry and Zhu, Shenghua and Seah, Jarrel C. Y. and others},
  title   = {{Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy}},
  journal = {American Journal of Neuroradiology},
  year    = {2026},
  doi     = {10.3174/ajnr.a9056},
  pmid    = {41781178},
  url     = {https://doi.org/10.3174/ajnr.a9056}
}

@article{yan2026-41778859,
  author  = {Yan, Jingsi and Zhang, Jiayu and Ye, Xinyi and Wang, Hao and Li, Hang and Li, Weirong and Wu, Huifei and Zhao, Wei},
  title   = {{The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71243},
  pmid    = {41778859},
  url     = {https://doi.org/10.1002/alz.71243}
}

@article{suswidiantoro2026-41808871,
  author  = {Suswidiantoro, V. and Tang, K. S. and Rahman, K. and Ariestanti, D. M. and James, R. J. and Yan, C. C. and Kato, M. and Saputri, F. C.},
  title   = {{Natural compounds as multitarget agents in Alzheimer's diseases: evidence from in vivo and in vitro models}},
  journal = {Frontiers in pharmacology},
  year    = {2026},
  doi     = {10.3389/fphar.2026.1766470},
  pmid    = {41808871},
  url     = {https://doi.org/10.3389/fphar.2026.1766470}
}

@article{mikko2026-41709289,
  author  = {Mikko, Koivumäki and Henna, Martiskainen and Mari, Takalo and Jenni, Lehtisalo and Tiia, Ngandu and Anniina, Snellman and Mikko, Hiltunen and Rinne Juha, O.},
  title   = {{Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals}},
  journal = {Alzheimer's research \& therapy},
  year    = {2026},
  doi     = {10.1186/s13195-026-01984-y},
  pmid    = {41709289},
  url     = {https://doi.org/10.1186/s13195-026-01984-y}
}

@article{mahsa2026-41674810,
  author  = {Mahsa, Mayeli and Riya, Saraiya and Mecca Adam, P. and David, Matuskey},
  title   = {{Neighborhood Socioeconomic Deprivation is Associated with Worse Cognitive Performance and in vivo Amyloid Accumulation}},
  journal = {NPJ dementia},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-8546338/v1},
  pmid    = {41674810},
  url     = {https://doi.org/10.21203/rs.3.rs-8546338/v1}
}

@article{bouwman2026-41664510,
  author  = {Bouwman, Maud M. A. and Frigerio, Irene and Graaf, Yvon Galis-de and van de Berg, Wilma D. J. and Jonkman, Laura E.},
  title   = {{Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease}},
  journal = {Brain Pathology},
  year    = {2026},
  doi     = {10.1111/bpa.70081},
  pmid    = {41664510},
  url     = {https://doi.org/10.1111/bpa.70081}
}

@article{brutman2026-41629326,
  author  = {Brutman, J. N. and Busald, T. and Nizamis, E. and Kaufman, E. J. and Lin, E. and Hendricks, N. E. and Chintamen, S. and Sulovari, A. and Smukowski, S. N. and Ye, Y. and Peikon, I. and Jayadev, S. and others},
  title   = {{A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans}},
  journal = {Nature Communications},
  year    = {2026},
  doi     = {10.1038/s41467-026-68808-3},
  pmid    = {41629326},
  url     = {https://doi.org/10.1038/s41467-026-68808-3}
}

@article{windon2026-41816196,
  author  = {Windon, Charles and Tsoy, Elena and Livaudais‐Toman, Jennifer and Neilands, Torsten B. and Palmer, Nynikka R. and Heston, Margo B. and Johnson, Julene K. and Hanna, Lucy S. and others},
  title   = {{Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals}},
  journal = {Alzheimer s \& Dementia Behavior \& Socioeconomics of Aging},
  year    = {2026},
  doi     = {10.1002/bsa3.70058},
  pmid    = {41816196},
  url     = {https://doi.org/10.1002/bsa3.70058}
}

@article{hartmann2026-41566484,
  author  = {Hartmann, Carla and Haferkamp, Undine and Appelt‐Menzel, Antje and Barenberg, Janica and Brachner, Andreas and Ehrhard, Toni and Feldhaus, Julia Silvia and Gerhartl, Anna and others},
  title   = {{Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease}},
  journal = {Fluids and Barriers of the CNS},
  year    = {2026},
  doi     = {10.1186/s12987-025-00753-7},
  pmid    = {41566484},
  url     = {https://doi.org/10.1186/s12987-025-00753-7}
}

@article{anschuetz2026-41609044,
  author  = {Anschuetz, Anne and Listyono, Renny and Vorley, Thomas and Platt, Bettina and Harrington, Charles R. and Riedel, Gernot and Schwab, Karima},
  title   = {{The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model}},
  journal = {Journal of Integrative Neuroscience},
  year    = {2026},
  doi     = {10.31083/jin48581},
  pmid    = {41609044},
  url     = {https://doi.org/10.31083/jin48581}
}

@article{patel2026-41560705,
  author  = {Patel, Prachetas Jai and Yan, Zhen},
  title   = {{Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1177/13872877251414887},
  pmid    = {41560705},
  url     = {https://doi.org/10.1177/13872877251414887}
}

@article{acostauribe2026-41586258,
  author  = {Acosta‐Uribe, Juliana and Piña‐Escudero, Stefanie Danielle and Cochran, J. Nicholas and Taylor, Jared W. and Castruita, P. Alejandra and Jonson, Caroline and Barinaga, Erin A. and Roberts, Kevin and others},
  title   = {{Genetic contributions to Alzheimer’s disease and frontotemporal dementia in admixed Latin American populations}},
  journal = {npj Dementia},
  year    = {2026},
  doi     = {10.1038/s44400-025-00025-z},
  pmid    = {41586258},
  url     = {https://doi.org/10.1038/s44400-025-00025-z}
}

@article{xiao2026-41518198,
  author  = {Xiao, Fan and Tan, Xue and He, Aojie and Zhou, Yulan and Xu, Kaicheng and Yuan, Ziqi and Zhu, Yufei and Liang, Chensi and others},
  title   = {{Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy}},
  journal = {Autophagy},
  year    = {2026},
  doi     = {10.1080/15548627.2026.2615978},
  pmid    = {41518198},
  url     = {https://doi.org/10.1080/15548627.2026.2615978}
}

@article{fandos2026-41513583,
  author  = {Fandos, Noelia and Pascual‐Lucas, María and Sarasa, Leticia and Terencio, Jose Vicente and Sáez, Mª Eugenia and Tartari, Juan Pablo and Sanabria, Ángela and Sotolongo‐Grau, Óscar and others},
  title   = {{Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2025.100465},
  pmid    = {41513583},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100465}
}

@article{zhang2026-41490095,
  author  = {Zhang, Xiaoling and Xie, Guomin and Zhao, Cui and Lv, Zhongyue},
  title   = {{Plasma lipid subspecies and Alzheimer’s disease: genetic evidence for risk and protection}},
  journal = {QJM},
  year    = {2026},
  doi     = {10.1093/qjmed/hcag006},
  pmid    = {41490095},
  url     = {https://doi.org/10.1093/qjmed/hcag006}
}

@article{ayyubova2026-41596124,
  author  = {Ayyubova, Gunel and Bablu, Fariha E and Rahimli, Nazrin and Aghayeva, Leyla and Springer, Elijah M. and Alghenaim, Fada A. and Suzuki, Yuichiro J.},
  title   = {{Roles of Reactive Oxygen Species in Relationships Between Viral Infections and Alzheimer’s Disease and Related Dementia}},
  journal = {Antioxidants},
  year    = {2026},
  doi     = {10.3390/antiox15010066},
  pmid    = {41596124},
  url     = {https://doi.org/10.3390/antiox15010066}
}

@article{jo2026-c42da504,
  author  = {Jo, Sang Won and Park, Bo-yong and Yoo, Roh‐Eul and Choi, Seung Hong and Ji, Sooyeon and Park, Tae Young and Kim, Hyungmin and Park, Seongbeom and others},
  title   = {{Effects of Low‐Intensity Ultrasound on Amyloid‐ β Clearance in Early‐Stage Alzheimer′s Disease: A Potential Role of Glymphatic Activity}},
  journal = {Acta Neurologica Scandinavica},
  year    = {2026},
  doi     = {10.1155/ane/1538313},
  url     = {https://doi.org/10.1155/ane/1538313}
}

@article{anlidino2026-8d167666,
  author  = {Anli Dino, A. and Sangeetha, Baskaran and Varnika, S.},
  title   = {{In silico structure-based multi-targeted molecular docking analysis of ginkgo biloba phytocompounds against Alzheimer’s disease associated proteins}},
  journal = {In Silico Research in Biomedicine},
  year    = {2026},
  doi     = {10.1016/j.insi.2026.100411},
  url     = {https://doi.org/10.1016/j.insi.2026.100411}
}

@article{subramaniapillai2026-00ddbfb1,
  author  = {Subramaniapillai, Sivaniya and Verdi, Serena and Keuss, Sarah E and Lu, Kirsty and James, Sarah‐Naomi and Coath, William and Cash, David M. and Barkhof, Frederik and others},
  title   = {{Mapping sex differences in brain and cognition in relation to APOE ε4 and amyloid burden: A longitudinal normative modelling study}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2026},
  doi     = {10.1002/trc2.70223},
  url     = {https://doi.org/10.1002/trc2.70223}
}

@article{zhao2025-41460601,
  author  = {Zhao, Bo and Geng, Chaofan and Zhou, Shaojiong and Wei, Tao and Li, Aonan and Zhao, Yiwei and Tang, Yi},
  title   = {{Inflammation as a mediator of air pollution's role in Alzheimer's disease and related dementias}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251408422},
  pmid    = {41460601},
  url     = {https://doi.org/10.1177/13872877251408422}
}

@article{zhang2025-41404739,
  author  = {Zhang, Chong‐Hui and Huang, Liang‐Yu and Feng, Yu‐Gong and Tan, Chen‐Chen and Tan, Lan and Xu, Wei},
  title   = {{APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.125.043446},
  pmid    = {41404739},
  url     = {https://doi.org/10.1161/jaha.125.043446}
}

@article{cacerespalomo2025-41388301,
  author  = {Cáceres-Palomo, Laura and Sánchez‐Mejías, Elisabeth and Trujillo‐Estrada, Laura and Pérez-Moreno, Juan José and Lopez-Oliva, Elba and Lim, Tau En and DeFlitch, Leah and Chang, Serena H. and others},
  title   = {{Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03607-z},
  pmid    = {41388301},
  url     = {https://doi.org/10.1186/s12974-025-03607-z}
}

@article{sumadewi2025-d3e2c144,
  author  = {Sumadewi, Komang Trisna},
  title   = {{The Role of GFAP as a Marker of Astrocyte Activation in the Pathogenesis of Alzheimer's Dementia: A Literature Review}},
  journal = {Health \& Medical Sciences},
  year    = {2025},
  doi     = {10.47134/phms.v3i1.519},
  url     = {https://doi.org/10.47134/phms.v3i1.519}
}

@article{christensen2025-41435356,
  author  = {Christensen, Amy and McGill, Cassandra Joan and Zaidi, Ali Hussainy and Pike, Christian J.},
  title   = {{Alzheimer‐related neuropathology is improved by treatment with longevity‐enhancing treatments in aged male EFAD mice}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_099102},
  pmid    = {41435356},
  url     = {https://doi.org/10.1002/alz70855_099102}
}

@article{norgren2025-41434470,
  author  = {Norgren, Jakob and Carballo‐Casla, Adrián and Börjesson‐Hanson, Anne and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia},
  title   = {{APOE‐Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC‐K}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_107412},
  pmid    = {41434470},
  url     = {https://doi.org/10.1002/alz70860_107412}
}

@article{fernandez2025-41435289,
  author  = {Fernández, Anllely and Hoq, Md Rejaul and Vago, Frank S. and Hallinan, Grace I. and Bharath, S.R. and Li, Daoyi and Ozcan, Kadir A. and Garringer, Holly J. and others},
  title   = {{Cryo‐EM structures of amyloid β filaments from cotton wool plaques in Alzheimer disease caused by the PSEN1 V261I and A431E mutations}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_098033},
  pmid    = {41435289},
  url     = {https://doi.org/10.1002/alz70855_098033}
}

@article{wadia2025-41448718,
  author  = {Wadia, Lyla and Garriga, Stella M. and Belliveau, Timothy and Arias, Franchesca and Carrión, Carmen I.},
  title   = {{Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning?}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_103936},
  pmid    = {41448718},
  url     = {https://doi.org/10.1002/alz70857_103936}
}

@article{holstege2025-41442609,
  author  = {Holstege, Henne H. and Salazar, Alex and Knoop, Lydian and Pijnenburg, Yolande A.L. and van der Lee, Sven J and Wijesekera, Sanduni and Křížová, Jana and Hiltunen, Mikko O. and others},
  title   = {{Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_104407},
  pmid    = {41442609},
  url     = {https://doi.org/10.1002/alz70855_104407}
}

@article{ruhela2025-41447294,
  author  = {Ruhela, Vivek and Cieza, Basilio and Mayeux, Richard P and Reyes‐Dumeyer, Dolly and Teich, Andrew F. and Tosto, Giuseppe},
  title   = {{Genetic Colocalization of Expression Quantitative Trait Loci (eQTL) Mapping and GWAS in a multiethnic brain bank: An Insight into ancestry‐specific Regulatory Architecture in Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_107199},
  pmid    = {41447294},
  url     = {https://doi.org/10.1002/alz70855_107199}
}

@article{scott2025-41442684,
  author  = {Scott, Kyle M and Emekci, Azra and Aguiar‐Pulido, Vanessa and Rajabli, Farid},
  title   = {{Genome‐Wide Analysis of Memory, Language, and Executive Function Reveals Domain‐Specific Genetic Architecture in Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_105459},
  pmid    = {41442684},
  url     = {https://doi.org/10.1002/alz70855_105459}
}

@article{kurniansyah2025-41434242,
  author  = {Kurniansyah, Nuzulul and Tasaki, Shinya and Zhu, Congcong and Farrell, John Joseph and Rehman, Habbiburr and Sherva, Richard and Hauger, Richard L. and Merritt, Victoria C. and others},
  title   = {{Hormone replacement therapy in women and vascular risk factors modify the association of a multi‐ancestry polygenic risk score with Alzheimer disease and related traits}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70861_108536},
  pmid    = {41434242},
  url     = {https://doi.org/10.1002/alz70861_108536}
}

@article{moore2025-41439341,
  author  = {Moore, Noel C. and Song, Yeunjoo E. and Gulyayev, Alex V. and Miskimen, Kristy L. S. and Laux, Reneé A. and Lynn, Audrey H. and Fuzzell, Sarada L. and Hochstetler, Sherri D. and others},
  title   = {{Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_106578},
  pmid    = {41439341},
  url     = {https://doi.org/10.1002/alz70855_106578}
}

@article{kanyinda2025-41436024,
  author  = {Kanyinda, Jonathan Nyandu and Marola, Olivia J. and Howell, Gareth R.},
  title   = {{Investigation of the roles of microglia and astrocytes in cerebral amyloid angiopathy across diverse murine strains}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_101282},
  pmid    = {41436024},
  url     = {https://doi.org/10.1002/alz70855_101282}
}

@article{song2025-dff7ac55,
  author  = {Song, Yeunjoo E. and Wang, Ping and Laux, Reneé A. and Fuzzell, Sarada L. and Hochstetler, Sherri D. and Miskimen, Kristy L. S. and Lynn, Audrey H. and Wang, Weihuan and others},
  title   = {{Mosaic Loss of Chromosome Y and Plasma Aβ42/p‐tau181 Ratio as Biomarkers for Alzheimer's Disease in the Midwestern Amish}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106620},
  url     = {https://doi.org/10.1002/alz70856_106620}
}

@article{bradley2025-41444475,
  author  = {Bradley, Joseph L. and Western, Daniel and Wang, Ciyang and da Fonseca, Eder Lúcio and Neupane, Asmita and Kurup, Jiji Thulaseedhara and Ray, Nicholas R. and Jean‐Francois, Melissa N. and others},
  title   = {{Novel early‐onset Alzheimer‐associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_107379},
  pmid    = {41444475},
  url     = {https://doi.org/10.1002/alz70855_107379}
}

@article{kunkle2025-41437928,
  author  = {Kunkle, Brian W. and Gomez, Lissette and Tosto, Giuseppe and Rodriguez, Omar Garcia and Slifer, Susan H. and Hamilton‐Nelson, Kara L. and Naj, Adam Christian and Kushch, Nicholas A. and others},
  title   = {{Novel sex‐specific candidate loci associated with Alzheimer disease identified through sex‐aware multi‐ancestry genome‐wide meta‐analysis}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_106407},
  pmid    = {41437928},
  url     = {https://doi.org/10.1002/alz70855_106407}
}

@article{akgun2025-41434771,
  author  = {Akgün, Bilçağ and Xu, Wanying and Hamilton‐Nelson, Kara L. and Nasciben, Luciana Bertholim and Scott, Kyle M. and Adams, Larry Deon and Sanchez, Jose J. and Valladares, Glenies S and others},
  title   = {{Significant association between SCN8A and Alzheimer disease in Puerto Ricans}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_098248},
  pmid    = {41434771},
  url     = {https://doi.org/10.1002/alz70855_098248}
}

@article{celis2025-41443185,
  author  = {Celis, Katrina and Griswold, Anthony J. and Rajabli, Farid and Ramírez, Aura María and Nam, Younji and Adams, Larry Deon and Whitehead, Patrice G. and Mena, Pedro Ramon and others},
  title   = {{Transcriptomic analysis from 3D cultures of Presilinin‐1 G206A carriers reveals genetic expression differences associated with age‐of‐onset variability}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_104923},
  pmid    = {41443185},
  url     = {https://doi.org/10.1002/alz70855_104923}
}

@article{langbaum2025-41319675,
  author  = {Langbaum, J. B. and Bradbury, A. R. and Egleston, B. L. and McCarty Wood, E. and Langlois, C. M. and Largent, E. A. and Harkins, K. and Erickson, C. M. and Stites, S. D. and Oyen, E. and others},
  title   = {{Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1}},
  journal = {The Lancet Healthy Longevity},
  year    = {2025},
  doi     = {10.1016/j.lanhl.2025.100778},
  pmid    = {41319675},
  url     = {https://doi.org/10.1016/j.lanhl.2025.100778}
}

@article{bondar2025-41462898,
  author  = {Bondar, Andrei-Cristian and Iordache, Marius P. and Coroescu, Mirela and Buliman, Anca and Rusu, Elena Emanuela and Budișteanu, Magdalena and Tănase, Cristiana},
  title   = {{Unlocking the Sugar Code: Implications and Consequences of Glycosylation in Alzheimer’s Disease and Other Tauopathies}},
  journal = {Biomedicines},
  year    = {2025},
  doi     = {10.3390/biomedicines13122884},
  pmid    = {41462898},
  url     = {https://doi.org/10.3390/biomedicines13122884}
}

@article{lin2025-41284956,
  author  = {Lin, Miao and Zeng, Qingze and Zhong, Siyan and Nie, Shouping and Zhang, Ruiting and Hong, Hui and Liu, Lingyun and Wang, Shuyue and others},
  title   = {{Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213953},
  pmid    = {41284956},
  url     = {https://doi.org/10.1212/wnl.0000000000213953}
}

@article{finn2025-41260674,
  author  = {Finn, Quentin and Pascual, Belén and Schulz, Paul E. and Masdeu, Joseph C.},
  title   = {{β-Amyloid PET Signal Reduction in Prior ARIA-E Regions after Antiamyloid Therapy for Alzheimer Disease}},
  journal = {American Journal of Neuroradiology},
  year    = {2025},
  doi     = {10.3174/ajnr.a9111},
  pmid    = {41260674},
  url     = {https://doi.org/10.3174/ajnr.a9111}
}

@article{zhang2025-41242996,
  author  = {Zhang, Biao and Sun, Zhiyu and Song, Weihong and Huang, He and Wu, Yili},
  title   = {{Engineered butyrate-producing yeasts mitigate Alzheimer-associated phenotypes}},
  journal = {Signal Transduction and Targeted Therapy},
  year    = {2025},
  doi     = {10.1038/s41392-025-02474-7},
  pmid    = {41242996},
  url     = {https://doi.org/10.1038/s41392-025-02474-7}
}

@article{tsoy2025-48774eb9,
  author  = {Tsoy, Andrey and Askarova, Sholpan and Kaupbayeva, Bibifatima},
  title   = {{Polymer-Engineered Aβ-Degrading Proteases via Photo-ATRP for Alzheimer's Disease Therapeutics}},
  journal = {Eurasian journal of applied biotechnology},
  year    = {2025},
  doi     = {10.11134/btp.3s.2025.73},
  url     = {https://doi.org/10.11134/btp.3s.2025.73}
}

@article{ferrarisouza2026-41198899,
  author  = {Ferrari-Souza, J. P. and Povala, G. and Rahmouni, N. and Bellaver, B. and Ferreira, P. C. L. and De Bastiani, M. A. and Leffa, D. T. and Lussier, F. Z. and Aguzzoli, C. S. and Brum, W. S. and Carello-Collar, G. and Borelli, W. V. and others},
  title   = {{Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease}},
  journal = {Nature Neuroscience},
  year    = {2026},
  doi     = {10.1038/s41593-025-02103-0},
  pmid    = {41198899},
  url     = {https://doi.org/10.1038/s41593-025-02103-0}
}

@article{zupan2025-41281549,
  author  = {Zupan, Matija and Splavski, Bruno and Frol, Senta},
  title   = {{Iatrogenic cerebral proteinopathies—The dawn of transmissible neurodegeneration? The example of cerebral amyloid angiopathy}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1693566},
  pmid    = {41281549},
  url     = {https://doi.org/10.3389/fneur.2025.1693566}
}

@article{ramoscejudo2025-41187307,
  author  = {Ramos‐Cejudo, Jaime and Beiser, Alexa S. and Lu, Sophia Francesca DP and Tanner, Jeremy A. and Scott, Matthew R. and He, Tianshe and Ghosh, Saptaparni and Johnson, Keith A. and others},
  title   = {{Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000214314},
  pmid    = {41187307},
  url     = {https://doi.org/10.1212/wnl.0000000000214314}
}

@article{rehra2025-41187812,
  author  = {Rehra, Lena and Erdinger, Susanne and Wagner, Lelia and Baltissen, Danny and Just, Jennifer and König, Leo and Mühlberg, Eric and Eisenzapf, Tom and others},
  title   = {{Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease}},
  journal = {Journal of Controlled Release},
  year    = {2025},
  doi     = {10.1016/j.jconrel.2025.114374},
  pmid    = {41187812},
  url     = {https://doi.org/10.1016/j.jconrel.2025.114374}
}

@article{ray2025-41216864,
  author  = {Ray, Sudipta and Kumar, Mohit and Chemparathy, Divya T. and Dash, Prasanta K. and Sil, Susmita},
  title   = {{HIF‐1 Targeting Intervention Renders Protection From Alzheimer's‐Like Pathology in a Humanized Mice Model of HIV Infection}},
  journal = {Journal of Extracellular Vesicles},
  year    = {2025},
  doi     = {10.1002/jev2.70191},
  pmid    = {41216864},
  url     = {https://doi.org/10.1002/jev2.70191}
}

@article{chen2025-1d3c79ca,
  author  = {Chen, Xiaoying},
  title   = {{T cell drives microglia specific metabolic plasticity and neurodegeneration in Alzheimer disease 4098}},
  journal = {The Journal of Immunology},
  year    = {2025},
  doi     = {10.1093/jimmun/vkaf283.1823},
  url     = {https://doi.org/10.1093/jimmun/vkaf283.1823}
}

@article{sharma2025-41171842,
  author  = {Sharma, Amit and Parekh, Bhavin K and Patil, Vinay and Renuka Jyothi, S. and Nayak, Priya Priyadarshini and Janney, J Bethanney and Singh, Gurjant and Al-Hasnaawei, Shaker},
  title   = {{Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?}},
  journal = {Developmental Neurobiology},
  year    = {2025},
  doi     = {10.1002/dneu.23015},
  pmid    = {41171842},
  url     = {https://doi.org/10.1002/dneu.23015}
}

@article{zhang2025-41261637,
  author  = {Zhang, Jiuchang and Xie, Anmu and Yan, Zhongrui},
  title   = {{Identifying potential drug targets for cerebral amyloid angiopathy: A Mendelian randomization study based on the druggable genes}},
  journal = {Medicine},
  year    = {2025},
  doi     = {10.1097/md.0000000000045643},
  pmid    = {41261637},
  url     = {https://doi.org/10.1097/md.0000000000045643}
}

@article{lehrer2025-41195593,
  author  = {Lehrer, Steven P. and Rheinstein, Peter H.},
  title   = {{rs140926439 Variant in the Fibronectin FN1 Gene Lowers Risk of Alzheimer Disease in APOEε4 Carriers in the UK Biobank Cohort}},
  journal = {Alzheimer Disease \& Associated Disorders},
  year    = {2025},
  doi     = {10.1097/wad.0000000000000692},
  pmid    = {41195593},
  url     = {https://doi.org/10.1097/wad.0000000000000692}
}

@article{deger2025-41167194,
  author  = {Deger, Jennifer and Hannan, Shabab B. and Gu, Mingxue and Strohlein, Colleen E and Goodman, Lindsey D. and Pasupuleti, Sasidhar and Shaik, Zahid and Ma, Liwen and others},
  title   = {{Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila}},
  journal = {The American Journal of Human Genetics},
  year    = {2025},
  doi     = {10.1016/j.ajhg.2025.10.003},
  pmid    = {41167194},
  url     = {https://doi.org/10.1016/j.ajhg.2025.10.003}
}

@article{fiero2025-65f4fa6e,
  author  = {Fiero, Nur Rizky and Saepuloh, Uus and Darusman, Huda Shalahudin and Noviana, Rachmitasari},
  title   = {{Development of Biotin and Horseradish Peroxidase Labelling against Monoclonal Antibody Amyloid-β42 and Its Application on Enzyme-Linked Immunosorbent Assay}},
  journal = {Jurnal Penelitian Pendidikan IPA},
  year    = {2025},
  doi     = {10.29303/jppipa.v11i10.12528},
  url     = {https://doi.org/10.29303/jppipa.v11i10.12528}
}

@article{xu2025-41134126,
  author  = {Xu, Yan and Li, Xiangdong and Zhao, Qingchun and Xu, Xiangbo},
  title   = {{The role of neutrophils, red blood cells, and platelets in the pathology of Alzheimer’s disease}},
  journal = {Annals of Medicine},
  year    = {2025},
  doi     = {10.1080/07853890.2025.2575110},
  pmid    = {41134126},
  url     = {https://doi.org/10.1080/07853890.2025.2575110}
}

@article{krogsaeter2025-41103078,
  author  = {Krogsaeter, Einar Kleinhans and McKetney, Justin and Valiente‐Banuet, Leopoldo and Marquez, Angelica and Willis, Alexandra R. and Cakir, Zeynep and Stevenson, Erica J. and Jang, Gwendolyn Μ. and others},
  title   = {{Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2576613},
  pmid    = {41103078},
  url     = {https://doi.org/10.1080/15548627.2025.2576613}
}

@article{liu2025-41044651,
  author  = {Liu, Hongwei and Yin, Zhaoxu and Chen, Xuan and Wang, Zhijun},
  title   = {{Exploring causal relationships between epigenetic age acceleration and Alzheimer’s disease: a bidirectional Mendelian randomization study}},
  journal = {Clinical Epigenetics},
  year    = {2025},
  doi     = {10.1186/s13148-025-01976-z},
  pmid    = {41044651},
  url     = {https://doi.org/10.1186/s13148-025-01976-z}
}

@article{ye2025-41074912,
  author  = {Ye, Rong and Goodheart, Anna E. and Locascio, Joseph J. and Peterec, Erin and Stancu, Patrick and Wang, Yanhong and Gomperts, Stephen N.},
  title   = {{APOE ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70795},
  pmid    = {41074912},
  url     = {https://doi.org/10.1002/alz.70795}
}

@article{mcwilliam2025-41211301,
  author  = {McWilliam, Oskar Hoffmann and Bsoul, Remarh and Lund, Eva Løbner and Waldemar, Gunhild and Hasselbalch, Steen Gregers and Simonsen, Anja Hviid and Bruun, Marie and von Buchwald, Christian and others},
  title   = {{α‐Synuclein seed amplification assay in Lewy body dementia versus Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70203},
  pmid    = {41211301},
  url     = {https://doi.org/10.1002/dad2.70203}
}

@article{atanasova2025-41155570,
  author  = {Atanasova, Mariyana},
  title   = {{Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part B: Natural Compounds}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18101457},
  pmid    = {41155570},
  url     = {https://doi.org/10.3390/ph18101457}
}

@article{lazaro2025-41022152,
  author  = {Lázaro, Iolanda and Brugulat‐Serrat, Anna and Suárez‐Calvet, Marc and Fauria, Karine and Minguillón, Carolina and Gispert, Juan Domingo and Molinuevo, José Luís and Harris, William S. and others},
  title   = {{Red blood cell ω-3 status and longitudinal cognition in individuals at risk of Alzheimer disease}},
  journal = {Journal of Nutrition},
  year    = {2025},
  doi     = {10.1016/j.tjnut.2025.09.032},
  pmid    = {41022152},
  url     = {https://doi.org/10.1016/j.tjnut.2025.09.032}
}

@article{porchietto2025-41009578,
  author  = {Porchietto, Elisa and Morello, Giulia and Cicilese, Giulia and Rainero, Innocenzo and Rubino, Elisa and Tamagno, Elena and Boschi, Silvia and Guglielmotto, Michela},
  title   = {{UCH-L1 in Alzheimer’s Disease: A Crucial Player in Dementia-Associated Mechanisms}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26189012},
  pmid    = {41009578},
  url     = {https://doi.org/10.3390/ijms26189012}
}

@article{wang2025-40905109,
  author  = {Wang, Yuying and Gao, Yang and Wang, Yarong and Zhang, Fuqiang and Sun, Fei and Wang, Xin and Xie, Jiazhao and Xu, Zhipeng and others},
  title   = {{ApoE4 Upregulates GSK ‐3β to Aggravate Alzheimer‐Like Pathologies and Cognitive Impairment in Type 2 Diabetic Mice}},
  journal = {CNS Neuroscience \& Therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70575},
  pmid    = {40905109},
  url     = {https://doi.org/10.1111/cns.70575}
}

@article{tylek2025-40887534,
  author  = {Tylek, Kinga and Basta‐Kaim, Agnieszka},
  title   = {{Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease}},
  journal = {Journal of Neuroimmune Pharmacology},
  year    = {2025},
  doi     = {10.1007/s11481-025-10236-z},
  pmid    = {40887534},
  url     = {https://doi.org/10.1007/s11481-025-10236-z}
}

@article{blazier2025-40889683,
  author  = {Blazier, Danielle M. and Lewandowski, Eric M. and Ram, Natasha and Zhang, Xiujun and Wang, Shuai and Patel, Om and Collier, Lisa A. and Defilippi, Paola and others},
  title   = {{A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap}},
  journal = {Journal of Biological Chemistry},
  year    = {2025},
  doi     = {10.1016/j.jbc.2025.110665},
  pmid    = {40889683},
  url     = {https://doi.org/10.1016/j.jbc.2025.110665}
}

@article{jiao2025-40877951,
  author  = {Jiao, Haishan and Ge, Yi‐Jun and Huang, Liang-Yu and Liu, Ying and Wu, Bang‐Sheng and Lian, Piaopiao and Hao, Yizhe and Han, Shanshan and others},
  title   = {{MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00887-0},
  pmid    = {40877951},
  url     = {https://doi.org/10.1186/s13024-025-00887-0}
}

@article{manca2025-40851051,
  author  = {Manca, Riccardo and Mitolo, Micaela and Bacalini, Maria Giulia and Capellari, Sabina and Venneri, Annalena},
  title   = {{The impact of polygenic risk for alzheimer’s disease on neurotransmitter-related grey matter atrophy in the alzheimer continuum}},
  journal = {Neurological Sciences},
  year    = {2025},
  doi     = {10.1007/s10072-025-08393-3},
  pmid    = {40851051},
  url     = {https://doi.org/10.1007/s10072-025-08393-3}
}

@article{oveisgharan2025-40845264,
  author  = {Oveisgharan, Shahram and Yu, Lei and Yang, Jingyun and Agrawal, Sonal and Vialle, Ricardo A. and Lopes, Kátia de Paiva and Tasaki, Shinya and Wang, Yanling and others},
  title   = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000214024},
  pmid    = {40845264},
  url     = {https://doi.org/10.1212/wnl.0000000000214024}
}

@article{seok2025-40918735,
  author  = {Seok, Ji‐Woo and Kim, Kahye and Hwang, Soonjo and Lee, Kun Ho and Kim, Jaeuk U.},
  title   = {{Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1592341},
  pmid    = {40918735},
  url     = {https://doi.org/10.3389/fnagi.2025.1592341}
}

@article{zeng2025-40816274,
  author  = {Zeng, Peng-Ming and Sun, Xin-Yao and Li, Yang and Wu, Wen-di and Huang, Jing and Cao, Dongdong and Qian, Pin-jue and Ju, Xiang-Chun and others},
  title   = {{Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids}},
  journal = {Stem Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.stemcr.2025.102601},
  pmid    = {40816274},
  url     = {https://doi.org/10.1016/j.stemcr.2025.102601}
}

@article{mandal2025-40817583,
  author  = {Mandal, Nabanita and Skepö, Marie},
  title   = {{Unraveling the conformational landscape of amyloid precursor protein intracellular domain}},
  journal = {Biophysical Journal},
  year    = {2025},
  doi     = {10.1016/j.bpj.2025.08.010},
  pmid    = {40817583},
  url     = {https://doi.org/10.1016/j.bpj.2025.08.010}
}

@article{cen2025-40731233,
  author  = {Cen, Si and Wang, Lijuan and Qiu, Meiling and Xu, Zhongqiang and Xu, Li and Bao, Rui and Tang, Xiaolei and Gong, Juanyu and others},
  title   = {{Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100315},
  pmid    = {40731233},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100315}
}

@article{dangiolini2025-40806433,
  author  = {D’Angiolini, Simone and Gugliandolo, Agnese and Calì, Gabriella and Chiricosta, Luigi},
  title   = {{Early Dysregulation of RNA Splicing and Translation Processes Are Key Markers from Mild Cognitive Impairment to Alzheimer’s Disease: An In Silico Transcriptomic Analysis}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26157303},
  pmid    = {40806433},
  url     = {https://doi.org/10.3390/ijms26157303}
}

@article{ohno2025-40706761,
  author  = {Ohno, Masuo},
  title   = {{BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease}},
  journal = {Brain Research Bulletin},
  year    = {2025},
  doi     = {10.1016/j.brainresbull.2025.111475},
  pmid    = {40706761},
  url     = {https://doi.org/10.1016/j.brainresbull.2025.111475}
}

@article{ramanan2025-40703204,
  author  = {Ramanan, Vijay K. and Heckman, Michael G. and Hofrenning, Ekaterina I. and Przybelski, Scott A. and Graff‐Radford, Jonathan and Lowe, Val J. and Machulda, Mary M. and Murray, Melissa Erin and others},
  title   = {{Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain β-Amyloid Deposition}},
  journal = {Neurology Genetics},
  year    = {2025},
  doi     = {10.1212/nxg.0000000000200266},
  pmid    = {40703204},
  url     = {https://doi.org/10.1212/nxg.0000000000200266}
}

@article{cheng2025-fccc56a0,
  author  = {Cheng, Bo and Feng, Yuliang and Luo, Zhang-Hong and Xiao, Wei and Yang, Fei and Jia, C. and Zhu, Tao and Zhang, Shushan},
  title   = {{Reduced retinal thickness and risk of Alzheimer’s disease: a bidirectional two-sample Mendelian randomization study}},
  journal = {Ageing and Neurodegenerative Diseases},
  year    = {2025},
  doi     = {10.20517/and.2025.34},
  url     = {https://doi.org/10.20517/and.2025.34}
}

@article{rajabli2025-40676597,
  author  = {Rajabli, F. and Benchek, P. and Tosto, G. and Kushch, N. and Sha, J. and Bazemore, K. and Zhu, C. and Lee, W. P. and others},
  title   = {{Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease}},
  journal = {Genome biology},
  year    = {2025},
  doi     = {10.1186/s13059-025-03564-z},
  pmid    = {40676597},
  url     = {https://doi.org/10.1186/s13059-025-03564-z}
}

@article{shvetcov2025-40665049,
  author  = {Shvetcov, A. and Johnson, E. C. B. and Winchester, L. M. and Walker, K. A. and Wilkins, H. M. and Thompson, T. G. and Rothstein, J. D. and Krish, V. and others},
  title   = {{APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03835-z},
  pmid    = {40665049},
  url     = {https://doi.org/10.1038/s41591-025-03835-z}
}

@article{brezani2025-40665351,
  author  = {Brezáni, Veronika and Joshi, Radhika and Ortega‐Ribera, Martí and Nagesh, Prashanth Thevkar and Zivny, Adam and Kurt‐Jones, Evelyn A. and Golenbock, Douglas Taylor and others},
  title   = {{Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03501-8},
  pmid    = {40665351},
  url     = {https://doi.org/10.1186/s12974-025-03501-8}
}

@article{krick2025-40602729,
  author  = {Krick, Katelynn E. and Weekman, Erica M. and Johnson, Sherika N. and Sudduth, Tiffany L. and Rogers, Colin B. and Nicolayson, Emma J and Kleinhenz, Maureen T. and Wilcock, Donna M.},
  title   = {{Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107013},
  pmid    = {40602729},
  url     = {https://doi.org/10.1016/j.nbd.2025.107013}
}

@article{nasciben2025-40704449,
  author  = {Nasciben, Luciana Bertholim and Nuytemans, Karen and Van Booven, Derek J. and Rajabli, Farid and Moura, Sofia and Ramírez, Aura María and Parker, Griffin S. and Dykxhoorn, Derek M. and others},
  title   = {{Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70500},
  pmid    = {40704449},
  url     = {https://doi.org/10.1002/alz.70500}
}

@article{devkota2025-40723827,
  author  = {Devkota, Sujan and Maesako, Masato and Wolfe, Michael S.},
  title   = {{Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation}},
  journal = {Biomolecules},
  year    = {2025},
  doi     = {10.3390/biom15070955},
  pmid    = {40723827},
  url     = {https://doi.org/10.3390/biom15070955}
}

@article{wang2025-40592256,
  author  = {Wang, Tingting and Arnold, Matthias and Huynh, Kevin and Weinisch, Patrick and Giles, Corey and Mellett, Natalie A. and Duong, Thy and Marella, Bharadwaj and others},
  title   = {{Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study}},
  journal = {EBioMedicine},
  year    = {2025},
  doi     = {10.1016/j.ebiom.2025.105826},
  pmid    = {40592256},
  url     = {https://doi.org/10.1016/j.ebiom.2025.105826}
}

@article{beydoun2025-40588577,
  author  = {Beydoun, May A. and Hu, Yi‐Han and Li, Zhiguang and Georgescu, Michael F. and Beydoun, Hind A. and Hooten, Nicole Noren and Walker, Keenan A. and Bouhrara, Mustapha and others},
  title   = {{Alzheimer’s disease polygenic risk’s association with all-cause dementia through the plasma metabolome in the UK Biobank study}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-01724-4},
  pmid    = {40588577},
  url     = {https://doi.org/10.1007/s11357-025-01724-4}
}

@article{antinori2025-40591736,
  author  = {Antinori, Daniele and Lucarelli, Marco and Fuso, Andrea},
  title   = {{Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic}},
  journal = {Essays in Biochemistry},
  year    = {2025},
  doi     = {10.1042/ebc20253019},
  pmid    = {40591736},
  url     = {https://doi.org/10.1042/ebc20253019}
}

@article{hayashi2025-40589441,
  author  = {Hayashi, Masahiro and Ikeda, Mayumi and Kobayashi, Katsuji},
  title   = {{Cerebral Amyloid Angiopathy With Progressive Cortical Superficial Siderosis and Convexity Subarachnoid Hemorrhage in an Apolipoprotein E (APOE) ε2/ε2 Homozygous Patient: A Case Report and Literature Review}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.87007},
  pmid    = {40589441},
  url     = {https://doi.org/10.7759/cureus.87007}
}

@article{geng2025-40580389,
  author  = {Geng, Zhao and Yu, Zhong-Yuan and Tan, Jun and Wang, Xuan-Yue and Zeng, Gui‐Hua and Li, JL and Bai, Yu-Di and Zeng, Xiaoqin and others},
  title   = {{Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/PS1 Mouse Model}},
  journal = {Neuroscience Bulletin},
  year    = {2025},
  doi     = {10.1007/s12264-025-01442-z},
  pmid    = {40580389},
  url     = {https://doi.org/10.1007/s12264-025-01442-z}
}

@article{vanderlip2025-40577676,
  author  = {Vanderlip, Casey R. and Stark, Craig E.L.},
  title   = {{Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213853},
  pmid    = {40577676},
  url     = {https://doi.org/10.1212/wnl.0000000000213853}
}

@article{hung2025-40570368,
  author  = {Hung, Christy and Llorian, Miriam and Pal, Koustav and Livesey, Frederick J. and Choudhary, Jyoti Sharma and Roumeliotis, Theodoros I. and Patani, Rickie},
  title   = {{Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115867},
  pmid    = {40570368},
  url     = {https://doi.org/10.1016/j.celrep.2025.115867}
}

@article{clocchiattituozzo2025-40549373,
  author  = {Clocchiatti‐Tuozzo, Santiago and Rivier, Cyprien A. and Renedo, Daniela B. and Huo, Shufan and de Havenon, Adam and Hawkes, Maximiliano A. and Gilmore, Emily J. and Schwamm, Lee H. and others},
  title   = {{APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.0182},
  pmid    = {40549373},
  url     = {https://doi.org/10.1001/jamaneurol.2025.0182}
}

@article{mcgill2025-40494894,
  author  = {McGill, Cassandra Joan and Christensen, Amy and Qian, Wenjie and Thorwald, Max Andrew and Godoy-Lugo, José Arquimides and Namvari, Sara and White, Olivia S. and Finch, Caleb E. and others},
  title   = {{Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice}},
  journal = {Communications Medicine},
  year    = {2025},
  doi     = {10.1038/s43856-025-00942-3},
  pmid    = {40494894},
  url     = {https://doi.org/10.1038/s43856-025-00942-3}
}

@article{planalp2025-40461705,
  author  = {Planalp, Elizabeth M. and Langhough, Rebecca E. and Jonaitis, Erin McMullen and Van Hulle, Carol Ann and Wilson, Rachael E. and Kollmorgen, Gwendlyn and Quijano‐Rubio, Clara and Okonkwo, Ozioma C. and others},
  title   = {{Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer’s disease cohort}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-04319-3},
  pmid    = {40461705},
  url     = {https://doi.org/10.1038/s41598-025-04319-3}
}

@article{gan2025-40457423,
  author  = {Gan, Jinghuan and Xu, Ziming and Chen, Wen and Wu, Hao and Chen, Zhichao and Shi, Zhihong and Lu, Hao and Wang, Yajie and others},
  title   = {{Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01770-2},
  pmid    = {40457423},
  url     = {https://doi.org/10.1186/s13195-025-01770-2}
}

@article{bradley2025-40556318,
  author  = {Bradley, J. and Pottier, C. and da Fonseca, E. L. and Kurup, J. T. and Western, D. and Wang, C. and Neupane, A. and Ray, N. R. and Jean-Francois, M. and Ali, M. and Timsina, J. and Bergmann, K. and others},
  title   = {{Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70377},
  pmid    = {40556318},
  url     = {https://doi.org/10.1002/alz.70377}
}

@article{bonham2025-40443531,
  author  = {Bonham, Luke W. and Sirkis, Daniel W. and Pang, Alina P.S. and Sugrue, Leo P. and Santamaría‐García, Hernando A and Ibáñez, Agustín M. and Miller, Bruce Leonard and Yokoyama, Jennifer S. and others},
  title   = {{DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy}},
  journal = {npj Dementia},
  year    = {2025},
  doi     = {10.1038/s44400-025-00007-1},
  pmid    = {40443531},
  url     = {https://doi.org/10.1038/s44400-025-00007-1}
}

@article{butler2025-35ab99e8,
  author  = {Butler, P. M. and Francis, A. and Meunier, A. L. and Anderson, A. K. and Hennessey, E. L. and Miller, M. B. and Lemere, C. A. and Selkoe, D. J. and others},
  title   = {{Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain}},
  journal = {bioRxiv},
  year    = {2025},
  doi     = {10.1101/2025.05.20.654902},
  url     = {https://doi.org/10.1101/2025.05.20.654902}
}

@article{marongiu2025-40438709,
  author  = {Marongiu, Roberta and Platholi, Jimcy and Park, Laibaik and Yu, Fangmin and Sommer, Garrett and Woods, Clara and Milner, Teresa A. and Glass, Michael J.},
  title   = {{Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease}},
  journal = {Frontiers in Molecular Biosciences},
  year    = {2025},
  doi     = {10.3389/fmolb.2025.1597130},
  pmid    = {40438709},
  url     = {https://doi.org/10.3389/fmolb.2025.1597130}
}

@article{taha2025-40359012,
  author  = {Taha, Ameer Y. and Shen, Qing Xiang and Otoki, Yurika and Liang, Nuanyi and Patten, Kelley T. and Valenzuela, Anthony E. and Wallis, Christopher and Rowland, Douglas J. and others},
  title   = {{Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain}},
  journal = {JCI Insight},
  year    = {2025},
  doi     = {10.1172/jci.insight.175917},
  pmid    = {40359012},
  url     = {https://doi.org/10.1172/jci.insight.175917}
}

@article{alvarezsanchez2025-40348819,
  author  = {Álvarez‐Sánchez, Lourdes and Peña‐Bautista, Carmen and Ferré‐González, Laura and Balaguer, Ángel and Amengual, Julián Luis and Baquero, Miguel and Cháfer‐Pericás, Consuelo},
  title   = {{Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-01511-3},
  pmid    = {40348819},
  url     = {https://doi.org/10.1038/s41598-025-01511-3}
}

@article{claus2025-40344552,
  author  = {Claus, Jacqueline Josephine and Rosbergen, Mathijs T. and Labrecque, Jeremy Alexander and Vernooij, Meike Willemijn and Wolters, Frank J. and Ikram, M. Arfan},
  title   = {{Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213679},
  pmid    = {40344552},
  url     = {https://doi.org/10.1212/wnl.0000000000213679}
}

@article{chen2025-40349252,
  author  = {Chen, Jia‐Hung and Chan, Lung and Hong, Chien‐Tai and Hu, Chaur Jong and Hsieh, Yi‐Chen},
  title   = {{Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study}},
  journal = {Aging},
  year    = {2025},
  doi     = {10.18632/aging.206248},
  pmid    = {40349252},
  url     = {https://doi.org/10.18632/aging.206248}
}

@article{chaigneau2025-40304030,
  author  = {Chaigneau, Thomas and Sha, Sha and Roux, Candice M. and Aïd, Saba and Faucher, Alice and Chantran, Yannick and Dorothée, Guillaume and Krantic, Slavica},
  title   = {{Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.70029},
  pmid    = {40304030},
  url     = {https://doi.org/10.1002/glia.70029}
}

@article{mafe2025-40361641,
  author  = {Mafe, Alice Njolke and Büsselberg, Dietrich},
  title   = {{Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration}},
  journal = {Foods},
  year    = {2025},
  doi     = {10.3390/foods14091559},
  pmid    = {40361641},
  url     = {https://doi.org/10.3390/foods14091559}
}

@article{ilgun2025-40301248,
  author  = {İlgün, Atılay and Çakır, Tunahan},
  title   = {{Functional Specificity of Astrocyte Subtypes in Alzheimer’s Disease: Decoding Disease Mechanisms Through Network-based Analysis of Integrated Single-Nuclei Multi-Omic Data}},
  journal = {Molecular Neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-04965-8},
  pmid    = {40301248},
  url     = {https://doi.org/10.1007/s12035-025-04965-8}
}

@article{martiskainen2025-40301889,
  author  = {Martiskainen, Henna and Willman, Roosa-Maria and Harju, Päivi and Heikkinen, Sami V. and Heiskanen, Mette and Müller, Stephan A. and Sinisalo, Rosa and Takalo, Mari and others},
  title   = {{Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00830-3},
  pmid    = {40301889},
  url     = {https://doi.org/10.1186/s13024-025-00830-3}
}

@article{litus2025-50e87e79,
  author  = {Litus, E. A. and Shevelyova, M. P. and Vologzhannikova, A. A. and Deryusheva, E. I. and Chaplygina, A. V. and Rastrygina, V. A. and Machulin, A. V. and Alikova, V. D. and others},
  title   = {{Interaction of Glucagon-Like Peptide 1 and Its Analogues with Amyloid-β Peptide Affects Its Fibrillation and Cytotoxicity}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.20944/preprints202504.2038.v1},
  url     = {https://doi.org/10.20944/preprints202504.2038.v1}
}

@article{barral2025-40219824,
  author  = {Barral, S. and Yang, Z. and Phillips, N. and Barber, R. C. and Brickman, A. M. and Honig, L. S. and Cieza, B. and Reyes-Dumeyer, D. and Mayeux, R. and Rajabli, F. and others},
  title   = {{APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70138},
  pmid    = {40219824},
  url     = {https://doi.org/10.1002/alz.70138}
}

@article{bao2025-40221240,
  author  = {Bao, Cuiping and Luo, Hongbin and Wang, Jiao and Liu, Xuehuan and Li, Yiming and Yang, Jun and Chen, Chong and Yang, Rongrong and others},
  title   = {{Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100156},
  pmid    = {40221240},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100156}
}

@article{prajapati2025-87e1f767,
  author  = {Prajapati, Mittal S and Cheung, Richard Yun-Hing and Bawaneh, Saif and Verma, Himanshu and Al‐Salahat, Ali and Morawo, Adeolu},
  title   = {{Relapsing Remitting Rapidly Progressive Dementia Due to Cerebral Amyloid Angiopathy-Related Inflammation (P11-3.012)}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000208952},
  url     = {https://doi.org/10.1212/wnl.0000000000208952}
}

@article{nemati2025-40170060,
  author  = {Nemati, Reza and Sohrabi-Ashlaghi, Ahmadreza and Saberian, Parsa and Sadeghi, Mohammad and Mardani, Sajjad and Abadi, Alireza and Yaghoobpoor, Ali and Heydari, Atefeh Sadat and others},
  title   = {{Growth associated protein 43 (GAP-43) predicts brain amyloidosis in Alzheimer’s dementia continuum: an [18 F] AV-45 study}},
  journal = {BMC Neurology},
  year    = {2025},
  doi     = {10.1186/s12883-025-04140-5},
  pmid    = {40170060},
  url     = {https://doi.org/10.1186/s12883-025-04140-5}
}

@article{mondal2025-40280630,
  author  = {Mondal, R. and Deb, Shramana and Shome, Gourav and Sarkar, Vramanti and Lahiri, Durjoy and Datta, Sayan and Benito‐León, Julián},
  title   = {{Molecular dynamics of amyloid-β transport in Alzheimer's disease: Exploring therapeutic plasma exchange with albumin replacement – Current insights and future perspectives}},
  journal = {Neurología (English Edition)},
  year    = {2025},
  doi     = {10.1016/j.nrleng.2025.03.008},
  pmid    = {40280630},
  url     = {https://doi.org/10.1016/j.nrleng.2025.03.008}
}

@article{jung2025-40149001,
  author  = {Jung, E. S. and Choi, H. and Mook-Jung, I.},
  title   = {{Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00825-0},
  pmid    = {40149001},
  url     = {https://doi.org/10.1186/s13024-025-00825-0}
}

@article{richter2025-40116674,
  author  = {Richter, Nils and Breidenbach, Laura and Schmieschek, Maximilian H.T. and Heiss, Wolf‐Dieter and Fink, Gereon R. and Onur, Oezguer A.},
  title   = {{Alzheimer-typical temporo-parietal atrophy and hypoperfusion are associated with a more significant cholinergic impairment in amnestic neurodegenerative syndromes}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251324080},
  pmid    = {40116674},
  url     = {https://doi.org/10.1177/13872877251324080}
}

@article{jacques2025-40108015,
  author  = {Jacques, Stout and Anderson Robert, J. and Ali, Mahzarnia and Yar, Han Zay and Kate, Beck and Jeffrey, Browndyke and Kim, Johnson and O'Brien Richard, J. and others},
  title   = {{Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis}},
  journal = {Brain structure \& function},
  year    = {2025},
  doi     = {10.1007/s00429-025-02905-9},
  pmid    = {40108015},
  url     = {https://doi.org/10.1007/s00429-025-02905-9}
}

@article{ray2025-40096060,
  author  = {Ray, Nicholas R. and Bradley, Joseph L. and Yılmaz, Elanur and Kızıl, Çağhan and Kurup, Jiji Thulaseedhara and Martin, Eden R. and Klein, Hans‐Ulrich and Kunkle, Brian W. and others},
  title   = {{Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease}},
  journal = {PLoS Genetics},
  year    = {2025},
  doi     = {10.1371/journal.pgen.1011631},
  pmid    = {40096060},
  url     = {https://doi.org/10.1371/journal.pgen.1011631}
}

@article{sturno2025-40089786,
  author  = {Sturno, Annalise M. and Hassell, James E. and Lanaspa, Miguel Angel and Bruce, Kimberley D.},
  title   = {{Do microglia metabolize fructose in Alzheimer’s disease?}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03401-x},
  pmid    = {40089786},
  url     = {https://doi.org/10.1186/s12974-025-03401-x}
}

@article{radermacher2025-40073745,
  author  = {Radermacher, Juliane and Erhardt, Vincent Konrad Johannes and Walzer, Oliver and Haas, Elodie Christiane and Kuppler, Konstantin Nicolas and Zügner, Jill Sven René and Lauer, Anna Andrea and Hartmann, Tobias and others},
  title   = {{Influence of Ibuprofen on glycerophospholipids and sphingolipids in context of Alzheimer´s Disease}},
  journal = {Biomedicine \& Pharmacotherapy},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.117969},
  pmid    = {40073745},
  url     = {https://doi.org/10.1016/j.biopha.2025.117969}
}

@article{nataraj2025-40116546,
  author  = {Nataraj, Andrew and Blahna, Karel and Ježek, Karel},
  title   = {{Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease Research}},
  journal = {Physiological Research},
  year    = {2025},
  doi     = {10.33549/physiolres.935464},
  pmid    = {40116546},
  url     = {https://doi.org/10.33549/physiolres.935464}
}

@article{vanolst2025-40050704,
  author  = {van Olst, L. and Simonton, B. and Edwards, A. J. and Forsyth, A. V. and Boles, J. and Jamshidi, P. and Watson, T. and Shepard, N. and Krainc, T. and Argue, B. M. and Zhang, Z. and Kuruvilla, J. and others},
  title   = {{Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03574-1},
  pmid    = {40050704},
  url     = {https://doi.org/10.1038/s41591-025-03574-1}
}

@article{xu2025-40067298,
  author  = {Xu, X. and Kwon, J. and Yan, R. and Apio, C. and Song, S. and Heo, G. and Yang, Q. and Timsina, J. and others},
  title   = {{Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries}},
  journal = {JAMA network open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2025.0562},
  pmid    = {40067298},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.0562}
}

@article{gonzalez2025-40063372,
  author  = {Gonzalez, Amanda Inez and Edwards, Lauren C. and Thomas, Kelsey R. and Weigand, Alexandra J. and Bordyug, Maria and Brenner, Einat K. and Urias, Uriel A. and Bangen, Katherine J.},
  title   = {{Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment}},
  journal = {Neuropsychology},
  year    = {2025},
  doi     = {10.1037/neu0000981},
  pmid    = {40063372},
  url     = {https://doi.org/10.1037/neu0000981}
}

@article{jakalski2025-39998604,
  author  = {Jąkalski, Marcin and Bruhn‐Olszewska, Bożena and Rychlicka-Buniowska, Edyta and Davies, Hanna and Sarkisyan, Daniil and Siedlar, Maciej and Baran, Jarosław and Węglarczyk, Kazimierz and others},
  title   = {{DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease}},
  journal = {Cellular and Molecular Life Sciences},
  year    = {2025},
  doi     = {10.1007/s00018-025-05618-8},
  pmid    = {39998604},
  url     = {https://doi.org/10.1007/s00018-025-05618-8}
}

@article{atanasova2025-40143085,
  author  = {Atanasova, Mariyana},
  title   = {{Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part A: Endogenous Compounds and Repurposed Drugs}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18030306},
  pmid    = {40143085},
  url     = {https://doi.org/10.3390/ph18030306}
}

@article{hadzibegovic2025-40004200,
  author  = {Hadžibegović, Senka and Bontempi, Bruno and Nicole, Olivier},
  title   = {{Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26041737},
  pmid    = {40004200},
  url     = {https://doi.org/10.3390/ijms26041737}
}

@article{arafi2025-99d20e91,
  author  = {Arafi, Parnian and Devkota, Sujan and Williams, Emily L. and Maesako, Masato and Wolfe, Michael S.},
  title   = {{Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production}},
  journal = {eLife},
  year    = {2025},
  doi     = {10.7554/elife.102274.3},
  url     = {https://doi.org/10.7554/elife.102274.3}
}

@article{kuriyama2025-39939242,
  author  = {Kuriyama, Mai and Wang, Chu Fan and Nagase, Tatsuya and Sohma, Youhei and Kanai, Motomu and Hori, Yukiko and Tomita, Taisuke},
  title   = {{Proteolytic therapeutic modalities for amyloidoses: Insights into immunotherapy, PROTAC, and photo-oxygenation}},
  journal = {Neurotherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00548},
  pmid    = {39939242},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00548}
}

@article{mikkelsen2025-39900278,
  author  = {Mikkelsen, Jens Damsgaard and Linde-Atkins, Phoebe and Pazarlar, Burcu Azak},
  title   = {{Higher level of [3H]UCB-J binding in ApoE Ɛ4 allele carriers with Alzheimer disease}},
  journal = {Neuroscience Letters},
  year    = {2025},
  doi     = {10.1016/j.neulet.2025.138135},
  pmid    = {39900278},
  url     = {https://doi.org/10.1016/j.neulet.2025.138135}
}

@article{park2025-39924830,
  author  = {Park, Chang-Hyun and Lee, Hyunji and Lee, Young Min and Lee, Byung Dae and Moon, Eunsoo and Suh, Hwagyu and Kim, Kyungwon and Kim, Hak Jin and others},
  title   = {{Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877241313066},
  pmid    = {39924830},
  url     = {https://doi.org/10.1177/13872877241313066}
}

@article{duff2025-39885359,
  author  = {Duff, E. P. and Zetterberg, H. and Heslegrave, A. and Dehghan, A. and Elliott, P. and Allen, N. and Runz, H. and Laban, R. and others},
  title   = {{Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection}},
  journal = {Nature medicine},
  year    = {2025},
  doi     = {10.1038/s41591-024-03426-4},
  pmid    = {39885359},
  url     = {https://doi.org/10.1038/s41591-024-03426-4}
}

@article{islam2025-39944166,
  author  = {Islam, Sadequl and Noorani, Arshad Ali and Sun, Yang and Michikawa, Makoto and Zou, Kun},
  title   = {{Multi-functional role of apolipoprotein E in neurodegenerative diseases}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1535280},
  pmid    = {39944166},
  url     = {https://doi.org/10.3389/fnagi.2025.1535280}
}

@article{ehn2025-39849058,
  author  = {Ehn, Emma and Eisfeldt, Jesper and Laffita‐Mesa, José Miguel and Thonberg, Håkan and Schoumans, Jacqueline and Portaankorva, Anne M. and Viitanen, Matti H. and Lindstrand, Anna and others},
  title   = {{A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-86645-0},
  pmid    = {39849058},
  url     = {https://doi.org/10.1038/s41598-025-86645-0}
}

@article{wu2025-39840463,
  author  = {Wu, Liangwei and Zhao, Yang and Gong, Xiaokang and Liang, Zheng and Yu, Jing Hua and Wang, Jiaquan and Zhang, Yuheng and Wang, Xiaochuan and others},
  title   = {{Intermittent Fasting Ameliorates β‐Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model}},
  journal = {Molecular Nutrition \& Food Research},
  year    = {2025},
  doi     = {10.1002/mnfr.202400660},
  pmid    = {39840463},
  url     = {https://doi.org/10.1002/mnfr.202400660}
}

@article{hansen2025-39855473,
  author  = {Hansen, N. and Teegen, B. and Hirschel, S. and Fox, J. and Fitzner, D. and Wiltfang, J. and Bartels, C.},
  title   = {{Longitudinally persisting KCNA2-autoantibodies in mild amnestic dementia with Alzheimer´s pathology - Report and literature review}},
  journal = {Behavioural brain research},
  year    = {2025},
  doi     = {10.1016/j.bbr.2025.115437},
  pmid    = {39855473},
  url     = {https://doi.org/10.1016/j.bbr.2025.115437}
}

@article{ma2025-39825947,
  author  = {Ma, Xin and Wang, Xin-Meng and Tang, Guozhang and Wang, Yi and Liu, Xue‑Chun and Wang, Shuai-Deng and Peng, Peng and others},
  title   = {{Alterations of amino acids in older adults with Alzheimer’s Disease and Vascular Dementia}},
  journal = {Amino Acids},
  year    = {2025},
  doi     = {10.1007/s00726-024-03442-1},
  pmid    = {39825947},
  url     = {https://doi.org/10.1007/s00726-024-03442-1}
}

@article{shen2025-39813987,
  author  = {Shen, Hongtao and Xie, Yuying and Wang, Yan and Xie, Yusheng and Wang, Yongxiang and Su, Zhenyan and Zhao, Laixi and Yao, Shi and others},
  title   = {{The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2024.2447206},
  pmid    = {39813987},
  url     = {https://doi.org/10.1080/15548627.2024.2447206}
}

@article{cairns2025-39772530,
  author  = {Cairns, Dana M. and Smiley, Brooke M. and Smiley, Jordan A. and Khorsandian, Yasaman A and Kelly, Marilyn F. and Itzhaki, Ruth F. and Kaplan, David Lee},
  title   = {{Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model}},
  journal = {Science Signaling},
  year    = {2025},
  doi     = {10.1126/scisignal.ado6430},
  pmid    = {39772530},
  url     = {https://doi.org/10.1126/scisignal.ado6430}
}

@article{liu2025-39755715,
  author  = {Liu, Qing H. and Sun, Ye and He, Baodong and Chen, Haodong and Wang, Lijing and Wang, Gaojie and Zhang, Kang and Zhao, Ximeng and others},
  title   = {{Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-024-01919-4},
  pmid    = {39755715},
  url     = {https://doi.org/10.1186/s40478-024-01919-4}
}

@article{delva2025-39761530,
  author  = {Delva, Aline and Pelletier, Amélie and Somerville, Emma N. and Montplaisir, Jacques Yves and Gagnon, Jean‐François and Kollmorgen, Gwendlyn and Kam‐Thong, Tony and Kustermann, Thomas and others},
  title   = {{Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf003},
  pmid    = {39761530},
  url     = {https://doi.org/10.1093/brain/awaf003}
}

@article{richter2025-e6dc4520,
  author  = {Richter, Nils and Breidenbach, Laura and Schmieschek, Maximilian H.T. and Heiss, Wolf‐Dieter and Fink, Gereon R. and Onur, Özgür},
  title   = {{Alzheimer-typical temporo-parietal atrophy and hypoperfusion are associated with a more significant cholinergic impairment in amnestic neurodegenerative syndromes}},
  journal = {JuSER Publikationsportal},
  year    = {2025},
  doi     = {10.34734/fzj-2025-01978},
  url     = {https://doi.org/10.34734/fzj-2025-01978}
}

@article{kumar2025-41040848,
  author  = {Kumar, Atul and Binette, Alexa Pichet and Bali, Divya and Janelidze, Shorena and Stomrud, Erik and Palmqvist, Sebastian and Vogel, Jacob W. and Hansson, Oskar and others},
  title   = {{Cell-weighted polygenic risk scores are associated with β-amyloid and tau biomarkers in Alzheimer’s disease}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf353},
  pmid    = {41040848},
  url     = {https://doi.org/10.1093/braincomms/fcaf353}
}

@article{achou2025-0c99f57b,
  author  = {Achou, Rayene and Ayachi, Ouarda Sariyah and Boukhenaf, Yasmina and Laouar, Rania and Razika, Gharzouli and Abderrahim, M’zahem and Boulala, Houda and Abadi, Noureddine and others},
  title   = {{Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors}},
  journal = {Archives of Biological Sciences},
  year    = {2025},
  doi     = {10.2298/abs250208005a},
  url     = {https://doi.org/10.2298/abs250208005a}
}

@article{vilortejedor2025-41092763,
  author  = {Vilor‐Tejedor, Natàlia and Rodrigo, Albert and Genius, Patricia and Rodríguez‐Fernández, Blanca and Anastasi, Federica and Pelkmans, Wiesje and Navarro, Arcadi and Adams, Hieab H.H. and others},
  title   = {{Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103889},
  pmid    = {41092763},
  url     = {https://doi.org/10.1016/j.nicl.2025.103889}
}

@article{garniercrussard2025-41312509,
  author  = {Garnier‐Crussard, Antoine and Sadr, Alexandre Bani and Quadrio, Isabelle and Formaglio, Maïté and Desestret, Virginie and Tournier‐Lasserve, Elisabeth and Coste, Thibault},
  title   = {{Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100518},
  pmid    = {41312509},
  url     = {https://doi.org/10.1016/j.cccb.2025.100518}
}

@article{escariao2025-40423635,
  author  = {Escarião, Wellydo Kesllowd Marinho and Silva, Guilherme Henrique and de Castro, Hellen Suzane Clemente and da Silva, Sayonara Pereira and Santana, Nelyane N. M. and Lima, Ramon Hypólito and Fiuza, Felipe Porto},
  title   = {{Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease}},
  journal = {Aging and Disease},
  year    = {2025},
  doi     = {10.14336/ad.2025.0409},
  pmid    = {40423635},
  url     = {https://doi.org/10.14336/ad.2025.0409}
}

@article{chen2025-40630682,
  author  = {Chen, Xi and Chen, Silu and Chen, Liangliang and Zheng, Hong and Nie, Jing and Yang, Lingyan and Li, Xia and Ju, Kang},
  title   = {{Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease}},
  journal = {RSC Advances},
  year    = {2025},
  doi     = {10.1039/d5ra02993g},
  pmid    = {40630682},
  url     = {https://doi.org/10.1039/d5ra02993g}
}

@article{johansson2025-41005266,
  author  = {Johansson, Charlotte and Koenig, Thomas W. and Smailović, Una and Hallström, Vanessa and Jelić, Vesna and Graff, Caroline},
  title   = {{Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103879},
  pmid    = {41005266},
  url     = {https://doi.org/10.1016/j.nicl.2025.103879}
}

@article{zhao2025-39749650,
  author  = {Zhao, B. and Zang, P. and Quan, M. and Wang, Q. and Guo, D. and Jia, J. and Wang, W.},
  title   = {{The Effect of APOE ε4 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST}},
  journal = {CNS neuroscience \& therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70202},
  pmid    = {39749650},
  url     = {https://doi.org/10.1111/cns.70202}
}

@article{o2025-39652363,
  author  = {Ö, İş and Min, Y. and Wang, X. and Oatman, SR. and Abraham Daniel, A. and Ertekin-Taner, N.},
  title   = {{Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.24652},
  pmid    = {39652363},
  url     = {https://doi.org/10.1002/glia.24652}
}

@article{baligacs2024-39639016,
  author  = {Baligács, N. and Albertini, G. and Borrie, S. C. and Serneels, L. and Pridans, C. and Balusu, S. and De Strooper, B.},
  title   = {{Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-54779-w},
  pmid    = {39639016},
  url     = {https://doi.org/10.1038/s41467-024-54779-w}
}

@article{windon2024-23bc1148,
  author  = {Windon, Charles and Tsoy, Elena and Livaudais‐Toman, Jennifer and Hanna, Lucy and Gatsonis, Constantine G. and Carrillo, Marı́a C. and Apgar, Charles S. and Dilworth‐Anderson, Peggye and others},
  title   = {{Residential Neighborhood Disadvantage and Amyloid Positivity: Findings from IDEAS}},
  journal = {Alzheimer s \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.094017},
  url     = {https://doi.org/10.1002/alz.094017}
}

@article{windon2024-765dd107,
  author  = {Windon, Charles and Tsoy, Elena and Livaudais‐Toman, Jennifer and Hanna, Lucy and Gatsonis, Constantine A. and Carrillo, María C. and Apgar, Charles S. and Dilworth‐Anderson, Peggye and others},
  title   = {{Residential Neighborhood Disadvantage and Amyloid Positivity: Findings from IDEAS}},
  journal = {Alzheimer s \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.091995},
  url     = {https://doi.org/10.1002/alz.091995}
}

@article{gunaydin2024-39511891,
  author  = {Günaydin, C. and Sondhi, D. and Kaminsky, S. M. and Lephart, H. C. and Leopold, P. L. and Hackett, N. R. and Khanna, R. and Crystal, R. G.},
  title   = {{AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice}},
  journal = {Molecular Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.11.003},
  pmid    = {39511891},
  url     = {https://doi.org/10.1016/j.ymthe.2024.11.003}
}

@article{younis2024-39541691,
  author  = {Younis, Inas Youssef and Sedeek, Mohamed S. and Essa, Ahmed F. and Elgamal, Abdelbaset M. and Eltanany, Basma Mohamed and Goda, Zeinab M. and Pont, Laura and Benavente, Fernando and others},
  title   = {{Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis}},
  journal = {Food Chemistry},
  year    = {2024},
  doi     = {10.1016/j.foodchem.2024.141918},
  pmid    = {39541691},
  url     = {https://doi.org/10.1016/j.foodchem.2024.141918}
}

@article{tong2024-39444005,
  author  = {Tong, T. and Zhu, C. and Farrell, J. J. and Khurshid, Z. and {Alzheimer’s Disease Sequencing Project} and {Alzheimer’s Disease Neuroimaging Initiative} and Martin, E. R. and Pericak-Vance, M. A. and others},
  title   = {{Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites}},
  journal = {Alzheimer's research \& therapy},
  year    = {2024},
  doi     = {10.1186/s13195-024-01601-w},
  pmid    = {39444005},
  url     = {https://doi.org/10.1186/s13195-024-01601-w}
}

@article{zhang2024-39363202,
  author  = {Zhang, X. X. and Wei, M. and Wang, H. R. and Hu, Y. Z. and Sun, H. M. and Jia, J. J.},
  title   = {{Mitochondrial dysfunction gene expression, DNA methylation, and inflammatory cytokines interaction activate Alzheimer's disease: a multi-omics Mendelian randomization study}},
  journal = {Journal of translational medicine},
  year    = {2024},
  doi     = {10.1186/s12967-024-05680-z},
  pmid    = {39363202},
  url     = {https://doi.org/10.1186/s12967-024-05680-z}
}

@article{carling2024-39353433,
  author  = {Carling, G. K. and Fan, L. and Foxe, N. R. and Norman, K. and Wong, M. Y. and Zhu, D. and Corona, C. and Razzoli, A. and others},
  title   = {{Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model}},
  journal = {Neuron},
  year    = {2024},
  doi     = {10.1016/j.neuron.2024.09.006},
  pmid    = {39353433},
  url     = {https://doi.org/10.1016/j.neuron.2024.09.006}
}

@article{minhas2024-39172838,
  author  = {Minhas, P. S. and Jones, JR. and Latif-Hernandez, A. and Sugiura, Y. and Durairaj, A. S. and Wang, Q. and Mhatre, S. D. and Uenaka, T. and others},
  title   = {{Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies}},
  journal = {Science (New York, N.Y.)},
  year    = {2024},
  doi     = {10.1126/science.abm6131},
  pmid    = {39172838},
  url     = {https://doi.org/10.1126/science.abm6131}
}

@article{schultz2024-39074479,
  author  = {Schultz, S. A. and Liu, L. and Schultz, A. P. and Fitzpatrick, C. D. and Levin, R. and Bellier, J. P. and Shirzadi, Z. and Joseph-Mathurin, N. and others},
  title   = {{γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)}},
  journal = {The Lancet. Neurology},
  year    = {2024},
  doi     = {10.1016/s1474-4422(24)00236-9},
  pmid    = {39074479},
  url     = {https://doi.org/10.1016/s1474-4422(24)00236-9}
}

@article{jacques2024-38979335,
  author  = {Jacques, Stout and Anderson Robert, J. and Ali, Mahzarnia and Zay, Han and Kate, Beck and Jeffrey, Browndyke and Kim, Johnson and O'Brien Richard, J. and others},
  title   = {{Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis}},
  journal = {Brain structure \& function},
  year    = {2024},
  doi     = {10.1101/2024.06.24.599407},
  pmid    = {38979335},
  url     = {https://doi.org/10.1101/2024.06.24.599407}
}

@article{hung2024-38527856,
  author  = {Hung, C. and Fertan, E. and Livesey, F. J. and Klenerman, D. and Patani, R.},
  title   = {{APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease}},
  journal = {Brain},
  year    = {2024},
  doi     = {10.1093/brain/awae092},
  pmid    = {38527856},
  url     = {https://doi.org/10.1093/brain/awae092}
}

@article{grossojasutkar2024-38949671,
  author  = {Grosso Jasutkar, H. and Wasserlein, E. M. and Ishola, A. and Litt, N. and Staniszewski, A. and Arancio, O. and Yamamoto, A.},
  title   = {{Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease}},
  journal = {Autophagy},
  year    = {2024},
  doi     = {10.1080/15548627.2024.2368335},
  pmid    = {38949671},
  url     = {https://doi.org/10.1080/15548627.2024.2368335}
}

@article{lesne2024-6acae23c,
  author  = {Lesné, S. and Koh, M. T. and Kotilinek, L. and Kayed, R. and Glabe, C. G. and Yang, A. and Gallagher, M. and Ashe, K. H.},
  title   = {{Retraction Note: A specific amyloid-beta protein assembly in the brain impairs memory}},
  journal = {Nature},
  year    = {2024}
}

@article{quiroz2024-38899694,
  author  = {Quiroz, Y. T. and Aguillon, D. and Aguirre-Acevedo, D. C. and Vasquez, D. and Zuluaga, Y. and Baena, A. Y. and Madrigal, L. and Hincapié, L. and Sanchez, J. S. and Langella, S. and Posada-Duque, R. and Littau, J. L. and others},
  title   = {{APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease}},
  journal = {New England Journal of Medicine},
  year    = {2024},
  doi     = {10.1056/NEJMoa2308583},
  pmid    = {38899694},
  url     = {https://doi.org/10.1056/NEJMoa2308583}
}

@article{tosun2024-38770829,
  author  = {Tosun, D. and Hausle, Z. and Iwaki, H. and Thropp, P. and Lamoureux, J. and Lee, E. B. and MacLeod, K. and McEvoy, S. and others},
  title   = {{A cross-sectional study of α-synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.13858},
  pmid    = {38770829},
  url     = {https://doi.org/10.1002/alz.13858}
}

@article{fortea2024-38710950,
  author  = {Fortea, J. and Pegueroles, J. and Alcolea, D. and Belbin, O. and Dols-Icardo, O. and Vaqué-Alcázar, L. and Videla, L. and Gispert, J. D. and others},
  title   = {{APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02931-w},
  pmid    = {38710950},
  url     = {https://doi.org/10.1038/s41591-024-02931-w}
}

@article{fortea2024-3b742ebe,
  author  = {Fortea, J. and Pegueroles, J. and Alcolea, D. and others},
  title   = {{APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {2024}
}

@article{lemche2024-38643861,
  author  = {Lemche, E. and Killick, R. and Mitchell, J. and Caton, P. W. and Choudhary, P. and Howard, J. K.},
  title   = {{Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis}},
  journal = {Neurobiology of disease},
  year    = {2024},
  doi     = {10.1016/j.nbd.2024.106485},
  pmid    = {38643861},
  url     = {https://doi.org/10.1016/j.nbd.2024.106485}
}

@article{bhattarai2024-38598053,
  author  = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others},
  title   = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}},
  journal = {Acta Neuropathologica},
  year    = {2024},
  doi     = {10.1007/s00401-024-02721-1},
  pmid    = {38598053},
  url     = {https://doi.org/10.1007/s00401-024-02721-1}
}

@article{lane2024-38594621,
  author  = {Lane, R. M. and Darreh-Shori, T. and Junge, C. and Li, D. and Yang, Q. and Edwards, A. L. and Graham, D. L. and Moore, K. and others},
  title   = {{Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers}},
  journal = {BMC neurology},
  year    = {2024},
  doi     = {10.1186/s12883-024-03611-5},
  pmid    = {38594621},
  url     = {https://doi.org/10.1186/s12883-024-03611-5}
}

@article{deng2024-38604526,
  author  = {Deng, J. and Liu, B. and Tao, Q. and Luo, Y. and Zhu, Y. and Huang, X. and Yue, F.},
  title   = {{The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level}},
  journal = {Neuroscience},
  year    = {2024},
  doi     = {10.1016/j.neuroscience.2024.04.002},
  pmid    = {38604526},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.04.002}
}

@article{mancuso2024-38539015,
  author  = {Mancuso, R. and Fattorelli, N. and Martinez-Muriana, A. and Davis, E. and Wolfs, L. and Van Den Daele, J. and Geric, I. and Premereur, J. and others},
  title   = {{Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology}},
  journal = {Nature neuroscience},
  year    = {2024},
  doi     = {10.1038/s41593-024-01600-y},
  pmid    = {38539015},
  url     = {https://doi.org/10.1038/s41593-024-01600-y}
}

@article{jackson2024-38504517,
  author  = {Jackson, R. J. and Keiser, M. S. and Meltzer, J. C. and Fykstra, D. P. and Dierksmeier, S. E. and Hajizadeh, S. and Kreuzer, J. and Morris, R. and others},
  title   = {{APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.03.024},
  pmid    = {38504517},
  url     = {https://doi.org/10.1016/j.ymthe.2024.03.024}
}

@article{huang2024-38501315,
  author  = {Huang, S. Y. and Zhang, Y. R. and Guo, Y. and Du, J. and Ren, P. and Wu, B. S. and Feng, J. F. and {Alzheimer's Disease Neuroimaging Initiative} and Cheng, W. and Yu, J. T.},
  title   = {{Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease}},
  journal = {Alzheimer's \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.13789},
  pmid    = {38501315},
  url     = {https://doi.org/10.1002/alz.13789}
}

@article{ferrari2024-a3b419d0,
  author  = {Ferrari, IV.},
  title   = {{Exploring Natural Compounds for Alzheimer's Disease: Virtual Screening and Docking Study with KIBRA Protein}},
  journal = {Preprints.org},
  year    = {2024},
  doi     = {10.20944/preprints202402.0232.v1},
  url     = {https://doi.org/10.20944/preprints202402.0232.v1}
}

@article{blumenfeld2024-38191720,
  author  = {Blumenfeld, J. and Yip, O. and Kim, M. J. and Huang, Y.},
  title   = {{Cell type-specific roles of APOE4 in Alzheimer disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2024},
  doi     = {10.1038/s41583-023-00776-9},
  pmid    = {38191720},
  url     = {https://doi.org/10.1038/s41583-023-00776-9}
}

@article{lane2024-2fcd5460,
  author  = {Lane, R. M. and Darreh-Shori, T. and Junge, C. and Li, D. and Yang, Q. and Edwards, A. L. and Graham, D. L. and Moore, K. and others},
  title   = {{Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers}},
  journal = {BMC neurology},
  year    = {2024},
  doi     = {10.1101/2024.01.02.24300718},
  url     = {https://doi.org/10.1101/2024.01.02.24300718}
}

@article{sushma2024-38143280,
  author  = {Sushma and Sahu, M. R. and Murugan, N. A. and Mondal, A. C.},
  title   = {{Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling}},
  journal = {Molecular nutrition \& food research},
  year    = {2024},
  doi     = {10.1002/mnfr.202300245},
  pmid    = {38143280},
  url     = {https://doi.org/10.1002/mnfr.202300245}
}

@article{belloy2023-37930705,
  author  = {Belloy, M. E. and Andrews, S. J. and Le Guen, Y. and Cuccaro, M. and Farrer, L. A. and Napolioni, V. and Greicius, M. D.},
  title   = {{APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry}},
  journal = {JAMA Neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3599},
  pmid    = {37930705},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3599}
}

@article{shirzadi2023-37843849,
  author  = {Shirzadi, Z. and Schultz, S. A. and Yau, W. W. and Joseph-Mathurin, N. and Fitzpatrick, C. D. and Levin, R. and Kantarci, K. and Preboske, G. M. and others},
  title   = {{Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.3618},
  pmid    = {37843849},
  url     = {https://doi.org/10.1001/jamaneurol.2023.3618}
}

@article{tang2024-37915255,
  author  = {Tang, X. and Walter, E. and Wohleb, E. and Fan, Y. and Wang, C.},
  title   = {{ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease}},
  journal = {Autophagy},
  year    = {2024},
  doi     = {10.1080/15548627.2023.2277634},
  pmid    = {37915255},
  url     = {https://doi.org/10.1080/15548627.2023.2277634}
}

@article{xie2023-37859748,
  author  = {Xie, X. and Song, Q. and Dai, C. and Cui, S. and Tang, R. and Li, S. and Chang, J. and Li, P. and others},
  title   = {{Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer's disease: a phase I/II clinical trial}},
  journal = {General psychiatry},
  year    = {2023},
  doi     = {10.1136/gpsych-2023-101143},
  pmid    = {37859748},
  url     = {https://doi.org/10.1136/gpsych-2023-101143}
}

@article{delgadoperaza2023-37730689,
  author  = {Delgado-Peraza, F. and Nogueras-Ortiz, C. and Simonsen, A. H. and Knight, D. D. and Yao, P. J. and Goetzl, E. J. and Jensen, C. S. and Høgh, P. and others},
  title   = {{Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2023},
  doi     = {10.1186/s13195-023-01303-9},
  pmid    = {37730689},
  url     = {https://doi.org/10.1186/s13195-023-01303-9}
}

@article{plascenciavilla2023-37627623,
  author  = {Plascencia-Villa, G. and Perry, G.},
  title   = {{Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer's Disease}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2023},
  doi     = {10.3390/antiox12081628},
  pmid    = {37627623},
  url     = {https://doi.org/10.3390/antiox12081628}
}

@article{ergin2023-37506768,
  author  = {Ergin, A. D. and Üner, B. and Ş, Balcı and Ç, Demirbağ and Benetti, C. and Ç, Oltulu},
  title   = {{Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes}},
  journal = {Journal of pharmaceutical sciences},
  year    = {2023},
  doi     = {10.1016/j.xphs.2023.07.020},
  pmid    = {37506768},
  url     = {https://doi.org/10.1016/j.xphs.2023.07.020}
}

@article{wisch2023-36542469,
  author  = {Wisch, J. K. and Butt, O. H. and Gordon, B. A. and Schindler, S. E. and Fagan, A. M. and Henson, R. L. and Yang, C. and Boerwinkle, A. H. and others},
  title   = {{Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac484},
  pmid    = {36542469},
  url     = {https://doi.org/10.1093/brain/awac484}
}

@article{bouzid2023-37322115,
  author  = {Bouzid, H. and Belk, J. A. and Jan, M. and Qi, Y. and Sarnowski, C. and Wirth, S. and Ma, L. and Chrostek, M. R. and others},
  title   = {{Clonal hematopoiesis is associated with protection from Alzheimer's disease}},
  journal = {Nature medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02397-2},
  pmid    = {37322115},
  url     = {https://doi.org/10.1038/s41591-023-02397-2}
}

@article{schultz2023-37291760,
  author  = {Schultz, S. A. and Shirzadi, Z. and Schultz, A. P. and Liu, L. and Fitzpatrick, C. D. and McDade, E. and Barthelemy, N. R. and Renton, A. and others},
  title   = {{Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2023},
  doi     = {10.1111/acel.13871},
  pmid    = {37291760},
  url     = {https://doi.org/10.1111/acel.13871}
}

@article{li2023-37260021,
  author  = {Li, D. and Farrell, J. J. and Mez, J. and Martin, E. R. and Bush, W. S. and Ruiz, A. and Boada, M. and de Rojas, I. and Mayeux, R. and Haines, J. L. and Vance, M. A. P. and Wang, L. S. and others},
  title   = {{Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews}},
  journal = {Alzheimer's \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.13117},
  pmid    = {37260021},
  url     = {https://doi.org/10.1002/alz.13117}
}

@article{depp2023-37258678,
  author  = {Depp, C. and Sun, T. and Sasmita, A. O. and Spieth, L. and Berghoff, S. A. and Nazarenko, T. and Overhoff, K. and Steixner-Kumar, A. A. and others},
  title   = {{Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease}},
  journal = {Nature},
  year    = {2023},
  doi     = {10.1038/s41586-023-06120-6},
  pmid    = {37258678},
  url     = {https://doi.org/10.1038/s41586-023-06120-6}
}

@article{lopera2023-37188781,
  author  = {Lopera, F. and Marino, C. and Chandrahas, A. S. and O'Hare, M. and Villalba-Moreno, N. D. and Aguillon, D. and Baena, A. and Sanchez, J. S. and Vila-Castelar, C. and Ramirez Gomez, L. and Chmielewska, N. and Oliveira, G. M. and others},
  title   = {{Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man}},
  journal = {Nature Medicine},
  year    = {2023},
  doi     = {10.1038/s41591-023-02318-3},
  pmid    = {37188781},
  url     = {https://doi.org/10.1038/s41591-023-02318-3}
}

@article{brase2023-37085492,
  author  = {Brase, L. and You, S. F. and D'Oliveira Albanus, R. and Del-Aguila, J. L. and Dai, Y. and Novotny, B. C. and Soriano-Tarraga, C. and Dykstra, T. and others},
  title   = {{Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-37437-5},
  pmid    = {37085492},
  url     = {https://doi.org/10.1038/s41467-023-37437-5}
}

@article{kumar2023-37071449,
  author  = {Kumar, A. and Su, Y. and Sharma, M. and Singh, S. and Kim, S. and Peavey, J. J. and Suerken, C. K. and Lockhart, S. N. and others},
  title   = {{MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13055},
  pmid    = {37071449},
  url     = {https://doi.org/10.1002/alz.13055}
}

@article{oeckl2023-37052206,
  author  = {Oeckl, P. and Bluma, M. and Bucci, M. and Halbgebauer, S. and Chiotis, K. and Sandebring-Matton, A. and Ashton, N. J. and Molfetta, G. D. and others},
  title   = {{Blood β-synuclein is related to amyloid PET positivity in memory clinic patients}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.13046},
  pmid    = {37052206},
  url     = {https://doi.org/10.1002/alz.13046}
}

@article{alves2023-36973044,
  author  = {Alves, F. and Kalinowski, P. and Ayton, S.},
  title   = {{Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis}},
  journal = {Neurology},
  year    = {2023},
  doi     = {10.1212/wnl.0000000000207156},
  pmid    = {36973044},
  url     = {https://doi.org/10.1212/wnl.0000000000207156}
}

@article{leguen2023-36809323,
  author  = {Le Guen, Y. and Raulin, A. C. and Logue, M. W. and Sherva, R. and Belloy, M. E. and Eger, S. J. and Chen, A. and Kennedy, G. and Kuchenbecker, L. and O'Leary, J. P. and Zhang, R. and Merritt, V. C. and others},
  title   = {{Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease}},
  journal = {JAMA},
  year    = {2023},
  doi     = {10.1001/jama.2023.0268},
  pmid    = {36809323},
  url     = {https://doi.org/10.1001/jama.2023.0268}
}

@article{matsuzaki2023-36721026,
  author  = {Matsuzaki, M. and Yokoyama, M. and Yoshizawa, Y. and Kaneko, N. and Naito, H. and Kobayashi, H. and Korenaga, A. and Sekiya, S. and others},
  title   = {{ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711}},
  journal = {Molecular psychiatry},
  year    = {2023},
  doi     = {10.1038/s41380-023-01946-y},
  pmid    = {36721026},
  url     = {https://doi.org/10.1038/s41380-023-01946-y}
}

@article{zhou2023-36658241,
  author  = {Zhou, Y. and Tada, M. and Cai, Z. and Andhey, P. S. and Swain, A. and Miller, K. R. and Gilfillan, S. and Artyomov, M. N. and others},
  title   = {{Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-022-01403-y},
  pmid    = {36658241},
  url     = {https://doi.org/10.1038/s41590-022-01403-y}
}

@article{vanarendonk2023-36374264,
  author  = {van Arendonk, J. and Neitzel, J. and Steketee, R. M. E. and van Assema, D. M. E. and Vrooman, H. A. and Segbers, M. and Ikram, M. A. and Vernooij, M. W.},
  title   = {{Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study}},
  journal = {Brain : a journal of neurology},
  year    = {2023},
  doi     = {10.1093/brain/awac354},
  pmid    = {36374264},
  url     = {https://doi.org/10.1093/brain/awac354}
}

@article{rajabli2023-36539198,
  author  = {Rajabli, F. and Tosto, G. and Hamilton-Nelson, K. L. and Kunkle, B. W. and Vardarajan, B. N. and Naj, A. and Whitehead, P. G. and Gardner, O. K. and Bush, W. S. and Sariya, S. and Mayeux, R. P. and Farrer, L. A. and others},
  title   = {{Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans}},
  journal = {Alzheimer's \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.12865},
  pmid    = {36539198},
  url     = {https://doi.org/10.1002/alz.12865}
}

@article{lin2023-36524682,
  author  = {Lin, P. B. and Tsai, A. P. and Soni, D. and Lee-Gosselin, A. and Moutinho, M. and Puntambekar, S. S. and Landreth, G. E. and Lamb, B. T. and others},
  title   = {{INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12849},
  pmid    = {36524682},
  url     = {https://doi.org/10.1002/alz.12849}
}

@article{adhikari2023-36515320,
  author  = {Adhikari, U. K. and Khan, R. and Mikhael, M. and Balez, R. and David, M. A. and Mahns, D. and Hardy, J. and Tayebi, M.},
  title   = {{Therapeutic anti-amyloid β antibodies cause neuronal disturbances}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12833},
  pmid    = {36515320},
  url     = {https://doi.org/10.1002/alz.12833}
}

@article{kamagata2022-36123122,
  author  = {Kamagata, K. and Andica, C. and Takabayashi, K. and Saito, Y. and Taoka, T. and Nozaki, H. and Kikuta, J. and Fujita, S. and others},
  title   = {{Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201300},
  pmid    = {36123122},
  url     = {https://doi.org/10.1212/wnl.0000000000201300}
}

@article{torresmendoza2022-36327127,
  author  = {Torres-Mendoza, B. M. G. and Ortiz, G. G. and Sánchez-Romero, L. and Delgado-Lara, D. L. C. and García Martínez, M. T. and Mireles-Ramírez, M. A. and Cruz Serrano, J. A. and Pacheco Moisés, F. P.},
  title   = {{Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease}},
  journal = {Nutricion hospitalaria},
  year    = {2022},
  doi     = {10.20960/nh.04153},
  pmid    = {36327127},
  url     = {https://doi.org/10.20960/nh.04153}
}

@article{chen2023-36455485,
  author  = {Chen, L. L. and Fan, Y. G. and Zhao, L. X. and Zhang, Q. and Wang, Z. Y.},
  title   = {{The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators}},
  journal = {Bioorganic chemistry},
  year    = {2023},
  doi     = {10.1016/j.bioorg.2022.106301},
  pmid    = {36455485},
  url     = {https://doi.org/10.1016/j.bioorg.2022.106301}
}

@article{holstege2022-36411364,
  author  = {Holstege, H. and Hulsman, M. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Grozeva, D. and van Rooij, J. G. J. and Sims, R. and others},
  title   = {{Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2022},
  doi     = {10.1038/s41588-022-01208-7},
  pmid    = {36411364},
  url     = {https://doi.org/10.1038/s41588-022-01208-7}
}

@article{grontvedt2022-36413367,
  author  = {Grøntvedt, G. R. and Sando, S. B. and Lauridsen, C. and Bråthen, G. and White, L. R. and Ø, Salvesen and Aarsland, D. and Hessen, E. and others},
  title   = {{Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden}},
  journal = {JAMA network open},
  year    = {2022},
  doi     = {10.1001/jamanetworkopen.2022.43232},
  pmid    = {36413367},
  url     = {https://doi.org/10.1001/jamanetworkopen.2022.43232}
}

@article{jurcau2022-36358538,
  author  = {Jurcău, M. C. and Andronie-Cioara, F. L. and Jurcău, A. and Marcu, F. and Ţiț, D. M. and Pașcalău, N. and Nistor-Cseppentö, D. C.},
  title   = {{The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer's Disease: Therapeutic Implications and Future Perspectives}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2022},
  doi     = {10.3390/antiox11112167},
  pmid    = {36358538},
  url     = {https://doi.org/10.3390/antiox11112167}
}

@article{flores2022-36220815,
  author  = {Flores, J. and Fillion, M. L. and LeBlanc, A. C.},
  title   = {{Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05290-x},
  pmid    = {36220815},
  url     = {https://doi.org/10.1038/s41419-022-05290-x}
}

@article{morris2022-35580594,
  author  = {Morris, J. C. and Weiner, M. and Xiong, C. and Beckett, L. and Coble, D. and Saito, N. and Aisen, P. S. and Allegri, R. and others},
  title   = {{Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac181},
  pmid    = {35580594},
  url     = {https://doi.org/10.1093/brain/awac181}
}

@article{katsumata2022-36191742,
  author  = {Katsumata, Y. and Shade, L. M. and Hohman, T. J. and Schneider, J. A. and Bennett, D. A. and Farfel, J. M. and {Alzheimer’s Disease Genetics Consortium} and Kukull, W. A. and others},
  title   = {{Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105880},
  pmid    = {36191742},
  url     = {https://doi.org/10.1016/j.nbd.2022.105880}
}

@article{shireby2022-36153390,
  author  = {Shireby, G. and Dempster, E. L. and Policicchio, S. and Smith, R. G. and Pishva, E. and Chioza, B. and Davies, J. P. and others},
  title   = {{DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-33394-7},
  pmid    = {36153390},
  url     = {https://doi.org/10.1038/s41467-022-33394-7}
}

@article{dibenedetto2022-36078138,
  author  = {Di Benedetto, G. and Burgaletto, C. and Bellanca, C. M. and Munafò, A. and Bernardini, R. and Cantarella, G.},
  title   = {{Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11172728},
  pmid    = {36078138},
  url     = {https://doi.org/10.3390/cells11172728}
}

@article{saunders2022-36041266,
  author  = {Saunders, T. S. and Jenkins, N. and Blennow, K. and Ritchie, C. and Muniz-Terrera, G.},
  title   = {{Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)}},
  journal = {EBioMedicine},
  year    = {2022},
  doi     = {10.1016/j.ebiom.2022.104241},
  pmid    = {36041266},
  url     = {https://doi.org/10.1016/j.ebiom.2022.104241}
}

@article{piazza2022-35940900,
  author  = {Piazza, F. and Caminiti, S. P. and Zedde, M. and Presotto, L. and DiFrancesco, J. C. and Pascarella, R. and Giossi, A. and others},
  title   = {{Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000200892},
  pmid    = {35940900},
  url     = {https://doi.org/10.1212/wnl.0000000000200892}
}

@article{atherton2022-35759276,
  author  = {Atherton, K. and Han, X. and Chung, J. and Cherry, J. D. and Baucom, Z. and Saltiel, N. and Nair, E. and Abdolmohammadi, B. and others},
  title   = {{Association of APOE Genotypes and Chronic Traumatic Encephalopathy}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.1634},
  pmid    = {35759276},
  url     = {https://doi.org/10.1001/jamaneurol.2022.1634}
}

@article{rabin2022-35759327,
  author  = {Rabin, J. S. and Nichols, E. and La Joie, R. and Casaletto, K. B. and Palta, P. and Dams-O'Connor, K. and Kumar, R. G. and George, K. M. and others},
  title   = {{Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline}},
  journal = {Brain : a journal of neurology},
  year    = {2022},
  doi     = {10.1093/brain/awac178},
  pmid    = {35759327},
  url     = {https://doi.org/10.1093/brain/awac178}
}

@article{leguen2022-35639372,
  author  = {Le Guen, Y. and Belloy, M. E. and Grenier-Boley, B. and de Rojas, I. and Castillo-Morales, A. and Jansen, I. and Nicolas, A. and Bellenguez, C. and others},
  title   = {{Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.1166},
  pmid    = {35639372},
  url     = {https://doi.org/10.1001/jamaneurol.2022.1166}
}

@article{kianishabestari2022-35705056,
  author  = {Kiani Shabestari, S. and Morabito, S. and Danhash, E. P. and McQuade, A. and Sanchez, JR. and Miyoshi, E. and Chadarevian, J. P. and Claes, C. and others},
  title   = {{Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.110961},
  pmid    = {35705056},
  url     = {https://doi.org/10.1016/j.celrep.2022.110961}
}

@article{ali2022-35617280,
  author  = {Ali, M. and Sung, Y. J. and Wang, F. and Fernández, M. V. and Morris, J. C. and Fagan, A. M. and Blennow, K. and Zetterberg, H. and others},
  title   = {{Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk}},
  journal = {PloS one},
  year    = {2022},
  doi     = {10.1371/journal.pone.0267298},
  pmid    = {35617280},
  url     = {https://doi.org/10.1371/journal.pone.0267298}
}

@article{hoilundcarlsen2022-35452007,
  author  = {Høilund-Carlsen, P. F. and Werner, T. J. and Alavi, A. and Revheim, M. E.},
  title   = {{Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?}},
  journal = {Clinical nuclear medicine},
  year    = {2022},
  doi     = {10.1097/rlu.0000000000004250},
  pmid    = {35452007},
  url     = {https://doi.org/10.1097/rlu.0000000000004250}
}

@article{martens2022-35298921,
  author  = {Martens, Y. A. and Zhao, N. and Liu, C. C. and Kanekiyo, T. and Yang, A. J. and Goate, A. M. and Holtzman, D. M. and Bu, G.},
  title   = {{ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.03.004},
  pmid    = {35298921},
  url     = {https://doi.org/10.1016/j.neuron.2022.03.004}
}

@article{kenkhuis2022-35247551,
  author  = {Kenkhuis, B. and Somarakis, A. and Kleindouwel, L. R. T. and van Roon-Mom, W. M. C. and Höllt, T. and van der Weerd, L.},
  title   = {{Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105684},
  pmid    = {35247551},
  url     = {https://doi.org/10.1016/j.nbd.2022.105684}
}

@article{mahan2022-35109920,
  author  = {Mahan, T. E. and Wang, C. and Bao, X. and Choudhury, A. and Ulrich, J. D. and Holtzman, D. M.},
  title   = {{Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00516-0},
  pmid    = {35109920},
  url     = {https://doi.org/10.1186/s13024-022-00516-0}
}

@article{tideman2022-35022305,
  author  = {Tideman, P. and Stomrud, E. and Leuzy, A. and Mattsson-Carlgren, N. and Palmqvist, S. and Hansson, O. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000013299},
  pmid    = {35022305},
  url     = {https://doi.org/10.1212/wnl.0000000000013299}
}

@article{nordestgaard2022-34613338,
  author  = {Nordestgaard, L. T. and Christoffersen, M. and Lauridsen, B. K. and Afzal, S. and Nordestgaard, B. G. and Frikke-Schmidt, R. and Tybjærg-Hansen, A.},
  title   = {{Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population}},
  journal = {JAMA cardiology},
  year    = {2022},
  doi     = {10.1001/jamacardio.2021.3728},
  pmid    = {34613338},
  url     = {https://doi.org/10.1001/jamacardio.2021.3728}
}

@article{cohn2021-34925024,
  author  = {Cohn, W. and Melnik, M. and Huang, C. and Teter, B. and Chandra, S. and Zhu, C. and McIntire, L. B. and John, V. and others},
  title   = {{Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.766082},
  pmid    = {34925024},
  url     = {https://doi.org/10.3389/fphar.2021.766082}
}

@article{kumar2022-34699027,
  author  = {Kumar, M. and Bansal, N.},
  title   = {{Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-021-02611-7},
  pmid    = {34699027},
  url     = {https://doi.org/10.1007/s12035-021-02611-7}
}

@article{cruchaga2021-91194d89,
  author  = {Cruchaga, C. and Sung, Y. J. and Yang, C. and Wang, F. and Suhy, A. and Norton, J. and Novotny, B. and Etelleb, A. and others},
  title   = {{Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease cases}},
  journal = {Research Square},
  year    = {2021},
  doi     = {10.21203/rs.3.rs-923492/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-923492/v1}
}

@article{li2021-34654479,
  author  = {Li, Q. S. and Vasanthakumar, A. and Davis, J. W. and Idler, K. B. and Nho, K. and Waring, J. F. and Saykin, A. J.},
  title   = {{Association of peripheral blood DNA methylation level with Alzheimer's disease progression}},
  journal = {Clinical epigenetics},
  year    = {2021},
  doi     = {10.1186/s13148-021-01179-2},
  pmid    = {34654479},
  url     = {https://doi.org/10.1186/s13148-021-01179-2}
}

@article{paranjpe2021-34658838,
  author  = {Paranjpe, M. D. and Belonwu, S. and Wang, J. K. and Oskotsky, T. and Gupta, A. and Taubes, A. and Zalocusky, K. A. and Paranjpe, I. and others},
  title   = {{Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735611},
  pmid    = {34658838},
  url     = {https://doi.org/10.3389/fnagi.2021.735611}
}

@article{antolini2021-34531298,
  author  = {Antolini, L. and DiFrancesco, J. C. and Zedde, M. and Basso, G. and Arighi, A. and Shima, A. and Cagnin, A. and Caulo, M. and others},
  title   = {{Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000012778},
  pmid    = {34531298},
  url     = {https://doi.org/10.1212/wnl.0000000000012778}
}

@article{qiu2021-34526055,
  author  = {Qiu, S. and Palavicini, J. P. and Wang, J. and Gonzalez, N. S. and He, S. and Dustin, E. and Zou, C. and Ding, L. and others},
  title   = {{Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00488-7},
  pmid    = {34526055},
  url     = {https://doi.org/10.1186/s13024-021-00488-7}
}

@article{wightman2021-34493870,
  author  = {Wightman, D. P. and Jansen, I. E. and Savage, J. E. and Shadrin, A. A. and Bahrami, S. and Holland, D. and Rongve, A. and Børte, S. and others},
  title   = {{A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2021},
  doi     = {10.1038/s41588-021-00921-z},
  pmid    = {34493870},
  url     = {https://doi.org/10.1038/s41588-021-00921-z}
}

@article{panitch2021-34480088,
  author  = {Panitch, R. and Hu, J. and Chung, J. and Zhu, C. and Meng, G. and Xia, W. and Bennett, D. A. and Lunetta, K. L. and others},
  title   = {{Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2021},
  doi     = {10.1038/s41380-021-01266-z},
  pmid    = {34480088},
  url     = {https://doi.org/10.1038/s41380-021-01266-z}
}

@article{choi2021-34465358,
  author  = {Choi, H. and Choi, Y. and Lee, E. J. and Kim, H. and Lee, Y. and Kwon, S. and Hwang, D. W. and Lee, D. S. and others},
  title   = {{Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-021-02244-6},
  pmid    = {34465358},
  url     = {https://doi.org/10.1186/s12974-021-02244-6}
}

@article{jeong2021-34380754,
  author  = {Jeong, S. H. and Kim, H. R. and Kim, J. and Kim, H. and Hong, N. and Jung, J. H. and Baik, K. and Cho, H. and others},
  title   = {{Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000012534},
  pmid    = {34380754},
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}

@article{baril2022-34310026,
  author  = {Baril, A. A. and Beiser, A. S. and Sanchez, E. and Mysliwiec, V. and Redline, S. and Gottlieb, D. J. and O'Connor, G. T. and Gonzales, M. M. and others},
  title   = {{Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12405},
  pmid    = {34310026},
  url     = {https://doi.org/10.1002/alz.12405}
}

@article{claes2021-34301296,
  author  = {Claes, C. and Danhash, E. P. and Hasselmann, J. and Chadarevian, J. P. and Shabestari, S. K. and England, W. E. and Lim, T. E. and Hidalgo, J. L. S. and others},
  title   = {{Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00473-0},
  pmid    = {34301296},
  url     = {https://doi.org/10.1186/s13024-021-00473-0}
}

@article{benitez2021-34266459,
  author  = {Benitez, D. P. and Jiang, S. and Wood, J. and Wang, R. and Hall, C. M. and Peerboom, C. and Wong, N. and Stringer, K. M. and others},
  title   = {{Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00457-0},
  pmid    = {34266459},
  url     = {https://doi.org/10.1186/s13024-021-00457-0}
}

@article{insel2021-34297074,
  author  = {Insel, P. S. and Mohlenhoff, B. S. and Neylan, T. C. and Krystal, A. D. and Mackin, R. S.},
  title   = {{Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults}},
  journal = {JAMA network open},
  year    = {2021},
  doi     = {10.1001/jamanetworkopen.2021.17573},
  pmid    = {34297074},
  url     = {https://doi.org/10.1001/jamanetworkopen.2021.17573}
}

@article{fitz2021-34099706,
  author  = {Fitz, N. F. and Nam, K. N. and Wolfe, C. M. and Letronne, F. and Playso, B. E. and Iordanova, B. E. and Kozai, T. D. Y. and Biedrzycki, R. J. and others},
  title   = {{Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23762-0},
  pmid    = {34099706},
  url     = {https://doi.org/10.1038/s41467-021-23762-0}
}

@article{jin2021-34061824,
  author  = {Jin, X. and He, W. and Zhang, Y. and Gong, E. and Niu, Z. and Ji, J. and Li, Y. and Zeng, Y. and others},
  title   = {{Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study}},
  journal = {PLoS medicine},
  year    = {2021},
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  pmid    = {34061824},
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}

@article{biechele2022-34016733,
  author  = {Biechele, G. and Monasor, L. S. and Wind, K. and Blume, T. and Parhizkar, S. and Arzberger, T. and Sacher, C. and Beyer, L. and others},
  title   = {{Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2022},
  doi     = {10.2967/jnumed.120.261858},
  pmid    = {34016733},
  url     = {https://doi.org/10.2967/jnumed.120.261858}
}

@article{walker2021-37118015,
  author  = {Walker, K. A. and Chen, J. and Zhang, J. and Fornage, M. and Yang, Y. and Zhou, L. and Grams, M. E. and Tin, A. and others},
  title   = {{Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk}},
  journal = {Nature aging},
  year    = {2021},
  doi     = {10.1038/s43587-021-00064-0},
  pmid    = {37118015},
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}

@article{gockley2021-33947463,
  author  = {Gockley, J. and Montgomery, K. S. and Poehlman, W. L. and Wiley, J. C. and Liu, Y. and Gerasimov, E. and Greenwood, A. K. and Sieberts, S. K. and others},
  title   = {{Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease}},
  journal = {Genome medicine},
  year    = {2021},
  doi     = {10.1186/s13073-021-00890-2},
  pmid    = {33947463},
  url     = {https://doi.org/10.1186/s13073-021-00890-2}
}

@article{dmitry2021-33797837,
  author  = {Dmitry, Prokopenko and Morgan Sarah, L. and Kristina, Mullin and Oliver, Hofmann and Brad, Chapman and Rory, Kirchner and Sandeep, Amberkar and Inken, Wohlers and others},
  title   = {{Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12319},
  pmid    = {33797837},
  url     = {https://doi.org/10.1002/alz.12319}
}

@article{moelgg2021-33804246,
  author  = {Moelgg, K. and Jummun, F. and Humpel, C.},
  title   = {{Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons}},
  journal = {Biomolecules},
  year    = {2021},
  doi     = {10.3390/biom11030434},
  pmid    = {33804246},
  url     = {https://doi.org/10.3390/biom11030434}
}

@article{rocaagujetas2021-33685483,
  author  = {Roca-Agujetas, V. and Barbero-Camps, E. and de Dios, C. and Podlesniy, P. and Abadin, X. and Morales, A. and Marí, M. and Trullàs, R. and others},
  title   = {{Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00435-6},
  pmid    = {33685483},
  url     = {https://doi.org/10.1186/s13024-021-00435-6}
}

@article{apodaca2021-33676561,
  author  = {Apodaca, L. A. and Baddour, A. A. D. and Garcia, C. and Alikhani, L. and Giedzinski, E. and Ru, N. and Agrawal, A. and Acharya, M. M. and others},
  title   = {{Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00791-x},
  pmid    = {33676561},
  url     = {https://doi.org/10.1186/s13195-021-00791-x}
}

@article{li2021-34589742,
  author  = {Li, Q. S. and De Muynck, L.},
  title   = {{Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2021},
  doi     = {10.1016/j.bbih.2021.100227},
  pmid    = {34589742},
  url     = {https://doi.org/10.1016/j.bbih.2021.100227}
}

@article{zheng2021-33622188,
  author  = {Zheng, X. and Lin, W. and Jiang, Y. and Lu, K. and Wei, W. and Huo, Q. and Cui, S. and Yang, X. and others},
  title   = {{Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)}},
  journal = {Autophagy},
  year    = {2021},
  doi     = {10.1080/15548627.2021.1886720},
  pmid    = {33622188},
  url     = {https://doi.org/10.1080/15548627.2021.1886720}
}

@article{shabbir2021-33669988,
  author  = {Shabbir, U. and Arshad, M. S. and Sameen, A. and Oh, D. H.},
  title   = {{Crosstalk between Gut and Brain in Alzheimer's Disease: The Role of Gut Microbiota Modulation Strategies}},
  journal = {Nutrients},
  year    = {2021},
  doi     = {10.3390/nu13020690},
  pmid    = {33669988},
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}

@article{kenkhuis2021-33597025,
  author  = {Kenkhuis, B. and Somarakis, A. and de Haan, L. and Dzyubachyk, O. and IJsselsteijn, M. E. and de Miranda, N. F. C. C. and Lelieveldt, B. P. F. and Dijkstra, J. and others},
  title   = {{Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01126-5},
  pmid    = {33597025},
  url     = {https://doi.org/10.1186/s40478-021-01126-5}
}

@article{salvado2021-33521872,
  author  = {Salvadó, G. and Grothe, M. J. and Groot, C. and Moscoso, A. and Schöll, M. and Gispert, J. D. and Ossenkoppele, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2021},
  doi     = {10.1007/s00259-021-05192-8},
  pmid    = {33521872},
  url     = {https://doi.org/10.1007/s00259-021-05192-8}
}

@article{griswold2021-33522086,
  author  = {Griswold, A. J. and Celis, K. and Bussies, P. L. and Rajabli, F. and Whitehead, P. L. and Hamilton-Nelson, K. L. and Beecham, G. W. and Dykxhoorn, D. M. and others},
  title   = {{Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2021},
  doi     = {10.1002/alz.12287},
  pmid    = {33522086},
  url     = {https://doi.org/10.1002/alz.12287}
}

@article{yang2021-33567283,
  author  = {Yang, H. S. and Onos, K. D. and Choi, K. and Keezer, K. J. and Skelly, D. A. and Carter, G. W. and Howell, G. R.},
  title   = {{Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.108739},
  pmid    = {33567283},
  url     = {https://doi.org/10.1016/j.celrep.2021.108739}
}

@article{setti2021-33508413,
  author  = {Setti, S. E. and Raymick, J. and Hanig, J. and Sarkar, S.},
  title   = {{In vivo demonstration of Congo Red labeled amyloid plaques via perfusion in the Alzheimer disease rat model}},
  journal = {Journal of neuroscience methods},
  year    = {2021},
  doi     = {10.1016/j.jneumeth.2021.109082},
  pmid    = {33508413},
  url     = {https://doi.org/10.1016/j.jneumeth.2021.109082}
}

@article{hu2021-33461566,
  author  = {Hu, Y. and Sun, J. Y. and Zhang, Y. and Zhang, H. and Gao, S. and Wang, T. and Han, Z. and Wang, L. and others},
  title   = {{rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues}},
  journal = {BMC medicine},
  year    = {2021},
  doi     = {10.1186/s12916-020-01883-5},
  pmid    = {33461566},
  url     = {https://doi.org/10.1186/s12916-020-01883-5}
}

@article{wu2021-33466861,
  author  = {Wu, L. and Han, Y. and Zheng, Z. and Peng, G. and Liu, P. and Yue, S. and Zhu, S. and Chen, J. and others},
  title   = {{Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Signals in Host-Microbe Interplay}},
  journal = {Nutrients},
  year    = {2021},
  doi     = {10.3390/nu13010228},
  pmid    = {33466861},
  url     = {https://doi.org/10.3390/nu13010228}
}

@article{olajide2021-33420680,
  author  = {Olajide, O. J. and Gbadamosi, I. T. and Yawson, E. O. and Arogundade, T. and Lewu, F. S. and Ogunrinola, K. Y. and Adigun, O. O. and Bamisi, O. and others},
  title   = {{Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity}},
  journal = {Journal of molecular neuroscience : MN},
  year    = {2021},
  doi     = {10.1007/s12031-020-01747-w},
  pmid    = {33420680},
  url     = {https://doi.org/10.1007/s12031-020-01747-w}
}

@article{shafik2021-33402207,
  author  = {Shafik, A. M. and Zhang, F. and Guo, Z. and Dai, Q. and Pajdzik, K. and Li, Y. and Kang, Y. and Yao, B. and others},
  title   = {{N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease}},
  journal = {Genome biology},
  year    = {2021},
  doi     = {10.1186/s13059-020-02249-z},
  pmid    = {33402207},
  url     = {https://doi.org/10.1186/s13059-020-02249-z}
}

@article{kunkle2021-33074286,
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  title   = {{Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis}},
  journal = {JAMA neurology},
  year    = {2021},
  doi     = {10.1001/jamaneurol.2020.3536},
  pmid    = {33074286},
  url     = {https://doi.org/10.1001/jamaneurol.2020.3536}
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@article{armstrong2021-33180114,
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  title   = {{Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms}},
  journal = {JAMA ophthalmology},
  year    = {2021},
  doi     = {10.1001/jamaophthalmol.2020.4909},
  pmid    = {33180114},
  url     = {https://doi.org/10.1001/jamaophthalmol.2020.4909}
}

@article{megur2020-33374235,
  author  = {Megur, A. and Baltriukienė, D. and Bukelskienė, V. and Burokas, A.},
  title   = {{The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?}},
  journal = {Nutrients},
  year    = {2020},
  doi     = {10.3390/nu13010037},
  pmid    = {33374235},
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@article{lajoie2021-33262228,
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  title   = {{Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000011270},
  pmid    = {33262228},
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@article{liu2020-32941599,
  author  = {Liu, T. and Zhu, B. and Liu, Y. and Zhang, X. and Yin, J. and Li, X. and Jiang, L. and Hodges, A. P. and others},
  title   = {{Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE}},
  journal = {The Journal of experimental medicine},
  year    = {2020},
  doi     = {10.1084/jem.20200474},
  pmid    = {32941599},
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}

@article{panitch2020-51e773db,
  author  = {Panitch, R. and Hu, J. and Chung, J. and Zhu, C. and Meng, G. and Xia, W. and Bennett, D. A. and Lunetta, K. L. and others},
  title   = {{Integrative Brain Transcriptome Analysis Links Complement Component 4 andHSPA2to theAPOEε2 Protective Effect in Alzheimer Disease}},
  journal = {Molecular psychiatry},
  year    = {2020},
  doi     = {10.1101/2020.11.23.20235762},
  url     = {https://doi.org/10.1101/2020.11.23.20235762}
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@article{uhlmann2020-33199898,
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  title   = {{Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life}},
  journal = {Nature neuroscience},
  year    = {2020},
  doi     = {10.1038/s41593-020-00737-w},
  pmid    = {33199898},
  url     = {https://doi.org/10.1038/s41593-020-00737-w}
}

@article{dmitry2020-33173892,
  author  = {Dmitry, Prokopenko and Morgan Sarah, L. and Kristina, Mullin and Oliver, Hofmann and Brad, Chapman and Rory, Kirchner and Sandeep, Amberkar and Inken, Wohlers and others},
  title   = {{Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1101/2020.11.03.20225540},
  pmid    = {33173892},
  url     = {https://doi.org/10.1101/2020.11.03.20225540}
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@article{chen2021-33176118,
  author  = {Chen, Y. and Strickland, M. R. and Soranno, A. and Holtzman, D. M.},
  title   = {{Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2020.10.008},
  pmid    = {33176118},
  url     = {https://doi.org/10.1016/j.neuron.2020.10.008}
}

@article{zhao2020-33139712,
  author  = {Zhao, J. and Fu, Y. and Yamazaki, Y. and Ren, Y. and Davis, M. D. and Liu, C. C. and Lu, W. and Wang, X. and others},
  title   = {{APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-19264-0},
  pmid    = {33139712},
  url     = {https://doi.org/10.1038/s41467-020-19264-0}
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@article{kesika2021-33169684,
  author  = {Kesika, P. and Suganthy, N. and Sivamaruthi, B. S. and Chaiyasut, C.},
  title   = {{Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease}},
  journal = {Life sciences},
  year    = {2021},
  doi     = {10.1016/j.lfs.2020.118627},
  pmid    = {33169684},
  url     = {https://doi.org/10.1016/j.lfs.2020.118627}
}

@article{shinohara2020-685d61d2,
  author  = {Shinohara, M. and Kanekiyo, T. and Tachibana, M. and Kurti, A. and Fu, Y. and Zhao, J. and Han, X. and Sullivan, P. M. and Rebeck, G. W. and Fryer, J. D. and Heckman, M. G. and Bu, G.},
  title   = {{APOE2 is associated with longevity independent of Alzheimer's disease}},
  journal = {eLife},
  year    = {2020}
}

@article{raghavan2020-32568366,
  author  = {Raghavan, N. S. and Dumitrescu, L. and Mormino, E. and Mahoney, E. R. and Lee, A. J. and Gao, Y. and Bilgel, M. and Goldstein, D. and others},
  title   = {{Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1760},
  pmid    = {32568366},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1760}
}

@article{bartels2020-33004513,
  author  = {Bartels, T. and De Schepper, S. and Hong, S.},
  title   = {{Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases}},
  journal = {Science (New York, N.Y.)},
  year    = {2020},
  doi     = {10.1126/science.abb8587},
  pmid    = {33004513},
  url     = {https://doi.org/10.1126/science.abb8587}
}

@article{karanth2020-32568358,
  author  = {Karanth, S. and Nelson, P. T. and Katsumata, Y. and Kryscio, R. J. and Schmitt, F. A. and Fardo, D. W. and Cykowski, M. D. and Jicha, G. A. and others},
  title   = {{Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.1741},
  pmid    = {32568358},
  url     = {https://doi.org/10.1001/jamaneurol.2020.1741}
}

@article{hanslik2020-33071950,
  author  = {Hanslik, K. L. and Ulland, T. K.},
  title   = {{The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease}},
  journal = {Frontiers in neurology},
  year    = {2020},
  doi     = {10.3389/fneur.2020.570711},
  pmid    = {33071950},
  url     = {https://doi.org/10.3389/fneur.2020.570711}
}

@article{takalo2020-32917267,
  author  = {Takalo, M. and Wittrahm, R. and Wefers, B. and Parhizkar, S. and Jokivarsi, K. and Kuulasmaa, T. and Mäkinen, P. and Martiskainen, H. and others},
  title   = {{The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00402-7},
  pmid    = {32917267},
  url     = {https://doi.org/10.1186/s13024-020-00402-7}
}

@article{floresdorantes2020-32982666,
  author  = {Flores-Dorantes, M. T. and Díaz-López, Y. E. and Gutiérrez-Aguilar, R.},
  title   = {{Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00863},
  pmid    = {32982666},
  url     = {https://doi.org/10.3389/fnins.2020.00863}
}

@article{saddiki2020-32817639,
  author  = {Saddiki, H. and Fayosse, A. and Cognat, E. and Sabia, S. and Engelborghs, S. and Wallon, D. and Alexopoulos, P. and Blennow, K. and others},
  title   = {{Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study}},
  journal = {PLoS medicine},
  year    = {2020},
  doi     = {10.1371/journal.pmed.1003289},
  pmid    = {32817639},
  url     = {https://doi.org/10.1371/journal.pmed.1003289}
}

@article{agrawal2020-32973488,
  author  = {Agrawal, I. and Jha, S.},
  title   = {{Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia}},
  journal = {Frontiers in aging neuroscience},
  year    = {2020},
  doi     = {10.3389/fnagi.2020.00252},
  pmid    = {32973488},
  url     = {https://doi.org/10.3389/fnagi.2020.00252}
}

@article{ewers2020-32790063,
  author  = {Ewers, M. and Biechele, G. and Suárez-Calvet, M. and Sacher, C. and Blume, T. and Morenas-Rodriguez, E. and Deming, Y. and Piccio, L. and others},
  title   = {{Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.202012308},
  pmid    = {32790063},
  url     = {https://doi.org/10.15252/emmm.202012308}
}

@article{kim2020-32690787,
  author  = {Kim, J. W. and Byun, M. S. and Lee, J. H. and Yi, D. and Jeon, S. Y. and Sohn, B. K. and Lee, J. Y. and Shin, S. A. and others},
  title   = {{Serum albumin and beta-amyloid deposition in the human brain}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000010005},
  pmid    = {32690787},
  url     = {https://doi.org/10.1212/wnl.0000000000010005}
}

@article{hammond2020-32632135,
  author  = {Hammond, T. C. and Xing, X. and Wang, C. and Ma, D. and Nho, K. and Crane, P. K. and Elahi, F. and Ziegler, D. A. and others},
  title   = {{β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline}},
  journal = {Communications biology},
  year    = {2020},
  doi     = {10.1038/s42003-020-1079-x},
  pmid    = {32632135},
  url     = {https://doi.org/10.1038/s42003-020-1079-x}
}

@article{belloy2020-32282020,
  author  = {Belloy, M. E. and Napolioni, V. and Han, S. S. and Le Guen, Y. and Greicius, M. D. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2020.0414},
  pmid    = {32282020},
  url     = {https://doi.org/10.1001/jamaneurol.2020.0414}
}

@article{saezatienzar2020-32601397,
  author  = {Saez-Atienzar, S. and Masliah, E.},
  title   = {{Cellular senescence and Alzheimer disease: the egg and the chicken scenario}},
  journal = {Nature reviews. Neuroscience},
  year    = {2020},
  doi     = {10.1038/s41583-020-0325-z},
  pmid    = {32601397},
  url     = {https://doi.org/10.1038/s41583-020-0325-z}
}

@article{yin2020-32457210,
  author  = {Yin, J. and Reiman, E. M. and Beach, T. G. and Serrano, G. E. and Sabbagh, M. N. and Nielsen, M. and Caselli, R. J. and Shi, J.},
  title   = {{Effect of ApoE isoforms on mitochondria in Alzheimer disease}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000009582},
  pmid    = {32457210},
  url     = {https://doi.org/10.1212/wnl.0000000000009582}
}

@article{hosseinian2020-32433480,
  author  = {Hosseinian, S. and Arefian, E. and Rakhsh-Khorshid, H. and Eivani, M. and Rezayof, A. and Pezeshk, H. and Marashi, S. A.},
  title   = {{A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2020},
  doi     = {10.1038/s41598-020-64452-z},
  pmid    = {32433480},
  url     = {https://doi.org/10.1038/s41598-020-64452-z}
}

@article{lee2020-32419307,
  author  = {Lee, M. Y. and Lee, J. and Hyeon, S. J. and Cho, H. and Hwang, Y. J. and Shin, J. Y. and McKee, A. C. and Kowall, N. W. and others},
  title   = {{Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2020},
  doi     = {10.1111/acel.13153},
  pmid    = {32419307},
  url     = {https://doi.org/10.1111/acel.13153}
}

@article{vilaplana2020-32291295,
  author  = {Vilaplana, E. and Rodriguez-Vieitez, E. and Ferreira, D. and Montal, V. and Almkvist, O. and Wall, A. and Lleó, A. and Westman, E. and others},
  title   = {{Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease}},
  journal = {Neurology},
  year    = {2020},
  doi     = {10.1212/wnl.0000000000009405},
  pmid    = {32291295},
  url     = {https://doi.org/10.1212/wnl.0000000000009405}
}

@article{li2020-32180217,
  author  = {Li, S. and Selkoe, D. J.},
  title   = {{A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain}},
  journal = {Journal of neurochemistry},
  year    = {2020},
  doi     = {10.1111/jnc.15007},
  pmid    = {32180217},
  url     = {https://doi.org/10.1111/jnc.15007}
}

@article{roy2020-31917687,
  author  = {Roy, E. R. and Wang, B. and Wan, Y. W. and Chiu, G. and Cole, A. and Yin, Z. and Propson, N. E. and Xu, Y. and others},
  title   = {{Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2020},
  doi     = {10.1172/jci133737},
  pmid    = {31917687},
  url     = {https://doi.org/10.1172/jci133737}
}

@article{zhao2020-32199103,
  author  = {Zhao, N. and Ren, Y. and Yamazaki, Y. and Qiao, W. and Li, F. and Felton, L. M. and Mahmoudiandehkordi, S. and Kueider-Paisley, A. and others},
  title   = {{Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2020.02.034},
  pmid    = {32199103},
  url     = {https://doi.org/10.1016/j.neuron.2020.02.034}
}

@article{wojtowicz2020-32170673,
  author  = {Wójtowicz, S. and Strosznajder, A. K. and Jeżyna, M. and Strosznajder, J. B.},
  title   = {{The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders}},
  journal = {Neurochemical research},
  year    = {2020},
  doi     = {10.1007/s11064-020-02993-5},
  pmid    = {32170673},
  url     = {https://doi.org/10.1007/s11064-020-02993-5}
}

@article{gottesman2020-31860001,
  author  = {Gottesman, R. F. and Mosley, T. H. and Knopman, D. S. and Hao, Q. and Wong, D. and Wagenknecht, L. E. and Hughes, T. M. and Qiao, Y. and others},
  title   = {{Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.4339},
  pmid    = {31860001},
  url     = {https://doi.org/10.1001/jamaneurol.2019.4339}
}

@article{paudel2020-32046119,
  author  = {Paudel, Y. N. and Angelopoulou, E. and Piperi, C. and Othman, I. and Aamir, K. and Shaikh, M. F.},
  title   = {{Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9020383},
  pmid    = {32046119},
  url     = {https://doi.org/10.3390/cells9020383}
}

@article{butterfield2020-32036033,
  author  = {Butterfield, D. A. and Mattson, M. P.},
  title   = {{Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2020},
  doi     = {10.1016/j.nbd.2020.104795},
  pmid    = {32036033},
  url     = {https://doi.org/10.1016/j.nbd.2020.104795}
}

@article{insel2020-32140682,
  author  = {Insel, P. S. and Mormino, E. C. and Aisen, P. S. and Thompson, W. K. and Donohue, M. C.},
  title   = {{Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention}},
  journal = {Brain communications},
  year    = {2020},
  doi     = {10.1093/braincomms/fcaa007},
  pmid    = {32140682},
  url     = {https://doi.org/10.1093/braincomms/fcaa007}
}

@article{reiman2020-32015339,
  author  = {Reiman, E. M. and Arboleda-Velasquez, J. F. and Quiroz, Y. T. and Huentelman, M. J. and Beach, T. G. and Caselli, R. J. and Chen, Y. and Su, Y. and others},
  title   = {{Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-019-14279-8},
  pmid    = {32015339},
  url     = {https://doi.org/10.1038/s41467-019-14279-8}
}

@article{zhao2020-32024798,
  author  = {Zhao, N. and Attrebi, O. N. and Ren, Y. and Qiao, W. and Sonustun, B. and Martens, Y. A. and Meneses, A. D. and Li, F. and others},
  title   = {{APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid}},
  journal = {Science translational medicine},
  year    = {2020},
  doi     = {10.1126/scitranslmed.aay1809},
  pmid    = {32024798},
  url     = {https://doi.org/10.1126/scitranslmed.aay1809}
}

@article{davis2020-32024799,
  author  = {Davis, A. A. and Inman, C. E. and Wargel, Z. M. and Dube, U. and Freeberg, B. M. and Galluppi, A. and Haines, J. N. and Dhavale, D. D. and others},
  title   = {{APOE genotype regulates pathology and disease progression in synucleinopathy}},
  journal = {Science translational medicine},
  year    = {2020},
  doi     = {10.1126/scitranslmed.aay3069},
  pmid    = {32024799},
  url     = {https://doi.org/10.1126/scitranslmed.aay3069}
}

@article{lauretti2020-32006534,
  author  = {Lauretti, E. and Dincer, O. and Praticò, D.},
  title   = {{Glycogen synthase kinase-3 signaling in Alzheimer's disease}},
  journal = {Biochimica et biophysica acta. Molecular cell research},
  year    = {2020},
  doi     = {10.1016/j.bbamcr.2020.118664},
  pmid    = {32006534},
  url     = {https://doi.org/10.1016/j.bbamcr.2020.118664}
}

@article{sierksma2020-31951107,
  author  = {Sierksma, A. and Lu, A. and Mancuso, R. and Fattorelli, N. and Thrupp, N. and Salta, E. and Zoco, J. and Blum, D. and others},
  title   = {{Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology}},
  journal = {EMBO molecular medicine},
  year    = {2020},
  doi     = {10.15252/emmm.201910606},
  pmid    = {31951107},
  url     = {https://doi.org/10.15252/emmm.201910606}
}

@article{gourmaud2020-31834353,
  author  = {Gourmaud, S. and Shou, H. and Irwin, D. J. and Sansalone, K. and Jacobs, L. M. and Lucas, T. H. and Marsh, E. D. and Davis, K. A. and others},
  title   = {{Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awz381},
  pmid    = {31834353},
  url     = {https://doi.org/10.1093/brain/awz381}
}

@article{fani2020-31839608,
  author  = {Fani, L. and Hilal, S. and Sedaghat, S. and Broer, L. and Licher, S. and Arp, P. P. and van Meurs, J. B. J. and Ikram, M. K. and others},
  title   = {{Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-190759},
  pmid    = {31839608},
  url     = {https://doi.org/10.3233/jad-190759}
}

@article{albrahim2020-31982903,
  author  = {Albrahim, T.},
  title   = {{The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies}},
  journal = {Neurosciences (Riyadh, Saudi Arabia)},
  year    = {2020},
  doi     = {10.17712/nsj.2020.1.20190037},
  pmid    = {31982903},
  url     = {https://doi.org/10.17712/nsj.2020.1.20190037}
}

@article{bortolotti2019-31831060,
  author  = {Bortolotti, D. and Gentili, V. and Rotola, A. and Caselli, E. and Rizzo, R.},
  title   = {{HHV-6A infection induces amyloid-beta expression and activation of microglial cells}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0552-6},
  pmid    = {31831060},
  url     = {https://doi.org/10.1186/s13195-019-0552-6}
}

@article{greenberg2020-31827267,
  author  = {Greenberg, S. M. and Bacskai, B. J. and Hernandez-Guillamon, M. and Pruzin, J. and Sperling, R. and van Veluw, S. J.},
  title   = {{Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways}},
  journal = {Nature reviews. Neurology},
  year    = {2020},
  doi     = {10.1038/s41582-019-0281-2},
  pmid    = {31827267},
  url     = {https://doi.org/10.1038/s41582-019-0281-2}
}

@article{bassil2020-31759806,
  author  = {Bassil, F. and Brown, H. J. and Pattabhiraman, S. and Iwasyk, J. E. and Maghames, C. M. and Meymand, E. S. and Cox, T. O. and Riddle, D. M. and others},
  title   = {{Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.10.010},
  pmid    = {31759806},
  url     = {https://doi.org/10.1016/j.neuron.2019.10.010}
}

@article{huynh2019-31623648,
  author  = {Huynh, T. V. and Wang, C. and Tran, A. C. and Tabor, G. T. and Mahan, T. E. and Francis, C. M. and Finn, M. B. and Spellman, R. and others},
  title   = {{Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0337-1},
  pmid    = {31623648},
  url     = {https://doi.org/10.1186/s13024-019-0337-1}
}

@article{pan2019-31597550,
  author  = {Pan, Y. and Li, H. and Wang, Y. and Meng, X.},
  title   = {{Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study}},
  journal = {Stroke},
  year    = {2019},
  doi     = {10.1161/strokeaha.119.026872},
  pmid    = {31597550},
  url     = {https://doi.org/10.1161/strokeaha.119.026872}
}

@article{salih2019-32274467,
  author  = {Salih, D. A. and Bayram, S. and Guelfi, S. and Reynolds, R. H. and Shoai, M. and Ryten, M. and Brenton, J. W. and Zhang, D. and others},
  title   = {{Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk}},
  journal = {Brain communications},
  year    = {2019},
  doi     = {10.1093/braincomms/fcz022},
  pmid    = {32274467},
  url     = {https://doi.org/10.1093/braincomms/fcz022}
}

@article{dube2019-31591557,
  author  = {Dube, U. and Del-Aguila, J. L. and Li, Z. and Budde, J. P. and Jiang, S. and Hsu, S. and Ibanez, L. and Fernandez, M. V. and others},
  title   = {{An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0501-5},
  pmid    = {31591557},
  url     = {https://doi.org/10.1038/s41593-019-0501-5}
}

@article{mirza2019-31575706,
  author  = {Mirza, S. S. and Saeed, U. and Knight, J. and Ramirez, J. and Stuss, D. T. and Keith, J. and Nestor, S. M. and Yu, D. and others},
  title   = {{APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia}},
  journal = {Neurology},
  year    = {2019},
  doi     = {10.1212/wnl.0000000000008377},
  pmid    = {31575706},
  url     = {https://doi.org/10.1212/wnl.0000000000008377}
}

@article{wells2019-31564434,
  author  = {Wells, H. R. R. and Freidin, M. B. and Zainul Abidin, F. N. and Payton, A. and Dawes, P. and Munro, K. J. and Morton, C. C. and Moore, D. R. and others},
  title   = {{GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank}},
  journal = {American journal of human genetics},
  year    = {2019},
  doi     = {10.1016/j.ajhg.2019.09.008},
  pmid    = {31564434},
  url     = {https://doi.org/10.1016/j.ajhg.2019.09.008}
}

@article{konttinen2019-31522977,
  author  = {Konttinen, H. and Cabral-da-Silva, M. E. C. and Ohtonen, S. and Wojciechowski, S. and Shakirzyanova, A. and Caligola, S. and Giugno, R. and Ishchenko, Y. and others},
  title   = {{PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia}},
  journal = {Stem cell reports},
  year    = {2019},
  doi     = {10.1016/j.stemcr.2019.08.004},
  pmid    = {31522977},
  url     = {https://doi.org/10.1016/j.stemcr.2019.08.004}
}

@article{morenograu2019-31473137,
  author  = {Moreno-Grau, S. and de Rojas, I. and Hernández, I. and Quintela, I. and Montrreal, L. and Alegret, M. and Hernández-Olasagarre, B. and Madrid, L. and others},
  title   = {{Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2019},
  doi     = {10.1016/j.jalz.2019.06.4950},
  pmid    = {31473137},
  url     = {https://doi.org/10.1016/j.jalz.2019.06.4950}
}

@article{gomes2019-31414210,
  author  = {Gomes, L. A. and Hipp, S. A. and Rijal Upadhaya, A. and Balakrishnan, K. and Ospitalieri, S. and Koper, M. J. and Largo-Barrientos, P. and Uytterhoeven, V. and others},
  title   = {{Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-02053-5},
  pmid    = {31414210},
  url     = {https://doi.org/10.1007/s00401-019-02053-5}
}

@article{yamazaki2019-31367008,
  author  = {Yamazaki, Y. and Zhao, N. and Caulfield, T. R. and Liu, C. C. and Bu, G.},
  title   = {{Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies}},
  journal = {Nature reviews. Neurology},
  year    = {2019},
  doi     = {10.1038/s41582-019-0228-7},
  pmid    = {31367008},
  url     = {https://doi.org/10.1038/s41582-019-0228-7}
}

@article{wingo2019-31135820,
  author  = {Wingo, T. S. and Cutler, D. J. and Wingo, A. P. and Le, N. A. and Rabinovici, G. D. and Miller, B. L. and Lah, J. J. and Levey, A. I.},
  title   = {{Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.0648},
  pmid    = {31135820},
  url     = {https://doi.org/10.1001/jamaneurol.2019.0648}
}

@article{wilkins2019-107a9626,
  author  = {Wilkins, Consuelo Hopkins and Dilworth‐Anderson, Peggye and Whitmer, Rachel A. and Hanna, Lucy and Gatsonis, Constantine A. and Hillner, Bruce E. and Siegel, Barry Alan and Carrillo, María C. and others},
  title   = {{F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY}},
  journal = {Alzheimer s \& Dementia},
  year    = {2019},
  doi     = {10.1016/j.jalz.2019.06.4717},
  url     = {https://doi.org/10.1016/j.jalz.2019.06.4717}
}

@article{hossain2019-31209782,
  author  = {Hossain, M. F. and Uddin, M. S. and Uddin, G. M. S. and Sumsuzzman, D. M. and Islam, M. S. and Barreto, G. E. and Mathew, B. and Ashraf, G. M.},
  title   = {{Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology}},
  journal = {Molecular neurobiology},
  year    = {2019},
  doi     = {10.1007/s12035-019-01660-3},
  pmid    = {31209782},
  url     = {https://doi.org/10.1007/s12035-019-01660-3}
}

@article{omar2019-31181669,
  author  = {Omar, S. H.},
  title   = {{Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2019},
  doi     = {10.3390/ijms20112797},
  pmid    = {31181669},
  url     = {https://doi.org/10.3390/ijms20112797}
}

@article{vanacker2019-31159836,
  author  = {Van Acker, Z. P. and Bretou, M. and Annaert, W.},
  title   = {{Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0323-7},
  pmid    = {31159836},
  url     = {https://doi.org/10.1186/s13024-019-0323-7}
}

@article{stephen2019-31113487,
  author  = {Stephen, T. L. and Cacciottolo, M. and Balu, D. and Morgan, T. E. and LaDu, M. J. and Finch, C. E. and Pike, C. J.},
  title   = {{APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice}},
  journal = {Acta neuropathologica communications},
  year    = {2019},
  doi     = {10.1186/s40478-019-0729-z},
  pmid    = {31113487},
  url     = {https://doi.org/10.1186/s40478-019-0729-z}
}

@article{nizami2019-30740661,
  author  = {Nizami, S. and Hall-Roberts, H. and Warrier, S. and Cowley, S. A. and Di Daniel, E.},
  title   = {{Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets}},
  journal = {British journal of pharmacology},
  year    = {2019},
  doi     = {10.1111/bph.14618},
  pmid    = {30740661},
  url     = {https://doi.org/10.1111/bph.14618}
}

@article{haran2019-31064831,
  author  = {Haran, J. P. and Bhattarai, S. K. and Foley, S. E. and Dutta, P. and Ward, D. V. and Bucci, V. and McCormick, B. A.},
  title   = {{Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway}},
  journal = {mBio},
  year    = {2019},
  doi     = {10.1128/mbio.00632-19},
  pmid    = {31064831},
  url     = {https://doi.org/10.1128/mbio.00632-19}
}

@article{liu2019-31063846,
  author  = {Liu, P. and Wu, L. and Peng, G. and Han, Y. and Tang, R. and Ge, J. and Zhang, L. and Jia, L. and others},
  title   = {{Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort}},
  journal = {Brain, behavior, and immunity},
  year    = {2019},
  doi     = {10.1016/j.bbi.2019.05.008},
  pmid    = {31063846},
  url     = {https://doi.org/10.1016/j.bbi.2019.05.008}
}

@article{melzer2019-31105633,
  author  = {Melzer, T. R. and Stark, M. R. and Keenan, R. J. and Myall, D. J. and MacAskill, M. R. and Pitcher, T. L. and Livingston, L. and Grenfell, S. and others},
  title   = {{Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease}},
  journal = {Frontiers in neurology},
  year    = {2019},
  doi     = {10.3389/fneur.2019.00391},
  pmid    = {31105633},
  url     = {https://doi.org/10.3389/fneur.2019.00391}
}

@article{luo2020-30898012,
  author  = {Luo, R. and Su, L. Y. and Li, G. and Yang, J. and Liu, Q. and Yang, L. X. and Zhang, D. F. and Zhou, H. and others},
  title   = {{Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model}},
  journal = {Autophagy},
  year    = {2020},
  doi     = {10.1080/15548627.2019.1596488},
  pmid    = {30898012},
  url     = {https://doi.org/10.1080/15548627.2019.1596488}
}

@article{teter2019-30951849,
  author  = {Teter, B. and Morihara, T. and Lim, G. P. and Chu, T. and Jones, M. R. and Zuo, X. and Paul, R. M. and Frautschy, S. A. and others},
  title   = {{Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis}},
  journal = {Neurobiology of disease},
  year    = {2019},
  doi     = {10.1016/j.nbd.2019.02.015},
  pmid    = {30951849},
  url     = {https://doi.org/10.1016/j.nbd.2019.02.015}
}

@article{wadhwani2019-30840313,
  author  = {Wadhwani, A. R. and Affaneh, A. and Van Gulden, S. and Kessler, J. A.},
  title   = {{Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2019},
  doi     = {10.1002/ana.25455},
  pmid    = {30840313},
  url     = {https://doi.org/10.1002/ana.25455}
}

@article{fedeli2019-30892128,
  author  = {Fedeli, C. and Filadi, R. and Rossi, A. and Mammucari, C. and Pizzo, P.},
  title   = {{PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis}},
  journal = {Autophagy},
  year    = {2019},
  doi     = {10.1080/15548627.2019.1596489},
  pmid    = {30892128},
  url     = {https://doi.org/10.1080/15548627.2019.1596489}
}

@article{campion2019-30911827,
  author  = {Campion, D. and Charbonnier, C. and Nicolas, G.},
  title   = {{SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data}},
  journal = {Acta neuropathologica},
  year    = {2019},
  doi     = {10.1007/s00401-019-01991-4},
  pmid    = {30911827},
  url     = {https://doi.org/10.1007/s00401-019-01991-4}
}

@article{loeravalencia2019-30878503,
  author  = {Loera-Valencia, R. and Goikolea, J. and Parrado-Fernandez, C. and Merino-Serrais, P. and Maioli, S.},
  title   = {{Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment}},
  journal = {The Journal of steroid biochemistry and molecular biology},
  year    = {2019},
  doi     = {10.1016/j.jsbmb.2019.03.003},
  pmid    = {30878503},
  url     = {https://doi.org/10.1016/j.jsbmb.2019.03.003}
}

@article{rossidare2019-30844418,
  author  = {Rossi Dare, L. and Garcia, A. and Alves, N. and Ventura Dias, D. and de Souza, M. A. and Mello-Carpes, P. B.},
  title   = {{Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity}},
  journal = {Behavioural brain research},
  year    = {2019},
  doi     = {10.1016/j.bbr.2019.03.007},
  pmid    = {30844418},
  url     = {https://doi.org/10.1016/j.bbr.2019.03.007}
}

@article{baldacci2019-30826968,
  author  = {Baldacci, F. and Daniele, S. and Piccarducci, R. and Giampietri, L. and Pietrobono, D. and Giorgi, F. S. and Nicoletti, V. and Frosini, D. and others},
  title   = {{Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease}},
  journal = {Molecular neurobiology},
  year    = {2019},
  doi     = {10.1007/s12035-019-1531-4},
  pmid    = {30826968},
  url     = {https://doi.org/10.1007/s12035-019-1531-4}
}

@article{patel2019-30924900,
  author  = {Patel, D. and Mez, J. and Vardarajan, B. N. and Staley, L. and Chung, J. and Zhang, X. and Farrell, J. J. and Rynkiewicz, M. J. and others},
  title   = {{Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry}},
  journal = {JAMA network open},
  year    = {2019},
  doi     = {10.1001/jamanetworkopen.2019.1350},
  pmid    = {30924900},
  url     = {https://doi.org/10.1001/jamanetworkopen.2019.1350}
}

@article{kunkle2019-30820047,
  author  = {Kunkle, B. W. and Grenier-Boley, B. and Sims, R. and Bis, J. C. and Damotte, V. and Naj, A. C. and Boland, A. and Vronskaya, M. and others},
  title   = {{Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing}},
  journal = {Nature genetics},
  year    = {2019},
  doi     = {10.1038/s41588-019-0358-2},
  pmid    = {30820047},
  url     = {https://doi.org/10.1038/s41588-019-0358-2}
}

@article{jansen2019-30617256,
  author  = {Jansen, Iris E. and Savage, Jeanne E. and Watanabe, Kyoko and Bryois, Julien and Williams, Dylan M. and Steinberg, Stacy and Sealock, Julia and Karlsson, Ida and others},
  title   = {{Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk}},
  journal = {Nature Genetics},
  year    = {2019},
  doi     = {10.1038/s41588-018-0311-9},
  pmid    = {30617256},
  url     = {https://doi.org/10.1038/s41588-018-0311-9}
}

@article{oeckl2019-30594925,
  author  = {Oeckl, P. and Halbgebauer, S. and Anderl-Straub, S. and Steinacker, P. and Huss, A. M. and Neugebauer, H. and von Arnim, C. A. F. and Diehl-Schmid, J. and others},
  title   = {{Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2019},
  doi     = {10.3233/jad-180325},
  pmid    = {30594925},
  url     = {https://doi.org/10.3233/jad-180325}
}

@article{rajabli2018-30517106,
  author  = {Rajabli, F. and Feliciano, B. E. and Celis, K. and Hamilton-Nelson, K. L. and Whitehead, P. L. and Adams, L. D. and Bussies, P. L. and Manrique, C. P. and others},
  title   = {{Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations}},
  journal = {PLoS genetics},
  year    = {2018},
  doi     = {10.1371/journal.pgen.1007791},
  pmid    = {30517106},
  url     = {https://doi.org/10.1371/journal.pgen.1007791}
}

@article{zhang2018-30383244,
  author  = {Zhang, M. and Cheng, X. and Dang, R. and Zhang, W. and Zhang, J. and Yao, Z.},
  title   = {{Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2018},
  doi     = {10.1093/jnen/nly102},
  pmid    = {30383244},
  url     = {https://doi.org/10.1093/jnen/nly102}
}

@article{butterfield2019-30216447,
  author  = {Butterfield, D. A. and Boyd-Kimball, D.},
  title   = {{Redox proteomics and amyloid β-peptide: insights into Alzheimer disease}},
  journal = {Journal of neurochemistry},
  year    = {2019},
  doi     = {10.1111/jnc.14589},
  pmid    = {30216447},
  url     = {https://doi.org/10.1111/jnc.14589}
}

@article{bergeron2018-30255971,
  author  = {Bergeron, D. and Gorno-Tempini, M. L. and Rabinovici, G. D. and Santos-Santos, M. A. and Seeley, W. and Miller, B. L. and Pijnenburg, Y. and Keulen, M. A. and others},
  title   = {{Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25333},
  pmid    = {30255971},
  url     = {https://doi.org/10.1002/ana.25333}
}

@article{raineysmith2018-30375373,
  author  = {Rainey-Smith, SR. and Gu, Y. and Gardener, S. L. and Doecke, J. D. and Villemagne, V. L. and Brown, B. M. and Taddei, K. and Laws, S. M. and others},
  title   = {{Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing}},
  journal = {Translational psychiatry},
  year    = {2018},
  doi     = {10.1038/s41398-018-0293-5},
  pmid    = {30375373},
  url     = {https://doi.org/10.1038/s41398-018-0293-5}
}

@article{steiner2018-31225454,
  author  = {Steiner, H. and Fukumori, A. and Tagami, S. and Okochi, M.},
  title   = {{Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase}},
  journal = {Cell stress},
  year    = {2018},
  doi     = {10.15698/cst2018.11.162},
  pmid    = {31225454},
  url     = {https://doi.org/10.15698/cst2018.11.162}
}

@article{huttenrauch2018-30340518,
  author  = {Hüttenrauch, M. and Ogorek, I. and Klafki, H. and Otto, M. and Stadelmann, C. and Weggen, S. and Wiltfang, J. and Wirths, O.},
  title   = {{Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia}},
  journal = {Acta neuropathologica communications},
  year    = {2018},
  doi     = {10.1186/s40478-018-0612-3},
  pmid    = {30340518},
  url     = {https://doi.org/10.1186/s40478-018-0612-3}
}

@article{conway2018-30326945,
  author  = {Conway, O. J. and Carrasquillo, M. M. and Wang, X. and Bredenberg, J. M. and Reddy, J. S. and Strickland, S. L. and Younkin, C. S. and Burgess, J. D. and others},
  title   = {{ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0289-x},
  pmid    = {30326945},
  url     = {https://doi.org/10.1186/s13024-018-0289-x}
}

@article{farrell2018-30305451,
  author  = {Farrell, M. E. and Chen, X. and Rundle, M. M. and Chan, M. Y. and Wig, G. S. and Park, D. C.},
  title   = {{Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000006469},
  pmid    = {30305451},
  url     = {https://doi.org/10.1212/wnl.0000000000006469}
}

@article{tao2018-30646251,
  author  = {Tao, Q. and Ang, T. F. A. and DeCarli, C. and Auerbach, S. H. and Devine, S. and Stein, T. D. and Zhang, X. and Massaro, J. and others},
  title   = {{Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers}},
  journal = {JAMA network open},
  year    = {2018},
  doi     = {10.1001/jamanetworkopen.2018.3597},
  pmid    = {30646251},
  url     = {https://doi.org/10.1001/jamanetworkopen.2018.3597}
}

@article{hauremirande2019-30283032,
  author  = {Haure-Mirande, J. V. and Wang, M. and Audrain, M. and Fanutza, T. and Kim, S. H. and Heja, S. and Readhead, B. and Dudley, J. T. and others},
  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0255-6},
  pmid    = {30283032},
  url     = {https://doi.org/10.1038/s41380-018-0255-6}
}

@article{ma2018-30239611,
  author  = {MÁ, Araque Caballero and Suárez-Calvet, M. and Duering, M. and Franzmeier, N. and Benzinger, T. and Fagan, A. M. and Bateman, R. J. and Jack, C. R. and others},
  title   = {{White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy229},
  pmid    = {30239611},
  url     = {https://doi.org/10.1093/brain/awy229}
}

@article{focke2019-30262517,
  author  = {Focke, C. and Blume, T. and Zott, B. and Shi, Y. and Deussing, M. and Peters, F. and Schmidt, C. and Kleinberger, G. and others},
  title   = {{Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.217703},
  pmid    = {30262517},
  url     = {https://doi.org/10.2967/jnumed.118.217703}
}

@article{tesi2019-30258121,
  author  = {Tesi, N. and van der Lee, S. J. and Hulsman, M. and Jansen, I. E. and Stringa, N. and van Schoor, N. and Meijers-Heijboer, H. and Huisman, M. and others},
  title   = {{Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease}},
  journal = {European journal of human genetics : EJHG},
  year    = {2019},
  doi     = {10.1038/s41431-018-0273-5},
  pmid    = {30258121},
  url     = {https://doi.org/10.1038/s41431-018-0273-5}
}

@article{dickson2018-30143564,
  author  = {Dickson, D. W. and Heckman, M. G. and Murray, M. E. and Soto, A. I. and Walton, R. L. and Diehl, N. N. and van Gerpen, J. A. and Uitti, R. J. and others},
  title   = {{APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000006212},
  pmid    = {30143564},
  url     = {https://doi.org/10.1212/wnl.0000000000006212}
}

@article{bis2020-30108311,
  author  = {Bis, J. C. and Jian, X. and Kunkle, B. W. and Chen, Y. and Hamilton-Nelson, K. L. and Bush, W. S. and Salerno, W. J. and Lancour, D. and others},
  title   = {{Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation}},
  journal = {Molecular psychiatry},
  year    = {2020},
  doi     = {10.1038/s41380-018-0112-7},
  pmid    = {30108311},
  url     = {https://doi.org/10.1038/s41380-018-0112-7}
}

@article{yang2018-30099679,
  author  = {Yang, J. T. and Wang, Z. J. and Cai, H. Y. and Yuan, L. and Hu, M. M. and Wu, M. N. and Qi, J. S.},
  title   = {{Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease}},
  journal = {Neuroscience bulletin},
  year    = {2018},
  doi     = {10.1007/s12264-018-0268-9},
  pmid    = {30099679},
  url     = {https://doi.org/10.1007/s12264-018-0268-9}
}

@article{yang2018-30093249,
  author  = {Yang, H. S. and Yu, L. and White, C. C. and Chibnik, L. B. and Chhatwal, J. P. and Sperling, R. A. and Bennett, D. A. and Schneider, J. A. and others},
  title   = {{Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30251-5},
  pmid    = {30093249},
  url     = {https://doi.org/10.1016/s1474-4422(18)30251-5}
}

@article{weise2018-30101060,
  author  = {Weise, C. M. and Chen, K. and Chen, Y. and Kuang, X. and Savage, C. R. and Reiman, E. M. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment}},
  journal = {NeuroImage. Clinical},
  year    = {2018},
  doi     = {10.1016/j.nicl.2018.07.016},
  pmid    = {30101060},
  url     = {https://doi.org/10.1016/j.nicl.2018.07.016}
}

@article{rafii2018-29582053,
  author  = {Rafii, M. S. and Tuszynski, M. H. and Thomas, R. G. and Barba, D. and Brewer, J. B. and Rissman, R. A. and Siffert, J. and Aisen, P. S. and others},
  title   = {{Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2018.0233},
  pmid    = {29582053},
  url     = {https://doi.org/10.1001/jamaneurol.2018.0233}
}

@article{li2018-29880032,
  author  = {Li, Z. and Del-Aguila, J. L. and Dube, U. and Budde, J. and Martinez, R. and Black, K. and Xiao, Q. and Cairns, N. J. and others},
  title   = {{Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure}},
  journal = {Genome medicine},
  year    = {2018},
  doi     = {10.1186/s13073-018-0551-4},
  pmid    = {29880032},
  url     = {https://doi.org/10.1186/s13073-018-0551-4}
}

@article{grimaldi2018-29880901,
  author  = {Grimaldi, A. and Brighi, C. and Peruzzi, G. and Ragozzino, D. and Bonanni, V. and Limatola, C. and Ruocco, G. and Di Angelantonio, S.},
  title   = {{Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-018-0740-5},
  pmid    = {29880901},
  url     = {https://doi.org/10.1038/s41419-018-0740-5}
}

@article{barberocamps2018-29862881,
  author  = {Barbero-Camps, E. and Roca-Agujetas, V. and Bartolessis, I. and de Dios, C. and Fernández-Checa, J. C. and Marí, M. and Morales, A. and Hartmann, T. and others},
  title   = {{Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion}},
  journal = {Autophagy},
  year    = {2018},
  doi     = {10.1080/15548627.2018.1438807},
  pmid    = {29862881},
  url     = {https://doi.org/10.1080/15548627.2018.1438807}
}

@article{buckley2018-29803541,
  author  = {Buckley, R. F. and Mormino, E. C. and Amariglio, R. E. and Properzi, M. J. and Rabin, J. S. and Lim, Y. Y. and Papp, K. V. and Jacobs, H. I. L. and others},
  title   = {{Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2018.04.010},
  pmid    = {29803541},
  url     = {https://doi.org/10.1016/j.jalz.2018.04.010}
}

@article{chiao2019-29777003,
  author  = {Chiao, P. and Bedell, B. J. and Avants, B. and Zijdenbos, A. P. and Grand'Maison, M. and O'Neill, P. and O'Gorman, J. and Chen, T. and others},
  title   = {{Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.209130},
  pmid    = {29777003},
  url     = {https://doi.org/10.2967/jnumed.118.209130}
}

@article{suidan2018-29700007,
  author  = {Suidan, G. L. and Singh, P. K. and Patel-Hett, S. and Chen, Z. L. and Volfson, D. and Yamamoto-Imoto, H. and Norris, E. H. and Bell, R. D. and others},
  title   = {{Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability}},
  journal = {Blood advances},
  year    = {2018},
  doi     = {10.1182/bloodadvances.2018017798},
  pmid    = {29700007},
  url     = {https://doi.org/10.1182/bloodadvances.2018017798}
}

@article{garciaesparcia2018-29755340,
  author  = {Garcia-Esparcia, P. and Diaz-Lucena, D. and Ainciburu, M. and Torrejón-Escribano, B. and Carmona, M. and Llorens, F. and Ferrer, I.},
  title   = {{Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00122},
  pmid    = {29755340},
  url     = {https://doi.org/10.3389/fnagi.2018.00122}
}

@article{bauerl2018-29575030,
  author  = {Bäuerl, C. and Collado, M. C. and Diaz Cuevas, A. and Viña, J. and Pérez Martínez, G.},
  title   = {{Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan}},
  journal = {Letters in applied microbiology},
  year    = {2018},
  doi     = {10.1111/lam.12882},
  pmid    = {29575030},
  url     = {https://doi.org/10.1111/lam.12882}
}

@article{lim2018-29356823,
  author  = {Lim, Y. Y. and Kalinowski, P. and Pietrzak, R. H. and Laws, S. M. and Burnham, S. C. and Ames, D. and Villemagne, V. L. and Fowler, C. J. and others},
  title   = {{Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4325},
  pmid    = {29356823},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4325}
}

@article{solomon2018-29356827,
  author  = {Solomon, A. and Turunen, H. and Ngandu, T. and Peltonen, M. and Levälahti, E. and Helisalmi, S. and Antikainen, R. and Bäckman, L. and others},
  title   = {{Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4365},
  pmid    = {29356827},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4365}
}

@article{marsh2018-29722304,
  author  = {Marsh, J. and Alifragis, P.},
  title   = {{Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention}},
  journal = {Neural regeneration research},
  year    = {2018},
  doi     = {10.4103/1673-5374.230276},
  pmid    = {29722304},
  url     = {https://doi.org/10.4103/1673-5374.230276}
}

@article{liao2018-29600961,
  author  = {Liao, F. and Li, A. and Xiong, M. and Bien-Ly, N. and Jiang, H. and Zhang, Y. and Finn, M. B. and Hoyle, R. and others},
  title   = {{Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation}},
  journal = {The Journal of clinical investigation},
  year    = {2018},
  doi     = {10.1172/jci96429},
  pmid    = {29600961},
  url     = {https://doi.org/10.1172/jci96429}
}

@article{ge2018-29592889,
  author  = {Ge, T. and Sabuncu, M. R. and Smoller, J. W. and Sperling, R. A. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition}},
  journal = {Neurology},
  year    = {2018},
  doi     = {10.1212/wnl.0000000000005415},
  pmid    = {29592889},
  url     = {https://doi.org/10.1212/wnl.0000000000005415}
}

@article{vanderlee2018-29555425,
  author  = {van der Lee, S. J. and Wolters, F. J. and Ikram, M. K. and Hofman, A. and Ikram, M. A. and Amin, N. and van Duijn, C. M.},
  title   = {{The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30053-x},
  pmid    = {29555425},
  url     = {https://doi.org/10.1016/s1474-4422(18)30053-x}
}

@article{goetzl2018-29406582,
  author  = {Goetzl, E. J. and Schwartz, J. B. and Abner, E. L. and Jicha, G. A. and Kapogiannis, D.},
  title   = {{High complement levels in astrocyte-derived exosomes of Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25172},
  pmid    = {29406582},
  url     = {https://doi.org/10.1002/ana.25172}
}

@article{areagomez2018-29491396,
  author  = {Area-Gomez, E. and de Groof, A. and Bonilla, E. and Montesinos, J. and Tanji, K. and Boldogh, I. and Pon, L. and Schon, E. A.},
  title   = {{A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease}},
  journal = {Cell death \& disease},
  year    = {2018},
  doi     = {10.1038/s41419-017-0215-0},
  pmid    = {29491396},
  url     = {https://doi.org/10.1038/s41419-017-0215-0}
}

@article{dong2018-29369398,
  author  = {Dong, Y. and Lagarde, J. and Xicota, L. and Corne, H. and Chantran, Y. and Chaigneau, T. and Crestani, B. and Bottlaender, M. and others},
  title   = {{Neutrophil hyperactivation correlates with Alzheimer's disease progression}},
  journal = {Annals of neurology},
  year    = {2018},
  doi     = {10.1002/ana.25159},
  pmid    = {29369398},
  url     = {https://doi.org/10.1002/ana.25159}
}

@article{ren2018-29321592,
  author  = {Ren, S. Q. and Yao, W. and Yan, J. Z. and Jin, C. and Yin, J. J. and Yuan, J. and Yu, S. and Cheng, Z.},
  title   = {{Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex}},
  journal = {Scientific reports},
  year    = {2018},
  doi     = {10.1038/s41598-017-18729-5},
  pmid    = {29321592},
  url     = {https://doi.org/10.1038/s41598-017-18729-5}
}

@article{broce2018-29315334,
  author  = {Broce, I. and Karch, C. M. and Wen, N. and Fan, C. C. and Wang, Y. and Tan, C. H. and Kouri, N. and Ross, O. A. and others},
  title   = {{Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies}},
  journal = {PLoS medicine},
  year    = {2018},
  doi     = {10.1371/journal.pmed.1002487},
  pmid    = {29315334},
  url     = {https://doi.org/10.1371/journal.pmed.1002487}
}

@article{butterfield2018-29562527,
  author  = {Butterfield, D. A. and Boyd-Kimball, D.},
  title   = {{Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-170543},
  pmid    = {29562527},
  url     = {https://doi.org/10.3233/jad-170543}
}

@article{nelson2018-29186501,
  author  = {Nelson, P. T. and Abner, E. L. and Patel, E. and Anderson, S. and Wilcock, D. M. and Kryscio, R. J. and Van Eldik, L. J. and Jicha, G. A. and others},
  title   = {{The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2018},
  doi     = {10.1093/jnen/nlx099},
  pmid    = {29186501},
  url     = {https://doi.org/10.1093/jnen/nlx099}
}

@article{friedland2017-29267402,
  author  = {Friedland, R. P. and Chapman, M. R.},
  title   = {{The role of microbial amyloid in neurodegeneration}},
  journal = {PLoS pathogens},
  year    = {2017},
  doi     = {10.1371/journal.ppat.1006654},
  pmid    = {29267402},
  url     = {https://doi.org/10.1371/journal.ppat.1006654}
}

@article{castillo2017-29259249,
  author  = {Castillo, E. and Leon, J. and Mazzei, G. and Abolhassani, N. and Haruyama, N. and Saito, T. and Saido, T. and Hokama, M. and others},
  title   = {{Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-17999-3},
  pmid    = {29259249},
  url     = {https://doi.org/10.1038/s41598-017-17999-3}
}

@article{gonzalezreyes2017-29311817,
  author  = {González-Reyes, R. E. and Nava-Mesa, M. O. and Vargas-Sánchez, K. and Ariza-Salamanca, D. and Mora-Muñoz, L.},
  title   = {{Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00427},
  pmid    = {29311817},
  url     = {https://doi.org/10.3389/fnmol.2017.00427}
}

@article{kommaddi2018-29246925,
  author  = {Kommaddi, R. P. and Das, D. and Karunakaran, S. and Nanguneri, S. and Bapat, D. and Ray, A. and Shaw, E. and Bennett, D. A. and others},
  title   = {{Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2018},
  doi     = {10.1523/jneurosci.2127-17.2017},
  pmid    = {29246925},
  url     = {https://doi.org/10.1523/jneurosci.2127-17.2017}
}

@article{clayton2017-29311768,
  author  = {Clayton, K. A. and Van Enoo, A. A. and Ikezu, T.},
  title   = {{Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy}},
  journal = {Frontiers in neuroscience},
  year    = {2017},
  doi     = {10.3389/fnins.2017.00680},
  pmid    = {29311768},
  url     = {https://doi.org/10.3389/fnins.2017.00680}
}

@article{an2017-29371969,
  author  = {An, F. and Gong, G. and Wang, Y. and Bian, M. and Yu, L. and Wei, C.},
  title   = {{MiR-124 acts as a target for Alzheimer's disease by regulating BACE1}},
  journal = {Oncotarget},
  year    = {2017},
  doi     = {10.18632/oncotarget.23119},
  pmid    = {29371969},
  url     = {https://doi.org/10.18632/oncotarget.23119}
}

@article{huynh2017-29216448,
  author  = {Huynh, T. V. and Liao, F. and Francis, C. M. and Robinson, G. O. and Serrano, JR. and Jiang, H. and Roh, J. and Finn, M. B. and others},
  title   = {{Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis}},
  journal = {Neuron},
  year    = {2017},
  doi     = {10.1016/j.neuron.2017.11.014},
  pmid    = {29216448},
  url     = {https://doi.org/10.1016/j.neuron.2017.11.014}
}

@article{neth2017-29163128,
  author  = {Neth, B. J. and Craft, S.},
  title   = {{Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00345},
  pmid    = {29163128},
  url     = {https://doi.org/10.3389/fnagi.2017.00345}
}

@article{palmqvist2017-29089479,
  author  = {Palmqvist, Sebastian and Schöll, Michael and Strandberg, Olof T. and Mattsson, Niklas and Stomrud, Erik and Zetterberg, Henrik and Blennow, Kaj and Landau, Susan M. and Jagust, William J. and Hansson, Oskar},
  title   = {{Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity}},
  journal = {Nature Communications},
  year    = {2017},
  doi     = {10.1038/s41467-017-01150-x},
  pmid    = {29089479},
  url     = {https://doi.org/10.1038/s41467-017-01150-x}
}

@article{pera2017-29018038,
  author  = {Pera, M. and Larrea, D. and Guardia-Laguarta, C. and Montesinos, J. and Velasco, K. R. and Agrawal, R. R. and Xu, Y. and Chan, R. B. and others},
  title   = {{Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2017},
  doi     = {10.15252/embj.201796797},
  pmid    = {29018038},
  url     = {https://doi.org/10.15252/embj.201796797}
}

@article{wirths2017-28978359,
  author  = {Wirths, O. and Walter, S. and Kraus, I. and Klafki, H. W. and Stazi, M. and Oberstein, T. J. and Ghiso, J. and Wiltfang, J. and others},
  title   = {{N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0309-z},
  pmid    = {28978359},
  url     = {https://doi.org/10.1186/s13195-017-0309-z}
}

@article{neu2017-28846757,
  author  = {Neu, S. C. and Pa, J. and Kukull, W. and Beekly, D. and Kuzma, A. and Gangadharan, P. and Wang, L. S. and Romero, K. and others},
  title   = {{Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.2188},
  pmid    = {28846757},
  url     = {https://doi.org/10.1001/jamaneurol.2017.2188}
}

@article{carter2017-30480234,
  author  = {Carter, C. J.},
  title   = {{Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease reports},
  year    = {2017},
  doi     = {10.3233/adr-170017},
  pmid    = {30480234},
  url     = {https://doi.org/10.3233/adr-170017}
}

@article{parcon2018-28945989,
  author  = {Parcon, P. A. and Balasubramaniam, M. and Ayyadevara, S. and Jones, R. A. and Liu, L. and Shmookler Reis, R. J. and Barger, S. W. and Mrak, R. E. and others},
  title   = {{Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2018},
  doi     = {10.1016/j.jalz.2017.07.754},
  pmid    = {28945989},
  url     = {https://doi.org/10.1016/j.jalz.2017.07.754}
}

@article{kunkle2017-28738127,
  author  = {Kunkle, B. W. and Vardarajan, B. N. and Naj, A. C. and Whitehead, P. L. and Rolati, S. and Slifer, S. and Carney, R. M. and Cuccaro, M. L. and others},
  title   = {{Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1518},
  pmid    = {28738127},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1518}
}

@article{caldeira2017-28912710,
  author  = {Caldeira, C. and Cunha, C. and Vaz, A. R. and Falcão, A. S. and Barateiro, A. and Seixas, E. and Fernandes, A. and Brites, D.},
  title   = {{Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00277},
  pmid    = {28912710},
  url     = {https://doi.org/10.3389/fnagi.2017.00277}
}

@article{wildburger2017-28842697,
  author  = {Wildburger, N. C. and Esparza, T. J. and LeDuc, R. D. and Fellers, R. T. and Thomas, P. M. and Cairns, N. J. and Kelleher, N. L. and Bateman, R. J. and others},
  title   = {{Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-10422-x},
  pmid    = {28842697},
  url     = {https://doi.org/10.1038/s41598-017-10422-x}
}

@article{lim2017-28794245,
  author  = {Lim, Y. Y. and Mormino, E. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{APOE genotype and early β-amyloid accumulation in older adults without dementia}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000004336},
  pmid    = {28794245},
  url     = {https://doi.org/10.1212/wnl.0000000000004336}
}

@article{bellenguez2017-28789839,
  author  = {Bellenguez, C. and Charbonnier, C. and Grenier-Boley, B. and Quenez, O. and Le Guennec, K. and Nicolas, G. and Chauhan, G. and Wallon, D. and others},
  title   = {{Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.07.001},
  pmid    = {28789839},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.07.001}
}

@article{ramirez2017-28729832,
  author  = {Ramirez, A. I. and de Hoz, R. and Salobrar-Garcia, E. and Salazar, J. J. and Rojas, B. and Ajoy, D. and López-Cuenca, I. and Rojas, P. and others},
  title   = {{The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00214},
  pmid    = {28729832},
  url     = {https://doi.org/10.3389/fnagi.2017.00214}
}

@article{kind2017-4fec9d5a,
  author  = {Kind, Amy and Bendlin, Barbara B. and Kim, Alice J. and Koscik, Rebecca L. and Buckingham, William R. and Gleason, Carey Elizabeth and Blennow, Kaj and Zetterberg, Henrik and others},
  title   = {{[O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY}},
  journal = {Alzheimer s \& Dementia},
  year    = {2017},
  doi     = {10.1016/j.jalz.2017.07.054},
  url     = {https://doi.org/10.1016/j.jalz.2017.07.054}
}

@article{nam2017-28655926,
  author  = {Nam, K. N. and Mounier, A. and Wolfe, C. M. and Fitz, N. F. and Carter, A. Y. and Castranio, E. L. and Kamboh, H. I. and Reeves, V. L. and others},
  title   = {{Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/s41598-017-04412-2},
  pmid    = {28655926},
  url     = {https://doi.org/10.1038/s41598-017-04412-2}
}

@article{drenth2017-28558966,
  author  = {Drenth, H. and Zuidema, S. U. and Krijnen, W. P. and Bautmans, I. and van der Schans, C. and Hobbelen, H.},
  title   = {{Advanced Glycation End-Products Are Associated With the Presence and Severity of Paratonia in Early Stage Alzheimer Disease}},
  journal = {Journal of the American Medical Directors Association},
  year    = {2017},
  doi     = {10.1016/j.jamda.2017.04.004},
  pmid    = {28558966},
  url     = {https://doi.org/10.1016/j.jamda.2017.04.004}
}

@article{efthymiou2017-28549481,
  author  = {Efthymiou, A. G. and Goate, A. M.},
  title   = {{Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk}},
  journal = {Molecular neurodegeneration},
  year    = {2017},
  doi     = {10.1186/s13024-017-0184-x},
  pmid    = {28549481},
  url     = {https://doi.org/10.1186/s13024-017-0184-x}
}

@article{drenth2017-28539135,
  author  = {Drenth, H. and Zuidema, S. U. and Krijnen, W. P. and Bautmans, I. and van der Schans, C. and Hobbelen, H.},
  title   = {{Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia}},
  journal = {International psychogeriatrics},
  year    = {2017},
  doi     = {10.1017/s1041610217000886},
  pmid    = {28539135},
  url     = {https://doi.org/10.1017/s1041610217000886}
}

@article{holstege2017-28537274,
  author  = {Holstege, H. and van der Lee, S. J. and Hulsman, M. and Wong, T. H. and van Rooij, J. G. and Weiss, M. and Louwersheimer, E. and Wolters, F. J. and others},
  title   = {{Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy}},
  journal = {European journal of human genetics : EJHG},
  year    = {2017},
  doi     = {10.1038/ejhg.2017.87},
  pmid    = {28537274},
  url     = {https://doi.org/10.1038/ejhg.2017.87}
}

@article{park2017-28515043,
  author  = {Park, L. and Uekawa, K. and Garcia-Bonilla, L. and Koizumi, K. and Murphy, M. and Pistik, R. and Younkin, L. and Younkin, S. and others},
  title   = {{Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides}},
  journal = {Circulation research},
  year    = {2017},
  doi     = {10.1161/circresaha.117.311054},
  pmid    = {28515043},
  url     = {https://doi.org/10.1161/circresaha.117.311054}
}

@article{jin2017-28477083,
  author  = {Jin, W. S. and Shen, L. L. and Bu, X. L. and Zhang, W. W. and Chen, S. H. and Huang, Z. L. and Xiong, J. X. and Gao, C. Y. and others},
  title   = {{Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1721-y},
  pmid    = {28477083},
  url     = {https://doi.org/10.1007/s00401-017-1721-y}
}

@article{slattery2017-28578156,
  author  = {Slattery, C. F. and Zhang, J. and Paterson, R. W. and Foulkes, A. J. M. and Carton, A. and Macpherson, K. and Mancini, L. and Thomas, D. L. and others},
  title   = {{ApoE influences regional white-matter axonal density loss in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.04.021},
  pmid    = {28578156},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.04.021}
}

@article{smith2017-27940601,
  author  = {Smith, L. M. and Strittmatter, S. M.},
  title   = {{Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2017},
  doi     = {10.1101/cshperspect.a024075},
  pmid    = {27940601},
  url     = {https://doi.org/10.1101/cshperspect.a024075}
}

@article{moser2017-28612048,
  author  = {Moser, V. A. and Pike, C. J.},
  title   = {{Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice}},
  journal = {eNeuro},
  year    = {2017},
  doi     = {10.1523/eneuro.0077-17.2017},
  pmid    = {28612048},
  url     = {https://doi.org/10.1523/eneuro.0077-17.2017}
}

@article{muller2017-28360418,
  author  = {Müller, U. C. and Deller, T. and Korte, M.},
  title   = {{Not just amyloid: physiological functions of the amyloid precursor protein family}},
  journal = {Nature reviews. Neuroscience},
  year    = {2017},
  doi     = {10.1038/nrn.2017.29},
  pmid    = {28360418},
  url     = {https://doi.org/10.1038/nrn.2017.29}
}

@article{lanoiselee2017-28350801,
  author  = {Lanoiselée, H. M. and Nicolas, G. and Wallon, D. and Rovelet-Lecrux, A. and Lacour, M. and Rousseau, S. and Richard, A. C. and Pasquier, F. and others},
  title   = {{APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases}},
  journal = {PLoS medicine},
  year    = {2017},
  doi     = {10.1371/journal.pmed.1002270},
  pmid    = {28350801},
  url     = {https://doi.org/10.1371/journal.pmed.1002270}
}

@article{steele2017-28350795,
  author  = {Steele, N. Z. and Carr, J. S. and Bonham, L. W. and Geier, E. G. and Damotte, V. and Miller, Z. A. and Desikan, R. S. and Boehme, K. L. and others},
  title   = {{Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study}},
  journal = {PLoS medicine},
  year    = {2017},
  doi     = {10.1371/journal.pmed.1002272},
  pmid    = {28350795},
  url     = {https://doi.org/10.1371/journal.pmed.1002272}
}

@article{shen2018-28359566,
  author  = {Shen, Y. and Wang, H. and Sun, Q. and Yao, H. and Keegan, A. P. and Mullan, M. and Wilson, J. and Lista, S. and others},
  title   = {{Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.02.007},
  pmid    = {28359566},
  url     = {https://doi.org/10.1016/j.biopsych.2017.02.007}
}

@article{johnson2017-28272510,
  author  = {Johnson, L. A. and Torres, E. R. and Impey, S. and Stevens, J. F. and Raber, J.},
  title   = {{Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome}},
  journal = {Scientific reports},
  year    = {2017},
  doi     = {10.1038/srep43701},
  pmid    = {28272510},
  url     = {https://doi.org/10.1038/srep43701}
}

@article{yassine2017-28114437,
  author  = {Yassine, H. N. and Braskie, M. N. and Mack, W. J. and Castor, K. J. and Fonteh, A. N. and Schneider, L. S. and Harrington, M. G. and Chui, H. C.},
  title   = {{Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.4899},
  pmid    = {28114437},
  url     = {https://doi.org/10.1001/jamaneurol.2016.4899}
}

@article{jun2017-28183528,
  author  = {Jun, G. R. and Chung, J. and Mez, J. and Barber, R. and Beecham, G. W. and Bennett, D. A. and Buxbaum, J. D. and Byrd, G. S. and others},
  title   = {{Transethnic genome-wide scan identifies novel Alzheimer's disease loci}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.12.012},
  pmid    = {28183528},
  url     = {https://doi.org/10.1016/j.jalz.2016.12.012}
}

@article{liao2017-27922847,
  author  = {Liao, F. and Yoon, H. and Kim, J.},
  title   = {{Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease}},
  journal = {Current opinion in lipidology},
  year    = {2017},
  doi     = {10.1097/mol.0000000000000383},
  pmid    = {27922847},
  url     = {https://doi.org/10.1097/mol.0000000000000383}
}

@article{cacciottolo2017-28140404,
  author  = {Cacciottolo, M. and Wang, X. and Driscoll, I. and Woodward, N. and Saffari, A. and Reyes, J. and Serre, M. L. and Vizuete, W. and others},
  title   = {{Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models}},
  journal = {Translational psychiatry},
  year    = {2017},
  doi     = {10.1038/tp.2016.280},
  pmid    = {28140404},
  url     = {https://doi.org/10.1038/tp.2016.280}
}

@article{whyte2017-28027395,
  author  = {Whyte, L. S. and Lau, A. A. and Hemsley, K. M. and Hopwood, J. J. and Sargeant, T. J.},
  title   = {{Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?}},
  journal = {Journal of neurochemistry},
  year    = {2017},
  doi     = {10.1111/jnc.13935},
  pmid    = {28027395},
  url     = {https://doi.org/10.1111/jnc.13935}
}

@article{yu2017-28108637,
  author  = {Yu, L. and Lutz, M. W. and Wilson, R. S. and Burns, D. K. and Roses, A. D. and Saunders, A. M. and Gaiteri, C. and De Jager, P. L. and others},
  title   = {{TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype}},
  journal = {Neurology},
  year    = {2017},
  doi     = {10.1212/wnl.0000000000003614},
  pmid    = {28108637},
  url     = {https://doi.org/10.1212/wnl.0000000000003614}
}

@article{dean2017-27842175,
  author  = {Dean, D. C. and Hurley, S. A. and Kecskemeti, SR. and O'Grady, J. P. and Canda, C. and Davenport-Sis, N. J. and Carlsson, C. M. and Zetterberg, H. and others},
  title   = {{Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.3232},
  pmid    = {27842175},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3232}
}

@article{nadkarni2017-27842173,
  author  = {Nadkarni, N. K. and Perera, S. and Snitz, B. E. and Mathis, C. A. and Price, J. and Williamson, J. D. and DeKosky, S. T. and Klunk, W. E. and others},
  title   = {{Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.3474},
  pmid    = {27842173},
  url     = {https://doi.org/10.1001/jamaneurol.2016.3474}
}

@article{zeppenfeld2017-27893874,
  author  = {Zeppenfeld, D. M. and Simon, M. and Haswell, J. D. and D'Abreo, D. and Murchison, C. and Quinn, J. F. and Grafe, M. R. and Woltjer, R. L. and others},
  title   = {{Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2016.4370},
  pmid    = {27893874},
  url     = {https://doi.org/10.1001/jamaneurol.2016.4370}
}

@article{domingues2017-28317487,
  author  = {Domingues, C. and da Cruz E Silva, O. A. B. and Henriques, A. G.},
  title   = {{Impact of Cytokines and Chemokines on Alzheimer's Disease Neuropathological Hallmarks}},
  journal = {Current Alzheimer research},
  year    = {2017},
  doi     = {10.2174/1567205014666170317113606},
  pmid    = {28317487},
  url     = {https://doi.org/10.2174/1567205014666170317113606}
}

@article{yang2017-28053038,
  author  = {Yang, T. and Li, S. and Xu, H. and Walsh, D. M. and Selkoe, D. J.},
  title   = {{Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.1698-16.2016},
  pmid    = {28053038},
  url     = {https://doi.org/10.1523/jneurosci.1698-16.2016}
}

@article{sennik2017-27911311,
  author  = {Sennik, S. and Schweizer, T. A. and Fischer, C. E. and Munoz, D. G.},
  title   = {{Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160780},
  pmid    = {27911311},
  url     = {https://doi.org/10.3233/jad-160780}
}

@article{suarezcalvet2016-27974666,
  author  = {Suárez-Calvet, M. and MÁ, Araque Caballero and Kleinberger, G. and Bateman, R. J. and Fagan, A. M. and Morris, J. C. and Levin, J. and Danek, A. and others},
  title   = {{Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury}},
  journal = {Science translational medicine},
  year    = {2016},
  doi     = {10.1126/scitranslmed.aag1767},
  pmid    = {27974666},
  url     = {https://doi.org/10.1126/scitranslmed.aag1767}
}

@article{mokry2016-27856775,
  author  = {Mokry, L. E. and Ross, S. and Morris, J. A. and Manousaki, D. and Forgetta, V. and Richards, J. B.},
  title   = {{Genetically decreased vitamin D and risk of Alzheimer disease}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000003430},
  pmid    = {27856775},
  url     = {https://doi.org/10.1212/wnl.0000000000003430}
}

@article{mastroeni2017-27793643,
  author  = {Mastroeni, D. and Khdour, O. M. and Delvaux, E. and Nolz, J. and Olsen, G. and Berchtold, N. and Cotman, C. and Hecht, S. M. and others},
  title   = {{Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.09.003},
  pmid    = {27793643},
  url     = {https://doi.org/10.1016/j.jalz.2016.09.003}
}

@article{rasmussen2016-28340945,
  author  = {Rasmussen, K. L.},
  title   = {{Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review}},
  journal = {Atherosclerosis},
  year    = {2016},
  doi     = {10.1016/j.atherosclerosis.2016.10.037},
  pmid    = {28340945},
  url     = {https://doi.org/10.1016/j.atherosclerosis.2016.10.037}
}

@article{arendt2017-27564538,
  author  = {Arendt, T. and Morawski, M. and Gärtner, U. and Fröhlich, N. and Schulze, F. and Wohmann, N. and Jäger, C. and Eisenlöffel, C. and others},
  title   = {{Inhomogeneous distribution of Alzheimer pathology along the isocortical relief. Are cortical convolutions an Achilles heel of evolution?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2017},
  doi     = {10.1111/bpa.12442},
  pmid    = {27564538},
  url     = {https://doi.org/10.1111/bpa.12442}
}

@article{vanbergen2016-27748454,
  author  = {van Bergen, J. M. and Li, X. and Hua, J. and Schreiner, S. J. and Steininger, S. C. and Quevenco, F. C. and Wyss, M. and Gietl, A. F. and others},
  title   = {{Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment}},
  journal = {Scientific reports},
  year    = {2016},
  doi     = {10.1038/srep35514},
  pmid    = {27748454},
  url     = {https://doi.org/10.1038/srep35514}
}

@article{martin2017-27723233,
  author  = {Martin, E. and Boucher, C. and Fontaine, B. and Delarasse, C.},
  title   = {{Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology}},
  journal = {Aging cell},
  year    = {2017},
  doi     = {10.1111/acel.12522},
  pmid    = {27723233},
  url     = {https://doi.org/10.1111/acel.12522}
}

@article{yassine2016-27532692,
  author  = {Yassine, H. N. and Feng, Q. and Azizkhanian, I. and Rawat, V. and Castor, K. and Fonteh, A. N. and Harrington, M. G. and Zheng, L. and others},
  title   = {{Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis}},
  journal = {JAMA neurology},
  year    = {2016},
  doi     = {10.1001/jamaneurol.2016.1924},
  pmid    = {27532692},
  url     = {https://doi.org/10.1001/jamaneurol.2016.1924}
}

@article{testa2016-27687218,
  author  = {Testa, G. and Staurenghi, E. and Zerbinati, C. and Gargiulo, S. and Iuliano, L. and Giaccone, G. and Fantò, F. and Poli, G. and others},
  title   = {{Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation}},
  journal = {Redox biology},
  year    = {2016},
  doi     = {10.1016/j.redox.2016.09.001},
  pmid    = {27687218},
  url     = {https://doi.org/10.1016/j.redox.2016.09.001}
}

@article{yamazaki2016-27328687,
  author  = {Yamazaki, Y. and Painter, M. M. and Bu, G. and Kanekiyo, T.},
  title   = {{Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence}},
  journal = {CNS drugs},
  year    = {2016},
  doi     = {10.1007/s40263-016-0361-4},
  pmid    = {27328687},
  url     = {https://doi.org/10.1007/s40263-016-0361-4}
}

@article{goetzl2016-27511944,
  author  = {Goetzl, E. J. and Mustapic, M. and Kapogiannis, D. and Eitan, E. and Lobach, IV. and Goetzl, L. and Schwartz, J. B. and Miller, B. L.},
  title   = {{Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2016},
  doi     = {10.1096/fj.201600756r},
  pmid    = {27511944},
  url     = {https://doi.org/10.1096/fj.201600756r}
}

@article{pottier2016-27658901,
  author  = {Pottier, C. and Ravenscroft, T. A. and Brown, P. H. and Finch, N. A. and Baker, M. and Parsons, M. and Asmann, Y. W. and Ren, Y. and others},
  title   = {{TYROBP genetic variants in early-onset Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.07.028},
  pmid    = {27658901},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.07.028}
}

@article{andrew2016-27474742,
  author  = {Andrew, R. J. and Kellett, K. A. and Thinakaran, G. and Hooper, N. M.},
  title   = {{A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis}},
  journal = {The Journal of biological chemistry},
  year    = {2016},
  doi     = {10.1074/jbc.r116.746032},
  pmid    = {27474742},
  url     = {https://doi.org/10.1074/jbc.r116.746032}
}

@article{ayyadevara2016-27448508,
  author  = {Ayyadevara, S. and Balasubramaniam, M. and Parcon, P. A. and Barger, S. W. and Griffin, W. S. and Alla, R. and Tackett, A. J. and Mackintosh, S. G. and others},
  title   = {{Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls}},
  journal = {Aging cell},
  year    = {2016},
  doi     = {10.1111/acel.12501},
  pmid    = {27448508},
  url     = {https://doi.org/10.1111/acel.12501}
}

@article{minett2016-27256292,
  author  = {Minett, T. and Classey, J. and Matthews, F. E. and Fahrenhold, M. and Taga, M. and Brayne, C. and Ince, P. G. and Nicoll, J. A. and others},
  title   = {{Microglial immunophenotype in dementia with Alzheimer's pathology}},
  journal = {Journal of neuroinflammation},
  year    = {2016},
  doi     = {10.1186/s12974-016-0601-z},
  pmid    = {27256292},
  url     = {https://doi.org/10.1186/s12974-016-0601-z}
}

@article{areagomez2016-27235807,
  author  = {Area-Gomez, E. and Schon, E. A.},
  title   = {{Mitochondria-associated ER membranes and Alzheimer disease}},
  journal = {Current opinion in genetics \& development},
  year    = {2016},
  doi     = {10.1016/j.gde.2016.04.006},
  pmid    = {27235807},
  url     = {https://doi.org/10.1016/j.gde.2016.04.006}
}

@article{abolhassani2017-27233446,
  author  = {Abolhassani, N. and Leon, J. and Sheng, Z. and Oka, S. and Hamasaki, H. and Iwaki, T. and Nakabeppu, Y.},
  title   = {{Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain}},
  journal = {Mechanisms of ageing and development},
  year    = {2017},
  doi     = {10.1016/j.mad.2016.05.005},
  pmid    = {27233446},
  url     = {https://doi.org/10.1016/j.mad.2016.05.005}
}

@article{dumanski2016-27231129,
  author  = {Dumanski, J. P. and Lambert, J. C. and Rasi, C. and Giedraitis, V. and Davies, H. and Grenier-Boley, B. and Lindgren, C. M. and Campion, D. and others},
  title   = {{Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease}},
  journal = {American journal of human genetics},
  year    = {2016},
  doi     = {10.1016/j.ajhg.2016.05.014},
  pmid    = {27231129},
  url     = {https://doi.org/10.1016/j.ajhg.2016.05.014}
}

@article{bereczki2016-27224930,
  author  = {Bereczki, E. and Francis, P. T. and Howlett, D. and Pereira, J. B. and Höglund, K. and Bogstedt, A. and Cedazo-Minguez, A. and Baek, J. H. and others},
  title   = {{Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.04.005},
  pmid    = {27224930},
  url     = {https://doi.org/10.1016/j.jalz.2016.04.005}
}

@article{cukier2016-27231719,
  author  = {Cukier, H. N. and Kunkle, B. W. and Vardarajan, B. N. and Rolati, S. and Hamilton-Nelson, K. L. and Kohli, M. A. and Whitehead, P. L. and Dombroski, B. A. and others},
  title   = {{ABCA7 frameshift deletion associated with Alzheimer disease in African Americans}},
  journal = {Neurology. Genetics},
  year    = {2016},
  doi     = {10.1212/nxg.0000000000000079},
  pmid    = {27231719},
  url     = {https://doi.org/10.1212/nxg.0000000000000079}
}

@article{mahley2016-27174096,
  author  = {Mahley, R. W.},
  title   = {{Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2016},
  doi     = {10.1161/atvbaha.116.307023},
  pmid    = {27174096},
  url     = {https://doi.org/10.1161/atvbaha.116.307023}
}

@article{kreisl2016-27318133,
  author  = {Kreisl, W. C. and Lyoo, C. H. and Liow, J. S. and Wei, M. and Snow, J. and Page, E. and Jenko, K. J. and Morse, C. L. and others},
  title   = {{(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.04.011},
  pmid    = {27318133},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.04.011}
}

@article{lyall2016-27103599,
  author  = {Lyall, D. M. and Ward, J. and Ritchie, S. J. and Davies, G. and Cullen, B. and Celis, C. and Bailey, M. E. and Anderson, J. and others},
  title   = {{Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants}},
  journal = {Age and ageing},
  year    = {2016},
  doi     = {10.1093/ageing/afw068},
  pmid    = {27103599},
  url     = {https://doi.org/10.1093/ageing/afw068}
}

@article{voevodskaya2016-27164711,
  author  = {Voevodskaya, O. and Sundgren, P. C. and Strandberg, O. and Zetterberg, H. and Minthon, L. and Blennow, K. and Wahlund, L. O. and Westman, E. and others},
  title   = {{Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002672},
  pmid    = {27164711},
  url     = {https://doi.org/10.1212/wnl.0000000000002672}
}

@article{roostaei2017-27021820,
  author  = {Roostaei, T. and Nazeri, A. and Felsky, D. and De Jager, P. L. and Schneider, J. A. and Pollock, B. G. and Bennett, D. A. and Voineskos, A. N. and others},
  title   = {{Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease}},
  journal = {Molecular psychiatry},
  year    = {2017},
  doi     = {10.1038/mp.2016.35},
  pmid    = {27021820},
  url     = {https://doi.org/10.1038/mp.2016.35}
}

@article{kovacs2016-27016065,
  author  = {Kovacs, G. G. and Lutz, M. I. and Ricken, G. and Ströbel, T. and Höftberger, R. and Preusser, M. and Regelsberger, G. and Hönigschnabl, S. and others},
  title   = {{Dura mater is a potential source of Aβ seeds}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-016-1565-x},
  pmid    = {27016065},
  url     = {https://doi.org/10.1007/s00401-016-1565-x}
}

@article{bamburg2016-26873625,
  author  = {Bamburg, JR. and Bernstein, B. W.},
  title   = {{Actin dynamics and cofilin-actin rods in alzheimer disease}},
  journal = {Cytoskeleton (Hoboken, N.J.)},
  year    = {2016},
  doi     = {10.1002/cm.21282},
  pmid    = {26873625},
  url     = {https://doi.org/10.1002/cm.21282}
}

@article{blanch2016-26776077,
  author  = {Blanch, M. and Mosquera, J. L. and Ansoleaga, B. and Ferrer, I. and Barrachina, M.},
  title   = {{Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease-Related Pathology and in Parkinson Disease}},
  journal = {The American journal of pathology},
  year    = {2016},
  doi     = {10.1016/j.ajpath.2015.10.004},
  pmid    = {26776077},
  url     = {https://doi.org/10.1016/j.ajpath.2015.10.004}
}

@article{morris2016-26836731,
  author  = {Morris, M. C. and Brockman, J. and Schneider, J. A. and Wang, Y. and Bennett, D. A. and Tangney, C. C. and van de Rest, O.},
  title   = {{Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults}},
  journal = {JAMA},
  year    = {2016},
  doi     = {10.1001/jama.2015.19451},
  pmid    = {26836731},
  url     = {https://doi.org/10.1001/jama.2015.19451}
}

@article{dansokho2016-26912648,
  author  = {Dansokho, C. and Ait Ahmed, D. and Aid, S. and Toly-Ndour, C. and Chaigneau, T. and Calle, V. and Cagnard, N. and Holzenberger, M. and others},
  title   = {{Regulatory T cells delay disease progression in Alzheimer-like pathology}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/awv408},
  pmid    = {26912648},
  url     = {https://doi.org/10.1093/brain/awv408}
}

@article{lubitz2016-26781037,
  author  = {Lubitz, I. and Ricny, J. and Atrakchi-Baranes, D. and Shemesh, C. and Kravitz, E. and Liraz-Zaltsman, S. and Maksin-Matveev, A. and Cooper, I. and others},
  title   = {{High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model}},
  journal = {Aging cell},
  year    = {2016},
  doi     = {10.1111/acel.12436},
  pmid    = {26781037},
  url     = {https://doi.org/10.1111/acel.12436}
}

@article{lupton2016-26973105,
  author  = {Lupton, M. K. and Strike, L. and Hansell, N. K. and Wen, W. and Mather, K. A. and Armstrong, N. J. and Thalamuthu, A. and McMahon, K. L. and others},
  title   = {{The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2015.12.023},
  pmid    = {26973105},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.12.023}
}

@article{cox2016-26791617,
  author  = {Cox, P. A. and Davis, D. A. and Mash, D. C. and Metcalf, J. S. and Banack, S. A.},
  title   = {{Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain}},
  journal = {Proceedings. Biological sciences},
  year    = {2016},
  doi     = {10.1098/rspb.2015.2397},
  pmid    = {26791617},
  url     = {https://doi.org/10.1098/rspb.2015.2397}
}

@article{kohler2016-27604604,
  author  = {Köhler, C. A. and Maes, M. and Slyepchenko, A. and Berk, M. and Solmi, M. and Lanctôt, K. L. and Carvalho, A. F.},
  title   = {{The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease}},
  journal = {Current pharmaceutical design},
  year    = {2016},
  doi     = {10.2174/1381612822666160907093807},
  pmid    = {27604604},
  url     = {https://doi.org/10.2174/1381612822666160907093807}
}

@article{guedes2016-27239545,
  author  = {Guedes, JR. and Santana, I. and Cunha, C. and Duro, D. and Almeida, M. R. and Cardoso, A. M. and de Lima, M. C. and Cardoso, A. L.},
  title   = {{MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2016},
  doi     = {10.1016/j.dadm.2015.11.004},
  pmid    = {27239545},
  url     = {https://doi.org/10.1016/j.dadm.2015.11.004}
}

@article{delcampo2016-26643548,
  author  = {Del Campo, N. and Payoux, P. and Djilali, A. and Delrieu, J. and Hoogendijk, E. O. and Rolland, Y. and Cesari, M. and Weiner, M. W. and others},
  title   = {{Relationship of regional brain β-amyloid to gait speed}},
  journal = {Neurology},
  year    = {2016},
  doi     = {10.1212/wnl.0000000000002235},
  pmid    = {26643548},
  url     = {https://doi.org/10.1212/wnl.0000000000002235}
}

@article{suberbielle2015-26615780,
  author  = {Suberbielle, E. and Djukic, B. and Evans, M. and Kim, D. H. and Taneja, P. and Wang, X. and Finucane, M. and Knox, J. and others},
  title   = {{DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice}},
  journal = {Nature communications},
  year    = {2015},
  doi     = {10.1038/ncomms9897},
  pmid    = {26615780},
  url     = {https://doi.org/10.1038/ncomms9897}
}

@article{wang2016-26611835,
  author  = {Wang, Z. and Lei, H. and Zheng, M. and Li, Y. and Cui, Y. and Hao, F.},
  title   = {{Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1}},
  journal = {Molecular neurobiology},
  year    = {2016},
  doi     = {10.1007/s12035-015-9546-y},
  pmid    = {26611835},
  url     = {https://doi.org/10.1007/s12035-015-9546-y}
}

@article{verdile2015-26693205,
  author  = {Verdile, G. and Keane, K. N. and Cruzat, V. F. and Medic, S. and Sabale, M. and Rowles, J. and Wijesekara, N. and Martins, R. N. and others},
  title   = {{Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease}},
  journal = {Mediators of inflammation},
  year    = {2015},
  doi     = {10.1155/2015/105828},
  pmid    = {26693205},
  url     = {https://doi.org/10.1155/2015/105828}
}

@article{ishiki2016-26485083,
  author  = {Ishiki, A. and Kamada, M. and Kawamura, Y. and Terao, C. and Shimoda, F. and Tomita, N. and Arai, H. and Furukawa, K.},
  title   = {{Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13399},
  pmid    = {26485083},
  url     = {https://doi.org/10.1111/jnc.13399}
}

@article{fol2016-26538149,
  author  = {Fol, R. and Braudeau, J. and Ludewig, S. and Abel, T. and Weyer, S. W. and Roederer, J. P. and Brod, F. and others},
  title   = {{Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model}},
  journal = {Acta neuropathologica},
  year    = {2016},
  doi     = {10.1007/s00401-015-1498-9},
  pmid    = {26538149},
  url     = {https://doi.org/10.1007/s00401-015-1498-9}
}

@article{villegasllerena2016-26517285,
  author  = {Villegas-Llerena, C. and Phillips, A. and Garcia-Reitboeck, P. and Hardy, J. and Pocock, J. M.},
  title   = {{Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease}},
  journal = {Current opinion in neurobiology},
  year    = {2016},
  doi     = {10.1016/j.conb.2015.10.004},
  pmid    = {26517285},
  url     = {https://doi.org/10.1016/j.conb.2015.10.004}
}

@article{sato2015-26557086,
  author  = {Sato, N. and Morishita, R.},
  title   = {{The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2015},
  doi     = {10.3389/fnagi.2015.00199},
  pmid    = {26557086},
  url     = {https://doi.org/10.3389/fnagi.2015.00199}
}

@article{asadi2015-26484504,
  author  = {Asadi, F. and Jamshidi, A. H. and Khodagholi, F. and Yans, A. and Azimi, L. and Faizi, M. and Vali, L. and Abdollahi, M. and others},
  title   = {{Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers}},
  journal = {Pharmacology, biochemistry, and behavior},
  year    = {2015},
  doi     = {10.1016/j.pbb.2015.10.011},
  pmid    = {26484504},
  url     = {https://doi.org/10.1016/j.pbb.2015.10.011}
}

@article{varvel2015-26458770,
  author  = {Varvel, N. H. and Grathwohl, S. A. and Degenhardt, K. and Resch, C. and Bosch, A. and Jucker, M. and Neher, J. J.},
  title   = {{Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease}},
  journal = {The Journal of experimental medicine},
  year    = {2015},
  doi     = {10.1084/jem.20150478},
  pmid    = {26458770},
  url     = {https://doi.org/10.1084/jem.20150478}
}

@article{ebbert2016-26449541,
  author  = {Ebbert, M. T. W. and Boehme, K. L. and Wadsworth, M. E. and Staley, L. A. and {Alzheimer's Disease Neuroimaging Initiative} and {Alzheimer's Disease Genetics Consortium} and Mukherjee, S. and Crane, P. K. and others},
  title   = {{Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.08.163},
  pmid    = {26449541},
  url     = {https://doi.org/10.1016/j.jalz.2015.08.163}
}

@article{malik2015-26438529,
  author  = {Malik, M. and Parikh, I. and Vasquez, J. B. and Smith, C. and Tai, L. and Bu, G. and LaDu, M. J. and Fardo, D. W. and others},
  title   = {{Genetics ignite focus on microglial inflammation in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0048-1},
  pmid    = {26438529},
  url     = {https://doi.org/10.1186/s13024-015-0048-1}
}

@article{lugli2015-26426747,
  author  = {Lugli, G. and Cohen, A. M. and Bennett, D. A. and Shah, R. C. and Fields, C. J. and Hernandez, A. G. and Smalheiser, N. R.},
  title   = {{Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers}},
  journal = {PloS one},
  year    = {2015},
  doi     = {10.1371/journal.pone.0139233},
  pmid    = {26426747},
  url     = {https://doi.org/10.1371/journal.pone.0139233}
}

@article{sampedro2015-26397226,
  author  = {Sampedro, F. and Vilaplana, E. and de Leon, M. J. and Alcolea, D. and Pegueroles, J. and Montal, V. and Carmona-Iragui, M. and Sala, I. and others},
  title   = {{APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls}},
  journal = {Oncotarget},
  year    = {2015},
  doi     = {10.18632/oncotarget.5185},
  pmid    = {26397226},
  url     = {https://doi.org/10.18632/oncotarget.5185}
}

@article{multhaup2015-26296890,
  author  = {Multhaup, G. and Huber, O. and Buée, L. and Galas, M. C.},
  title   = {{Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.r115.677211},
  pmid    = {26296890},
  url     = {https://doi.org/10.1074/jbc.r115.677211}
}

@article{satoh2015-26260791,
  author  = {Satoh, K. and Abe-Dohmae, S. and Yokoyama, S. and St George-Hyslop, P. and Fraser, P. E.},
  title   = {{ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.655076},
  pmid    = {26260791},
  url     = {https://doi.org/10.1074/jbc.m115.655076}
}

@article{vardarajan2015-26101835,
  author  = {Vardarajan, B. N. and Ghani, M. and Kahn, A. and Sheikh, S. and Sato, C. and Barral, S. and Lee, J. H. and Cheng, R. and others},
  title   = {{Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24466},
  pmid    = {26101835},
  url     = {https://doi.org/10.1002/ana.24466}
}

@article{li2015-26202100,
  author  = {Li, X. and Long, J. and He, T. and Belshaw, R. and Scott, J.},
  title   = {{Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease}},
  journal = {Scientific reports},
  year    = {2015},
  doi     = {10.1038/srep12393},
  pmid    = {26202100},
  url     = {https://doi.org/10.1038/srep12393}
}

@article{roveletlecrux2015-26194182,
  author  = {Rovelet-Lecrux, A. and Charbonnier, C. and Wallon, D. and Nicolas, G. and Seaman, M. N. and Pottier, C. and Breusegem, S. Y. and Mathur, P. P. and others},
  title   = {{De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2015},
  doi     = {10.1038/mp.2015.100},
  pmid    = {26194182},
  url     = {https://doi.org/10.1038/mp.2015.100}
}

@article{giau2015-26213471,
  author  = {Giau, V. V. and Bagyinszky, E. and An, S. S. and Kim, S. Y.},
  title   = {{Role of apolipoprotein E in neurodegenerative diseases}},
  journal = {Neuropsychiatric disease and treatment},
  year    = {2015},
  doi     = {10.2147/ndt.s84266},
  pmid    = {26213471},
  url     = {https://doi.org/10.2147/ndt.s84266}
}

@article{alcolea2015-26180139,
  author  = {Alcolea, D. and Martínez-Lage, P. and Sánchez-Juan, P. and Olazarán, J. and Antúnez, C. and Izagirre, A. and Ecay-Torres, M. and Estanga, A. and others},
  title   = {{Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001859},
  pmid    = {26180139},
  url     = {https://doi.org/10.1212/wnl.0000000000001859}
}

@article{alemany2015-26174813,
  author  = {Alemany, S. and Ribasés, M. and Vilor-Tejedor, N. and Bustamante, M. and Sánchez-Mora, C. and Bosch, R. and Richarte, V. and Cormand, B. and others},
  title   = {{New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder}},
  journal = {American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year    = {2015},
  doi     = {10.1002/ajmg.b.32341},
  pmid    = {26174813},
  url     = {https://doi.org/10.1002/ajmg.b.32341}
}

@article{zhao2015-26097896,
  author  = {Zhao, Y. and Lukiw, W. J.},
  title   = {{Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD)}},
  journal = {Journal of nature and science},
  year    = {2015},
  pmid    = {26097896}
}

@article{swomley2015-26126631,
  author  = {Swomley, A. M. and Butterfield, D. A.},
  title   = {{Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics}},
  journal = {Archives of toxicology},
  year    = {2015},
  doi     = {10.1007/s00204-015-1556-z},
  pmid    = {26126631},
  url     = {https://doi.org/10.1007/s00204-015-1556-z}
}

@article{cuyvers2015-26141617,
  author  = {Cuyvers, E. and De Roeck, A. and Van den Bossche, T. and Van Cauwenberghe, C. and Bettens, K. and Vermeulen, S. and Mattheijssens, M. and Peeters, K. and others},
  title   = {{Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study}},
  journal = {The Lancet. Neurology},
  year    = {2015},
  doi     = {10.1016/s1474-4422(15)00133-7},
  pmid    = {26141617},
  url     = {https://doi.org/10.1016/s1474-4422(15)00133-7}
}

@article{goetzl2015-26062630,
  author  = {Goetzl, E. J. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and Miller, B. L. and Kapogiannis, D.},
  title   = {{Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001702},
  pmid    = {26062630},
  url     = {https://doi.org/10.1212/wnl.0000000000001702}
}

@article{serranopozo2015-25623662,
  author  = {Serrano-Pozo, A. and Qian, J. and Monsell, S. E. and Betensky, R. A. and Hyman, B. T.},
  title   = {{APOEε2 is associated with milder clinical and pathological Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24369},
  pmid    = {25623662},
  url     = {https://doi.org/10.1002/ana.24369}
}

@article{kostylev2015-26018073,
  author  = {Kostylev, M. A. and Kaufman, A. C. and Nygaard, H. B. and Patel, P. and Haas, L. T. and Gunther, E. C. and Vortmeyer, A. and Strittmatter, S. M.},
  title   = {{Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.643577},
  pmid    = {26018073},
  url     = {https://doi.org/10.1074/jbc.m115.643577}
}

@article{petrov2015-26003667,
  author  = {Petrov, D. and Pedrós, I. and Artiach, G. and Sureda, F. X. and Barroso, E. and Pallàs, M. and Casadesús, G. and Beas-Zarate, C. and others},
  title   = {{High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents}},
  journal = {Biochimica et biophysica acta},
  year    = {2015},
  doi     = {10.1016/j.bbadis.2015.05.004},
  pmid    = {26003667},
  url     = {https://doi.org/10.1016/j.bbadis.2015.05.004}
}

@article{stein2015-25943889,
  author  = {Stein, T. D. and Montenigro, P. H. and Alvarez, V. E. and Xia, W. and Crary, J. F. and Tripodis, Y. and Daneshvar, D. H. and Mez, J. and others},
  title   = {{Beta-amyloid deposition in chronic traumatic encephalopathy}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-015-1435-y},
  pmid    = {25943889},
  url     = {https://doi.org/10.1007/s00401-015-1435-y}
}

@article{jack2015-25775353,
  author  = {Jack, C. R. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Vemuri, P. and Mielke, M. M. and Lowe, V. and Senjem, M. L. and others},
  title   = {{Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.4821},
  pmid    = {25775353},
  url     = {https://doi.org/10.1001/jamaneurol.2014.4821}
}

@article{jansen2015-25988462,
  author  = {Jansen, W. J. and Ossenkoppele, R. and Knol, D. L. and Tijms, B. M. and Scheltens, P. and Verhey, F. R. and Visser, P. J. and {Amyloid Biomarker Study Group} and others},
  title   = {{Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.4668},
  pmid    = {25988462},
  url     = {https://doi.org/10.1001/jama.2015.4668}
}

@article{rodriguezvieitez2015-25893384,
  author  = {Rodriguez-Vieitez, E. and Ni, R. and Gulyás, B. and Tóth, M. and Häggkvist, J. and Halldin, C. and Voytenko, L. and Marutle, A. and others},
  title   = {{Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2015},
  doi     = {10.1007/s00259-015-3047-0},
  pmid    = {25893384},
  url     = {https://doi.org/10.1007/s00259-015-3047-0}
}

@article{shen2015-25890254,
  author  = {Shen, L. and Chen, C. and Yang, A. and Chen, Y. and Liu, Q. and Ni, J.},
  title   = {{Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage}},
  journal = {Journal of proteomics},
  year    = {2015},
  doi     = {10.1016/j.jprot.2015.04.005},
  pmid    = {25890254},
  url     = {https://doi.org/10.1016/j.jprot.2015.04.005}
}

@article{desikan2015-25862742,
  author  = {Desikan, R. S. and Schork, A. J. and Wang, Y. and Thompson, W. K. and Dehghan, A. and Ridker, P. M. and Chasman, D. I. and McEvoy, L. K. and others},
  title   = {{Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease}},
  journal = {Circulation},
  year    = {2015},
  doi     = {10.1161/circulationaha.115.015489},
  pmid    = {25862742},
  url     = {https://doi.org/10.1161/circulationaha.115.015489}
}

@article{humpel2015-25914642,
  author  = {Humpel, C.},
  title   = {{Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques}},
  journal = {Frontiers in aging neuroscience},
  year    = {2015},
  doi     = {10.3389/fnagi.2015.00047},
  pmid    = {25914642},
  url     = {https://doi.org/10.3389/fnagi.2015.00047}
}

@article{mota2015-25857617,
  author  = {Mota, S. I. and Costa, R. O. and Ferreira, I. L. and Santana, I. and Caldeira, G. L. and Padovano, C. and Fonseca, A. C. and Baldeiras, I. and others},
  title   = {{Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease}},
  journal = {Biochimica et biophysica acta},
  year    = {2015},
  doi     = {10.1016/j.bbadis.2015.03.015},
  pmid    = {25857617},
  url     = {https://doi.org/10.1016/j.bbadis.2015.03.015}
}

@article{fu2015-25814669,
  author  = {Fu, W. and Shi, D. and Westaway, D. and Jhamandas, J. H.},
  title   = {{Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m114.618157},
  pmid    = {25814669},
  url     = {https://doi.org/10.1074/jbc.m114.618157}
}

@article{murray2015-25805643,
  author  = {Murray, M. E. and Lowe, V. J. and Graff-Radford, N. R. and Liesinger, A. M. and Cannon, A. and Przybelski, S. A. and Rawal, B. and Parisi, J. E. and others},
  title   = {{Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv050},
  pmid    = {25805643},
  url     = {https://doi.org/10.1093/brain/awv050}
}

@article{pietrzak2015-25629787,
  author  = {Pietrzak, R. H. and Lim, Y. Y. and Neumeister, A. and Ames, D. and Ellis, K. A. and Harrington, K. and Lautenschlager, N. T. and Restrepo, C. and others},
  title   = {{Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study}},
  journal = {JAMA psychiatry},
  year    = {2015},
  doi     = {10.1001/jamapsychiatry.2014.2476},
  pmid    = {25629787},
  url     = {https://doi.org/10.1001/jamapsychiatry.2014.2476}
}

@article{bakernigh2015-25732182,
  author  = {Baker-Nigh, A. and Vahedi, S. and Davis, E. G. and Weintraub, S. and Bigio, E. H. and Klein, W. L. and Geula, C.},
  title   = {{Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv024},
  pmid    = {25732182},
  url     = {https://doi.org/10.1093/brain/awv024}
}

@article{tramutola2015-25645581,
  author  = {Tramutola, A. and Triplett, J. C. and Di Domenico, F. and Niedowicz, D. M. and Murphy, M. P. and Coccia, R. and Perluigi, M. and Butterfield, D. A.},
  title   = {{Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD}},
  journal = {Journal of neurochemistry},
  year    = {2015},
  doi     = {10.1111/jnc.13037},
  pmid    = {25645581},
  url     = {https://doi.org/10.1111/jnc.13037}
}

@article{wang2015-25716355,
  author  = {Wang, L. and Benzinger, T. L. and Hassenstab, J. and Blazey, T. and Owen, C. and Liu, J. and Fagan, A. M. and Morris, J. C. and others},
  title   = {{Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2015},
  doi     = {10.1212/wnl.0000000000001401},
  pmid    = {25716355},
  url     = {https://doi.org/10.1212/wnl.0000000000001401}
}

@article{huijbers2015-25678559,
  author  = {Huijbers, W. and Mormino, E. C. and Schultz, A. P. and Wigman, S. and Ward, A. M. and Larvie, M. and Amariglio, R. E. and Marshall, G. A. and others},
  title   = {{Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression}},
  journal = {Brain : a journal of neurology},
  year    = {2015},
  doi     = {10.1093/brain/awv007},
  pmid    = {25678559},
  url     = {https://doi.org/10.1093/brain/awv007}
}

@article{vardarajan2015-25382023,
  author  = {Vardarajan, B. N. and Zhang, Y. and Lee, J. H. and Cheng, R. and Bohm, C. and Ghani, M. and Reitz, C. and Reyes-Dumeyer, D. and others},
  title   = {{Coding mutations in SORL1 and Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24305},
  pmid    = {25382023},
  url     = {https://doi.org/10.1002/ana.24305}
}

@article{lei2015-25973041,
  author  = {Lei, X. and Lei, L. and Zhang, Z. and Cheng, Y.},
  title   = {{Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease}},
  journal = {International journal of clinical and experimental pathology},
  year    = {2015},
  pmid    = {25973041}
}

@article{ayton2015-25716857,
  author  = {Ayton, S. and Lei, P. and Hare, D. J. and Duce, J. A. and George, J. L. and Adlard, P. A. and McLean, C. and Rogers, J. T. and others},
  title   = {{Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3439-14.2015},
  pmid    = {25716857},
  url     = {https://doi.org/10.1523/jneurosci.3439-14.2015}
}

@article{guillotsestier2015-25619654,
  author  = {Guillot-Sestier, M. V. and Doty, K. R. and Gate, D. and Rodriguez, J. and Leung, B. P. and Rezai-Zadeh, K. and Town, T.},
  title   = {{Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2014.12.068},
  pmid    = {25619654},
  url     = {https://doi.org/10.1016/j.neuron.2014.12.068}
}

@article{rasmussen2015-25469919,
  author  = {Rasmussen, K. L. and Tybjaerg-Hansen, A. and Nordestgaard, B. G. and Frikke-Schmidt, R.},
  title   = {{Plasma levels of apolipoprotein E and risk of dementia in the general population}},
  journal = {Annals of neurology},
  year    = {2015},
  doi     = {10.1002/ana.24326},
  pmid    = {25469919},
  url     = {https://doi.org/10.1002/ana.24326}
}

@article{chauhan2015-25670335,
  author  = {Chauhan, G. and Adams, H. H. H. and Bis, J. C. and Weinstein, G. and Yu, L. and Töglhofer, A. M. and Smith, A. V. and van der Lee, S. J. and others},
  title   = {{Association of Alzheimer's disease GWAS loci with MRI markers of brain aging}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.12.028},
  pmid    = {25670335},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.12.028}
}

@article{peric2015-25556159,
  author  = {Peric, A. and Annaert, W.},
  title   = {{Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-014-1379-7},
  pmid    = {25556159},
  url     = {https://doi.org/10.1007/s00401-014-1379-7}
}

@article{yu2015-25365775,
  author  = {Yu, L. and Chibnik, L. B. and Srivastava, G. P. and Pochet, N. and Yang, J. and Xu, J. and Kozubek, J. and Obholzer, N. and others},
  title   = {{Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2015},
  doi     = {10.1001/jamaneurol.2014.3049},
  pmid    = {25365775},
  url     = {https://doi.org/10.1001/jamaneurol.2014.3049}
}

@article{liguori2014-25322206,
  author  = {Liguori, C. and Romigi, A. and Nuccetelli, M. and Zannino, S. and Sancesario, G. and Martorana, A. and Albanese, M. and Mercuri, N. B. and others},
  title   = {{Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.2510},
  pmid    = {25322206},
  url     = {https://doi.org/10.1001/jamaneurol.2014.2510}
}

@article{hick2015-25432317,
  author  = {Hick, M. and Herrmann, U. and Weyer, S. W. and Mallm, J. P. and Tschäpe, J. A. and Borgers, M. and Mercken, M. and Roth, F. C. and others},
  title   = {{Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-014-1368-x},
  pmid    = {25432317},
  url     = {https://doi.org/10.1007/s00401-014-1368-x}
}

@article{mata2014-25178429,
  author  = {Mata, I. F. and Leverenz, J. B. and Weintraub, D. and Trojanowski, J. Q. and Hurtig, H. I. and Van Deerlin, V. M. and Ritz, B. and Rausch, R. and others},
  title   = {{APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1455},
  pmid    = {25178429},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1455}
}

@article{naj2014-25199842,
  author  = {Naj, A. C. and Jun, G. and Reitz, C. and Kunkle, B. W. and Perry, W. and Park, Y. S. and Beecham, G. W. and Rajbhandary, R. A. and others},
  title   = {{Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.1491},
  pmid    = {25199842},
  url     = {https://doi.org/10.1001/jamaneurol.2014.1491}
}

@article{cortescanteli2015-25475538,
  author  = {Cortes-Canteli, M. and Mattei, L. and Richards, A. T. and Norris, E. H. and Strickland, S.},
  title   = {{Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.10.030},
  pmid    = {25475538},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.10.030}
}

@article{kapogiannis2015-25342129,
  author  = {Kapogiannis, D. and Boxer, A. and Schwartz, J. B. and Abner, E. L. and Biragyn, A. and Masharani, U. and Frassetto, L. and Petersen, R. C. and others},
  title   = {{Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2015},
  doi     = {10.1096/fj.14-262048},
  pmid    = {25342129},
  url     = {https://doi.org/10.1096/fj.14-262048}
}

@article{zhu2014-25336656,
  author  = {Zhu, Y. and Shan, X. and Yuzwa, S. A. and Vocadlo, D. J.},
  title   = {{The emerging link between O-GlcNAc and Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.r114.601351},
  pmid    = {25336656},
  url     = {https://doi.org/10.1074/jbc.r114.601351}
}

@article{maloney2014-25253696,
  author  = {Maloney, J. A. and Bainbridge, T. and Gustafson, A. and Zhang, S. and Kyauk, R. and Steiner, P. and van der Brug, M. and Liu, Y. and others},
  title   = {{Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.589069},
  pmid    = {25253696},
  url     = {https://doi.org/10.1074/jbc.m114.589069}
}

@article{benilova2014-25253695,
  author  = {Benilova, I. and Gallardo, R. and Ungureanu, A. A. and Castillo Cano, V. and Snellinx, A. and Ramakers, M. and Bartic, C. and Rousseau, F. and others},
  title   = {{The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.599027},
  pmid    = {25253695},
  url     = {https://doi.org/10.1074/jbc.m114.599027}
}

@article{proitsi2014-25226301,
  author  = {Proitsi, P. and Lupton, M. K. and Velayudhan, L. and Newhouse, S. and Fogh, I. and Tsolaki, M. and Daniilidou, M. and Pritchard, M. and others},
  title   = {{Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis}},
  journal = {PLoS medicine},
  year    = {2014},
  doi     = {10.1371/journal.pmed.1001713},
  pmid    = {25226301},
  url     = {https://doi.org/10.1371/journal.pmed.1001713}
}

@article{fan2015-25239737,
  author  = {Fan, Z. and Aman, Y. and Ahmed, I. and Chetelat, G. and Landeau, B. and Ray Chaudhuri, K. and Brooks, D. J. and Edison, P.},
  title   = {{Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.06.016},
  pmid    = {25239737},
  url     = {https://doi.org/10.1016/j.jalz.2014.06.016}
}

@article{tai2014-25217640,
  author  = {Tai, L. M. and Koster, K. P. and Luo, J. and Lee, S. H. and Wang, Y. T. and Collins, N. C. and Ben Aissa, M. and Thatcher, G. R. J. and others},
  title   = {{Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.600833},
  pmid    = {25217640},
  url     = {https://doi.org/10.1074/jbc.m114.600833}
}

@article{chouraki2015-25217292,
  author  = {Chouraki, V. and Beiser, A. and Younkin, L. and Preis, SR. and Weinstein, G. and Hansson, O. and Skoog, I. and Lambert, J. C. and others},
  title   = {{Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.07.001},
  pmid    = {25217292},
  url     = {https://doi.org/10.1016/j.jalz.2014.07.001}
}

@article{martiskainen2015-25281018,
  author  = {Martiskainen, H. and Viswanathan, J. and Nykänen, N. P. and Kurki, M. and Helisalmi, S. and Natunen, T. and Sarajärvi, T. and Kurkinen, K. M. and others},
  title   = {{Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2014.09.003},
  pmid    = {25281018},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2014.09.003}
}

@article{fiandaca2015-25130657,
  author  = {Fiandaca, M. S. and Kapogiannis, D. and Mapstone, M. and Boxer, A. and Eitan, E. and Schwartz, J. B. and Abner, E. L. and Petersen, R. C. and others},
  title   = {{Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.06.008},
  pmid    = {25130657},
  url     = {https://doi.org/10.1016/j.jalz.2014.06.008}
}

@article{pensalfini2014-25092575,
  author  = {Pensalfini, A. and Albay, R. and Rasool, S. and Wu, J. W. and Hatami, A. and Arai, H. and Margol, L. and Milton, S. and others},
  title   = {{Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques}},
  journal = {Neurobiology of disease},
  year    = {2014},
  doi     = {10.1016/j.nbd.2014.07.011},
  pmid    = {25092575},
  url     = {https://doi.org/10.1016/j.nbd.2014.07.011}
}

@article{jun2014-25043464,
  author  = {Jun, G. and Asai, H. and Zeldich, E. and Drapeau, E. and Chen, C. and Chung, J. and Park, J. H. and Kim, S. and others},
  title   = {{PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24219},
  pmid    = {25043464},
  url     = {https://doi.org/10.1002/ana.24219}
}

@article{yuyama2014-25037226,
  author  = {Yuyama, K. and Sun, H. and Sakai, S. and Mitsutake, S. and Okada, M. and Tahara, H. and Furukawa, J. and Fujitani, N. and others},
  title   = {{Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m114.577213},
  pmid    = {25037226},
  url     = {https://doi.org/10.1074/jbc.m114.577213}
}

@article{squitti2014-25066791,
  author  = {Squitti, R.},
  title   = {{Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD}},
  journal = {Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)},
  year    = {2014},
  doi     = {10.1016/j.jtemb.2014.06.018},
  pmid    = {25066791},
  url     = {https://doi.org/10.1016/j.jtemb.2014.06.018}
}

@article{ringman2014-24797962,
  author  = {Ringman, J. M. and Sachs, M. C. and Zhou, Y. and Monsell, S. E. and Saver, J. L. and Vinters, H. V.},
  title   = {{Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2014.681},
  pmid    = {24797962},
  url     = {https://doi.org/10.1001/jamaneurol.2014.681}
}

@article{wang2014-25050378,
  author  = {Wang, X. X. and Tan, M. S. and Yu, J. T. and Tan, L.},
  title   = {{Matrix metalloproteinases and their multiple roles in Alzheimer's disease}},
  journal = {BioMed research international},
  year    = {2014},
  doi     = {10.1155/2014/908636},
  pmid    = {25050378},
  url     = {https://doi.org/10.1155/2014/908636}
}

@article{defelice2014-24931033,
  author  = {De Felice, F. G. and Ferreira, S. T.},
  title   = {{Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease}},
  journal = {Diabetes},
  year    = {2014},
  doi     = {10.2337/db13-1954},
  pmid    = {24931033},
  url     = {https://doi.org/10.2337/db13-1954}
}

@article{dauvilliers2014-24966833,
  author  = {Dauvilliers, Y. A. and Lehmann, S. and Jaussent, I. and Gabelle, A.},
  title   = {{Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy}},
  journal = {Frontiers in aging neuroscience},
  year    = {2014},
  doi     = {10.3389/fnagi.2014.00119},
  pmid    = {24966833},
  url     = {https://doi.org/10.3389/fnagi.2014.00119}
}

@article{delprete2014-24902695,
  author  = {Del Prete, D. and Checler, F. and Chami, M.},
  title   = {{Ryanodine receptors: physiological function and deregulation in Alzheimer disease}},
  journal = {Molecular neurodegeneration},
  year    = {2014},
  doi     = {10.1186/1750-1326-9-21},
  pmid    = {24902695},
  url     = {https://doi.org/10.1186/1750-1326-9-21}
}

@article{li2014-24644038,
  author  = {Li, J. G. and Chu, J. and Barrero, C. and Merali, S. and Praticò, D.},
  title   = {{Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24145},
  pmid    = {24644038},
  url     = {https://doi.org/10.1002/ana.24145}
}

@article{kook2014-24853300,
  author  = {Kook, S. Y. and Jeong, H. and Kang, M. J. and Park, R. and Shin, H. J. and Han, S. H. and Son, S. M. and Song, H. and others},
  title   = {{Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model}},
  journal = {Cell death and differentiation},
  year    = {2014},
  doi     = {10.1038/cdd.2014.67},
  pmid    = {24853300},
  url     = {https://doi.org/10.1038/cdd.2014.67}
}

@article{kanekiyo2014-24904407,
  author  = {Kanekiyo, T. and Bu, G.},
  title   = {{The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2014},
  doi     = {10.3389/fnagi.2014.00093},
  pmid    = {24904407},
  url     = {https://doi.org/10.3389/fnagi.2014.00093}
}

@article{liu2015-24838911,
  author  = {Liu, Y. and Yu, J. T. and Wang, H. F. and Han, P. R. and Tan, C. C. and Wang, C. and Meng, X. F. and Risacher, S. L. and others},
  title   = {{APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2015},
  doi     = {10.1136/jnnp-2014-307719},
  pmid    = {24838911},
  url     = {https://doi.org/10.1136/jnnp-2014-307719}
}

@article{belkhelfa2014-24831467,
  author  = {Belkhelfa, M. and Rafa, H. and Medjeber, O. and Arroul-Lammali, A. and Behairi, N. and Abada-Bendib, M. and Makrelouf, M. and Belarbi, S. and others},
  title   = {{IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients}},
  journal = {Journal of interferon \& cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year    = {2014},
  doi     = {10.1089/jir.2013.0085},
  pmid    = {24831467},
  url     = {https://doi.org/10.1089/jir.2013.0085}
}

@article{lowe2014-24793183,
  author  = {Lowe, V. J. and Weigand, S. D. and Senjem, M. L. and Vemuri, P. and Jordan, L. and Kantarci, K. and Boeve, B. and Jack, C. R. and others},
  title   = {{Association of hypometabolism and amyloid levels in aging, normal subjects}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000467},
  pmid    = {24793183},
  url     = {https://doi.org/10.1212/wnl.0000000000000467}
}

@article{nelson2014-24770881,
  author  = {Nelson, P. T. and Estus, S. and Abner, E. L. and Parikh, I. and Malik, M. and Neltner, J. H. and Ighodaro, E. and Wang, W. X. and others},
  title   = {{ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology}},
  journal = {Acta neuropathologica},
  year    = {2014},
  doi     = {10.1007/s00401-014-1282-2},
  pmid    = {24770881},
  url     = {https://doi.org/10.1007/s00401-014-1282-2}
}

@article{yuzwa2014-24759912,
  author  = {Yuzwa, S. A. and Vocadlo, D. J.},
  title   = {{O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond}},
  journal = {Chemical Society reviews},
  year    = {2014},
  doi     = {10.1039/c4cs00038b},
  pmid    = {24759912},
  url     = {https://doi.org/10.1039/c4cs00038b}
}

@article{mormino2014-24748674,
  author  = {Mormino, E. C. and Betensky, R. A. and Hedden, T. and Schultz, A. P. and Ward, A. and Huijbers, W. and Rentz, D. M. and Johnson, K. A. and others},
  title   = {{Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000431},
  pmid    = {24748674},
  url     = {https://doi.org/10.1212/wnl.0000000000000431}
}

@article{altmann2014-24623176,
  author  = {Altmann, A. and Tian, L. and Henderson, V. W. and Greicius, M. D. and {Alzheimer's Disease Neuroimaging Initiative Investigators}},
  title   = {{Sex modifies the APOE-related risk of developing Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2014},
  doi     = {10.1002/ana.24135},
  pmid    = {24623176},
  url     = {https://doi.org/10.1002/ana.24135}
}

@article{jack2014-24706010,
  author  = {Jack, C. R. and Wiste, H. J. and Knopman, D. S. and Vemuri, P. and Mielke, M. M. and Weigand, S. D. and Senjem, M. L. and Gunter, J. L. and others},
  title   = {{Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000386},
  pmid    = {24706010},
  url     = {https://doi.org/10.1212/wnl.0000000000000386}
}

@article{bloom2014-24493463,
  author  = {Bloom, G. S.},
  title   = {{Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.5847},
  pmid    = {24493463},
  url     = {https://doi.org/10.1001/jamaneurol.2013.5847}
}

@article{johnson2014-24686783,
  author  = {Johnson, J. O. and Pioro, E. P. and Boehringer, A. and Chia, R. and Feit, H. and Renton, A. E. and Pliner, H. A. and Abramzon, Y. and others},
  title   = {{Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis}},
  journal = {Nature neuroscience},
  year    = {2014},
  doi     = {10.1038/nn.3688},
  pmid    = {24686783},
  url     = {https://doi.org/10.1038/nn.3688}
}

@article{lathe2014-24656052,
  author  = {Lathe, R. and Sapronova, A. and Kotelevtsev, Y.},
  title   = {{Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature}},
  journal = {BMC geriatrics},
  year    = {2014},
  doi     = {10.1186/1471-2318-14-36},
  pmid    = {24656052},
  url     = {https://doi.org/10.1186/1471-2318-14-36}
}

@article{roberts2014-24652830,
  author  = {Roberts, R. O. and Knopman, D. S. and Cha, R. H. and Mielke, M. M. and Pankratz, V. S. and Boeve, B. F. and Kantarci, K. and Geda, Y. E. and others},
  title   = {{Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2014},
  doi     = {10.2967/jnumed.113.132647},
  pmid    = {24652830},
  url     = {https://doi.org/10.2967/jnumed.113.132647}
}

@article{mattsson2014-24625697,
  author  = {Mattsson, N. and Tosun, D. and Insel, P. S. and Simonson, A. and Jack, C. R. and Beckett, L. A. and Donohue, M. and Jagust, W. and others},
  title   = {{Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment}},
  journal = {Brain : a journal of neurology},
  year    = {2014},
  doi     = {10.1093/brain/awu043},
  pmid    = {24625697},
  url     = {https://doi.org/10.1093/brain/awu043}
}

@article{richardson2014-24473795,
  author  = {Richardson, JR. and Roy, A. and Shalat, S. L. and von Stein, R. T. and Hossain, M. M. and Buckley, B. and Gearing, M. and Levey, A. I. and others},
  title   = {{Elevated serum pesticide levels and risk for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2014},
  doi     = {10.1001/jamaneurol.2013.6030},
  pmid    = {24473795},
  url     = {https://doi.org/10.1001/jamaneurol.2013.6030}
}

@article{luedecke2014-24582897,
  author  = {Luedecke, D. and Becktepe, J. S. and Lehmbeck, J. T. and Finckh, U. and Yamamoto, R. and Jahn, H. and Boelmans, K.},
  title   = {{A novel presenilin 1 mutation (Ala275Val) as cause of early-onset familial Alzheimer disease}},
  journal = {Neuroscience letters},
  year    = {2014},
  doi     = {10.1016/j.neulet.2014.02.034},
  pmid    = {24582897},
  url     = {https://doi.org/10.1016/j.neulet.2014.02.034}
}

@article{hendrie2014-24565289,
  author  = {Hendrie, H. C. and Murrell, J. and Baiyewu, O. and Lane, K. A. and Purnell, C. and Ogunniyi, A. and Unverzagt, F. W. and Hall, K. and others},
  title   = {{APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba}},
  journal = {International psychogeriatrics},
  year    = {2014},
  doi     = {10.1017/s1041610214000167},
  pmid    = {24565289},
  url     = {https://doi.org/10.1017/s1041610214000167}
}

@article{chouraki2014-24535457,
  author  = {Chouraki, V. and De Bruijn, R. F. and Chapuis, J. and Bis, J. C. and Reitz, C. and Schraen, S. and Ibrahim-Verbaas, C. A. and Grenier-Boley, B. and others},
  title   = {{A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly}},
  journal = {Molecular psychiatry},
  year    = {2014},
  doi     = {10.1038/mp.2013.185},
  pmid    = {24535457},
  url     = {https://doi.org/10.1038/mp.2013.185}
}

@article{carrillomora2014-24683437,
  author  = {Carrillo-Mora, P. and Luna, R. and Colín-Barenque, L.},
  title   = {{Amyloid beta: multiple mechanisms of toxicity and only some protective effects?}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2014},
  doi     = {10.1155/2014/795375},
  pmid    = {24683437},
  url     = {https://doi.org/10.1155/2014/795375}
}

@article{kerchner2014-24453080,
  author  = {Kerchner, G. A. and Berdnik, D. and Shen, J. C. and Bernstein, J. D. and Fenesy, M. C. and Deutsch, G. K. and Wyss-Coray, T. and Rutt, B. K.},
  title   = {{APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory}},
  journal = {Neurology},
  year    = {2014},
  doi     = {10.1212/wnl.0000000000000154},
  pmid    = {24453080},
  url     = {https://doi.org/10.1212/wnl.0000000000000154}
}

@article{wood2014-24329875,
  author  = {Wood, W. G. and Li, L. and Müller, W. E. and Eckert, G. P.},
  title   = {{Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis}},
  journal = {Journal of neurochemistry},
  year    = {2014},
  doi     = {10.1111/jnc.12637},
  pmid    = {24329875},
  url     = {https://doi.org/10.1111/jnc.12637}
}

@article{brenowitz2014-24270205,
  author  = {Brenowitz, W. D. and Monsell, S. E. and Schmitt, F. A. and Kukull, W. A. and Nelson, P. T.},
  title   = {{Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2014},
  doi     = {10.3233/jad-131880},
  pmid    = {24270205},
  url     = {https://doi.org/10.3233/jad-131880}
}

@article{long2014-24352696,
  author  = {Long, J. M. and Ray, B. and Lahiri, D. K.},
  title   = {{MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.518241},
  pmid    = {24352696},
  url     = {https://doi.org/10.1074/jbc.m113.518241}
}

@article{bana2014-24333591,
  author  = {Bana, L. and Minniti, S. and Salvati, E. and Sesana, S. and Zambelli, V. and Cagnotto, A. and Orlando, A. and Cazzaniga, E. and others},
  title   = {{Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease}},
  journal = {Nanomedicine : nanotechnology, biology, and medicine},
  year    = {2014},
  doi     = {10.1016/j.nano.2013.12.001},
  pmid    = {24333591},
  url     = {https://doi.org/10.1016/j.nano.2013.12.001}
}

@article{han2013-24319058,
  author  = {Han, Sun-Ho and Kim, Jun Seok and Lee, Young-Ju and Choi, Hee-Sun and Kim, Jong‐Won and Na, Duk Lyul and Yang, Eun Gyeong and Yu, Myeong‐Hee and others},
  title   = {{Both Targeted Mass Spectrometry and Flow Sorting Analysis Methods Detected the Decreased Serum Apolipoprotein E Level in Alzheimer's Disease Patients}},
  journal = {Molecular \& Cellular Proteomics},
  year    = {2013},
  doi     = {10.1074/mcp.m113.028639},
  pmid    = {24319058},
  url     = {https://doi.org/10.1074/mcp.m113.028639}
}

@article{lim2013-24145819,
  author  = {Lim, A. S. and Yu, L. and Kowgier, M. and Schneider, J. A. and Buchman, A. S. and Bennett, D. A.},
  title   = {{Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.4215},
  pmid    = {24145819},
  url     = {https://doi.org/10.1001/jamaneurol.2013.4215}
}

@article{schedinweiss2014-24279329,
  author  = {Schedin-Weiss, S. and Winblad, B. and Tjernberg, L. O.},
  title   = {{The role of protein glycosylation in Alzheimer disease}},
  journal = {The FEBS journal},
  year    = {2014},
  doi     = {10.1111/febs.12590},
  pmid    = {24279329},
  url     = {https://doi.org/10.1111/febs.12590}
}

@article{olsson2014-24225948,
  author  = {Olsson, F. and Schmidt, S. and Althoff, V. and Munter, L. M. and Jin, S. and Rosqvist, S. and Lendahl, U. and Multhaup, G. and others},
  title   = {{Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.498246},
  pmid    = {24225948},
  url     = {https://doi.org/10.1074/jbc.m113.498246}
}

@article{rosenblum2014-24210593,
  author  = {Rosenblum, W. I.},
  title   = {{Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.10.085},
  pmid    = {24210593},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.10.085}
}

@article{tiribuzi2014-24064186,
  author  = {Tiribuzi, R. and Crispoltoni, L. and Porcellati, S. and Di Lullo, M. and Florenzano, F. and Pirro, M. and Bagaglia, F. and Kawarai, T. and others},
  title   = {{miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.003},
  pmid    = {24064186},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.003}
}

@article{mcgeer2013-24052108,
  author  = {McGeer, P. L. and McGeer, E. G.},
  title   = {{The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy}},
  journal = {Acta neuropathologica},
  year    = {2013},
  doi     = {10.1007/s00401-013-1177-7},
  pmid    = {24052108},
  url     = {https://doi.org/10.1007/s00401-013-1177-7}
}

@article{bai2013-24023061,
  author  = {Bai, B. and Hales, C. M. and Chen, P. C. and Gozal, Y. and Dammer, E. B. and Fritz, J. J. and Wang, X. and Xia, Q. and others},
  title   = {{U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2013},
  doi     = {10.1073/pnas.1310249110},
  pmid    = {24023061},
  url     = {https://doi.org/10.1073/pnas.1310249110}
}

@article{podlesniy2013-23794434,
  author  = {Podlesniy, P. and Figueiro-Silva, J. and Llado, A. and Antonell, A. and Sanchez-Valle, R. and Alcolea, D. and Lleo, A. and Molinuevo, J. L. and others},
  title   = {{Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23955},
  pmid    = {23794434},
  url     = {https://doi.org/10.1002/ana.23955}
}

@article{shulman2013-23836404,
  author  = {Shulman, J. M. and Chen, K. and Keenan, B. T. and Chibnik, L. B. and Fleisher, A. and Thiyyagura, P. and Roontiva, A. and McCabe, C. and others},
  title   = {{Genetic susceptibility for Alzheimer disease neuritic plaque pathology}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2815},
  pmid    = {23836404},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2815}
}

@article{notarianni2013-23906001,
  author  = {Notarianni, E.},
  title   = {{Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer's disease initiation and development}},
  journal = {Current Alzheimer research},
  year    = {2013},
  doi     = {10.2174/15672050113109990137},
  pmid    = {23906001},
  url     = {https://doi.org/10.2174/15672050113109990137}
}

@article{hanson2013-23779114,
  author  = {Hanson, A. J. and Bayer-Carter, J. L. and Green, P. S. and Montine, T. J. and Wilkinson, C. W. and Baker, L. D. and Watson, G. S. and Bonner, L. M. and others},
  title   = {{Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.396},
  pmid    = {23779114},
  url     = {https://doi.org/10.1001/jamaneurol.2013.396}
}

@article{jackson2013-23794448,
  author  = {Jackson, K. and Barisone, G. A. and Diaz, E. and Jin, L. W. and DeCarli, C. and Despa, F.},
  title   = {{Amylin deposition in the brain: A second amyloid in Alzheimer disease?}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23956},
  pmid    = {23794448},
  url     = {https://doi.org/10.1002/ana.23956}
}

@article{holland2013-23828104,
  author  = {Holland, D. and Desikan, R. S. and Dale, A. M. and McEvoy, L. K. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Higher rates of decline for women and apolipoprotein E epsilon4 carriers}},
  journal = {AJNR. American journal of neuroradiology},
  year    = {2013},
  doi     = {10.3174/ajnr.a3601},
  pmid    = {23828104},
  url     = {https://doi.org/10.3174/ajnr.a3601}
}

@article{nelson2013-23771217,
  author  = {Nelson, P. T. and Pious, N. M. and Jicha, G. A. and Wilcock, D. M. and Fardo, D. W. and Estus, S. and Rebeck, G. W.},
  title   = {{APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2013},
  doi     = {10.1097/nen.0b013e31829a25b9},
  pmid    = {23771217},
  url     = {https://doi.org/10.1097/nen.0b013e31829a25b9}
}

@article{kreisl2013-23775979,
  author  = {Kreisl, W. C. and Lyoo, C. H. and McGwier, M. and Snow, J. and Jenko, K. J. and Kimura, N. and Corona, W. and Morse, C. L. and others},
  title   = {{In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2013},
  doi     = {10.1093/brain/awt145},
  pmid    = {23775979},
  url     = {https://doi.org/10.1093/brain/awt145}
}

@article{leung2013-23762274,
  author  = {Leung, R. and Proitsi, P. and Simmons, A. and Lunnon, K. and Güntert, A. and Kronenberg, D. and Pritchard, M. and Tsolaki, M. and others},
  title   = {{Inflammatory proteins in plasma are associated with severity of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0064971},
  pmid    = {23762274},
  url     = {https://doi.org/10.1371/journal.pone.0064971}
}

@article{harms2013-23588422,
  author  = {Harms, M. and Benitez, B. A. and Cairns, N. and Cooper, B. and Cooper, P. and Mayo, K. and Carrell, D. and Faber, K. and others},
  title   = {{C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/2013.jamaneurol.537},
  pmid    = {23588422},
  url     = {https://doi.org/10.1001/2013.jamaneurol.537}
}

@article{serranopozo2013-23656989,
  author  = {Serrano-Pozo, A. and Muzikansky, A. and Gómez-Isla, T. and Growdon, J. H. and Betensky, R. A. and Frosch, M. P. and Hyman, B. T.},
  title   = {{Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2013},
  doi     = {10.1097/nen.0b013e3182933788},
  pmid    = {23656989},
  url     = {https://doi.org/10.1097/nen.0b013e3182933788}
}

@article{nalivaeva2013-23684647,
  author  = {Nalivaeva, N. N. and Turner, A. J.},
  title   = {{The amyloid precursor protein: a biochemical enigma in brain development, function and disease}},
  journal = {FEBS letters},
  year    = {2013},
  doi     = {10.1016/j.febslet.2013.05.010},
  pmid    = {23684647},
  url     = {https://doi.org/10.1016/j.febslet.2013.05.010}
}

@article{griciuc2013-23623698,
  author  = {Griciuc, Ana and Serrano‐Pozo, Alberto and Parrado, Antonio and Lesinski, Andrea N. and Asselin, Caroline and Mullin, Kristina and Hooli, Basavaraj V. and Choi, Se Hoon and Hyman, Bradley T. and Tanzi, Rudolph E.},
  title   = {{Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta}},
  journal = {Neuron},
  year    = {2013},
  doi     = {10.1016/j.neuron.2013.04.014},
  pmid    = {23623698},
  url     = {https://doi.org/10.1016/j.neuron.2013.04.014}
}

@article{hokama2014-23595620,
  author  = {Hokama, M. and Oka, S. and Leon, J. and Ninomiya, T. and Honda, H. and Sasaki, K. and Iwaki, T. and Ohara, T. and others},
  title   = {{Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2014},
  doi     = {10.1093/cercor/bht101},
  pmid    = {23595620},
  url     = {https://doi.org/10.1093/cercor/bht101}
}

@article{morbelli2013-23591639,
  author  = {Morbelli, S. and Perneczky, R. and Drzezga, A. and Frisoni, G. B. and Caroli, A. and van Berckel, B. N. and Ossenkoppele, R. and others},
  title   = {{Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2013},
  doi     = {10.2967/jnumed.112.113928},
  pmid    = {23591639},
  url     = {https://doi.org/10.2967/jnumed.112.113928}
}

@article{vancauwenberghe2013-23582656,
  author  = {Van Cauwenberghe, C. and Bettens, K. and Engelborghs, S. and Vandenbulcke, M. and Van Dongen, J. and Vermeulen, S. and Vandenberghe, R. and De Deyn, P. P. and others},
  title   = {{Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.03.008},
  pmid    = {23582656},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.03.008}
}

@article{krabbe2013-23577177,
  author  = {Krabbe, G. and Halle, A. and Matyash, V. and Rinnenthal, J. L. and Eom, G. D. and Bernhardt, U. and Miller, K. R. and Prokop, S. and others},
  title   = {{Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0060921},
  pmid    = {23577177},
  url     = {https://doi.org/10.1371/journal.pone.0060921}
}

@article{takeda2013-23561508,
  author  = {Takeda, S. and Sato, N. and Ikimura, K. and Nishino, H. and Rakugi, H. and Morishita, R.},
  title   = {{Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2013.02.010},
  pmid    = {23561508},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.02.010}
}

@article{miyashita2013-23565137,
  author  = {Miyashita, A. and Koike, A. and Jun, G. and Wang, L. S. and Takahashi, S. and Matsubara, E. and Kawarabayashi, T. and Shoji, M. and others},
  title   = {{SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians}},
  journal = {PloS one},
  year    = {2013},
  doi     = {10.1371/journal.pone.0058618},
  pmid    = {23565137},
  url     = {https://doi.org/10.1371/journal.pone.0058618}
}

@article{pierrot2013-23554170,
  author  = {Pierrot, N. and Tyteca, D. and D'auria, L. and Dewachter, I. and Gailly, P. and Hendrickx, A. and Tasiaux, B. and Haylani, L. E. and others},
  title   = {{Amyloid precursor protein controls cholesterol turnover needed for neuronal activity}},
  journal = {EMBO molecular medicine},
  year    = {2013},
  doi     = {10.1002/emmm.201202215},
  pmid    = {23554170},
  url     = {https://doi.org/10.1002/emmm.201202215}
}

@article{zlokovic2013-23400708,
  author  = {Zlokovic, B. V.},
  title   = {{Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.2152},
  pmid    = {23400708},
  url     = {https://doi.org/10.1001/jamaneurol.2013.2152}
}

@article{cheng2013-23546882,
  author  = {Cheng, C. and Li, W. and Zhang, Z. and Yoshimura, S. and Hao, Q. and Zhang, C. and Wang, Z.},
  title   = {{MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10)}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.381392},
  pmid    = {23546882},
  url     = {https://doi.org/10.1074/jbc.m112.381392}
}

@article{reitz2013-23571587,
  author  = {Reitz, C. and Jun, G. and Naj, A. and Rajbhandary, R. and Vardarajan, B. N. and Wang, L. S. and Valladares, O. and Lin, C. F. and others},
  title   = {{Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans}},
  journal = {JAMA},
  year    = {2013},
  doi     = {10.1001/jama.2013.2973},
  pmid    = {23571587},
  url     = {https://doi.org/10.1001/jama.2013.2973}
}

@article{provenzano2013-23420027,
  author  = {Provenzano, F. A. and Muraskin, J. and Tosto, G. and Narkhede, A. and Wasserman, B. T. and Griffith, E. Y. and Guzman, V. A. and Meier, I. B. and others},
  title   = {{White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.1321},
  pmid    = {23420027},
  url     = {https://doi.org/10.1001/jamaneurol.2013.1321}
}

@article{villemagne2013-23477989,
  author  = {Villemagne, V. L. and Burnham, S. and Bourgeat, P. and Brown, B. and Ellis, K. A. and Salvado, O. and Szoeke, C. and Macaulay, S. L. and others},
  title   = {{Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study}},
  journal = {The Lancet. Neurology},
  year    = {2013},
  doi     = {10.1016/s1474-4422(13)70044-9},
  pmid    = {23477989},
  url     = {https://doi.org/10.1016/s1474-4422(13)70044-9}
}

@article{protas2013-23599929,
  author  = {Protas, H. D. and Chen, K. and Langbaum, J. B. and Fleisher, A. S. and Alexander, G. E. and Lee, W. and Bandy, D. and de Leon, M. J. and others},
  title   = {{Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/2013.jamaneurol.286},
  pmid    = {23599929},
  url     = {https://doi.org/10.1001/2013.jamaneurol.286}
}

@article{jack2013-23446680,
  author  = {Jack, C. R. and Wiste, H. J. and Lesnick, T. G. and Weigand, S. D. and Knopman, D. S. and Vemuri, P. and Pankratz, V. S. and Senjem, M. L. and others},
  title   = {{Brain β-amyloid load approaches a plateau}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e3182840bbe},
  pmid    = {23446680},
  url     = {https://doi.org/10.1212/wnl.0b013e3182840bbe}
}

@article{butterfield2013-23249141,
  author  = {Butterfield, D. A. and Swomley, A. M. and Sultana, R.},
  title   = {{Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression}},
  journal = {Antioxidants \& redox signaling},
  year    = {2013},
  doi     = {10.1089/ars.2012.5027},
  pmid    = {23249141},
  url     = {https://doi.org/10.1089/ars.2012.5027}
}

@article{chapuis2013-23399914,
  author  = {Chapuis, J. and Hansmannel, F. and Gistelinck, M. and Mounier, A. and Van Cauwenberghe, C. and Kolen, K. V. and Geller, F. and Sottejeau, Y. and others},
  title   = {{Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology}},
  journal = {Molecular psychiatry},
  year    = {2013},
  doi     = {10.1038/mp.2013.1},
  pmid    = {23399914},
  url     = {https://doi.org/10.1038/mp.2013.1}
}

@article{tsuang2013-23407718,
  author  = {Tsuang, D. and Leverenz, J. B. and Lopez, O. L. and Hamilton, R. L. and Bennett, D. A. and Schneider, J. A. and Buchman, A. S. and Larson, E. B. and others},
  title   = {{APOE ε4 increases risk for dementia in pure synucleinopathies}},
  journal = {JAMA neurology},
  year    = {2013},
  doi     = {10.1001/jamaneurol.2013.600},
  pmid    = {23407718},
  url     = {https://doi.org/10.1001/jamaneurol.2013.600}
}

@article{liu2013-23296339,
  author  = {Liu, C. C. and Kanekiyo, T. and Xu, H. and Bu, G.},
  title   = {{Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy}},
  journal = {Nature reviews. Neurology},
  year    = {2013},
  doi     = {10.1038/nrneurol.2012.263},
  pmid    = {23296339},
  url     = {https://doi.org/10.1038/nrneurol.2012.263}
}

@article{tai2013-23293020,
  author  = {Tai, L. M. and Bilousova, T. and Jungbauer, L. and Roeske, S. K. and Youmans, K. L. and Yu, C. and Poon, W. W. and Cornwell, L. B. and others},
  title   = {{Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m112.442103},
  pmid    = {23293020},
  url     = {https://doi.org/10.1074/jbc.m112.442103}
}

@article{shin2014-24149893,
  author  = {Shin, J. Y. and Park, H. J. and Kim, H. N. and Oh, S. H. and Bae, J. S. and Ha, H. J. and Lee, P. H.},
  title   = {{Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models}},
  journal = {Autophagy},
  year    = {2014},
  doi     = {10.4161/auto.26508},
  pmid    = {24149893},
  url     = {https://doi.org/10.4161/auto.26508}
}

@article{ossenkoppele2013-23255822,
  author  = {Ossenkoppele, R. and van der Flier, W. M. and Zwan, M. D. and Adriaanse, S. F. and Boellaard, R. and Windhorst, A. D. and Barkhof, F. and Lammertsma, A. A. and others},
  title   = {{Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e31827f0889},
  pmid    = {23255822},
  url     = {https://doi.org/10.1212/wnl.0b013e31827f0889}
}

@article{heneka2013-23254930,
  author  = {Heneka, M. T. and Kummer, M. P. and Stutz, A. and Delekate, A. and Schwartz, S. and Vieira-Saecker, A. and Griep, A. and Axt, D. and others},
  title   = {{NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice}},
  journal = {Nature},
  year    = {2013},
  doi     = {10.1038/nature11729},
  pmid    = {23254930},
  url     = {https://doi.org/10.1038/nature11729}
}

@article{gomperts2013-23243071,
  author  = {Gomperts, S. N. and Locascio, J. J. and Rentz, D. and Santarlasci, A. and Marquie, M. and Johnson, K. A. and Growdon, J. H.},
  title   = {{Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia}},
  journal = {Neurology},
  year    = {2013},
  doi     = {10.1212/wnl.0b013e31827b1a07},
  pmid    = {23243071},
  url     = {https://doi.org/10.1212/wnl.0b013e31827b1a07}
}

@article{esparza2013-23225543,
  author  = {Esparza, T. J. and Zhao, H. and Cirrito, JR. and Cairns, N. J. and Bateman, R. J. and Holtzman, D. M. and Brody, D. L.},
  title   = {{Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls}},
  journal = {Annals of neurology},
  year    = {2013},
  doi     = {10.1002/ana.23748},
  pmid    = {23225543},
  url     = {https://doi.org/10.1002/ana.23748}
}

@article{ly2013-23202730,
  author  = {Ly, P. T. and Wu, Y. and Zou, H. and Wang, R. and Zhou, W. and Kinoshita, A. and Zhang, M. and Yang, Y. and others},
  title   = {{Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes}},
  journal = {The Journal of clinical investigation},
  year    = {2013},
  doi     = {10.1172/jci64516},
  pmid    = {23202730},
  url     = {https://doi.org/10.1172/jci64516}
}

@article{darnimrod2012-23079898,
  author  = {Dar-Nimrod, I. and Chapman, B. P. and Franks, P. and Robbins, J. and Porsteinsson, A. and Mapstone, M. and Duberstein, P. R.},
  title   = {{Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2012},
  doi     = {10.1097/jgp.0b013e318267016b},
  pmid    = {23079898},
  url     = {https://doi.org/10.1097/jgp.0b013e318267016b}
}

@article{li2012-23132858,
  author  = {Li, J. and Kanekiyo, T. and Shinohara, M. and Zhang, Y. and LaDu, M. J. and Xu, H. and Bu, G.},
  title   = {{Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.420224},
  pmid    = {23132858},
  url     = {https://doi.org/10.1074/jbc.m112.420224}
}

@article{westlye2012-23100402,
  author  = {Westlye, L. T. and Reinvang, I. and Rootwelt, H. and Espeseth, T.},
  title   = {{Effects of APOE on brain white matter microstructure in healthy adults}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e3182735c9c},
  pmid    = {23100402},
  url     = {https://doi.org/10.1212/wnl.0b013e3182735c9c}
}

@article{youmans2012-23060451,
  author  = {Youmans, K. L. and Tai, L. M. and Nwabuisi-Heath, E. and Jungbauer, L. and Kanekiyo, T. and Gan, M. and Kim, J. and Eimer, W. A. and others},
  title   = {{APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.407957},
  pmid    = {23060451},
  url     = {https://doi.org/10.1074/jbc.m112.407957}
}

@article{medeiros2013-23063604,
  author  = {Medeiros, R. and LaFerla, F. M.},
  title   = {{Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony}},
  journal = {Experimental neurology},
  year    = {2013},
  doi     = {10.1016/j.expneurol.2012.10.007},
  pmid    = {23063604},
  url     = {https://doi.org/10.1016/j.expneurol.2012.10.007}
}

@article{hashimoto2012-23100439,
  author  = {Hashimoto, T. and Serrano-Pozo, A. and Hori, Y. and Adams, K. W. and Takeda, S. and Banerji, A. O. and Mitani, A. and Joyner, D. and others},
  title   = {{Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2012},
  doi     = {10.1523/jneurosci.1542-12.2012},
  pmid    = {23100439},
  url     = {https://doi.org/10.1523/jneurosci.1542-12.2012}
}

@article{jun2012-22869155,
  author  = {Jun, G. and Vardarajan, B. N. and Buros, J. and Yu, C. E. and Hawk, M. V. and Dombroski, B. A. and Crane, P. K. and Larson, E. B. and others},
  title   = {{Comprehensive search for Alzheimer disease susceptibility loci in the APOE region}},
  journal = {Archives of neurology},
  year    = {2012},
  doi     = {10.1001/archneurol.2012.2052},
  pmid    = {22869155},
  url     = {https://doi.org/10.1001/archneurol.2012.2052}
}

@article{wang2012-23024364,
  author  = {Wang, C. and Sun, B. and Zhou, Y. and Grubb, A. and Gan, L.},
  title   = {{Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.371641},
  pmid    = {23024364},
  url     = {https://doi.org/10.1074/jbc.m112.371641}
}

@article{jun2012-22984439,
  author  = {Jun, G. and Moncaster, J. A. and Koutras, C. and Seshadri, S. and Buros, J. and McKee, A. C. and Levesque, G. and Wolf, P. A. and others},
  title   = {{δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0043728},
  pmid    = {22984439},
  url     = {https://doi.org/10.1371/journal.pone.0043728}
}

@article{greenough2013-22982299,
  author  = {Greenough, M. A. and Camakaris, J. and Bush, A. I.},
  title   = {{Metal dyshomeostasis and oxidative stress in Alzheimer's disease}},
  journal = {Neurochemistry international},
  year    = {2013},
  doi     = {10.1016/j.neuint.2012.08.014},
  pmid    = {22982299},
  url     = {https://doi.org/10.1016/j.neuint.2012.08.014}
}

@article{schon2013-22922446,
  author  = {Schon, E. A. and Area-Gomez, E.},
  title   = {{Mitochondria-associated ER membranes in Alzheimer disease}},
  journal = {Molecular and cellular neurosciences},
  year    = {2013},
  doi     = {10.1016/j.mcn.2012.07.011},
  pmid    = {22922446},
  url     = {https://doi.org/10.1016/j.mcn.2012.07.011}
}

@article{dehaan2012-22915996,
  author  = {de Haan, W. and Mott, K. and van Straaten, E. C. and Scheltens, P. and Stam, C. J.},
  title   = {{Activity dependent degeneration explains hub vulnerability in Alzheimer's disease}},
  journal = {PLoS computational biology},
  year    = {2012},
  doi     = {10.1371/journal.pcbi.1002582},
  pmid    = {22915996},
  url     = {https://doi.org/10.1371/journal.pcbi.1002582}
}

@article{areagomez2012-22892566,
  author  = {Area-Gomez, E. and Del Carmen Lara Castillo, M. and Tambini, M. D. and Guardia-Laguarta, C. and de Groof, A. J. and Madra, M. and Ikenouchi, J. and Umeda, M. and others},
  title   = {{Upregulated function of mitochondria-associated ER membranes in Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.202},
  pmid    = {22892566},
  url     = {https://doi.org/10.1038/emboj.2012.202}
}

@article{kim2013-22828738,
  author  = {Kim, S. M. and Kim, M. J. and Rhee, H. Y. and Ryu, C. W. and Kim, E. J. and Petersen, E. T. and Jahng, G. H.},
  title   = {{Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele}},
  journal = {Neuroradiology},
  year    = {2013},
  doi     = {10.1007/s00234-012-1077-x},
  pmid    = {22828738},
  url     = {https://doi.org/10.1007/s00234-012-1077-x}
}

@article{allen2012-22722634,
  author  = {Allen, M. and Zou, F. and Chai, H. S. and Younkin, C. S. and Crook, J. and Pankratz, V. S. and Carrasquillo, M. M. and Rowley, C. N. and others},
  title   = {{Novel late-onset Alzheimer disease loci variants associate with brain gene expression}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e3182605801},
  pmid    = {22722634},
  url     = {https://doi.org/10.1212/wnl.0b013e3182605801}
}

@article{vardarajan2012-22673115,
  author  = {Vardarajan, B. N. and Bruesegem, S. Y. and Harbour, M. E. and Inzelberg, R. and Friedland, R. and St George-Hyslop, P. and Seaman, M. N. and Farrer, L. A.},
  title   = {{Identification of Alzheimer disease-associated variants in genes that regulate retromer function}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2012.04.020},
  pmid    = {22673115},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.04.020}
}

@article{fleisher2013-22633529,
  author  = {Fleisher, A. S. and Chen, K. and Liu, X. and Ayutyanont, N. and Roontiva, A. and Thiyyagura, P. and Protas, H. and Joshi, A. D. and others},
  title   = {{Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2013},
  doi     = {10.1016/j.neurobiolaging.2012.04.017},
  pmid    = {22633529},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.04.017}
}

@article{ho2012-22606286,
  author  = {Ho, Y. S. and Yang, X. and Yeung, S. C. and Chiu, K. and Lau, C. F. and Tsang, A. W. and Mak, J. C. and Chang, R. C.},
  title   = {{Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0036752},
  pmid    = {22606286},
  url     = {https://doi.org/10.1371/journal.pone.0036752}
}

@article{maesako2012-22563077,
  author  = {Maesako, M. and Uemura, K. and Kubota, M. and Kuzuya, A. and Sasaki, K. and Hayashida, N. and Asada-Utsugi, M. and Watanabe, K. and others},
  title   = {{Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.367011},
  pmid    = {22563077},
  url     = {https://doi.org/10.1074/jbc.m112.367011}
}

@article{sparksstein2012-22546352,
  author  = {Sparks Stein, P. and Steffen, M. J. and Smith, C. and Jicha, G. and Ebersole, J. L. and Abner, E. and Dawson, D.},
  title   = {{Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2012},
  doi     = {10.1016/j.jalz.2011.04.006},
  pmid    = {22546352},
  url     = {https://doi.org/10.1016/j.jalz.2011.04.006}
}

@article{barral2012-22539578,
  author  = {Barral, S. and Bird, T. and Goate, A. and Farlow, M. R. and Diaz-Arrastia, R. and Bennett, D. A. and Graff-Radford, N. and Boeve, B. F. and others},
  title   = {{Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e3182553c48},
  pmid    = {22539578},
  url     = {https://doi.org/10.1212/wnl.0b013e3182553c48}
}

@article{winkler2012-22532566,
  author  = {Winkler, E. and Kamp, F. and Scheuring, J. and Ebke, A. and Fukumori, A. and Steiner, H.},
  title   = {{Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.356659},
  pmid    = {22532566},
  url     = {https://doi.org/10.1074/jbc.m112.356659}
}

@article{chavezgutierrez2012-22505025,
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  title   = {{The mechanism of γ-Secretase dysfunction in familial Alzheimer disease}},
  journal = {The EMBO journal},
  year    = {2012},
  doi     = {10.1038/emboj.2012.79},
  pmid    = {22505025},
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@article{allen2012-22494505,
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  title   = {{Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications}},
  journal = {Molecular neurodegeneration},
  year    = {2012},
  doi     = {10.1186/1750-1326-7-13},
  pmid    = {22494505},
  url     = {https://doi.org/10.1186/1750-1326-7-13}
}

@article{pottier2012-22472873,
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  title   = {{High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease}},
  journal = {Molecular psychiatry},
  year    = {2012},
  doi     = {10.1038/mp.2012.15},
  pmid    = {22472873},
  url     = {https://doi.org/10.1038/mp.2012.15}
}

@article{verret2012-22541439,
  author  = {Verret, L. and Mann, E. O. and Hang, G. B. and Barth, A. M. and Cobos, I. and Ho, K. and Devidze, N. and Masliah, E. and others},
  title   = {{Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model}},
  journal = {Cell},
  year    = {2012},
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  pmid    = {22541439},
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}

@article{holtzman2012-22393530,
  author  = {Holtzman, D. M. and Herz, J. and Bu, G.},
  title   = {{Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2012},
  doi     = {10.1101/cshperspect.a006312},
  pmid    = {22393530},
  url     = {https://doi.org/10.1101/cshperspect.a006312}
}

@article{morbelli2012-22365486,
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  title   = {{Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2012.01.005},
  pmid    = {22365486},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2012.01.005}
}

@article{vonbernhardi2012-22122400,
  author  = {von Bernhardi, R. and Eugenín, J.},
  title   = {{Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms}},
  journal = {Antioxidants \& redox signaling},
  year    = {2012},
  doi     = {10.1089/ars.2011.4082},
  pmid    = {22122400},
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@article{chetelat2012-22302548,
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  title   = {{Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318246d67a},
  pmid    = {22302548},
  url     = {https://doi.org/10.1212/wnl.0b013e318246d67a}
}

@article{rodrigue2012-22302550,
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  title   = {{β-Amyloid burden in healthy aging: regional distribution and cognitive consequences}},
  journal = {Neurology},
  year    = {2012},
  doi     = {10.1212/wnl.0b013e318245d295},
  pmid    = {22302550},
  url     = {https://doi.org/10.1212/wnl.0b013e318245d295}
}

@article{cruchaga2012-22312439,
  author  = {Cruchaga, C. and Haller, G. and Chakraverty, S. and Mayo, K. and Vallania, F. L. and Mitra, R. D. and Faber, K. and Williamson, J. and others},
  title   = {{Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0031039},
  pmid    = {22312439},
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}

@article{westin2012-22303443,
  author  = {Westin, K. and Buchhave, P. and Nielsen, H. and Minthon, L. and Janciauskiene, S. and Hansson, O.},
  title   = {{CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2012},
  doi     = {10.1371/journal.pone.0030525},
  pmid    = {22303443},
  url     = {https://doi.org/10.1371/journal.pone.0030525}
}

@article{bettens2012-22248099,
  author  = {Bettens, K. and Brouwers, N. and Engelborghs, S. and Lambert, J. C. and Rogaeva, E. and Vandenberghe, R. and Le Bastard, N. and Pasquier, F. and others},
  title   = {{Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk}},
  journal = {Molecular neurodegeneration},
  year    = {2012},
  doi     = {10.1186/1750-1326-7-3},
  pmid    = {22248099},
  url     = {https://doi.org/10.1186/1750-1326-7-3}
}

@article{delamonte2012-22191795,
  author  = {de la Monte, S. M.},
  title   = {{Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease}},
  journal = {Drugs},
  year    = {2012},
  doi     = {10.2165/11597760-000000000-00000},
  pmid    = {22191795},
  url     = {https://doi.org/10.2165/11597760-000000000-00000}
}

@article{wallon2012-22475797,
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  title   = {{The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2012},
  doi     = {10.3233/jad-2012-120172},
  pmid    = {22475797},
  url     = {https://doi.org/10.3233/jad-2012-120172}
}

@article{zetterberg2011-22194817,
  author  = {Zetterberg, H. and Mörtberg, E. and Song, L. and Chang, L. and Provuncher, G. K. and Patel, P. P. and Ferrell, E. and Fournier, D. R. and others},
  title   = {{Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans}},
  journal = {PloS one},
  year    = {2011},
  doi     = {10.1371/journal.pone.0028263},
  pmid    = {22194817},
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@article{sabuncu2012-22169231,
  author  = {Sabuncu, M. R. and Buckner, R. L. and Smoller, J. W. and Lee, P. H. and Fischl, B. and Sperling, R. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects}},
  journal = {Cerebral cortex (New York, N.Y. : 1991)},
  year    = {2012},
  doi     = {10.1093/cercor/bhr348},
  pmid    = {22169231},
  url     = {https://doi.org/10.1093/cercor/bhr348}
}

@article{fang2012-22178568,
  author  = {Fang, M. and Wang, J. and Zhang, X. and Geng, Y. and Hu, Z. and Rudd, J. A. and Ling, S. and Chen, W. and others},
  title   = {{The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease}},
  journal = {Toxicology letters},
  year    = {2012},
  doi     = {10.1016/j.toxlet.2011.11.032},
  pmid    = {22178568},
  url     = {https://doi.org/10.1016/j.toxlet.2011.11.032}
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@article{guo2012-22144675,
  author  = {Guo, Q. and Li, H. and Gaddam, S. S. and Justice, N. J. and Robertson, C. S. and Zheng, H.},
  title   = {{Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.315051},
  pmid    = {22144675},
  url     = {https://doi.org/10.1074/jbc.m111.315051}
}

@article{lee2012-22130662,
  author  = {Lee, C. Y. and Tse, W. and Smith, J. D. and Landreth, G. E.},
  title   = {{Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m111.295451},
  pmid    = {22130662},
  url     = {https://doi.org/10.1074/jbc.m111.295451}
}

@article{ma2012-22122128,
  author  = {Ma, T. and Klann, E.},
  title   = {{Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2012},
  doi     = {10.1111/j.1471-4159.2011.07506.x},
  pmid    = {22122128},
  url     = {https://doi.org/10.1111/j.1471-4159.2011.07506.x}
}

@article{roberts2012-22121980,
  author  = {Roberts, B. R. and Ryan, T. M. and Bush, A. I. and Masters, C. L. and Duce, J. A.},
  title   = {{The role of metallobiology and amyloid-β peptides in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2012},
  doi     = {10.1111/j.1471-4159.2011.07500.x},
  pmid    = {22121980},
  url     = {https://doi.org/10.1111/j.1471-4159.2011.07500.x}
}

@article{cassano2012-22035587,
  author  = {Cassano, T. and Serviddio, G. and Gaetani, S. and Romano, A. and Dipasquale, P. and Cianci, S. and Bellanti, F. and Laconca, L. and others},
  title   = {{Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2011.09.021},
  pmid    = {22035587},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2011.09.021}
}

@article{delay2011-21982160,
  author  = {Delay, C. and Calon, F. and Mathews, P. and Hébert, S. S.},
  title   = {{Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function}},
  journal = {Molecular neurodegeneration},
  year    = {2011},
  doi     = {10.1186/1750-1326-6-70},
  pmid    = {21982160},
  url     = {https://doi.org/10.1186/1750-1326-6-70}
}

@article{jucker2011-22028219,
  author  = {Jucker, M. and Walker, L. C.},
  title   = {{Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22615},
  pmid    = {22028219},
  url     = {https://doi.org/10.1002/ana.22615}
}

@article{aydin2012-21931985,
  author  = {Aydin, D. and Weyer, S. W. and Müller, U. C.},
  title   = {{Functions of the APP gene family in the nervous system: insights from mouse models}},
  journal = {Experimental brain research},
  year    = {2012},
  doi     = {10.1007/s00221-011-2861-2},
  pmid    = {21931985},
  url     = {https://doi.org/10.1007/s00221-011-2861-2}
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@article{wingo2012-21911656,
  author  = {Wingo, T. S. and Lah, J. J. and Levey, A. I. and Cutler, D. J.},
  title   = {{Autosomal recessive causes likely in early-onset Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2012},
  doi     = {10.1001/archneurol.2011.221},
  pmid    = {21911656},
  url     = {https://doi.org/10.1001/archneurol.2011.221}
}

@article{ferreira2011-21914486,
  author  = {Ferreira, S. T. and Klein, W. L.},
  title   = {{The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease}},
  journal = {Neurobiology of learning and memory},
  year    = {2011},
  doi     = {10.1016/j.nlm.2011.08.003},
  pmid    = {21914486},
  url     = {https://doi.org/10.1016/j.nlm.2011.08.003}
}

@article{matsuzaki2011-21911734,
  author  = {Matsuzaki, T. and Sasaki, K. and Hata, J. and Hirakawa, Y. and Fujimi, K. and Ninomiya, T. and Suzuki, S. O. and Kanba, S. and others},
  title   = {{Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e31822e145d},
  pmid    = {21911734},
  url     = {https://doi.org/10.1212/wnl.0b013e31822e145d}
}

@article{deng2011-21857683,
  author  = {Deng, H. X. and Chen, W. and Hong, S. T. and Boycott, K. M. and Gorrie, G. H. and Siddique, N. and Yang, Y. and Fecto, F. and others},
  title   = {{Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia}},
  journal = {Nature},
  year    = {2011},
  doi     = {10.1038/nature10353},
  pmid    = {21857683},
  url     = {https://doi.org/10.1038/nature10353}
}

@article{cruchaga2011-21825236,
  author  = {Cruchaga, C. and Nowotny, P. and Kauwe, J. S. and Ridge, P. G. and Mayo, K. and Bertelsen, S. and Hinrichs, A. and Fagan, A. M. and others},
  title   = {{Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2011.155},
  pmid    = {21825236},
  url     = {https://doi.org/10.1001/archneurol.2011.155}
}

@article{qiang2011-21816272,
  author  = {Qiang, L. and Fujita, R. and Yamashita, T. and Angulo, S. and Rhinn, H. and Rhee, D. and Doege, C. and Chau, L. and others},
  title   = {{Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons}},
  journal = {Cell},
  year    = {2011},
  doi     = {10.1016/j.cell.2011.07.007},
  pmid    = {21816272},
  url     = {https://doi.org/10.1016/j.cell.2011.07.007}
}

@article{alexandrov2011-21734608,
  author  = {Alexandrov, P. N. and Pogue, A. and Bhattacharjee, S. and Lukiw, W. J.},
  title   = {{Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease}},
  journal = {Neuroreport},
  year    = {2011},
  doi     = {10.1097/wnr.0b013e3283497334},
  pmid    = {21734608},
  url     = {https://doi.org/10.1097/wnr.0b013e3283497334}
}

@article{serranopozo2011-21777559,
  author  = {Serrano-Pozo, A. and Mielke, M. L. and Gómez-Isla, T. and Betensky, R. A. and Growdon, J. H. and Frosch, M. P. and Hyman, B. T.},
  title   = {{Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease}},
  journal = {The American journal of pathology},
  year    = {2011},
  doi     = {10.1016/j.ajpath.2011.05.047},
  pmid    = {21777559},
  url     = {https://doi.org/10.1016/j.ajpath.2011.05.047}
}

@article{zhou2011-21785276,
  author  = {Zhou, Z. D. and Chan, C. H. and Ma, Q. H. and Xu, X. H. and Xiao, Z. C. and Tan, E. K.},
  title   = {{The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease}},
  journal = {Cell adhesion \& migration},
  year    = {2011},
  doi     = {10.4161/cam.5.4.16986},
  pmid    = {21785276},
  url     = {https://doi.org/10.4161/cam.5.4.16986}
}

@article{castellano2011-21715678,
  author  = {Castellano, Joseph M. and Kim, Jungsu and Stewart, Floy R. and Jiang, Hong and Demattos, Ronald Bradley and Patterson, Bruce W. and Fagan, Anne M. and Morris, John C. and Mawuenyega, Kwasi G. and Cruchaga, Carlos C and Goate, Alison and Bales, Kelly R. and Paul, Steven M. and Bateman, Randall John and Holtzman, David M.},
  title   = {{Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance}},
  journal = {Science Translational Medicine},
  year    = {2011},
  doi     = {10.1126/scitranslmed.3002156},
  pmid    = {21715678},
  url     = {https://doi.org/10.1126/scitranslmed.3002156}
}

@article{simpson2011-21705112,
  author  = {Simpson, J. E. and Ince, P. G. and Shaw, P. J. and Heath, P. R. and Raman, R. and Garwood, C. J. and Gelsthorpe, C. and Baxter, L. and others},
  title   = {{Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2011.04.013},
  pmid    = {21705112},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2011.04.013}
}

@article{ikonomovic2011-21700583,
  author  = {Ikonomovic, M. D. and Klunk, W. E. and Abrahamson, E. E. and Wuu, J. and Mathis, C. A. and Scheff, S. W. and Mufson, E. J. and DeKosky, S. T.},
  title   = {{Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e3182231419},
  pmid    = {21700583},
  url     = {https://doi.org/10.1212/wnl.0b013e3182231419}
}

@article{rentz2011-21689670,
  author  = {Rentz, D. M. and Amariglio, R. E. and Becker, J. A. and Frey, M. and Olson, L. E. and Frishe, K. and Carmasin, J. and Maye, J. E. and others},
  title   = {{Face-name associative memory performance is related to amyloid burden in normal elderly}},
  journal = {Neuropsychologia},
  year    = {2011},
  doi     = {10.1016/j.neuropsychologia.2011.06.006},
  pmid    = {21689670},
  url     = {https://doi.org/10.1016/j.neuropsychologia.2011.06.006}
}

@article{liu2011-21598254,
  author  = {Liu, Y. and Liu, F. and Grundke-Iqbal, I. and Iqbal, K. and Gong, C. X.},
  title   = {{Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes}},
  journal = {The Journal of pathology},
  year    = {2011},
  doi     = {10.1002/path.2912},
  pmid    = {21598254},
  url     = {https://doi.org/10.1002/path.2912}
}

@article{genin2011-21556001,
  author  = {Genin, E. and Hannequin, D. and Wallon, D. and Sleegers, K. and Hiltunen, M. and Combarros, O. and Bullido, M. J. and Engelborghs, S. and others},
  title   = {{APOE and Alzheimer disease: a major gene with semi-dominant inheritance}},
  journal = {Molecular psychiatry},
  year    = {2011},
  doi     = {10.1038/mp.2011.52},
  pmid    = {21556001},
  url     = {https://doi.org/10.1038/mp.2011.52}
}

@article{darochasouto2011-21487307,
  author  = {DaRocha-Souto, B. and Scotton, T. C. and Coma, M. and Serrano-Pozo, A. and Hashimoto, T. and Serenó, L. and Rodríguez, M. and Sánchez, B. and others},
  title   = {{Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2011},
  doi     = {10.1097/nen.0b013e318217a118},
  pmid    = {21487307},
  url     = {https://doi.org/10.1097/nen.0b013e318217a118}
}

@article{balasa2011-21576687,
  author  = {Balasa, M. and Gelpi, E. and Antonell, A. and Rey, M. J. and Sánchez-Valle, R. and Molinuevo, J. L. and Lladó, A.},
  title   = {{Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e31821a44dd},
  pmid    = {21576687},
  url     = {https://doi.org/10.1212/wnl.0b013e31821a44dd}
}

@article{eliassonnenschein2011-21493755,
  author  = {Elias-Sonnenschein, L. S. and Viechtbauer, W. and Ramakers, I. H. and Verhey, F. R. and Visser, P. J.},
  title   = {{Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2011},
  doi     = {10.1136/jnnp.2010.231555},
  pmid    = {21493755},
  url     = {https://doi.org/10.1136/jnnp.2010.231555}
}

@article{drzezga2011-21490054,
  author  = {Drzezga, A. and Becker, J. A. and Van Dijk, K. R. and Sreenivasan, A. and Talukdar, T. and Sullivan, C. and Schultz, A. P. and Sepulcre, J. and others},
  title   = {{Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden}},
  journal = {Brain : a journal of neurology},
  year    = {2011},
  doi     = {10.1093/brain/awr066},
  pmid    = {21490054},
  url     = {https://doi.org/10.1093/brain/awr066}
}

@article{puzzo2011-21472769,
  author  = {Puzzo, D. and Privitera, L. and Fa', M. and Staniszewski, A. and Hashimoto, G. and Aziz, F. and Sakurai, M. and Ribe, E. M. and others},
  title   = {{Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22313},
  pmid    = {21472769},
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}

@article{study2011-21460840,
  author  = {{the Alzheimer's Disease Neuroimaging Initiative} and Hollingworth, Paul and Harold, Denise H. and Sims, Rebecca and Gerrish, Amy and Lambert, Jean‐Charles and Carrasquillo, Minerva M. and Abraham, Richard and others},
  title   = {{Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2011},
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@article{naj2011-21460841,
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  title   = {{Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2011},
  doi     = {10.1038/ng.801},
  pmid    = {21460841},
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@article{jimenez2011-21460223,
  author  = {Jimenez, S. and Torres, M. and Vizuete, M. and Sanchez-Varo, R. and Sanchez-Mejias, E. and Trujillo-Estrada, L. and Carmona-Cuenca, I. and Caballero, C. and others},
  title   = {{Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.209718},
  pmid    = {21460223},
  url     = {https://doi.org/10.1074/jbc.m110.209718}
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@article{caselli2011-21502596,
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  title   = {{Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e3182167147},
  pmid    = {21502596},
  url     = {https://doi.org/10.1212/wnl.0b013e3182167147}
}

@article{takeda2011-21431241,
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  title   = {{Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function}},
  journal = {Molecular bioSystems},
  year    = {2011},
  doi     = {10.1039/c0mb00302f},
  pmid    = {21431241},
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@article{brouwers2012-21403675,
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  title   = {{Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites}},
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  year    = {2012},
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@article{gupta2011-21422459,
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  title   = {{Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318211c352},
  pmid    = {21422459},
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@article{bonda2011-21349442,
  author  = {Bonda, D. J. and Lee, H. G. and Camins, A. and Pallàs, M. and Casadesus, G. and Smith, M. A. and Zhu, X.},
  title   = {{The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations}},
  journal = {The Lancet. Neurology},
  year    = {2011},
  doi     = {10.1016/s1474-4422(11)70013-8},
  pmid    = {21349442},
  url     = {https://doi.org/10.1016/s1474-4422(11)70013-8}
}

@article{hu2011-21390209,
  author  = {Hu, X. and Pickering, E. and Liu, Y. C. and Hall, S. and Fournier, H. and Katz, E. and Dechairo, B. and John, S. and others},
  title   = {{Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease}},
  journal = {PloS one},
  year    = {2011},
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  pmid    = {21390209},
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}

@article{verghese2011-21349439,
  author  = {Verghese, Philip B. and Castellano, Joseph M. and Holtzman, David M.},
  title   = {{Apolipoprotein E in Alzheimer's disease and other neurological disorders}},
  journal = {The Lancet Neurology},
  year    = {2011},
  doi     = {10.1016/s1474-4422(10)70325-2},
  pmid    = {21349439},
  url     = {https://doi.org/10.1016/s1474-4422(10)70325-2}
}

@article{wijsman2011-21379329,
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  title   = {{Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE}},
  journal = {PLoS genetics},
  year    = {2011},
  doi     = {10.1371/journal.pgen.1001308},
  pmid    = {21379329},
  url     = {https://doi.org/10.1371/journal.pgen.1001308}
}

@article{grimm2011-21324907,
  author  = {Grimm, M. O. and Kuchenbecker, J. and Grösgen, S. and Burg, V. K. and Hundsdörfer, B. and Rothhaar, T. L. and Friess, P. and de Wilde, M. C. and others},
  title   = {{Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.182329},
  pmid    = {21324907},
  url     = {https://doi.org/10.1074/jbc.m110.182329}
}

@article{li2011-21143158,
  author  = {Li, C. and Zhao, R. and Gao, K. and Wei, Z. and Yin, M. Y. and Lau, L. T. and Chui, D. and Yu, A. C.},
  title   = {{Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease}},
  journal = {Current Alzheimer research},
  year    = {2011},
  doi     = {10.2174/156720511794604543},
  pmid    = {21143158},
  url     = {https://doi.org/10.2174/156720511794604543}
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@article{penzes2011-21276817,
  author  = {Penzes, P. and Vanleeuwen, J. E.},
  title   = {{Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease}},
  journal = {Brain research reviews},
  year    = {2011},
  doi     = {10.1016/j.brainresrev.2011.01.003},
  pmid    = {21276817},
  url     = {https://doi.org/10.1016/j.brainresrev.2011.01.003}
}

@article{cruchaga2011-21220649,
  author  = {Cruchaga, C. and Graff, C. and Chiang, H. H. and Wang, J. and Hinrichs, A. L. and Spiegel, N. and Bertelsen, S. and Mayo, K. and others},
  title   = {{Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.350},
  pmid    = {21220649},
  url     = {https://doi.org/10.1001/archneurol.2010.350}
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@article{reitz2011-21220680,
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  title   = {{Meta-analysis of the association between variants in SORL1 and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.346},
  pmid    = {21220680},
  url     = {https://doi.org/10.1001/archneurol.2010.346}
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@article{mielke2011-21841258,
  author  = {Mielke, M. M. and Haughey, N. J. and Bandaru, V. V. and Weinberg, D. D. and Darby, E. and Zaidi, N. and Pavlik, V. and Doody, R. S. and others},
  title   = {{Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-110405},
  pmid    = {21841258},
  url     = {https://doi.org/10.3233/jad-2011-110405}
}

@article{mattsson2011-21205675,
  author  = {Mattsson, N. and Zetterberg, H. and Bianconi, S. and Yanjanin, N. M. and Fu, R. and Månsson, J. E. and Porter, F. D. and Blennow, K.},
  title   = {{Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318208f4ab},
  pmid    = {21205675},
  url     = {https://doi.org/10.1212/wnl.0b013e318208f4ab}
}

@article{johnson2010-21145000,
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  title   = {{Exome sequencing reveals VCP mutations as a cause of familial ALS}},
  journal = {Neuron},
  year    = {2010},
  doi     = {10.1016/j.neuron.2010.11.036},
  pmid    = {21145000},
  url     = {https://doi.org/10.1016/j.neuron.2010.11.036}
}

@article{chen2011-21118811,
  author  = {Chen, H. K. and Ji, Z. S. and Dodson, S. E. and Miranda, R. D. and Rosenblum, C. I. and Reynolds, I. J. and Freedman, S. B. and Weisgraber, K. H. and others},
  title   = {{Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.151084},
  pmid    = {21118811},
  url     = {https://doi.org/10.1074/jbc.m110.151084}
}

@article{cisse2011-21113149,
  author  = {Cissé, M. and Halabisky, B. and Harris, J. and Devidze, N. and Dubal, D. B. and Sun, B. and Orr, A. and Lotz, G. and others},
  title   = {{Reversing EphB2 depletion rescues cognitive functions in Alzheimer model}},
  journal = {Nature},
  year    = {2011},
  doi     = {10.1038/nature09635},
  pmid    = {21113149},
  url     = {https://doi.org/10.1038/nature09635}
}

@article{jones2010-21085570,
  author  = {Jones, L. and Holmans, P. A. and Hamshere, M. L. and Harold, D. and Moskvina, V. and Ivanov, D. and Pocklington, A. and Abraham, R. and others},
  title   = {{Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0013950},
  pmid    = {21085570},
  url     = {https://doi.org/10.1371/journal.pone.0013950}
}

@article{lee2011-21059989,
  author  = {Lee, J. H. and Cheng, R. and Barral, S. and Reitz, C. and Medrano, M. and Lantigua, R. and Jiménez-Velazquez, I. Z. and Rogaeva, E. and others},
  title   = {{Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.292},
  pmid    = {21059989},
  url     = {https://doi.org/10.1001/archneurol.2010.292}
}

@article{schrijvers2010-21115952,
  author  = {Schrijvers, E. M. and Witteman, J. C. and Sijbrands, E. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
  title   = {{Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181ffe4f6},
  pmid    = {21115952},
  url     = {https://doi.org/10.1212/wnl.0b013e3181ffe4f6}
}

@article{wan2011-21034809,
  author  = {Wan, L. and Nie, G. and Zhang, J. and Luo, Y. and Zhang, P. and Zhang, Z. and Zhao, B.},
  title   = {{β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2011},
  doi     = {10.1016/j.freeradbiomed.2010.10.707},
  pmid    = {21034809},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2010.10.707}
}

@article{kitazume2010-20952385,
  author  = {Kitazume, S. and Tachida, Y. and Kato, M. and Yamaguchi, Y. and Honda, T. and Hashimoto, Y. and Wada, Y. and Saito, T. and others},
  title   = {{Brain endothelial cells produce amyloid beta from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.144626},
  pmid    = {20952385},
  url     = {https://doi.org/10.1074/jbc.m110.144626}
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@article{dineley2010-20544830,
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  title   = {{Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice}},
  journal = {Journal of neuroscience research},
  year    = {2010},
  doi     = {10.1002/jnr.22445},
  pmid    = {20544830},
  url     = {https://doi.org/10.1002/jnr.22445}
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@article{silverberg2010-20838242,
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  title   = {{Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2010},
  doi     = {10.1097/nen.0b013e3181f46e25},
  pmid    = {20838242},
  url     = {https://doi.org/10.1097/nen.0b013e3181f46e25}
}

@article{hooshmand2010-20956786,
  author  = {Hooshmand, B. and Solomon, A. and Kåreholt, I. and Leiviskä, J. and Rusanen, M. and Ahtiluoto, S. and Winblad, B. and Laatikainen, T. and others},
  title   = {{Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181f88162},
  pmid    = {20956786},
  url     = {https://doi.org/10.1212/wnl.0b013e3181f88162}
}

@article{naj2010-20885792,
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  title   = {{Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities}},
  journal = {PLoS genetics},
  year    = {2010},
  doi     = {10.1371/journal.pgen.1001130},
  pmid    = {20885792},
  url     = {https://doi.org/10.1371/journal.pgen.1001130}
}

@article{sjolander2010-20849576,
  author  = {Sjölander, A. and Zetterberg, H. and Andreasson, U. and Minthon, L. and Blennow, K.},
  title   = {{BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2010},
  doi     = {10.1186/1750-1326-5-37},
  pmid    = {20849576},
  url     = {https://doi.org/10.1186/1750-1326-5-37}
}

@article{yokokura2011-20844871,
  author  = {Yokokura, M. and Mori, N. and Yagi, S. and Yoshikawa, E. and Kikuchi, M. and Yoshihara, Y. and Wakuda, T. and Sugihara, G. and others},
  title   = {{In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease}},
  journal = {European journal of nuclear medicine and molecular imaging},
  year    = {2011},
  doi     = {10.1007/s00259-010-1612-0},
  pmid    = {20844871},
  url     = {https://doi.org/10.1007/s00259-010-1612-0}
}

@article{lewis2010-20847045,
  author  = {Lewis, T. L. and Cao, D. and Lu, H. and Mans, R. A. and Su, Y. R. and Jungbauer, L. and Linton, M. F. and Fazio, S. and others},
  title   = {{Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.127829},
  pmid    = {20847045},
  url     = {https://doi.org/10.1074/jbc.m110.127829}
}

@article{lefterov2010-20739292,
  author  = {Lefterov, I. and Fitz, N. F. and Cronican, A. A. and Fogg, A. and Lefterov, P. and Kodali, R. and Wetzel, R. and Koldamova, R.},
  title   = {{Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.127738},
  pmid    = {20739292},
  url     = {https://doi.org/10.1074/jbc.m110.127738}
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@article{matsuzaki2010-20739649,
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  title   = {{Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181eee25f},
  pmid    = {20739649},
  url     = {https://doi.org/10.1212/wnl.0b013e3181eee25f}
}

@article{jun2010-20697030,
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  title   = {{Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.201},
  pmid    = {20697030},
  url     = {https://doi.org/10.1001/archneurol.2010.201}
}

@article{gandy2010-20641005,
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  title   = {{Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.22052},
  pmid    = {20641005},
  url     = {https://doi.org/10.1002/ana.22052}
}

@article{ginsberg2010-20655510,
  author  = {Ginsberg, S. D. and Alldred, M. J. and Counts, S. E. and Cataldo, A. M. and Neve, R. L. and Jiang, Y. and Wuu, J. and Chao, M. V. and others},
  title   = {{Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.05.030},
  pmid    = {20655510},
  url     = {https://doi.org/10.1016/j.biopsych.2010.05.030}
}

@article{beydoun2012-20619505,
  author  = {Beydoun, M. A. and Boueiz, A. and Abougergi, M. S. and Kitner-Triolo, M. H. and Beydoun, H. A. and Resnick, S. M. and O'Brien, R. and Zonderman, A. B.},
  title   = {{Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2010.05.017},
  pmid    = {20619505},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.05.017}
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@article{dickerson2011-20562467,
  author  = {Dickerson, B. C. and Wolk, D. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2011},
  doi     = {10.1136/jnnp.2009.199505},
  pmid    = {20562467},
  url     = {https://doi.org/10.1136/jnnp.2009.199505}
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@article{cho2010-20558735,
  author  = {Cho, H. H. and Cahill, C. M. and Vanderburg, C. R. and Scherzer, C. R. and Wang, B. and Huang, X. and Rogers, J. T.},
  title   = {{Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.149161},
  pmid    = {20558735},
  url     = {https://doi.org/10.1074/jbc.m110.149161}
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@article{jaeger2010-20559548,
  author  = {Jaeger, P. A. and Pickford, F. and Sun, C. H. and Lucin, K. M. and Masliah, E. and Wyss-Coray, T.},
  title   = {{Regulation of amyloid precursor protein processing by the Beclin 1 complex}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0011102},
  pmid    = {20559548},
  url     = {https://doi.org/10.1371/journal.pone.0011102}
}

@article{lee2010-20552234,
  author  = {Lee, C. Y. and Landreth, G. E.},
  title   = {{The role of microglia in amyloid clearance from the AD brain}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2010},
  doi     = {10.1007/s00702-010-0433-4},
  pmid    = {20552234},
  url     = {https://doi.org/10.1007/s00702-010-0433-4}
}

@article{carrasquillo2010-20554627,
  author  = {Carrasquillo, M. M. and Belbin, O. and Hunter, T. A. and Ma, L. and Bisceglio, G. D. and Zou, F. and Crook, J. E. and others},
  title   = {{Replication of CLU, CR1, and PICALM associations with alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.147},
  pmid    = {20554627},
  url     = {https://doi.org/10.1001/archneurol.2010.147}
}

@article{fisher2010-20520819,
  author  = {Fisher, Y. and Nemirovsky, A. and Baron, R. and Monsonego, A.},
  title   = {{T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0010830},
  pmid    = {20520819},
  url     = {https://doi.org/10.1371/journal.pone.0010830}
}

@article{wolk2010-20479234,
  author  = {Wolk, D. A. and Dickerson, B. C. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2010},
  doi     = {10.1073/pnas.1001412107},
  pmid    = {20479234},
  url     = {https://doi.org/10.1073/pnas.1001412107}
}

@article{seshadri2010-20460622,
  author  = {Seshadri, S. and Fitzpatrick, A. L. and Ikram, M. A. and DeStefano, A. L. and Gudnason, V. and Boada, M. and Bis, J. C. and Smith, A. V. and others},
  title   = {{Genome-wide analysis of genetic loci associated with Alzheimer disease}},
  journal = {JAMA},
  year    = {2010},
  doi     = {10.1001/jama.2010.574},
  pmid    = {20460622},
  url     = {https://doi.org/10.1001/jama.2010.574}
}

@article{harwood2010-19750560,
  author  = {Harwood, D. G. and Kalechstein, A. and Barker, W. W. and Strauman, S. and St George-Hyslop, P. and Iglesias, C. and Loewenstein, D. and Duara, R.},
  title   = {{The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease}},
  journal = {International journal of geriatric psychiatry},
  year    = {2010},
  doi     = {10.1002/gps.2372},
  pmid    = {19750560},
  url     = {https://doi.org/10.1002/gps.2372}
}

@article{mcdonald2010-20403962,
  author  = {Mc Donald, J. M. and Savva, G. M. and Brayne, C. and Welzel, A. T. and Forster, G. and Shankar, G. M. and Selkoe, D. J. and Ince, P. G. and others},
  title   = {{The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia}},
  journal = {Brain : a journal of neurology},
  year    = {2010},
  doi     = {10.1093/brain/awq065},
  pmid    = {20403962},
  url     = {https://doi.org/10.1093/brain/awq065}
}

@article{jayadev2010-20375137,
  author  = {Jayadev, S. and Leverenz, J. B. and Steinbart, E. and Stahl, J. and Klunk, W. and Yu, C. E. and Bird, T. D.},
  title   = {{Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2}},
  journal = {Brain : a journal of neurology},
  year    = {2010},
  doi     = {10.1093/brain/awq033},
  pmid    = {20375137},
  url     = {https://doi.org/10.1093/brain/awq033}
}

@article{candore2010-20462385,
  author  = {Candore, G. and Bulati, M. and Caruso, C. and Castiglia, L. and Colonna-Romano, G. and Di Bona, D. and Duro, G. and Lio, D. and others},
  title   = {{Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications}},
  journal = {Rejuvenation research},
  year    = {2010},
  doi     = {10.1089/rej.2009.0993},
  pmid    = {20462385},
  url     = {https://doi.org/10.1089/rej.2009.0993}
}

@article{arnold2010-20437581,
  author  = {Arnold, S. E. and Lee, E. B. and Moberg, P. J. and Stutzbach, L. and Kazi, H. and Han, L. Y. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21910},
  pmid    = {20437581},
  url     = {https://doi.org/10.1002/ana.21910}
}

@article{burns2010-20385908,
  author  = {Burns, J. M. and Johnson, D. K. and Watts, A. and Swerdlow, R. H. and Brooks, W. M.},
  title   = {{Reduced lean mass in early Alzheimer disease and its association with brain atrophy}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.38},
  pmid    = {20385908},
  url     = {https://doi.org/10.1001/archneurol.2010.38}
}

@article{portelius2010-20350302,
  author  = {Portelius, E. and Dean, R. A. and Gustavsson, M. K. and Andreasson, U. and Zetterberg, H. and Siemers, E. and Blennow, K.},
  title   = {{A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2010},
  doi     = {10.1186/alzrt30},
  pmid    = {20350302},
  url     = {https://doi.org/10.1186/alzrt30}
}

@article{fukumoto2010-20339023,
  author  = {Fukumoto, H. and Tokuda, T. and Kasai, T. and Ishigami, N. and Hidaka, H. and Kondo, M. and Allsop, D. and Nakagawa, M.},
  title   = {{High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2010},
  doi     = {10.1096/fj.09-150359},
  pmid    = {20339023},
  url     = {https://doi.org/10.1096/fj.09-150359}
}

@article{vemuri2010-20373342,
  author  = {Vemuri, P. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Shaw, L. M. and Trojanowski, J. Q. and Aisen, P. S. and Weiner, M. and others},
  title   = {{Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21953},
  pmid    = {20373342},
  url     = {https://doi.org/10.1002/ana.21953}
}

@article{sultana2010-19686046,
  author  = {Sultana, R. and Perluigi, M. and Newman, S. F. and Pierce, W. M. and Cini, C. and Coccia, R. and Butterfield, D. A.},
  title   = {{Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease}},
  journal = {Antioxidants \& redox signaling},
  year    = {2010},
  doi     = {10.1089/ars.2009.2810},
  pmid    = {19686046},
  url     = {https://doi.org/10.1089/ars.2009.2810}
}

@article{butterfield2010-20176130,
  author  = {Butterfield, D. A. and Bader Lange, M. L. and Sultana, R.},
  title   = {{Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease}},
  journal = {Biochimica et biophysica acta},
  year    = {2010},
  doi     = {10.1016/j.bbalip.2010.02.005},
  pmid    = {20176130},
  url     = {https://doi.org/10.1016/j.bbalip.2010.02.005}
}

@article{sultana2010-19774677,
  author  = {Sultana, R. and Banks, W. A. and Butterfield, D. A.},
  title   = {{Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2010},
  doi     = {10.1002/jnr.22227},
  pmid    = {19774677},
  url     = {https://doi.org/10.1002/jnr.22227}
}

@article{destrooper2010-20139999,
  author  = {De Strooper, B. and Vassar, R. and Golde, T.},
  title   = {{The secretases: enzymes with therapeutic potential in Alzheimer disease}},
  journal = {Nature reviews. Neurology},
  year    = {2010},
  doi     = {10.1038/nrneurol.2009.218},
  pmid    = {20139999},
  url     = {https://doi.org/10.1038/nrneurol.2009.218}
}

@article{sonoda2010-20056128,
  author  = {Sonoda, Y. and Mukai, H. and Matsuo, K. and Takahashi, M. and Ono, Y. and Maeda, K. and Akiyama, H. and Kawamata, T.},
  title   = {{Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles}},
  journal = {Neuroscience letters},
  year    = {2010},
  doi     = {10.1016/j.neulet.2009.12.078},
  pmid    = {20056128},
  url     = {https://doi.org/10.1016/j.neulet.2009.12.078}
}

@article{silverberg2010-20010299,
  author  = {Silverberg, G. D. and Miller, M. C. and Messier, A. A. and Majmudar, S. and Machan, J. T. and Donahue, J. E. and Stopa, E. G. and Johanson, C. E.},
  title   = {{Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2010},
  doi     = {10.1097/nen.0b013e3181c8ad2f},
  pmid    = {20010299},
  url     = {https://doi.org/10.1097/nen.0b013e3181c8ad2f}
}

@article{thambisetty2010-20065135,
  author  = {Thambisetty, M. and Beason-Held, L. and An, Y. and Kraut, M. A. and Resnick, S. M.},
  title   = {{APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2009.913},
  pmid    = {20065135},
  url     = {https://doi.org/10.1001/archneurol.2009.913}
}

@article{morris2010-20186853,
  author  = {Morris, J. C. and Roe, C. M. and Xiong, C. and Fagan, A. M. and Goate, A. M. and Holtzman, D. M. and Mintun, M. A.},
  title   = {{APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21843},
  pmid    = {20186853},
  url     = {https://doi.org/10.1002/ana.21843}
}

@article{sanders2010-20068209,
  author  = {Sanders, A. E. and Wang, C. and Katz, M. and Derby, C. A. and Barzilai, N. and Ozelius, L. and Lipton, R. B.},
  title   = {{Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia}},
  journal = {JAMA},
  year    = {2010},
  doi     = {10.1001/jama.2009.1988},
  pmid    = {20068209},
  url     = {https://doi.org/10.1001/jama.2009.1988}
}

@article{bourgeat2010-20065247,
  author  = {Bourgeat, P. and Chételat, G. and Villemagne, V. L. and Fripp, J. and Raniga, P. and Pike, K. and Acosta, O. and Szoeke, C. and others},
  title   = {{Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181c918b5},
  pmid    = {20065247},
  url     = {https://doi.org/10.1212/wnl.0b013e3181c918b5}
}

@article{ginsberg2010-20847427,
  author  = {Ginsberg, S. D. and Mufson, E. J. and Counts, S. E. and Wuu, J. and Alldred, M. J. and Nixon, R. A. and Che, S.},
  title   = {{Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-101080},
  pmid    = {20847427},
  url     = {https://doi.org/10.3233/jad-2010-101080}
}

@article{storandt2009-20008651,
  author  = {Storandt, M. and Mintun, M. A. and Head, D. and Morris, J. C.},
  title   = {{Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.272},
  pmid    = {20008651},
  url     = {https://doi.org/10.1001/archneurol.2009.272}
}

@article{villemagne2009-20008660,
  author  = {Villemagne, V. L. and Ataka, S. and Mizuno, T. and Brooks, W. S. and Wada, Y. and Kondo, M. and Jones, G. and Watanabe, Y. and others},
  title   = {{High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2009.285},
  pmid    = {20008660},
  url     = {https://doi.org/10.1001/archneurol.2009.285}
}

@article{uemura2009-19924286,
  author  = {Uemura, K. and Lill, C. M. and Li, X. and Peters, J. A. and Ivanov, A. and Fan, Z. and DeStrooper, B. and Bacskai, B. J. and others},
  title   = {{Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio}},
  journal = {PloS one},
  year    = {2009},
  doi     = {10.1371/journal.pone.0007893},
  pmid    = {19924286},
  url     = {https://doi.org/10.1371/journal.pone.0007893}
}

@article{butterfield2010-19854267,
  author  = {Butterfield, D. A. and Galvan, V. and Lange, M. B. and Tang, H. and Sowell, R. A. and Spilman, P. and Fombonne, J. and Gorostiza, O. and others},
  title   = {{In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP}},
  journal = {Free radical biology \& medicine},
  year    = {2010},
  doi     = {10.1016/j.freeradbiomed.2009.10.035},
  pmid    = {19854267},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2009.10.035}
}

@article{abdul2009-19828810,
  author  = {Abdul, H. M. and Sama, M. A. and Furman, J. L. and Mathis, D. M. and Beckett, T. L. and Weidner, A. M. and Patel, E. S. and Baig, I. and others},
  title   = {{Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.1064-09.2009},
  pmid    = {19828810},
  url     = {https://doi.org/10.1523/jneurosci.1064-09.2009}
}

@article{sultana2009-19777328,
  author  = {Sultana, R. and Butterfield, D. A.},
  title   = {{Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment}},
  journal = {Journal of bioenergetics and biomembranes},
  year    = {2009},
  doi     = {10.1007/s10863-009-9241-7},
  pmid    = {19777328},
  url     = {https://doi.org/10.1007/s10863-009-9241-7}
}

@article{kang2009-19779148,
  author  = {Kang, Jae-Eun and Lim, Miranda M. and Bateman, Randall John and Lee, James J. and Smyth, Liam P. and Cirrito, John R. and Fujiki, Nobuhiro and Nishino, Seiji and Holtzman, David M.},
  title   = {{Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1180962},
  pmid    = {19779148},
  url     = {https://doi.org/10.1126/science.1180962}
}

@article{butterfield2009-19780894,
  author  = {Butterfield, D. A. and Lange, M. L.},
  title   = {{Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06397.x},
  pmid    = {19780894},
  url     = {https://doi.org/10.1111/j.1471-4159.2009.06397.x}
}

@article{vanes2009-19734901,
  author  = {van Es, M. A. and Veldink, J. H. and Saris, C. G. and Blauw, H. M. and van Vught, P. W. and Birve, A. and Lemmens, R. and Schelhaas, H. J. and others},
  title   = {{Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis}},
  journal = {Nature genetics},
  year    = {2009},
  doi     = {10.1038/ng.442},
  pmid    = {19734901},
  url     = {https://doi.org/10.1038/ng.442}
}

@article{study2009-591259cf,
  author  = {{the European Alzheimer's Disease Initiative Investigators} and Lambert, Jean‐Charles and Heath, Simon Charles and Even, Gaël and Campion, Dominique and Sleegers, Kristel and Hiltunen, Mikko and Combarros, Onofre and others},
  title   = {{Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.439},
  url     = {https://doi.org/10.1038/ng.439}
}

@article{harold2009-19734902,
  author  = {Harold, Denise H. and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and others},
  title   = {{Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease}},
  journal = {Nature Genetics},
  year    = {2009},
  doi     = {10.1038/ng.440},
  pmid    = {19734902},
  url     = {https://doi.org/10.1038/ng.440}
}

@article{barrachina2009-19606065,
  author  = {Barrachina, M. and Ferrer, I.},
  title   = {{DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2009},
  doi     = {10.1097/nen.0b013e3181af2e46},
  pmid    = {19606065},
  url     = {https://doi.org/10.1097/nen.0b013e3181af2e46}
}

@article{kim2009-19679070,
  author  = {Kim, Jungsu and Basak, Jacob M. and Holtzman, David M.},
  title   = {{The Role of Apolipoprotein E in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2009},
  doi     = {10.1016/j.neuron.2009.06.026},
  pmid    = {19679070},
  url     = {https://doi.org/10.1016/j.neuron.2009.06.026}
}

@article{portelius2011-19604603,
  author  = {Portelius, E. and Price, E. and Brinkmalm, G. and Stiteler, M. and Olsson, M. and Persson, R. and Westman-Brinkmalm, A. and others},
  title   = {{A novel pathway for amyloid precursor protein processing}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2009.06.002},
  pmid    = {19604603},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.06.002}
}

@article{eggert2009-19596858,
  author  = {Eggert, S. and Midthune, B. and Cottrell, B. and Koo, E. H.},
  title   = {{Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m109.038646},
  pmid    = {19596858},
  url     = {https://doi.org/10.1074/jbc.m109.038646}
}

@article{sperling2009-19640477,
  author  = {Sperling, Reisa Anne and LaViolette, Peter S. and O’Keefe, Kelly and O’Brien, Jacqueline L. and Rentz, Dorene M. and Pihlajamaki, Maija M. and Marshall, Gad A. and Hyman, Bradley T. and Selkoe, Dennis J. and Hedden, Trey and Buckner, Randy Lee and Becker, John Alex and Johnson, Keith A.},
  title   = {{Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia}},
  journal = {Neuron},
  year    = {2009},
  doi     = {10.1016/j.neuron.2009.07.003},
  pmid    = {19640477},
  url     = {https://doi.org/10.1016/j.neuron.2009.07.003}
}

@article{caselli2009-19605830,
  author  = {Caselli, R. J. and Dueck, A. C. and Osborne, D. and Sabbagh, M. N. and Connor, D. J. and Ahern, G. L. and Baxter, L. C. and Rapcsak, S. Z. and others},
  title   = {{Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect}},
  journal = {The New England journal of medicine},
  year    = {2009},
  doi     = {10.1056/nejmoa0809437},
  pmid    = {19605830},
  url     = {https://doi.org/10.1056/nejmoa0809437}
}

@article{schlenzig2009-19518051,
  author  = {Schlenzig, D. and Manhart, S. and Cinar, Y. and Kleinschmidt, M. and Hause, G. and Willbold, D. and Funke, S. A. and Schilling, S. and others},
  title   = {{Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides}},
  journal = {Biochemistry},
  year    = {2009},
  doi     = {10.1021/bi900818a},
  pmid    = {19518051},
  url     = {https://doi.org/10.1021/bi900818a}
}

@article{poon2011-19540623,
  author  = {Poon, W. W. and Blurton-Jones, M. and Tu, C. H. and Feinberg, L. M. and Chabrier, M. A. and Harris, J. W. and Jeon, N. L. and Cotman, C. W.},
  title   = {{β-Amyloid impairs axonal BDNF retrograde trafficking}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2009.05.012},
  pmid    = {19540623},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.05.012}
}

@article{tomic2009-19523517,
  author  = {Tomic, J. L. and Pensalfini, A. and Head, E. and Glabe, C. G.},
  title   = {{Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction}},
  journal = {Neurobiology of disease},
  year    = {2009},
  doi     = {10.1016/j.nbd.2009.05.024},
  pmid    = {19523517},
  url     = {https://doi.org/10.1016/j.nbd.2009.05.024}
}

@article{kok2009-19557866,
  author  = {Kok, E. and Haikonen, S. and Luoto, T. and Huhtala, H. and Goebeler, S. and Haapasalo, H. and Karhunen, P. J.},
  title   = {{Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age}},
  journal = {Annals of neurology},
  year    = {2009},
  doi     = {10.1002/ana.21696},
  pmid    = {19557866},
  url     = {https://doi.org/10.1002/ana.21696}
}

@article{reed2009-19374891,
  author  = {Reed, T. T. and Pierce, W. M. and Markesbery, W. R. and Butterfield, D. A.},
  title   = {{Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD}},
  journal = {Brain research},
  year    = {2009},
  doi     = {10.1016/j.brainres.2009.04.009},
  pmid    = {19374891},
  url     = {https://doi.org/10.1016/j.brainres.2009.04.009}
}

@article{reiman2009-19346482,
  author  = {Reiman, Eric M. and Chen, Kewei and Liu, Xiaofen and Bandy, Daniel J. and Yu, Meixiang and Lee, Wendy and Ayutyanont, Napatkamon and Keppler, Jennifer S. and Reeder, Stephanie and Langbaum, Jessica B. S. and Alexander, Gene E. and Klunk, William E. and Mathis, Chester A. and Price, Julie C. and Aizenstein, Howard Jay and DeKosky, Steven T. and Caselli, Richard J.},
  title   = {{Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2009},
  doi     = {10.1073/pnas.0900345106},
  pmid    = {19346482},
  url     = {https://doi.org/10.1073/pnas.0900345106}
}

@article{bu2009-19339974,
  author  = {Bu, Guojun},
  title   = {{Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy}},
  journal = {Nature reviews. Neuroscience},
  year    = {2009},
  doi     = {10.1038/nrn2620},
  pmid    = {19339974},
  url     = {https://doi.org/10.1038/nrn2620}
}

@article{drzezga2009-19339712,
  author  = {Drzezga, A. and Grimmer, T. and Henriksen, G. and Mühlau, M. and Perneczky, R. and Miederer, I. and Praus, C. and Sorg, C. and others},
  title   = {{Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181a2e8d0},
  pmid    = {19339712},
  url     = {https://doi.org/10.1212/wnl.0b013e3181a2e8d0}
}

@article{webster2009-19361613,
  author  = {Webster, J. A. and Gibbs, JR. and Clarke, J. and Ray, M. and Zhang, W. and Holmans, P. and Rohrer, K. and Zhao, A. and others},
  title   = {{Genetic control of human brain transcript expression in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2009},
  doi     = {10.1016/j.ajhg.2009.03.011},
  pmid    = {19361613},
  url     = {https://doi.org/10.1016/j.ajhg.2009.03.011}
}

@article{bennett2009-19398704,
  author  = {Bennett, D. A. and De Jager, P. L. and Leurgans, S. E. and Schneider, J. A.},
  title   = {{Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/wnl.0b013e3181a2e87d},
  pmid    = {19398704},
  url     = {https://doi.org/10.1212/wnl.0b013e3181a2e87d}
}

@article{gralle2009-19336403,
  author  = {Gralle, M. and Botelho, M. G. and Wouters, F. S.},
  title   = {{Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m808755200},
  pmid    = {19336403},
  url     = {https://doi.org/10.1074/jbc.m808755200}
}

@article{sultana2009-19288120,
  author  = {Sultana, R. and Perluigi, M. and Butterfield, D. A.},
  title   = {{Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0517-0},
  pmid    = {19288120},
  url     = {https://doi.org/10.1007/s00401-009-0517-0}
}

@article{dutescu2009-19271231,
  author  = {Dutescu, R. M. and Li, Q. X. and Crowston, J. and Masters, C. L. and Baird, P. N. and Culvenor, J. G.},
  title   = {{Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease}},
  journal = {Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie},
  year    = {2009},
  doi     = {10.1007/s00417-009-1060-3},
  pmid    = {19271231},
  url     = {https://doi.org/10.1007/s00417-009-1060-3}
}

@article{berlau2009-19255410,
  author  = {Berlau, D. J. and Corrada, M. M. and Head, E. and Kawas, C. H.},
  title   = {{APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/01.wnl.0000343853.00346.a4},
  pmid    = {19255410},
  url     = {https://doi.org/10.1212/01.wnl.0000343853.00346.a4}
}

@article{qin2009-19273754,
  author  = {Qin, W. and Haroutunian, V. and Katsel, P. and Cardozo, C. P. and Ho, L. and Buxbaum, J. D. and Pasinetti, G. M.},
  title   = {{PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2008.588},
  pmid    = {19273754},
  url     = {https://doi.org/10.1001/archneurol.2008.588}
}

@article{kwiatkowski2009-19251627,
  author  = {Kwiatkowski, Thomas J. and Bosco, Daryl A. and Leclerc, Aurélie and Tamrazian, Eric and Vanderburg, Charles R. and Russ, C and Davis, Adam and Gilchrist, James M. and Kasarskis, Edward J. and Munsat, T. L. and Valdmanis, Paul N. and Rouleau, Guy Armand and Hosler, Betsy A. and Cortelli, Pietro and de Jong, Pieter J. and Yoshinaga, Yuko and Haines, Jonathan L. and Pericak‐Vance, Margaret A. and Yan, Jianing and Ticozzi, Nicola and Siddique, Teepu and McKenna‐Yasek, D. and Sapp, Peter C. and Horvitz, Howard Robert and Landers, John E. and Brown, Robert H.},
  title   = {{Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis}},
  journal = {Science},
  year    = {2009},
  doi     = {10.1126/science.1166066},
  pmid    = {19251627},
  url     = {https://doi.org/10.1126/science.1166066}
}

@article{revesz2009-19225789,
  author  = {Revesz, T. and Holton, J. L. and Lashley, T. and Plant, G. and Frangione, B. and Rostagno, A. and Ghiso, J.},
  title   = {{Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0501-8},
  pmid    = {19225789},
  url     = {https://doi.org/10.1007/s00401-009-0501-8}
}

@article{takei2009-19442637,
  author  = {Takei, N. and Miyashita, A. and Tsukie, T. and Arai, H. and Asada, T. and Imagawa, M. and Shoji, M. and Higuchi, S. and others},
  title   = {{Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese}},
  journal = {Genomics},
  year    = {2009},
  doi     = {10.1016/j.ygeno.2009.01.003},
  pmid    = {19442637},
  url     = {https://doi.org/10.1016/j.ygeno.2009.01.003}
}

@article{hoe2009-19164281,
  author  = {Hoe, H. S. and Fu, Z. and Makarova, A. and Lee, J. Y. and Lu, C. and Feng, L. and Pajoohesh-Ganji, A. and Matsuoka, Y. and others},
  title   = {{The effects of amyloid precursor protein on postsynaptic composition and activity}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m900141200},
  pmid    = {19164281},
  url     = {https://doi.org/10.1074/jbc.m900141200}
}

@article{boissonneault2009-19151372,
  author  = {Boissonneault, V. and Filali, M. and Lessard, M. and Relton, J. and Wong, G. and Rivest, S.},
  title   = {{Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awn331},
  pmid    = {19151372},
  url     = {https://doi.org/10.1093/brain/awn331}
}

@article{zhiyou2009-19123057,
  author  = {Zhiyou, C. and Yong, Y. and Shanquan, S. and Jun, Z. and Liangguo, H. and Ling, Y. and Jieying, L.},
  title   = {{Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease}},
  journal = {Neurochemical research},
  year    = {2009},
  doi     = {10.1007/s11064-008-9899-y},
  pmid    = {19123057},
  url     = {https://doi.org/10.1007/s11064-008-9899-y}
}

@article{beecham2009-19118814,
  author  = {Beecham, G. W. and Martin, E. R. and Li, Y. J. and Slifer, M. A. and Gilbert, JR. and Haines, J. L. and Pericak-Vance, M. A.},
  title   = {{Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2009},
  doi     = {10.1016/j.ajhg.2008.12.008},
  pmid    = {19118814},
  url     = {https://doi.org/10.1016/j.ajhg.2008.12.008}
}

@article{svedberg2009-19162107,
  author  = {Svedberg, M. M. and Hall, H. and Hellström-Lindahl, E. and Estrada, S. and Guan, Z. and Nordberg, A. and Långström, B.},
  title   = {{[(11)C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients}},
  journal = {Neurochemistry international},
  year    = {2009},
  doi     = {10.1016/j.neuint.2008.12.016},
  pmid    = {19162107},
  url     = {https://doi.org/10.1016/j.neuint.2008.12.016}
}

@article{hooijmans2009-19130883,
  author  = {Hooijmans, C. R. and Van der Zee, C. E. and Dederen, P. J. and Brouwer, K. M. and Reijmer, Y. D. and van Groen, T. and Broersen, L. M. and Lütjohann, D. and others},
  title   = {{DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice}},
  journal = {Neurobiology of disease},
  year    = {2009},
  doi     = {10.1016/j.nbd.2008.12.002},
  pmid    = {19130883},
  url     = {https://doi.org/10.1016/j.nbd.2008.12.002}
}

@article{vetrivel2009-19074428,
  author  = {Vetrivel, K. S. and Meckler, X. and Chen, Y. and Nguyen, P. D. and Seidah, N. G. and Vassar, R. and Wong, P. C. and Fukata, M. and others},
  title   = {{Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m808920200},
  pmid    = {19074428},
  url     = {https://doi.org/10.1074/jbc.m808920200}
}

@article{belyaev2009-19057576,
  author  = {Belyaev, N. D. and Nalivaeva, N. N. and Makova, N. Z. and Turner, A. J.},
  title   = {{Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2009},
  doi     = {10.1038/embor.2008.222},
  pmid    = {19057576},
  url     = {https://doi.org/10.1038/embor.2008.222}
}

@article{wang2008-19050078,
  author  = {Wang, X. and Su, B. and Siedlak, S. L. and Moreira, P. I. and Fujioka, H. and Wang, Y. and Casadesus, G. and Zhu, X.},
  title   = {{Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2008},
  doi     = {10.1073/pnas.0804871105},
  pmid    = {19050078},
  url     = {https://doi.org/10.1073/pnas.0804871105}
}

@article{mosconi2008-19076441,
  author  = {Mosconi, L. and Pupi, A. and De Leon, M. J.},
  title   = {{Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2008},
  doi     = {10.1196/annals.1427.007},
  pmid    = {19076441},
  url     = {https://doi.org/10.1196/annals.1427.007}
}

@article{mormino2009-19042931,
  author  = {Mormino, E. C. and Kluth, J. T. and Madison, C. M. and Rabinovici, G. D. and Baker, S. L. and Miller, B. L. and Koeppe, R. A. and Mathis, C. A. and others},
  title   = {{Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awn320},
  pmid    = {19042931},
  url     = {https://doi.org/10.1093/brain/awn320}
}

@article{deane2008-19033669,
  author  = {Deane, R. and Sagare, A. and Hamm, K. and Parisi, M. and Lane, S. and Finn, M. B. and Holtzman, D. M. and Zlokovic, B. V.},
  title   = {{apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci36663},
  pmid    = {19033669},
  url     = {https://doi.org/10.1172/jci36663}
}

@article{boissonneault2009-18986979,
  author  = {Boissonneault, V. and Plante, I. and Rivest, S. and Provost, P.},
  title   = {{MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m807530200},
  pmid    = {18986979},
  url     = {https://doi.org/10.1074/jbc.m807530200}
}

@article{roe2008-19001165,
  author  = {Roe, C. M. and Mintun, M. A. and D'Angelo, G. and Xiong, C. and Grant, E. A. and Morris, J. C.},
  title   = {{Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.11.1467},
  pmid    = {19001165},
  url     = {https://doi.org/10.1001/archneur.65.11.1467}
}

@article{jeynes2008-18855584,
  author  = {Jeynes, B. and Provias, J.},
  title   = {{Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis}},
  journal = {Current Alzheimer research},
  year    = {2008},
  doi     = {10.2174/156720508785908937},
  pmid    = {18855584},
  url     = {https://doi.org/10.2174/156720508785908937}
}

@article{reese2008-18782350,
  author  = {Reese, L. C. and Zhang, W. and Dineley, K. T. and Kayed, R. and Taglialatela, G.},
  title   = {{Selective induction of calcineurin activity and signaling by oligomeric amyloid beta}},
  journal = {Aging cell},
  year    = {2008},
  doi     = {10.1111/j.1474-9726.2008.00434.x},
  pmid    = {18782350},
  url     = {https://doi.org/10.1111/j.1474-9726.2008.00434.x}
}

@article{sotiropoulos2008-18691381,
  author  = {Sotiropoulos, I. and Catania, C. and Riedemann, T. and Fry, J. P. and Breen, K. C. and Michaelidis, T. M. and Almeida, O. F.},
  title   = {{Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05613.x},
  pmid    = {18691381},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05613.x}
}

@article{utter2008-18716559,
  author  = {Utter, S. and Tamboli, I. Y. and Walter, J. and Upadhaya, A. R. and Birkenmeier, G. and Pietrzik, C. U. and Ghebremedhin, E. and Thal, D. R.},
  title   = {{Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e3181836a71},
  pmid    = {18716559},
  url     = {https://doi.org/10.1097/nen.0b013e3181836a71}
}

@article{reed2009-18752637,
  author  = {Reed, T. T. and Pierce, W. M. and Turner, D. M. and Markesbery, W. R. and Allan Butterfield, D.},
  title   = {{Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule}},
  journal = {Journal of cellular and molecular medicine},
  year    = {2009},
  doi     = {10.1111/j.1582-4934.2008.00478.x},
  pmid    = {18752637},
  url     = {https://doi.org/10.1111/j.1582-4934.2008.00478.x}
}

@article{hickman2008-18701698,
  author  = {Hickman, Suzanne E. and Allison, Elizabeth K. and El Khoury, Joseph B.},
  title   = {{Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice}},
  journal = {Journal of Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.0616-08.2008},
  pmid    = {18701698},
  url     = {https://doi.org/10.1523/jneurosci.0616-08.2008}
}

@article{zetterberg2008-18695061,
  author  = {Zetterberg, H. and Andreasson, U. and Hansson, O. and Wu, G. and Sankaranarayanan, S. and Andersson, M. E. and Buchhave, P. and Londos, E. and others},
  title   = {{Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.8.1102},
  pmid    = {18695061},
  url     = {https://doi.org/10.1001/archneur.65.8.1102}
}

@article{thinakaran2008-18650430,
  author  = {Thinakaran, G. and Koo, E. H.},
  title   = {{Amyloid precursor protein trafficking, processing, and function}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800019200},
  pmid    = {18650430},
  url     = {https://doi.org/10.1074/jbc.r800019200}
}

@article{cole2008-18650431,
  author  = {Cole, S. L. and Vassar, R.},
  title   = {{The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800015200},
  pmid    = {18650431},
  url     = {https://doi.org/10.1074/jbc.r800015200}
}

@article{muller2008-18603345,
  author  = {Müller, T. and Meyer, H. E. and Egensperger, R. and Marcus, K.},
  title   = {{The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease}},
  journal = {Progress in neurobiology},
  year    = {2008},
  doi     = {10.1016/j.pneurobio.2008.05.002},
  pmid    = {18603345},
  url     = {https://doi.org/10.1016/j.pneurobio.2008.05.002}
}

@article{simpson2010-18586353,
  author  = {Simpson, J. E. and Ince, P. G. and Lace, G. and Forster, G. and Shaw, P. J. and Matthews, F. and Savva, G. and Brayne, C. and others},
  title   = {{Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2008.05.015},
  pmid    = {18586353},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.05.015}
}

@article{shankar2008-18568035,
  author  = {Shankar, Ganesh M. and Li, Shaomin and Mehta, Tapan and García-Muñoz, Amaya and Shepardson, Nina E. and Smith, Imelda M. and Brett, Francesca M. and Farrell, Michael Anthony and Rowan, Michael J. and Lemere, Cynthia Ann and Regan, Ciaran M. and Walsh, Dominic M. and Sabatini, Bernardo Luis and Selkoe, Dennis J.},
  title   = {{Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory}},
  journal = {Nature Medicine},
  year    = {2008},
  doi     = {10.1038/nm1782},
  pmid    = {18568035},
  url     = {https://doi.org/10.1038/nm1782}
}

@article{ning2008-18566467,
  author  = {Ning, A. and Cui, J. and To, E. and Ashe, K. H. and Matsubara, J.},
  title   = {{Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease}},
  journal = {Investigative ophthalmology \& visual science},
  year    = {2008},
  doi     = {10.1167/iovs.08-1849},
  pmid    = {18566467},
  url     = {https://doi.org/10.1167/iovs.08-1849}
}

@article{town2008-18516051,
  author  = {Town, T. and Laouar, Y. and Pittenger, C. and Mori, T. and Szekely, C. A. and Tan, J. and Duman, R. S. and Flavell, R. A.},
  title   = {{Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology}},
  journal = {Nature medicine},
  year    = {2008},
  doi     = {10.1038/nm1781},
  pmid    = {18516051},
  url     = {https://doi.org/10.1038/nm1781}
}

@article{pickford2008-18497889,
  author  = {Pickford, F. and Masliah, E. and Britschgi, M. and Lucin, K. and Narasimhan, R. and Jaeger, P. A. and Small, S. and Spencer, B. and others},
  title   = {{The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci33585},
  pmid    = {18497889},
  url     = {https://doi.org/10.1172/jci33585}
}

@article{sando2008-18416843,
  author  = {Sando, S. B. and Melquist, S. and Cannon, A. and Hutton, M. L. and Sletvold, O. and Saltvedt, I. and White, L. R. and Lydersen, S. and others},
  title   = {{APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway}},
  journal = {BMC neurology},
  year    = {2008},
  doi     = {10.1186/1471-2377-8-9},
  pmid    = {18416843},
  url     = {https://doi.org/10.1186/1471-2377-8-9}
}

@article{cosentino2008-18401023,
  author  = {Cosentino, S. and Scarmeas, N. and Helzner, E. and Glymour, M. M. and Brandt, J. and Albert, M. and Blacker, D. and Stern, Y.},
  title   = {{APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000304038.37421.cc},
  pmid    = {18401023},
  url     = {https://doi.org/10.1212/01.wnl.0000304038.37421.cc}
}

@article{nichol2008-18400101,
  author  = {Nichol, K. E. and Poon, W. W. and Parachikova, A. I. and Cribbs, D. H. and Glabe, C. G. and Cotman, C. W.},
  title   = {{Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-13},
  pmid    = {18400101},
  url     = {https://doi.org/10.1186/1742-2094-5-13}
}

@article{ronnemaa2008-18401020,
  author  = {Rönnemaa, E. and Zethelius, B. and Sundelöf, J. and Sundström, J. and Degerman-Gunnarsson, M. and Berne, C. and Lannfelt, L. and Kilander, L.},
  title   = {{Impaired insulin secretion increases the risk of Alzheimer disease}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000310646.32212.3a},
  pmid    = {18401020},
  url     = {https://doi.org/10.1212/01.wnl.0000310646.32212.3a}
}

@article{lopez2008-18401021,
  author  = {Lopez, O. L. and Kuller, L. H. and Mehta, P. D. and Becker, J. T. and Gach, H. M. and Sweet, R. A. and Chang, Y. F. and Tracy, R. and others},
  title   = {{Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000306696.82017.66},
  pmid    = {18401021},
  url     = {https://doi.org/10.1212/01.wnl.0000306696.82017.66}
}

@article{donahue2008-18379441,
  author  = {Donahue, J. E. and Johanson, C. E.},
  title   = {{Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e31816a0dc8},
  pmid    = {18379441},
  url     = {https://doi.org/10.1097/nen.0b013e31816a0dc8}
}

@article{basun2008-18413473,
  author  = {Basun, H. and Bogdanovic, N. and Ingelsson, M. and Almkvist, O. and Näslund, J. and Axelman, K. and Bird, T. D. and Nochlin, D. and others},
  title   = {{Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.4.499},
  pmid    = {18413473},
  url     = {https://doi.org/10.1001/archneur.65.4.499}
}

@article{weller2008-18363936,
  author  = {Weller, R. O. and Subash, M. and Preston, S. D. and Mazanti, I. and Carare, R. O.},
  title   = {{Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2008},
  doi     = {10.1111/j.1750-3639.2008.00133.x},
  pmid    = {18363936},
  url     = {https://doi.org/10.1111/j.1750-3639.2008.00133.x}
}

@article{grimm2008-18308724,
  author  = {Grimm, M. O. and Grimm, H. S. and Tomic, I. and Beyreuther, K. and Hartmann, T. and Bergmann, C.},
  title   = {{Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m801520200},
  pmid    = {18308724},
  url     = {https://doi.org/10.1074/jbc.m801520200}
}

@article{shaftel2008-18302763,
  author  = {Shaftel, S. S. and Griffin, W. S. and O'Banion, M. K.},
  title   = {{The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective}},
  journal = {Journal of neuroinflammation},
  year    = {2008},
  doi     = {10.1186/1742-2094-5-7},
  pmid    = {18302763},
  url     = {https://doi.org/10.1186/1742-2094-5-7}
}

@article{kivipelto2008-18318693,
  author  = {Kivipelto, M. and Rovio, S. and Ngandu, T. and Kåreholt, I. and Eskelinen, M. and Winblad, B. and Hachinski, V. and Cedazo-Minguez, A. and others},
  title   = {{Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study}},
  journal = {Journal of cellular and molecular medicine},
  year    = {2008},
  doi     = {10.1111/j.1582-4934.2008.00296.x},
  pmid    = {18318693},
  url     = {https://doi.org/10.1111/j.1582-4934.2008.00296.x}
}

@article{whalley2008-18258638,
  author  = {Whalley, L. J. and Deary, I. J. and Starr, J. M. and Wahle, K. W. and Rance, K. A. and Bourne, V. J. and Fox, H. C.},
  title   = {{n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood}},
  journal = {The American journal of clinical nutrition},
  year    = {2008},
  doi     = {10.1093/ajcn/87.2.449},
  pmid    = {18258638},
  url     = {https://doi.org/10.1093/ajcn/87.2.449}
}

@article{wahrle2008-18202749,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Kim, J. and Li, A. and Knoten, A. and Jain, S. and Hirsch-Reinshagen, V. and others},
  title   = {{Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci33622},
  pmid    = {18202749},
  url     = {https://doi.org/10.1172/jci33622}
}

@article{bermejo2008-18297609,
  author  = {Bermejo, P. and Martín-Aragón, S. and Benedí, J. and Susín, C. and Felici, E. and Gil, P. and Ribera, J. M. and Villar, A. M.},
  title   = {{Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment}},
  journal = {Free radical research},
  year    = {2008},
  doi     = {10.1080/10715760701861373},
  pmid    = {18297609},
  url     = {https://doi.org/10.1080/10715760701861373}
}

@article{meyerluehmann2008-18256671,
  author  = {Meyer-Luehmann, M. and Spires-Jones, T. L. and Prada, C. and Garcia-Alloza, M. and de Calignon, A. and Rozkalne, A. and Koenigsknecht-Talboo, J. and Holtzman, D. M. and others},
  title   = {{Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease}},
  journal = {Nature},
  year    = {2008},
  doi     = {10.1038/nature06616},
  pmid    = {18256671},
  url     = {https://doi.org/10.1038/nature06616}
}

@article{liu2008-18208556,
  author  = {Liu, R. and Zhou, X. W. and Tanila, H. and Bjorkdahl, C. and Wang, J. Z. and Guan, Z. Z. and Cao, Y. and Gustafsson, J. A. and others},
  title   = {{Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology}},
  journal = {Journal of cellular and molecular medicine},
  year    = {2008},
  doi     = {10.1111/j.1582-4934.2008.00249.x},
  pmid    = {18208556},
  url     = {https://doi.org/10.1111/j.1582-4934.2008.00249.x}
}

@article{kienlencampard2008-18201969,
  author  = {Kienlen-Campard, P. and Tasiaux, B. and Van Hees, J. and Li, M. and Huysseune, S. and Sato, T. and Fei, J. Z. and Aimoto, S. and others},
  title   = {{Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m707142200},
  pmid    = {18201969},
  url     = {https://doi.org/10.1074/jbc.m707142200}
}

@article{lashley2008-18185940,
  author  = {Lashley, T. and Holton, J. L. and Gray, E. and Kirkham, K. and O'Sullivan, S. S. and Hilbig, A. and Wood, N. W. and Lees, A. J. and others},
  title   = {{Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients}},
  journal = {Acta neuropathologica},
  year    = {2008},
  doi     = {10.1007/s00401-007-0336-0},
  pmid    = {18185940},
  url     = {https://doi.org/10.1007/s00401-007-0336-0}
}

@article{reed2008-18325775,
  author  = {Reed, T. and Perluigi, M. and Sultana, R. and Pierce, W. M. and Klein, J. B. and Turner, D. M. and Coccia, R. and Markesbery, W. R. and others},
  title   = {{Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2008},
  doi     = {10.1016/j.nbd.2007.12.007},
  pmid    = {18325775},
  url     = {https://doi.org/10.1016/j.nbd.2007.12.007}
}

@article{irie2008-18195144,
  author  = {Irie, F. and Fitzpatrick, A. L. and Lopez, O. L. and Kuller, L. H. and Peila, R. and Newman, A. B. and Launer, L. J.},
  title   = {{Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneurol.2007.29},
  pmid    = {18195144},
  url     = {https://doi.org/10.1001/archneurol.2007.29}
}

@article{takeuchi2008-18473848,
  author  = {Takeuchi, M. and Yamagishi, S.},
  title   = {{Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease}},
  journal = {Current pharmaceutical design},
  year    = {2008},
  doi     = {10.2174/138161208784139693},
  pmid    = {18473848},
  url     = {https://doi.org/10.2174/138161208784139693}
}

@article{wang2008-18234899,
  author  = {Wang, W. X. and Rajeev, B. W. and Stromberg, A. J. and Ren, N. and Tang, G. and Huang, Q. and Rigoutsos, I. and Nelson, P. T.},
  title   = {{The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.5065-07.2008},
  pmid    = {18234899},
  url     = {https://doi.org/10.1523/jneurosci.5065-07.2008}
}

@article{li2008-17998437,
  author  = {Li, H. and Wetten, S. and Li, L. and St Jean, P. L. and Upmanyu, R. and Surh, L. and Hosford, D. and Barnes, M. R. and others},
  title   = {{Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneurol.2007.3},
  pmid    = {17998437},
  url     = {https://doi.org/10.1001/archneurol.2007.3}
}

@article{page2008-17962197,
  author  = {Page, R. M. and Baumann, K. and Tomioka, M. and Pérez-Revuelta, B. I. and Fukumori, A. and Jacobsen, H. and Flohr, A. and Luebbers, T. and others},
  title   = {{Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m708754200},
  pmid    = {17962197},
  url     = {https://doi.org/10.1074/jbc.m708754200}
}

@article{caselli2007-17846270,
  author  = {Caselli, R. J. and Reiman, E. M. and Locke, D. E. and Hutton, M. L. and Hentz, J. G. and Hoffman-Snyder, C. and Woodruff, B. K. and Alexander, G. E. and others},
  title   = {{Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.9.1306},
  pmid    = {17846270},
  url     = {https://doi.org/10.1001/archneur.64.9.1306}
}

@article{burns2007-17846409,
  author  = {Burns, J. M. and Donnelly, J. E. and Anderson, H. S. and Mayo, M. S. and Spencer-Gardner, L. and Thomas, G. and Cronk, B. B. and Haddad, Z. and others},
  title   = {{Peripheral insulin and brain structure in early Alzheimer disease}},
  journal = {Neurology},
  year    = {2007},
  doi     = {10.1212/01.wnl.0000276952.91704.af},
  pmid    = {17846409},
  url     = {https://doi.org/10.1212/01.wnl.0000276952.91704.af}
}

@article{weissman2007-17704129,
  author  = {Weissman, L. and Jo, D. G. and Sørensen, M. M. and de Souza-Pinto, N. C. and Markesbery, W. R. and Mattson, M. P. and Bohr, V. A.},
  title   = {{Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment}},
  journal = {Nucleic acids research},
  year    = {2007},
  doi     = {10.1093/nar/gkm605},
  pmid    = {17704129},
  url     = {https://doi.org/10.1093/nar/gkm605}
}

@article{butterfield2007-17851195,
  author  = {Butterfield, D. A. and Sultana, R.},
  title   = {{Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2007},
  doi     = {10.3233/jad-2007-12107},
  pmid    = {17851195},
  url     = {https://doi.org/10.3233/jad-2007-12107}
}

@article{hemming2007-17760499,
  author  = {Hemming, M. L. and Patterson, M. and Reske-Nielsen, C. and Lin, L. and Isacson, O. and Selkoe, D. J.},
  title   = {{Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2007},
  doi     = {10.1371/journal.pmed.0040262},
  pmid    = {17760499},
  url     = {https://doi.org/10.1371/journal.pmed.0040262}
}

@article{marutle2007-17640880,
  author  = {Marutle, A. and Ohmitsu, M. and Nilbratt, M. and Greig, N. H. and Nordberg, A. and Sugaya, K.},
  title   = {{Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0705346104},
  pmid    = {17640880},
  url     = {https://doi.org/10.1073/pnas.0705346104}
}

@article{mcconlogue2007-17616527,
  author  = {McConlogue, L. and Buttini, M. and Anderson, J. P. and Brigham, E. F. and Chen, K. S. and Freedman, S. B. and Games, D. and Johnson-Wood, K. and others},
  title   = {{Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611687200},
  pmid    = {17616527},
  url     = {https://doi.org/10.1074/jbc.m611687200}
}

@article{hooijmans2007-17720508,
  author  = {Hooijmans, C. R. and Rutters, F. and Dederen, P. J. and Gambarota, G. and Veltien, A. and van Groen, T. and Broersen, L. M. and Lütjohann, D. and others},
  title   = {{Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)}},
  journal = {Neurobiology of disease},
  year    = {2007},
  doi     = {10.1016/j.nbd.2007.06.007},
  pmid    = {17720508},
  url     = {https://doi.org/10.1016/j.nbd.2007.06.007}
}

@article{yin2007-17556361,
  author  = {Yin, Y. I. and Bassit, B. and Zhu, L. and Yang, X. and Wang, C. and Li, Y. M.},
  title   = {{gamma-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m704601200},
  pmid    = {17556361},
  url     = {https://doi.org/10.1074/jbc.m704601200}
}

@article{jankowsky2007-17556372,
  author  = {Jankowsky, J. L. and Younkin, L. H. and Gonzales, V. and Fadale, D. J. and Slunt, H. H. and Lester, H. A. and Younkin, S. G. and Borchelt, D. R.},
  title   = {{Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611050200},
  pmid    = {17556372},
  url     = {https://doi.org/10.1074/jbc.m611050200}
}

@article{cheng2007-17548355,
  author  = {Cheng, I. H. and Scearce-Levie, K. and Legleiter, J. and Palop, J. J. and Gerstein, H. and Bien-Ly, N. and Puoliväli, J. and Lesné, S. and others},
  title   = {{Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m701078200},
  pmid    = {17548355},
  url     = {https://doi.org/10.1074/jbc.m701078200}
}

@article{kemppainen2007-17485647,
  author  = {Kemppainen, N. M. and Aalto, S. and Wilson, I. A. and Någren, K. and Helin, S. and Brück, A. and Oikonen, V. and Kailajärvi, M. and others},
  title   = {{PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment}},
  journal = {Neurology},
  year    = {2007},
  doi     = {10.1212/01.wnl.0000260969.94695.56},
  pmid    = {17485647},
  url     = {https://doi.org/10.1212/01.wnl.0000260969.94695.56}
}

@article{scheff2007-17470753,
  author  = {Scheff, S. W. and Price, D. A. and Schmitt, F. A. and DeKosky, S. T. and Mufson, E. J.},
  title   = {{Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment}},
  journal = {Neurology},
  year    = {2007},
  doi     = {10.1212/01.wnl.0000260698.46517.8f},
  pmid    = {17470753},
  url     = {https://doi.org/10.1212/01.wnl.0000260698.46517.8f}
}

@article{vingtdeux2007-17468104,
  author  = {Vingtdeux, V. and Hamdane, M. and Loyens, A. and Gelé, P. and Drobeck, H. and Bégard, S. and Galas, M. C. and Delacourte, A. and others},
  title   = {{Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m609475200},
  pmid    = {17468104},
  url     = {https://doi.org/10.1074/jbc.m609475200}
}

@article{yu2007-17434289,
  author  = {Yu, C. E. and Seltman, H. and Peskind, E. R. and Galloway, N. and Zhou, P. X. and Rosenthal, E. and Wijsman, E. M. and Tsuang, D. W. and others},
  title   = {{Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association}},
  journal = {Genomics},
  year    = {2007},
  doi     = {10.1016/j.ygeno.2007.02.002},
  pmid    = {17434289},
  url     = {https://doi.org/10.1016/j.ygeno.2007.02.002}
}

@article{nelson2007-17431506,
  author  = {Nelson, O. and Tu, H. and Lei, T. and Bentahir, M. and de Strooper, B. and Bezprozvanny, I.},
  title   = {{Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci30447},
  pmid    = {17431506},
  url     = {https://doi.org/10.1172/jci30447}
}

@article{dekosky2007-17420316,
  author  = {DeKosky, S. T. and Abrahamson, E. E. and Ciallella, JR. and Paljug, W. R. and Wisniewski, SR. and Clark, R. S. and Ikonomovic, M. D.},
  title   = {{Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.4.541},
  pmid    = {17420316},
  url     = {https://doi.org/10.1001/archneur.64.4.541}
}

@article{finch2007-17430245,
  author  = {Finch, C. E. and Morgan, T. E.},
  title   = {{Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper}},
  journal = {Current Alzheimer research},
  year    = {2007},
  doi     = {10.2174/156720507780362254},
  pmid    = {17430245},
  url     = {https://doi.org/10.2174/156720507780362254}
}

@article{lee2007-17420311,
  author  = {Lee, J. H. and Cheng, R. and Schupf, N. and Manly, J. and Lantigua, R. and Stern, Y. and Rogaeva, E. and Wakutani, Y. and others},
  title   = {{The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.4.501},
  pmid    = {17420311},
  url     = {https://doi.org/10.1001/archneur.64.4.501}
}

@article{elkhoury2007-17351623,
  author  = {El Khoury, J. and Toft, M. and Hickman, S. E. and Means, T. K. and Terada, K. and Geula, C. and Luster, A. D.},
  title   = {{Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease}},
  journal = {Nature medicine},
  year    = {2007},
  doi     = {10.1038/nm1555},
  pmid    = {17351623},
  url     = {https://doi.org/10.1038/nm1555}
}

@article{butterfield2007-17395167,
  author  = {Butterfield, D. A. and Reed, T. T. and Perluigi, M. and De Marco, C. and Coccia, R. and Keller, J. N. and Markesbery, W. R. and Sultana, R.},
  title   = {{Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease}},
  journal = {Brain research},
  year    = {2007},
  doi     = {10.1016/j.brainres.2007.02.084},
  pmid    = {17395167},
  url     = {https://doi.org/10.1016/j.brainres.2007.02.084}
}

@article{graffradford2007-17353377,
  author  = {Graff-Radford, N. R. and Crook, J. E. and Lucas, J. and Boeve, B. F. and Knopman, D. S. and Ivnik, R. J. and Smith, G. E. and Younkin, L. H. and others},
  title   = {{Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.3.354},
  pmid    = {17353377},
  url     = {https://doi.org/10.1001/archneur.64.3.354}
}

@article{flanary2007-17378753,
  author  = {Flanary, B. E. and Sammons, N. W. and Nguyen, C. and Walker, D. and Streit, W. J.},
  title   = {{Evidence that aging and amyloid promote microglial cell senescence}},
  journal = {Rejuvenation research},
  year    = {2007},
  doi     = {10.1089/rej.2006.9096},
  pmid    = {17378753},
  url     = {https://doi.org/10.1089/rej.2006.9096}
}

@article{majumdar2007-17314396,
  author  = {Majumdar, A. and Cruz, D. and Asamoah, N. and Buxbaum, A. and Sohar, I. and Lobel, P. and Maxfield, F. R.},
  title   = {{Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils}},
  journal = {Molecular biology of the cell},
  year    = {2007},
  doi     = {10.1091/mbc.e06-10-0975},
  pmid    = {17314396},
  url     = {https://doi.org/10.1091/mbc.e06-10-0975}
}

@article{ponomareva2008-17293007,
  author  = {Ponomareva, N. V. and Korovaitseva, G. I. and Rogaev, E. I.},
  title   = {{EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease}},
  journal = {Neurobiology of aging},
  year    = {2008},
  doi     = {10.1016/j.neurobiolaging.2006.12.019},
  pmid    = {17293007},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.12.019}
}

@article{leroy2007-17239007,
  author  = {Leroy, K. and Yilmaz, Z. and Brion, J. P.},
  title   = {{Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2007},
  doi     = {10.1111/j.1365-2990.2006.00795.x},
  pmid    = {17239007},
  url     = {https://doi.org/10.1111/j.1365-2990.2006.00795.x}
}

@article{destrooper2007-17268505,
  author  = {De Strooper, B.},
  title   = {{Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2007},
  doi     = {10.1038/sj.embor.7400897},
  pmid    = {17268505},
  url     = {https://doi.org/10.1038/sj.embor.7400897}
}

@article{haass2007-17245412,
  author  = {Haass, Christian and Selkoe, Dennis J.},
  title   = {{Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide}},
  journal = {Nature Reviews Molecular Cell Biology},
  year    = {2007},
  doi     = {10.1038/nrm2101},
  pmid    = {17245412},
  url     = {https://doi.org/10.1038/nrm2101}
}

@article{wegiel2007-17237937,
  author  = {Wegiel, J. and Kuchna, I. and Nowicki, K. and Frackowiak, J. and Mazur-Kolecka, B. and Imaki, H. and Mehta, P. D. and others},
  title   = {{Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration}},
  journal = {Acta neuropathologica},
  year    = {2007},
  doi     = {10.1007/s00401-006-0191-4},
  pmid    = {17237937},
  url     = {https://doi.org/10.1007/s00401-006-0191-4}
}

@article{rogaeva2007-17220890,
  author  = {Rogaeva, E. and Meng, Y. and Lee, J. H. and Gu, Y. and Kawarai, T. and Zou, F. and Katayama, T. and Baldwin, C. T. and others},
  title   = {{The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease}},
  journal = {Nature genetics},
  year    = {2007},
  doi     = {10.1038/ng1943},
  pmid    = {17220890},
  url     = {https://doi.org/10.1038/ng1943}
}

@article{walter2007-17982277,
  author  = {Walter, S. and Letiembre, M. and Liu, Y. and Heine, H. and Penke, B. and Hao, W. and Bode, B. and Manietta, N. and others},
  title   = {{Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease}},
  journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year    = {2007},
  doi     = {10.1159/000110455},
  pmid    = {17982277},
  url     = {https://doi.org/10.1159/000110455}
}

@article{wu2006-17167099,
  author  = {Wu, Y. and Wu, Z. and Butko, P. and Christen, Y. and Lambert, M. P. and Klein, W. L. and Link, C. D. and Luo, Y.},
  title   = {{Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3448-06.2006},
  pmid    = {17167099},
  url     = {https://doi.org/10.1523/jneurosci.3448-06.2006}
}

@article{townsend2006-17192927,
  author  = {Townsend, M. and Cleary, J. P. and Mehta, T. and Hofmeister, J. and Lesne, S. and O'Hare, E. and Walsh, D. M. and Selkoe, D. J.},
  title   = {{Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers}},
  journal = {Annals of neurology},
  year    = {2006},
  doi     = {10.1002/ana.21051},
  pmid    = {17192927},
  url     = {https://doi.org/10.1002/ana.21051}
}

@article{wilkinson2006-17094809,
  author  = {Wilkinson, B. L. and Landreth, G. E.},
  title   = {{The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-30},
  pmid    = {17094809},
  url     = {https://doi.org/10.1186/1742-2094-3-30}
}

@article{muller2007-17093061,
  author  = {Müller, T. and Concannon, C. G. and Ward, M. W. and Walsh, C. M. and Tirniceriu, A. L. and Tribl, F. and Kögel, D. and Prehn, J. H. and others},
  title   = {{Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)}},
  journal = {Molecular biology of the cell},
  year    = {2007},
  doi     = {10.1091/mbc.e06-04-0283},
  pmid    = {17093061},
  url     = {https://doi.org/10.1091/mbc.e06-04-0283}
}

@article{sultana2006-17034347,
  author  = {Sultana, R. and Perluigi, M. and Butterfield, D. A.},
  title   = {{Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics}},
  journal = {Antioxidants \& redox signaling},
  year    = {2006},
  doi     = {10.1089/ars.2006.8.2021},
  pmid    = {17034347},
  url     = {https://doi.org/10.1089/ars.2006.8.2021}
}

@article{garciaalloza2006-17029828,
  author  = {Garcia-Alloza, M. and Robbins, E. M. and Zhang-Nunes, S. X. and Purcell, S. M. and Betensky, R. A. and Raju, S. and Prada, C. and Greenberg, S. M. and others},
  title   = {{Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.08.017},
  pmid    = {17029828},
  url     = {https://doi.org/10.1016/j.nbd.2006.08.017}
}

@article{oakley2006-17021169,
  author  = {Oakley, Holly D. and Cole, Sarah L. and Logan, Sreemathi and Maus, Erika and Shao, Pei and Craft, Jeffery and Guillozet-Bongaarts, Angela L. and Ohno, Masuo and others},
  title   = {{Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation}},
  journal = {Journal of Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.1202-06.2006},
  pmid    = {17021169},
  url     = {https://doi.org/10.1523/jneurosci.1202-06.2006}
}

@article{carrasco2006-17027170,
  author  = {Carrasco, J. and Adlard, P. and Cotman, C. and Quintana, A. and Penkowa, M. and Xu, F. and Van Nostrand, W. E. and Hidalgo, J.},
  title   = {{Metallothionein-I and -III expression in animal models of Alzheimer disease}},
  journal = {Neuroscience},
  year    = {2006},
  doi     = {10.1016/j.neuroscience.2006.08.054},
  pmid    = {17027170},
  url     = {https://doi.org/10.1016/j.neuroscience.2006.08.054}
}

@article{miners2006-17021406,
  author  = {Miners, J. S. and Van Helmond, Z. and Chalmers, K. and Wilcock, G. and Love, S. and Kehoe, P. G.},
  title   = {{Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000240463.87886.9a},
  pmid    = {17021406},
  url     = {https://doi.org/10.1097/01.jnen.0000240463.87886.9a}
}

@article{gronwall2007-17088007,
  author  = {Grönwall, C. and Jonsson, A. and Lindström, S. and Gunneriusson, E. and Ståhl, S. and Herne, N.},
  title   = {{Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides}},
  journal = {Journal of biotechnology},
  year    = {2007},
  doi     = {10.1016/j.jbiotec.2006.09.013},
  pmid    = {17088007},
  url     = {https://doi.org/10.1016/j.jbiotec.2006.09.013}
}

@article{dai2006-16945610,
  author  = {Dai, Q. and Borenstein, A. R. and Wu, Y. and Jackson, J. C. and Larson, E. B.},
  title   = {{Fruit and vegetable juices and Alzheimer's disease: the Kame Project}},
  journal = {The American journal of medicine},
  year    = {2006},
  doi     = {10.1016/j.amjmed.2006.03.045},
  pmid    = {16945610},
  url     = {https://doi.org/10.1016/j.amjmed.2006.03.045}
}

@article{dodson2006-16957580,
  author  = {Dodson, S. E. and Gearing, M. and Lippa, C. F. and Montine, T. J. and Levey, A. I. and Lah, J. J.},
  title   = {{LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000228205.19915.20},
  pmid    = {16957580},
  url     = {https://doi.org/10.1097/01.jnen.0000228205.19915.20}
}

@article{sleegers2006-16921174,
  author  = {Sleegers, K. and Brouwers, N. and Gijselinck, I. and Theuns, J. and Goossens, D. and Wauters, J. and Del-Favero, J. and Cruts, M. and others},
  title   = {{APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy}},
  journal = {Brain : a journal of neurology},
  year    = {2006},
  doi     = {10.1093/brain/awl203},
  pmid    = {16921174},
  url     = {https://doi.org/10.1093/brain/awl203}
}

@article{honig2006-16807921,
  author  = {Honig, L. S. and Schupf, N. and Lee, J. H. and Tang, M. X. and Mayeux, R.},
  title   = {{Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia}},
  journal = {Annals of neurology},
  year    = {2006},
  doi     = {10.1002/ana.20894},
  pmid    = {16807921},
  url     = {https://doi.org/10.1002/ana.20894}
}

@article{peskind2006-16831961,
  author  = {Peskind, E. R. and Li, G. and Shofer, J. and Quinn, J. F. and Kaye, J. A. and Clark, C. M. and Farlow, M. R. and DeCarli, C. and others},
  title   = {{Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.7.936},
  pmid    = {16831961},
  url     = {https://doi.org/10.1001/archneur.63.7.936}
}

@article{kumarsingh2006-16752394,
  author  = {Kumar-Singh, S. and Theuns, J. and Van Broeck, B. and Pirici, D. and Vennekens, K. and Corsmit, E. and Cruts, M. and others},
  title   = {{Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40}},
  journal = {Human mutation},
  year    = {2006},
  doi     = {10.1002/humu.20336},
  pmid    = {16752394},
  url     = {https://doi.org/10.1002/humu.20336}
}

@article{boekhoorn2006-16814555,
  author  = {Boekhoorn, K. and Joels, M. and Lucassen, P. J.},
  title   = {{Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.04.017},
  pmid    = {16814555},
  url     = {https://doi.org/10.1016/j.nbd.2006.04.017}
}

@article{bateman2006-16799555,
  author  = {Bateman, R. J. and Munsell, L. Y. and Morris, J. C. and Swarm, R. and Yarasheski, K. E. and Holtzman, D. M.},
  title   = {{Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo}},
  journal = {Nature medicine},
  year    = {2006},
  doi     = {10.1038/nm1438},
  pmid    = {16799555},
  url     = {https://doi.org/10.1038/nm1438}
}

@article{gotz2006-16787410,
  author  = {Götz, J. and Ittner, L. M. and Kins, S.},
  title   = {{Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2006.03955.x},
  pmid    = {16787410},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.03955.x}
}

@article{qin2006-16751189,
  author  = {Qin, W. and Yang, T. and Ho, L. and Zhao, Z. and Wang, J. and Chen, L. and Zhao, W. and Thiyagarajan, M. and others},
  title   = {{Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602909200},
  pmid    = {16751189},
  url     = {https://doi.org/10.1074/jbc.m602909200}
}

@article{sokol2006-16948926,
  author  = {Sokol, D. K. and Chen, D. and Farlow, M. R. and Dunn, D. W. and Maloney, B. and Zimmer, J. A. and Lahiri, D. K.},
  title   = {{High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression}},
  journal = {Journal of child neurology},
  year    = {2006},
  doi     = {10.1177/08830738060210062201},
  pmid    = {16948926},
  url     = {https://doi.org/10.1177/08830738060210062201}
}

@article{ding2006-16770743,
  author  = {Ding, Q. and Markesbery, W. R. and Cecarini, V. and Keller, J. N.},
  title   = {{Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease}},
  journal = {Neurochemical research},
  year    = {2006},
  doi     = {10.1007/s11064-006-9071-5},
  pmid    = {16770743},
  url     = {https://doi.org/10.1007/s11064-006-9071-5}
}

@article{beeri2006-16682673,
  author  = {Beeri, M. S. and Rapp, M. and Silverman, J. M. and Schmeidler, J. and Grossman, H. T. and Fallon, J. T. and Purohit, D. P. and Perl, D. P. and others},
  title   = {{Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000210447.19748.0b},
  pmid    = {16682673},
  url     = {https://doi.org/10.1212/01.wnl.0000210447.19748.0b}
}

@article{johnson2006-16738250,
  author  = {Johnson, S. C. and Schmitz, T. W. and Trivedi, M. A. and Ries, M. L. and Torgerson, B. M. and Carlsson, C. M. and Asthana, S. and Hermann, B. P. and others},
  title   = {{The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.0959-06.2006},
  pmid    = {16738250},
  url     = {https://doi.org/10.1523/jneurosci.0959-06.2006}
}

@article{white2006-16648635,
  author  = {White, A. R. and Du, T. and Laughton, K. M. and Volitakis, I. and Sharples, R. A. and Xilinas, M. E. and Hoke, D. E. and Holsinger, R. M. and others},
  title   = {{Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602487200},
  pmid    = {16648635},
  url     = {https://doi.org/10.1074/jbc.m602487200}
}

@article{galvan2006-16641106,
  author  = {Galvan, V. and Gorostiza, O. F. and Banwait, S. and Ataie, M. and Logvinova, A. V. and Sitaraman, S. and Carlson, E. and Sagi, S. A. and others},
  title   = {{Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0509695103},
  pmid    = {16641106},
  url     = {https://doi.org/10.1073/pnas.0509695103}
}

@article{theuns2006-16685645,
  author  = {Theuns, J. and Brouwers, N. and Engelborghs, S. and Sleegers, K. and Bogaerts, V. and Corsmit, E. and De Pooter, T. and van Duijn, C. M. and others},
  title   = {{Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2006},
  doi     = {10.1086/504044},
  pmid    = {16685645},
  url     = {https://doi.org/10.1086/504044}
}

@article{persson2006-16606914,
  author  = {Persson, J. and Lind, J. and Larsson, A. and Ingvar, M. and Cruts, M. and Van Broeckhoven, C. and Adolfsson, R. and Nilsson, L. G. and others},
  title   = {{Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000204180.25361.48},
  pmid    = {16606914},
  url     = {https://doi.org/10.1212/01.wnl.0000204180.25361.48}
}

@article{nordberg2006-16772751,
  author  = {Nordberg, A.},
  title   = {{Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2006},
  doi     = {10.1097/01.wad.0000213804.59187.2d},
  pmid    = {16772751},
  url     = {https://doi.org/10.1097/01.wad.0000213804.59187.2d}
}

@article{griffin2006-16542445,
  author  = {Griffin, W. S. and Liu, L. and Li, Y. and Mrak, R. E. and Barger, S. W.},
  title   = {{Interleukin-1 mediates Alzheimer and Lewy body pathologies}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-5},
  pmid    = {16542445},
  url     = {https://doi.org/10.1186/1742-2094-3-5}
}

@article{vonkanel2006-16551309,
  author  = {von Känel, R. and Dimsdale, J. E. and Ancoli-Israel, S. and Mills, P. J. and Patterson, T. L. and McKibbin, C. L. and Archuleta, C. and Grant, I.},
  title   = {{Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's disease}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2006},
  doi     = {10.1111/j.1532-5415.2005.00642.x},
  pmid    = {16551309},
  url     = {https://doi.org/10.1111/j.1532-5415.2005.00642.x}
}

@article{butterfield2006-16466929,
  author  = {Butterfield, D. A. and Poon, H. F. and St Clair, D. and Keller, J. N. and Pierce, W. M. and Klein, J. B. and Markesbery, W. R.},
  title   = {{Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2005.11.002},
  pmid    = {16466929},
  url     = {https://doi.org/10.1016/j.nbd.2005.11.002}
}

@article{park2006-16452662,
  author  = {Park, J. H. and Gimbel, D. A. and GrandPre, T. and Lee, J. K. and Kim, J. E. and Li, W. and Lee, D. H. and Strittmatter, S. M.},
  title   = {{Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3291-05.2006},
  pmid    = {16452662},
  url     = {https://doi.org/10.1523/jneurosci.3291-05.2006}
}

@article{simard2006-16476660,
  author  = {Simard, Alain R. and Soulet, Denis and Gowing, Genevíève and Julien, Jean-Pierre and Rivest, Serge},
  title   = {{Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease}},
  journal = {Neuron},
  year    = {2006},
  doi     = {10.1016/j.neuron.2006.01.022},
  pmid    = {16476660},
  url     = {https://doi.org/10.1016/j.neuron.2006.01.022}
}

@article{heneka2006-16452658,
  author  = {Heneka, M. T. and Ramanathan, M. and Jacobs, A. H. and Dumitrescu-Ozimek, L. and Bilkei-Gorzo, A. and Debeir, T. and Sastre, M. and Galldiks, N. and others},
  title   = {{Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.4236-05.2006},
  pmid    = {16452658},
  url     = {https://doi.org/10.1523/jneurosci.4236-05.2006}
}

@article{kojro2006-16401644,
  author  = {Kojro, E. and Postina, R. and Buro, C. and Meiringer, C. and Gehrig-Burger, K. and Fahrenholz, F.},
  title   = {{The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2006},
  doi     = {10.1096/fj.05-4812fje},
  pmid    = {16401644},
  url     = {https://doi.org/10.1096/fj.05-4812fje}
}

@article{vetrivel2006-16432149,
  author  = {Vetrivel, K. S. and Thinakaran, G.},
  title   = {{Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000192107.17175.39},
  pmid    = {16432149},
  url     = {https://doi.org/10.1212/01.wnl.0000192107.17175.39}
}

@article{bartzokis2006-16389198,
  author  = {Bartzokis, G. and Lu, P. H. and Geschwind, D. H. and Edwards, N. and Mintz, J. and Cummings, J. L.},
  title   = {{Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia}},
  journal = {Archives of general psychiatry},
  year    = {2006},
  doi     = {10.1001/archpsyc.63.1.63},
  pmid    = {16389198},
  url     = {https://doi.org/10.1001/archpsyc.63.1.63}
}

@article{hall2006-16434658,
  author  = {Hall, K. and Murrell, J. and Ogunniyi, A. and Deeg, M. and Baiyewu, O. and Gao, S. and Gureje, O. and Dickens, J. and others},
  title   = {{Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000194507.39504.17},
  pmid    = {16434658},
  url     = {https://doi.org/10.1212/01.wnl.0000194507.39504.17}
}

@article{gurol2006-16401840,
  author  = {Gurol, M. E. and Irizarry, M. C. and Smith, E. E. and Raju, S. and Diaz-Arrastia, R. and Bottiglieri, T. and Rosand, J. and Growdon, J. H. and others},
  title   = {{Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000191403.95453.6a},
  pmid    = {16401840},
  url     = {https://doi.org/10.1212/01.wnl.0000191403.95453.6a}
}

@article{zhangnunes2006-16612980,
  author  = {Zhang-Nunes, S. X. and Maat-Schieman, M. L. and van Duinen, S. G. and Roos, R. A. and Frosch, M. P. and Greenberg, S. M.},
  title   = {{The cerebral beta-amyloid angiopathies: hereditary and sporadic}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2006},
  doi     = {10.1111/j.1750-3639.2006.tb00559.x},
  pmid    = {16612980},
  url     = {https://doi.org/10.1111/j.1750-3639.2006.tb00559.x}
}

@article{roveletlecrux2006-16369530,
  author  = {Rovelet-Lecrux, A. and Hannequin, D. and Raux, G. and Le Meur, N. and Laquerrière, A. and Vital, A. and Dumanchin, C. and Feuillette, S. and others},
  title   = {{APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy}},
  journal = {Nature genetics},
  year    = {2006},
  doi     = {10.1038/ng1718},
  pmid    = {16369530},
  url     = {https://doi.org/10.1038/ng1718}
}

@article{chen2006-16339765,
  author  = {Chen, K. and Iribarren, P. and Hu, J. and Chen, J. and Gong, W. and Cho, E. H. and Lockett, S. and Dunlop, N. M. and others},
  title   = {{Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m508125200},
  pmid    = {16339765},
  url     = {https://doi.org/10.1074/jbc.m508125200}
}

@article{martins2005-16380608,
  author  = {Martins, C. A. and Oulhaj, A. and de Jager, C. A. and Williams, J. H.},
  title   = {{APOE alleles predict the rate of cognitive decline in Alzheimer disease: a nonlinear model}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000188871.74093.12},
  pmid    = {16380608},
  url     = {https://doi.org/10.1212/01.wnl.0000188871.74093.12}
}

@article{snider2005-16344340,
  author  = {Snider, B. J. and Norton, J. and Coats, M. A. and Chakraverty, S. and Hou, C. E. and Jervis, R. and Lendon, C. L. and Goate, A. M. and others},
  title   = {{Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.12.1821},
  pmid    = {16344340},
  url     = {https://doi.org/10.1001/archneur.62.12.1821}
}

@article{reddy2006-16305625,
  author  = {Reddy, P. H.},
  title   = {{Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2005.03530.x},
  pmid    = {16305625},
  url     = {https://doi.org/10.1111/j.1471-4159.2005.03530.x}
}

@article{jankowsky2005-16279840,
  author  = {Jankowsky, J. L. and Slunt, H. H. and Gonzales, V. and Savonenko, A. V. and Wen, J. C. and Jenkins, N. A. and Copeland, N. G. and Younkin, L. H. and others},
  title   = {{Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease}},
  journal = {PLoS medicine},
  year    = {2005},
  doi     = {10.1371/journal.pmed.0020355},
  pmid    = {16279840},
  url     = {https://doi.org/10.1371/journal.pmed.0020355}
}

@article{emanuele2005-16286548,
  author  = {Emanuele, E. and D'Angelo, A. and Tomaino, C. and Binetti, G. and Ghidoni, R. and Politi, P. and Bernardi, L. and Maletta, R. and others},
  title   = {{Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.11.1734},
  pmid    = {16286548},
  url     = {https://doi.org/10.1001/archneur.62.11.1734}
}

@article{cirrito2005-16239972,
  author  = {Cirrito, JR. and Deane, R. and Fagan, A. M. and Spinner, M. L. and Parsadanian, M. and Finn, M. B. and Jiang, H. and Prior, J. L. and others},
  title   = {{P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci25247},
  pmid    = {16239972},
  url     = {https://doi.org/10.1172/jci25247}
}

@article{wahrle2005-16207708,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.},
  title   = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508780200},
  pmid    = {16207708},
  url     = {https://doi.org/10.1074/jbc.m508780200}
}

@article{koldamova2005-16207713,
  author  = {Koldamova, R. and Staufenbiel, M. and Lefterov, I.},
  title   = {{Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m504513200},
  pmid    = {16207713},
  url     = {https://doi.org/10.1074/jbc.m504513200}
}

@article{hirschreinshagen2005-16207707,
  author  = {Hirsch-Reinshagen, V. and Maia, L. F. and Burgess, B. L. and Blain, J. F. and Naus, K. E. and McIsaac, S. A. and Parkinson, P. F. and Chan, J. Y. and others},
  title   = {{The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508781200},
  pmid    = {16207707},
  url     = {https://doi.org/10.1074/jbc.m508781200}
}

@article{leblanc2005-16248844,
  author  = {LeBlanc, A. C.},
  title   = {{The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death}},
  journal = {Current Alzheimer research},
  year    = {2005},
  doi     = {10.2174/156720505774330573},
  pmid    = {16248844},
  url     = {https://doi.org/10.2174/156720505774330573}
}

@article{hemming2005-16154999,
  author  = {Hemming, M. L. and Selkoe, D. J.},
  title   = {{Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508460200},
  pmid    = {16154999},
  url     = {https://doi.org/10.1074/jbc.m508460200}
}

@article{morgan2005-16141783,
  author  = {Morgan, D. and Gordon, M. N. and Tan, J. and Wilcock, D. and Rojiani, A. M.},
  title   = {{Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1097/01.jnen.0000178444.33972.e0},
  pmid    = {16141783},
  url     = {https://doi.org/10.1097/01.jnen.0000178444.33972.e0}
}

@article{singer2005-16136043,
  author  = {Singer, O. and Marr, R. A. and Rockenstein, E. and Crews, L. and Coufal, N. G. and Gage, F. H. and Verma, I. M. and Masliah, E.},
  title   = {{Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model}},
  journal = {Nature neuroscience},
  year    = {2005},
  doi     = {10.1038/nn1531},
  pmid    = {16136043},
  url     = {https://doi.org/10.1038/nn1531}
}

@article{hatters2005-16076841,
  author  = {Hatters, D. M. and Budamagunta, M. S. and Voss, J. C. and Weisgraber, K. H.},
  title   = {{Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m506044200},
  pmid    = {16076841},
  url     = {https://doi.org/10.1074/jbc.m506044200}
}

@article{fotinopoulou2005-16027166,
  author  = {Fotinopoulou, A. and Tsachaki, M. and Vlavaki, M. and Poulopoulos, A. and Rostagno, A. and Frangione, B. and Ghiso, J. and Efthimiopoulos, S.},
  title   = {{BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.c500231200},
  pmid    = {16027166},
  url     = {https://doi.org/10.1074/jbc.c500231200}
}

@article{snyder2005-16025111,
  author  = {Snyder, E. M. and Nong, Y. and Almeida, C. G. and Paul, S. and Moran, T. and Choi, E. Y. and Nairn, A. C. and Salter, M. W. and others},
  title   = {{Regulation of NMDA receptor trafficking by amyloid-beta}},
  journal = {Nature neuroscience},
  year    = {2005},
  doi     = {10.1038/nn1503},
  pmid    = {16025111},
  url     = {https://doi.org/10.1038/nn1503}
}

@article{kelly2005-16002400,
  author  = {Kelly, B. L. and Vassar, R. and Ferreira, A.},
  title   = {{Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m503259200},
  pmid    = {16002400},
  url     = {https://doi.org/10.1074/jbc.m503259200}
}

@article{williams2006-15993986,
  author  = {Williams, T. I. and Lynn, B. C. and Markesbery, W. R. and Lovell, M. A.},
  title   = {{Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.06.004},
  pmid    = {15993986},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.06.004}
}

@article{matsuda2005-15983050,
  author  = {Matsuda, S. and Giliberto, L. and Matsuda, Y. and Davies, P. and McGowan, E. and Pickford, F. and Ghiso, J. and Frangione, B. and others},
  title   = {{The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.c500217200},
  pmid    = {15983050},
  url     = {https://doi.org/10.1074/jbc.c500217200}
}

@article{sultana2006-15950321,
  author  = {Sultana, R. and Boyd-Kimball, D. and Poon, H. F. and Cai, J. and Pierce, W. M. and Klein, J. B. and Markesbery, W. R. and Zhou, X. Z. and others},
  title   = {{Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.05.005},
  pmid    = {15950321},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.05.005}
}

@article{reiman2005-15932949,
  author  = {Reiman, E. M. and Chen, K. and Alexander, G. E. and Caselli, R. J. and Bandy, D. and Osborne, D. and Saunders, A. M. and Hardy, J.},
  title   = {{Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0500579102},
  pmid    = {15932949},
  url     = {https://doi.org/10.1073/pnas.0500579102}
}

@article{schliebs2005-16187224,
  author  = {Schliebs, R.},
  title   = {{Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling}},
  journal = {Neurochemical research},
  year    = {2005},
  doi     = {10.1007/s11064-005-6962-9},
  pmid    = {16187224},
  url     = {https://doi.org/10.1007/s11064-005-6962-9}
}

@article{devanand2005-15956169,
  author  = {Devanand, D. P. and Pelton, G. H. and Zamora, D. and Liu, X. and Tabert, M. H. and Goodkind, M. and Scarmeas, N. and Braun, I. and others},
  title   = {{Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.6.975},
  pmid    = {15956169},
  url     = {https://doi.org/10.1001/archneur.62.6.975}
}

@article{dufouil2005-15883313,
  author  = {Dufouil, C. and Richard, F. and Fiévet, N. and Dartigues, J. F. and Ritchie, K. and Tzourio, C. and Amouyel, P. and Alpérovitch, A.},
  title   = {{APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000160114.42643.31},
  pmid    = {15883313},
  url     = {https://doi.org/10.1212/01.wnl.0000160114.42643.31}
}

@article{jankowsky2005-15917461,
  author  = {Jankowsky, J. L. and Melnikova, T. and Fadale, D. J. and Xu, G. M. and Slunt, H. H. and Gonzales, V. and Younkin, L. H. and Younkin, S. G. and others},
  title   = {{Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.5080-04.2005},
  pmid    = {15917461},
  url     = {https://doi.org/10.1523/jneurosci.5080-04.2005}
}

@article{klunemann2005-15883308,
  author  = {Klünemann, H. H. and Ridha, B. H. and Magy, L. and Wherrett, JR. and Hemelsoet, D. M. and Keen, R. W. and De Bleecker, J. L. and Rossor, M. N. and others},
  title   = {{The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000160304.00003.ca},
  pmid    = {15883308},
  url     = {https://doi.org/10.1212/01.wnl.0000160304.00003.ca}
}

@article{schipper2006-16399210,
  author  = {Schipper, H. M. and Bennett, D. A. and Liberman, A. and Bienias, J. L. and Schneider, J. A. and Kelly, J. and Arvanitakis, Z.},
  title   = {{Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.01.016},
  pmid    = {16399210},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.01.016}
}

@article{savonenko2005-15755686,
  author  = {Savonenko, A. and Xu, G. M. and Melnikova, T. and Morton, J. L. and Gonzales, V. and Wong, M. P. and Price, D. L. and Tang, F. and others},
  title   = {{Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.10.022},
  pmid    = {15755686},
  url     = {https://doi.org/10.1016/j.nbd.2004.10.022}
}

@article{pamplona2005-15799962,
  author  = {Pamplona, R. and Dalfó, E. and Ayala, V. and Bellmunt, M. J. and Prat, J. and Ferrer, I. and Portero-Otín, M.},
  title   = {{Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m502255200},
  pmid    = {15799962},
  url     = {https://doi.org/10.1074/jbc.m502255200}
}

@article{schneider2005-15774818,
  author  = {Schneider, J. A. and Bienias, J. L. and Wilson, R. S. and Berry-Kravis, E. and Evans, D. A. and Bennett, D. A.},
  title   = {{The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons}},
  journal = {Stroke},
  year    = {2005},
  doi     = {10.1161/01.str.0000160747.27470.2a},
  pmid    = {15774818},
  url     = {https://doi.org/10.1161/01.str.0000160747.27470.2a}
}

@article{lim2005-15788759,
  author  = {Lim, G. P. and Calon, F. and Morihara, T. and Yang, F. and Teter, B. and Ubeda, O. and Salem, N. and Frautschy, S. A. and others},
  title   = {{A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.4225-04.2005},
  pmid    = {15788759},
  url     = {https://doi.org/10.1523/jneurosci.4225-04.2005}
}

@article{malm2005-15649704,
  author  = {Malm, T. M. and Koistinaho, M. and Pärepalo, M. and Vatanen, T. and Ooka, A. and Karlsson, S. and Koistinaho, J.},
  title   = {{Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.09.009},
  pmid    = {15649704},
  url     = {https://doi.org/10.1016/j.nbd.2004.09.009}
}

@article{bondi2005-15699382,
  author  = {Bondi, M. W. and Houston, W. S. and Eyler, L. T. and Brown, G. G.},
  title   = {{fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000150885.00929.7e},
  pmid    = {15699382},
  url     = {https://doi.org/10.1212/01.wnl.0000150885.00929.7e}
}

@article{pedrini2005-15647781,
  author  = {Pedrini, S. and Carter, T. L. and Prendergast, G. and Petanceska, S. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK}},
  journal = {PLoS medicine},
  year    = {2005},
  doi     = {10.1371/journal.pmed.0020018},
  pmid    = {15647781},
  url     = {https://doi.org/10.1371/journal.pmed.0020018}
}

@article{drzezga2005-15642911,
  author  = {Drzezga, A. and Riemenschneider, M. and Strassner, B. and Grimmer, T. and Peller, M. and Knoll, A. and Wagenpfeil, S. and Minoshima, S. and others},
  title   = {{Cerebral glucose metabolism in patients with AD and different APOE genotypes}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000148478.39691.d3},
  pmid    = {15642911},
  url     = {https://doi.org/10.1212/01.wnl.0000148478.39691.d3}
}

@article{garciaalloza2005-15707619,
  author  = {Garcia-Alloza, M. and Gil-Bea, F. J. and Diez-Ariza, M. and Chen, C. P. and Francis, P. T. and Lasheras, B. and Ramirez, M. J.},
  title   = {{Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease}},
  journal = {Neuropsychologia},
  year    = {2005},
  doi     = {10.1016/j.neuropsychologia.2004.06.007},
  pmid    = {15707619},
  url     = {https://doi.org/10.1016/j.neuropsychologia.2004.06.007}
}

@article{inestrosa2005-15748782,
  author  = {Inestrosa, N. C. and Reyes, A. E. and Chacón, M. A. and Cerpa, W. and Villalón, A. and Montiel, J. and Merabachvili, G. and Aldunate, R. and others},
  title   = {{Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.09.016},
  pmid    = {15748782},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.09.016}
}

@article{mosconi2004-15623696,
  author  = {Mosconi, L. and Perani, D. and Sorbi, S. and Herholz, K. and Nacmias, B. and Holthoff, V. and Salmon, E. and Baron, J. C. and others},
  title   = {{MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000147469.18313.3b},
  pmid    = {15623696},
  url     = {https://doi.org/10.1212/01.wnl.0000147469.18313.3b}
}

@article{patel2005-15748777,
  author  = {Patel, N. V. and Gordon, M. N. and Connor, K. E. and Good, R. A. and Engelman, R. W. and Mason, J. and Morgan, D. G. and Morgan, T. E. and others},
  title   = {{Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.09.014},
  pmid    = {15748777},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.09.014}
}

@article{apelt2004-15465277,
  author  = {Apelt, J. and Bigl, M. and Wunderlich, P. and Schliebs, R.},
  title   = {{Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology}},
  journal = {International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year    = {2004},
  doi     = {10.1016/j.ijdevneu.2004.07.006},
  pmid    = {15465277},
  url     = {https://doi.org/10.1016/j.ijdevneu.2004.07.006}
}

@article{butterfield2004-15605990,
  author  = {Butterfield, D. A. and Boyd-Kimball, D.},
  title   = {{Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2004},
  doi     = {10.1111/j.1750-3639.2004.tb00087.x},
  pmid    = {15605990},
  url     = {https://doi.org/10.1111/j.1750-3639.2004.tb00087.x}
}

@article{eckenhoff2004-15329595,
  author  = {Eckenhoff, R. G. and Johansson, J. S. and Wei, H. and Carnini, A. and Kang, B. and Wei, W. and Pidikiti, R. and Keller, J. M. and others},
  title   = {{Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity}},
  journal = {Anesthesiology},
  year    = {2004},
  doi     = {10.1097/00000542-200409000-00019},
  pmid    = {15329595},
  url     = {https://doi.org/10.1097/00000542-200409000-00019}
}

@article{green2004-15255951,
  author  = {Green, P. S. and Mendez, A. J. and Jacob, J. S. and Crowley, JR. and Growdon, W. and Hyman, B. T. and Heinecke, J. W.},
  title   = {{Neuronal expression of myeloperoxidase is increased in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02527.x},
  pmid    = {15255951},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02527.x}
}

@article{cataldo2004-15330337,
  author  = {Cataldo, A. M. and Peterhoff, C. M. and Schmidt, S. D. and Terio, N. B. and Duff, K. and Beard, M. and Mathews, P. M. and Nixon, R. A.},
  title   = {{Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.8.821},
  pmid    = {15330337},
  url     = {https://doi.org/10.1093/jnen/63.8.821}
}

@article{vanderwalt2004-15234467,
  author  = {van der Walt, J. M. and Dementieva, Y. A. and Martin, E. R. and Scott, W. K. and Nicodemus, K. K. and Kroner, C. C. and Welsh-Bohmer, K. A. and Saunders, A. M. and others},
  title   = {{Analysis of European mitochondrial haplogroups with Alzheimer disease risk}},
  journal = {Neuroscience letters},
  year    = {2004},
  doi     = {10.1016/j.neulet.2004.04.051},
  pmid    = {15234467},
  url     = {https://doi.org/10.1016/j.neulet.2004.04.051}
}

@article{schwab2004-15191802,
  author  = {Schwab, C. and Hosokawa, M. and McGeer, P. L.},
  title   = {{Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease}},
  journal = {Experimental neurology},
  year    = {2004},
  doi     = {10.1016/j.expneurol.2004.03.016},
  pmid    = {15191802},
  url     = {https://doi.org/10.1016/j.expneurol.2004.03.016}
}

@article{koistinaho2004-15195085,
  author  = {Koistinaho, M. and Lin, S. and Wu, X. and Esterman, M. and Koger, D. and Hanson, J. and Higgs, R. and Liu, F. and others},
  title   = {{Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides}},
  journal = {Nature medicine},
  year    = {2004},
  doi     = {10.1038/nm1058},
  pmid    = {15195085},
  url     = {https://doi.org/10.1038/nm1058}
}

@article{huang2004-15210882,
  author  = {Huang, X. and Chen, P. C. and Poole, C.},
  title   = {{APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000130159.28215.6a},
  pmid    = {15210882},
  url     = {https://doi.org/10.1212/01.wnl.0000130159.28215.6a}
}

@article{prince2004-15184629,
  author  = {Prince, J. A. and Zetterberg, H. and Andreasen, N. and Marcusson, J. and Blennow, K.},
  title   = {{APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000128088.08695.05},
  pmid    = {15184629},
  url     = {https://doi.org/10.1212/01.wnl.0000128088.08695.05}
}

@article{li2004-15184605,
  author  = {Li, Y. J. and Hauser, M. A. and Scott, W. K. and Martin, E. R. and Booze, M. W. and Qin, X. J. and Walter, J. W. and Nance, M. A. and others},
  title   = {{Apolipoprotein E controls the risk and age at onset of Parkinson disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000128089.53030.ac},
  pmid    = {15184605},
  url     = {https://doi.org/10.1212/01.wnl.0000128089.53030.ac}
}

@article{tiraboschi2004-15184600,
  author  = {Tiraboschi, P. and Hansen, L. A. and Masliah, E. and Alford, M. and Thal, L. J. and Corey-Bloom, J.},
  title   = {{Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000128091.92139.0f},
  pmid    = {15184600},
  url     = {https://doi.org/10.1212/01.wnl.0000128091.92139.0f}
}

@article{caselli2004-15184602,
  author  = {Caselli, R. J. and Reiman, E. M. and Osborne, D. and Hentz, J. G. and Baxter, L. C. and Hernandez, J. L. and Alexander, G. G.},
  title   = {{Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000129533.26544.bf},
  pmid    = {15184602},
  url     = {https://doi.org/10.1212/01.wnl.0000129533.26544.bf}
}

@article{brown2004-15252577,
  author  = {Brown, D. R. and Kozlowski, H.},
  title   = {{Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases}},
  journal = {Dalton transactions (Cambridge, England : 2003)},
  year    = {2004},
  doi     = {10.1039/b401985g},
  pmid    = {15252577},
  url     = {https://doi.org/10.1039/b401985g}
}

@article{dermaut2004-15122701,
  author  = {Dermaut, B. and Kumar-Singh, S. and Engelborghs, S. and Theuns, J. and Rademakers, R. and Saerens, J. and Pickut, B. A. and Peeters, K. and others},
  title   = {{A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques}},
  journal = {Annals of neurology},
  year    = {2004},
  doi     = {10.1002/ana.20083},
  pmid    = {15122701},
  url     = {https://doi.org/10.1002/ana.20083}
}

@article{sadowski2004-15198121,
  author  = {Sadowski, M. and Pankiewicz, J. and Scholtzova, H. and Ji, Y. and Quartermain, D. and Jensen, C. H. and Duff, K. and Nixon, R. A. and others},
  title   = {{Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.5.418},
  pmid    = {15198121},
  url     = {https://doi.org/10.1093/jnen/63.5.418}
}

@article{verdier2004-15160835,
  author  = {Verdier, Y. and Zarándi, M. and Penke, B.},
  title   = {{Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease}},
  journal = {Journal of peptide science : an official publication of the European Peptide Society},
  year    = {2004},
  doi     = {10.1002/psc.573},
  pmid    = {15160835},
  url     = {https://doi.org/10.1002/psc.573}
}

@article{khachaturian2004-15123497,
  author  = {Khachaturian, A. S. and Corcoran, C. D. and Mayer, L. S. and Zandi, P. P. and Breitner, J. C. and {Cache County Study Investigators}},
  title   = {{Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study}},
  journal = {Archives of general psychiatry},
  year    = {2004},
  doi     = {10.1001/archpsyc.61.5.518},
  pmid    = {15123497},
  url     = {https://doi.org/10.1001/archpsyc.61.5.518}
}

@article{nagele2004-15172746,
  author  = {Nagele, R. G. and Wegiel, J. and Venkataraman, V. and Imaki, H. and Wang, K. C.},
  title   = {{Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2004},
  doi     = {10.1016/j.neurobiolaging.2004.01.007},
  pmid    = {15172746},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.01.007}
}

@article{moolman2004-15475691,
  author  = {Moolman, D. L. and Vitolo, O. V. and Vonsattel, J. P. and Shelanski, M. L.},
  title   = {{Dendrite and dendritic spine alterations in Alzheimer models}},
  journal = {Journal of neurocytology},
  year    = {2004},
  doi     = {10.1023/b:neur.0000044197.83514.64},
  pmid    = {15475691},
  url     = {https://doi.org/10.1023/b:neur.0000044197.83514.64}
}

@article{dandrea2004-15172747,
  author  = {D'Andrea, M. R. and Cole, G. M. and Ard, M. D.},
  title   = {{The microglial phagocytic role with specific plaque types in the Alzheimer disease brain}},
  journal = {Neurobiology of aging},
  year    = {2004},
  doi     = {10.1016/j.neurobiolaging.2003.12.026},
  pmid    = {15172747},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2003.12.026}
}

@article{greeve2004-15102905,
  author  = {Greeve, I. and Kretzschmar, D. and Tschäpe, J. A. and Beyn, A. and Brellinger, C. and Schweizer, M. and Nitsch, R. M. and Reifegerste, R.},
  title   = {{Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.0283-04.2004},
  pmid    = {15102905},
  url     = {https://doi.org/10.1523/jneurosci.0283-04.2004}
}

@article{hoyer2004-15094078,
  author  = {Hoyer, S.},
  title   = {{Glucose metabolism and insulin receptor signal transduction in Alzheimer disease}},
  journal = {European journal of pharmacology},
  year    = {2004},
  doi     = {10.1016/j.ejphar.2004.02.049},
  pmid    = {15094078},
  url     = {https://doi.org/10.1016/j.ejphar.2004.02.049}
}

@article{ingelsson2004-15037694,
  author  = {Ingelsson, M. and Fukumoto, H. and Newell, K. L. and Growdon, J. H. and Hedley-Whyte, E. T. and Frosch, M. P. and Albert, M. S. and Hyman, B. T. and others},
  title   = {{Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000115115.98960.37},
  pmid    = {15037694},
  url     = {https://doi.org/10.1212/01.wnl.0000115115.98960.37}
}

@article{bennett2004-15023815,
  author  = {Bennett, D. A. and Schneider, J. A. and Wilson, R. S. and Bienias, J. L. and Arnold, S. E.},
  title   = {{Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function}},
  journal = {Archives of neurology},
  year    = {2004},
  doi     = {10.1001/archneur.61.3.378},
  pmid    = {15023815},
  url     = {https://doi.org/10.1001/archneur.61.3.378}
}

@article{hoglund2004-15023808,
  author  = {Höglund, K. and Wiklund, O. and Vanderstichele, H. and Eikenberg, O. and Vanmechelen, E. and Blennow, K.},
  title   = {{Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins}},
  journal = {Archives of neurology},
  year    = {2004},
  doi     = {10.1001/archneur.61.3.333},
  pmid    = {15023808},
  url     = {https://doi.org/10.1001/archneur.61.3.333}
}

@article{verdier2004-14965318,
  author  = {Verdier, Y. and Penke, B.},
  title   = {{Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease}},
  journal = {Current protein \& peptide science},
  year    = {2004},
  doi     = {10.2174/1389203043486937},
  pmid    = {14965318},
  url     = {https://doi.org/10.2174/1389203043486937}
}

@article{colciaghi2004-14872043,
  author  = {Colciaghi, F. and Marcello, E. and Borroni, B. and Zimmermann, M. and Caltagirone, C. and Cattabeni, F. and Padovani, A. and Di Luca, M.},
  title   = {{Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000106953.49802.9c},
  pmid    = {14872043},
  url     = {https://doi.org/10.1212/01.wnl.0000106953.49802.9c}
}

@article{hoyer2004-14977212,
  author  = {Hoyer, S.},
  title   = {{Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications}},
  journal = {Advances in experimental medicine and biology},
  year    = {2004},
  doi     = {10.1007/978-1-4419-8969-7_8},
  pmid    = {14977212},
  url     = {https://doi.org/10.1007/978-1-4419-8969-7_8}
}

@article{leissring2003-14687544,
  author  = {Leissring, M. A. and Farris, W. and Chang, A. Y. and Walsh, D. M. and Wu, X. and Sun, X. and Frosch, M. P. and Selkoe, D. J.},
  title   = {{Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00787-6},
  pmid    = {14687544},
  url     = {https://doi.org/10.1016/s0896-6273(03)00787-6}
}

@article{jankowsky2003-14692698,
  author  = {Jankowsky, J. L. and Xu, G. and Fromholt, D. and Gonzales, V. and Borchelt, D. R.},
  title   = {{Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2003},
  doi     = {10.1093/jnen/62.12.1220},
  pmid    = {14692698},
  url     = {https://doi.org/10.1093/jnen/62.12.1220}
}

@article{hansel2003-14612490,
  author  = {Hansel, D. E. and Rahman, A. and Wehner, S. and Herzog, V. and Yeo, C. J. and Maitra, A.},
  title   = {{Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation}},
  journal = {Cancer research},
  year    = {2003},
  pmid    = {14612490}
}

@article{angulo2003-14655750,
  author  = {Angulo, E. and Casadó, V. and Mallol, J. and Canela, E. I. and Viñals, F. and Ferrer, I. and Lluis, C. and Franco, R.},
  title   = {{A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2003},
  doi     = {10.1111/j.1750-3639.2003.tb00475.x},
  pmid    = {14655750},
  url     = {https://doi.org/10.1111/j.1750-3639.2003.tb00475.x}
}

@article{roher2003-14512367,
  author  = {Roher, A. E. and Esh, C. and Kokjohn, T. A. and Kalback, W. and Luehrs, D. C. and Seward, J. D. and Sue, L. I. and Beach, T. G.},
  title   = {{Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2003},
  doi     = {10.1161/01.atv.0000095973.42032.44},
  pmid    = {14512367},
  url     = {https://doi.org/10.1161/01.atv.0000095973.42032.44}
}

@article{weller2003-14503015,
  author  = {Weller, R. O. and Nicoll, J. A.},
  title   = {{Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain}},
  journal = {Neurological research},
  year    = {2003},
  doi     = {10.1179/016164103101202057},
  pmid    = {14503015},
  url     = {https://doi.org/10.1179/016164103101202057}
}

@article{olsson2003-12957490,
  author  = {Olsson, A. and Höglund, K. and Sjögren, M. and Andreasen, N. and Minthon, L. and Lannfelt, L. and Buerger, K. and Möller, H. J. and others},
  title   = {{Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients}},
  journal = {Experimental neurology},
  year    = {2003},
  doi     = {10.1016/s0014-4886(03)00027-x},
  pmid    = {12957490},
  url     = {https://doi.org/10.1016/s0014-4886(03)00027-x}
}

@article{hol2003-12931206,
  author  = {Hol, E. M. and Roelofs, R. F. and Moraal, E. and Sonnemans, M. A. and Sluijs, J. A. and Proper, E. A. and de Graan, P. N. and Fischer, D. F. and others},
  title   = {{Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms}},
  journal = {Molecular psychiatry},
  year    = {2003},
  doi     = {10.1038/sj.mp.4001379},
  pmid    = {12931206},
  url     = {https://doi.org/10.1038/sj.mp.4001379}
}

@article{mcphie2003-12890786,
  author  = {McPhie, D. L. and Coopersmith, R. and Hines-Peralta, A. and Chen, Y. and Ivins, K. J. and Manly, S. P. and Kozlowski, M. R. and Neve, K. A. and others},
  title   = {{DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-17-06914.2003},
  pmid    = {12890786},
  url     = {https://doi.org/10.1523/jneurosci.23-17-06914.2003}
}

@article{pappolla2003-12874399,
  author  = {Pappolla, M. A. and Bryant-Thomas, T. K. and Herbert, D. and Pacheco, J. and Fabra Garcia, M. and Manjon, M. and Girones, X. and Henry, T. L. and others},
  title   = {{Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology}},
  journal = {Neurology},
  year    = {2003},
  doi     = {10.1212/01.wnl.0000070182.02537.84},
  pmid    = {12874399},
  url     = {https://doi.org/10.1212/01.wnl.0000070182.02537.84}
}

@article{oddo2003-12895417,
  author  = {Oddo, Salvatore and Caccamo, Antonella and Shepherd, Jason D. and Murphy, Michael Paul and Golde, Todd Eliot and Kayed, Rakez and Metherate, Raju and Mattson, Mark P. and others},
  title   = {{Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00434-3},
  pmid    = {12895417},
  url     = {https://doi.org/10.1016/s0896-6273(03)00434-3}
}

@article{diazarrastia2003-12810485,
  author  = {Diaz-Arrastia, R. and Gong, Y. and Fair, S. and Scott, K. D. and Garcia, M. C. and Carlile, M. C. and Agostini, M. A. and Van Ness, P. C.},
  title   = {{Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele}},
  journal = {Archives of neurology},
  year    = {2003},
  doi     = {10.1001/archneur.60.6.818},
  pmid    = {12810485},
  url     = {https://doi.org/10.1001/archneur.60.6.818}
}

@article{sergeant2003-12787077,
  author  = {Sergeant, N. and Bombois, S. and Ghestem, A. and Drobecq, H. and Kostanjevecki, V. and Missiaen, C. and Wattez, A. and David, J. P. and others},
  title   = {{Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach}},
  journal = {Journal of neurochemistry},
  year    = {2003},
  doi     = {10.1046/j.1471-4159.2003.01818.x},
  pmid    = {12787077},
  url     = {https://doi.org/10.1046/j.1471-4159.2003.01818.x}
}

@article{nagele2003-12706236,
  author  = {Nagele, R. G. and D'Andrea, M. R. and Lee, H. and Venkataraman, V. and Wang, H. Y.},
  title   = {{Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains}},
  journal = {Brain research},
  year    = {2003},
  doi     = {10.1016/s0006-8993(03)02361-8},
  pmid    = {12706236},
  url     = {https://doi.org/10.1016/s0006-8993(03)02361-8}
}

@article{tan2003-12742802,
  author  = {Tan, Z. S. and Seshadri, S. and Beiser, A. and Wilson, P. W. and Kiel, D. P. and Tocco, M. and D'Agostino, R. B. and Wolf, P. A.},
  title   = {{Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study}},
  journal = {Archives of internal medicine},
  year    = {2003},
  doi     = {10.1001/archinte.163.9.1053},
  pmid    = {12742802},
  url     = {https://doi.org/10.1001/archinte.163.9.1053}
}

@article{tully2003-12654166,
  author  = {Tully, A. M. and Roche, H. M. and Doyle, R. and Fallon, C. and Bruce, I. and Lawlor, B. and Coakley, D. and Gibney, M. J.},
  title   = {{Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study}},
  journal = {The British journal of nutrition},
  year    = {2003},
  doi     = {10.1079/bjn2002804},
  pmid    = {12654166},
  url     = {https://doi.org/10.1079/bjn2002804}
}

@article{scarpa2003-12706835,
  author  = {Scarpa, S. and Fuso, A. and D'Anselmi, F. and Cavallaro, R. A.},
  title   = {{Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?}},
  journal = {FEBS letters},
  year    = {2003},
  doi     = {10.1016/s0014-5793(03)00277-1},
  pmid    = {12706835},
  url     = {https://doi.org/10.1016/s0014-5793(03)00277-1}
}

@article{nicoll2003-12640446,
  author  = {Nicoll, J. A. and Wilkinson, D. and Holmes, C. and Steart, P. and Markham, H. and Weller, R. O.},
  title   = {{Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report}},
  journal = {Nature medicine},
  year    = {2003},
  doi     = {10.1038/nm840},
  pmid    = {12640446},
  url     = {https://doi.org/10.1038/nm840}
}

@article{evans2003-12580702,
  author  = {Evans, D. A. and Bennett, D. A. and Wilson, R. S. and Bienias, J. L. and Morris, M. C. and Scherr, P. A. and Hebert, L. E. and Aggarwal, N. and others},
  title   = {{Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status}},
  journal = {Archives of neurology},
  year    = {2003},
  doi     = {10.1001/archneur.60.2.185},
  pmid    = {12580702},
  url     = {https://doi.org/10.1001/archneur.60.2.185}
}

@article{ehehalt2003-12515826,
  author  = {Ehehalt, R. and Keller, P. and Haass, C. and Thiele, C. and Simons, K.},
  title   = {{Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts}},
  journal = {The Journal of cell biology},
  year    = {2003},
  doi     = {10.1083/jcb.200207113},
  pmid    = {12515826},
  url     = {https://doi.org/10.1083/jcb.200207113}
}

@article{vandam2003-12542676,
  author  = {Van Dam, D. and D'Hooge, R. and Staufenbiel, M. and Van Ginneken, C. and Van Meir, F. and De Deyn, P. P.},
  title   = {{Age-dependent cognitive decline in the APP23 model precedes amyloid deposition}},
  journal = {The European journal of neuroscience},
  year    = {2003},
  doi     = {10.1046/j.1460-9568.2003.02444.x},
  pmid    = {12542676},
  url     = {https://doi.org/10.1046/j.1460-9568.2003.02444.x}
}

@article{nath2003-12665674,
  author  = {Nath, A. and Hall, E. and Tuzova, M. and Dobbs, M. and Jons, M. and Anderson, C. and Woodward, J. and Guo, Z. and others},
  title   = {{Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development}},
  journal = {Neuromolecular medicine},
  year    = {2003},
  doi     = {10.1385/nmm:3:1:29},
  pmid    = {12665674},
  url     = {https://doi.org/10.1385/nmm:3:1:29}
}

@article{kitazume2003-12473667,
  author  = {Kitazume, S. and Tachida, Y. and Oka, R. and Kotani, N. and Ogawa, K. and Suzuki, M. and Dohmae, N. and Takio, K. and others},
  title   = {{Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1)}},
  journal = {The Journal of biological chemistry},
  year    = {2003},
  doi     = {10.1074/jbc.m206262200},
  pmid    = {12473667},
  url     = {https://doi.org/10.1074/jbc.m206262200}
}

@article{tyler2002-12445809,
  author  = {Tyler, S. J. and Dawbarn, D. and Wilcock, G. K. and Allen, S. J.},
  title   = {{alpha- and beta-secretase: profound changes in Alzheimer's disease}},
  journal = {Biochemical and biophysical research communications},
  year    = {2002},
  doi     = {10.1016/s0006-291x(02)02635-9},
  pmid    = {12445809},
  url     = {https://doi.org/10.1016/s0006-291x(02)02635-9}
}

@article{iwata2002-12484568,
  author  = {Iwata, A. and Chen, X. H. and McIntosh, T. K. and Browne, K. D. and Smith, D. H.},
  title   = {{Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.12.1056},
  pmid    = {12484568},
  url     = {https://doi.org/10.1093/jnen/61.12.1056}
}

@article{buttini2002-12486146,
  author  = {Buttini, M. and Yu, G. Q. and Shockley, K. and Huang, Y. and Jones, B. and Masliah, E. and Mallory, M. and Yeo, T. and others},
  title   = {{Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-24-10539.2002},
  pmid    = {12486146},
  url     = {https://doi.org/10.1523/jneurosci.22-24-10539.2002}
}

@article{carro2002-12415260,
  author  = {Carro, E. and Trejo, J. L. and Gomez-Isla, T. and LeRoith, D. and Torres-Aleman, I.},
  title   = {{Serum insulin-like growth factor I regulates brain amyloid-beta levels}},
  journal = {Nature medicine},
  year    = {2002},
  doi     = {10.1038/nm1202-793},
  pmid    = {12415260},
  url     = {https://doi.org/10.1038/nm1202-793}
}

@article{klein2002-12176077,
  author  = {Klein, W. L.},
  title   = {{Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets}},
  journal = {Neurochemistry international},
  year    = {2002},
  doi     = {10.1016/s0197-0186(02)00050-5},
  pmid    = {12176077},
  url     = {https://doi.org/10.1016/s0197-0186(02)00050-5}
}

@article{hock2002-12379846,
  author  = {Hock, C. and Konietzko, U. and Papassotiropoulos, A. and Wollmer, A. and Streffer, J. and von Rotz, R. C. and Davey, G. and Moritz, E. and others},
  title   = {{Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease}},
  journal = {Nature medicine},
  year    = {2002},
  doi     = {10.1038/nm783},
  pmid    = {12379846},
  url     = {https://doi.org/10.1038/nm783}
}

@article{auld2002-12450488,
  author  = {Auld, D. S. and Kornecook, T. J. and Bastianetto, S. and Quirion, R.},
  title   = {{Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies}},
  journal = {Progress in neurobiology},
  year    = {2002},
  doi     = {10.1016/s0301-0082(02)00079-5},
  pmid    = {12450488},
  url     = {https://doi.org/10.1016/s0301-0082(02)00079-5}
}

@article{fukumoto2002-12223024,
  author  = {Fukumoto, H. and Cheung, B. S. and Hyman, B. T. and Irizarry, M. C.},
  title   = {{Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.9.1381},
  pmid    = {12223024},
  url     = {https://doi.org/10.1001/archneur.59.9.1381}
}

@article{kivipelto2002-12160362,
  author  = {Kivipelto, M. and Helkala, E. L. and Laakso, M. P. and Hänninen, T. and Hallikainen, M. and Alhainen, K. and Iivonen, S. and Mannermaa, A. and others},
  title   = {{Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease}},
  journal = {Annals of internal medicine},
  year    = {2002},
  doi     = {10.7326/0003-4819-137-3-200208060-00006},
  pmid    = {12160362},
  url     = {https://doi.org/10.7326/0003-4819-137-3-200208060-00006}
}

@article{palu2002-12111806,
  author  = {Palu, E. and Liesi, P.},
  title   = {{Differential distribution of laminins in Alzheimer disease and normal human brain tissue}},
  journal = {Journal of neuroscience research},
  year    = {2002},
  doi     = {10.1002/jnr.10292},
  pmid    = {12111806},
  url     = {https://doi.org/10.1002/jnr.10292}
}

@article{weksler2002-12086704,
  author  = {Weksler, M. E. and Relkin, N. and Turkenich, R. and LaRusse, S. and Zhou, L. and Szabo, P.},
  title   = {{Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals}},
  journal = {Experimental gerontology},
  year    = {2002},
  doi     = {10.1016/s0531-5565(02)00029-3},
  pmid    = {12086704},
  url     = {https://doi.org/10.1016/s0531-5565(02)00029-3}
}

@article{lutjohann2002-12091492,
  author  = {Lütjohann, D. and Brzezinka, A. and Barth, E. and Abramowski, D. and Staufenbiel, M. and von Bergmann, K. and Beyreuther, K. and Multhaup, G. and others},
  title   = {{Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain}},
  journal = {Journal of lipid research},
  year    = {2002},
  doi     = {10.1194/jlr.m200071-jlr200},
  pmid    = {12091492},
  url     = {https://doi.org/10.1194/jlr.m200071-jlr200}
}

@article{hoyer2002-12111436,
  author  = {Hoyer, S.},
  title   = {{The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2002},
  doi     = {10.1007/s007020200082},
  pmid    = {12111436},
  url     = {https://doi.org/10.1007/s007020200082}
}

@article{wilson2002-12117364,
  author  = {Wilson, R. S. and Schneider, J. A. and Barnes, L. L. and Beckett, L. A. and Aggarwal, N. T. and Cochran, E. J. and Berry-Kravis, E. and Bach, J. and others},
  title   = {{The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.7.1154},
  pmid    = {12117364},
  url     = {https://doi.org/10.1001/archneur.59.7.1154}
}

@article{thal2002-12084879,
  author  = {Thal, Dietmar Rudolf and Rüb, Udo and Orantes, Mario and Braak, Heiko},
  title   = {{Phases of Aβ-deposition in the human brain and its relevance for the development of AD}},
  journal = {Neurology},
  year    = {2002},
  doi     = {10.1212/wnl.58.12.1791},
  pmid    = {12084879},
  url     = {https://doi.org/10.1212/wnl.58.12.1791}
}

@article{butterfield2002-12226538,
  author  = {Butterfield, D. A. and Griffin, S. and Munch, G. and Pasinetti, G. M.},
  title   = {{Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2002},
  doi     = {10.3233/jad-2002-4309},
  pmid    = {12226538},
  url     = {https://doi.org/10.3233/jad-2002-4309}
}

@article{wiltfang2002-12065657,
  author  = {Wiltfang, J. and Esselmann, H. and Bibl, M. and Smirnov, A. and Otto, M. and Paul, S. and Schmidt, B. and Klafki, H. W. and others},
  title   = {{Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation}},
  journal = {Journal of neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.00818.x},
  pmid    = {12065657},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.00818.x}
}

@article{graffradford2002-11939894,
  author  = {Graff-Radford, N. R. and Green, R. C. and Go, R. C. and Hutton, M. L. and Edeki, T. and Bachman, D. and Adamson, J. L. and Griffith, P. and others},
  title   = {{Association between apolipoprotein E genotype and Alzheimer disease in African American subjects}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.4.594},
  pmid    = {11939894},
  url     = {https://doi.org/10.1001/archneur.59.4.594}
}

@article{kienlencampard2002-11861655,
  author  = {Kienlen-Campard, P. and Miolet, S. and Tasiaux, B. and Octave, J. N.},
  title   = {{Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis}},
  journal = {The Journal of biological chemistry},
  year    = {2002},
  doi     = {10.1074/jbc.m200887200},
  pmid    = {11861655},
  url     = {https://doi.org/10.1074/jbc.m200887200}
}

@article{weidemann2002-11851430,
  author  = {Weidemann, A. and Eggert, S. and Reinhard, F. B. and Vogel, M. and Paliga, K. and Baier, G. and Masters, C. L. and Beyreuther, K. and others},
  title   = {{A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing}},
  journal = {Biochemistry},
  year    = {2002},
  doi     = {10.1021/bi015794o},
  pmid    = {11851430},
  url     = {https://doi.org/10.1021/bi015794o}
}

@article{colciaghi2002-12080182,
  author  = {Colciaghi, F. and Borroni, B. and Pastorino, L. and Marcello, E. and Zimmermann, M. and Cattabeni, F. and Padovani, A. and Di Luca, M.},
  title   = {{[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients}},
  journal = {Molecular medicine (Cambridge, Mass.)},
  year    = {2002},
  doi     = {10.1007/bf03402076},
  pmid    = {12080182},
  url     = {https://doi.org/10.1007/bf03402076}
}

@article{gordon2002-11822882,
  author  = {Gordon, M. N. and Holcomb, L. A. and Jantzen, P. T. and DiCarlo, G. and Wilcock, D. and Boyett, K. W. and Connor, K. and Melachrino, J. and others},
  title   = {{Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse}},
  journal = {Experimental neurology},
  year    = {2002},
  doi     = {10.1006/exnr.2001.7754},
  pmid    = {11822882},
  url     = {https://doi.org/10.1006/exnr.2001.7754}
}

@article{greenfield2002-11823458,
  author  = {Greenfield, J. P. and Leung, L. W. and Cai, D. and Kaasik, K. and Gross, R. S. and Rodriguez-Boulan, E. and Greengard, P. and Xu, H.},
  title   = {{Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis}},
  journal = {The Journal of biological chemistry},
  year    = {2002},
  doi     = {10.1074/jbc.m110009200},
  pmid    = {11823458},
  url     = {https://doi.org/10.1074/jbc.m110009200}
}

@article{levinallerhand2002-12474021,
  author  = {Levin-Allerhand, J. A. and Lominska, C. E. and Smith, J. D.},
  title   = {{Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet}},
  journal = {The journal of nutrition, health \& aging},
  year    = {2002},
  pmid    = {12474021}
}

@article{basun2002-12218259,
  author  = {Basun, H. and Nilsberth, C. and Eckman, C. and Lannfelt, L. and Younkin, S.},
  title   = {{Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2002},
  doi     = {10.1159/000063605},
  pmid    = {12218259},
  url     = {https://doi.org/10.1159/000063605}
}

@article{uryu2002-11784789,
  author  = {Uryu, K. and Laurer, H. and McIntosh, T. and Praticò, D. and Martinez, D. and Leight, S. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-02-00446.2002},
  pmid    = {11784789},
  url     = {https://doi.org/10.1523/jneurosci.22-02-00446.2002}
}

@article{blass2001-11746411,
  author  = {Blass, J. P.},
  title   = {{Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?}},
  journal = {Journal of neuroscience research},
  year    = {2001},
  doi     = {10.1002/jnr.10087},
  pmid    = {11746411},
  url     = {https://doi.org/10.1002/jnr.10087}
}

@article{poeggeler2001-11732920,
  author  = {Poeggeler, B. and Miravalle, L. and Zagorski, M. G. and Wisniewski, T. and Chyan, Y. J. and Zhang, Y. and Shao, H. and Bryant-Thomas, T. and others},
  title   = {{Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide}},
  journal = {Biochemistry},
  year    = {2001},
  doi     = {10.1021/bi0114269},
  pmid    = {11732920},
  url     = {https://doi.org/10.1021/bi0114269}
}

@article{weggen2001-11700559,
  author  = {Weggen, Sascha and Eriksen, Jason L. and Das, Pritam and Sagi, Sarah A. and Wang, Rong and Pietrzik, Claus U. and Findlay, Kirk A. and Smith, Tawnya E. and Murphy, Michael P. and Bülter, Thomas and Kang, David E. and Marquez-Sterling, Numa R. and Golde, Todd Eliot and Koo, Edward H.},
  title   = {{A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity}},
  journal = {Nature},
  year    = {2001},
  doi     = {10.1038/35102591},
  pmid    = {11700559},
  url     = {https://doi.org/10.1038/35102591}
}

@article{le2001-11706935,
  author  = {Le, T. V. and Crook, R. and Hardy, J. and Dickson, D. W.},
  title   = {{Cotton wool plaques in non-familial late-onset Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.11.1051},
  pmid    = {11706935},
  url     = {https://doi.org/10.1093/jnen/60.11.1051}
}

@article{lim2001-11755007,
  author  = {Lim, G. P. and Yang, F. and Chu, T. and Gahtan, E. and Ubeda, O. and Beech, W. and Overmier, J. B. and Hsiao-Ashec, K. and others},
  title   = {{Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00299-8},
  pmid    = {11755007},
  url     = {https://doi.org/10.1016/s0197-4580(01)00299-8}
}

@article{yasojima2001-11689168,
  author  = {Yasojima, K. and McGeer, E. G. and McGeer, P. L.},
  title   = {{Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain}},
  journal = {Brain research},
  year    = {2001},
  doi     = {10.1016/s0006-8993(01)03008-6},
  pmid    = {11689168},
  url     = {https://doi.org/10.1016/s0006-8993(01)03008-6}
}

@article{mrak2001-11754999,
  author  = {Mrak, R. E. and Griffinbc, W. S.},
  title   = {{The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2001},
  doi     = {10.1016/s0197-4580(01)00293-7},
  pmid    = {11754999},
  url     = {https://doi.org/10.1016/s0197-4580(01)00293-7}
}

@article{hashimoto2001-11673590,
  author  = {Hashimoto, M. and Yasuda, M. and Tanimukai, S. and Matsui, M. and Hirono, N. and Kazui, H. and Mori, E.},
  title   = {{Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.57.8.1461},
  pmid    = {11673590},
  url     = {https://doi.org/10.1212/wnl.57.8.1461}
}

@article{du2001-11552007,
  author  = {Du, Y. and Dodel, R. and Hampel, H. and Buerger, K. and Lin, S. and Eastwood, B. and Bales, K. and Gao, F. and others},
  title   = {{Reduced levels of amyloid beta-peptide antibody in Alzheimer disease}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.57.5.801},
  pmid    = {11552007},
  url     = {https://doi.org/10.1212/wnl.57.5.801}
}

@article{kuo2001-11778650,
  author  = {Kuo, Y. M. and Beach, T. G. and Sue, L. I. and Scott, S. and Layne, K. J. and Kokjohn, T. A. and Kalback, W. M. and Luehrs, D. C. and others},
  title   = {{The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease}},
  journal = {Molecular medicine (Cambridge, Mass.)},
  year    = {2001},
  doi     = {10.1007/bf03401867},
  pmid    = {11778650},
  url     = {https://doi.org/10.1007/bf03401867}
}

@article{mori2001-11487052,
  author  = {Mori, T. and Paris, D. and Town, T. and Rojiani, A. M. and Sparks, D. L. and Delledonne, A. and Crawford, F. and Abdullah, L. I. and others},
  title   = {{Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.8.778},
  pmid    = {11487052},
  url     = {https://doi.org/10.1093/jnen/60.8.778}
}

@article{castellani2001-11440829,
  author  = {Castellani, R. J. and Harris, P. L. and Sayre, L. M. and Fujii, J. and Taniguchi, N. and Vitek, M. P. and Founds, H. and Atwood, C. S. and others},
  title   = {{Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine}},
  journal = {Free radical biology \& medicine},
  year    = {2001},
  doi     = {10.1016/s0891-5849(01)00570-6},
  pmid    = {11440829},
  url     = {https://doi.org/10.1016/s0891-5849(01)00570-6}
}

@article{kadotani2001-11401610,
  author  = {Kadotani, H. and Kadotani, T. and Young, T. and Peppard, P. E. and Finn, L. and Colrain, I. M. and Murphy, G. M. and Mignot, E.},
  title   = {{Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults}},
  journal = {JAMA},
  year    = {2001},
  doi     = {10.1001/jama.285.22.2888},
  pmid    = {11401610},
  url     = {https://doi.org/10.1001/jama.285.22.2888}
}

@article{grabowski2001-11409420,
  author  = {Grabowski, T. J. and Cho, H. S. and Vonsattel, J. P. and Rebeck, G. W. and Greenberg, S. M.},
  title   = {{Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy}},
  journal = {Annals of neurology},
  year    = {2001},
  doi     = {10.1002/ana.1009},
  pmid    = {11409420},
  url     = {https://doi.org/10.1002/ana.1009}
}

@article{sabo2001-11425871,
  author  = {Sabo, S. L. and Ikin, A. F. and Buxbaum, J. D. and Greengard, P.},
  title   = {{The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement}},
  journal = {The Journal of cell biology},
  year    = {2001},
  doi     = {10.1083/jcb.153.7.1403},
  pmid    = {11425871},
  url     = {https://doi.org/10.1083/jcb.153.7.1403}
}

@article{han2001-11359882,
  author  = {Han, X. and Holtzman, D. M. and McKeel, D. W.},
  title   = {{Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry}},
  journal = {Journal of neurochemistry},
  year    = {2001},
  doi     = {10.1046/j.1471-4159.2001.00332.x},
  pmid    = {11359882},
  url     = {https://doi.org/10.1046/j.1471-4159.2001.00332.x}
}

@article{wang2001-11342684,
  author  = {Wang, H. X. and Wahlin, A. and Basun, H. and Fastbom, J. and Winblad, B. and Fratiglioni, L.},
  title   = {{Vitamin B(12) and folate in relation to the development of Alzheimer's disease}},
  journal = {Neurology},
  year    = {2001},
  doi     = {10.1212/wnl.56.9.1188},
  pmid    = {11342684},
  url     = {https://doi.org/10.1212/wnl.56.9.1188}
}

@article{kaul2001-11309629,
  author  = {Kaul, M. and Garden, G. A. and Lipton, S. A.},
  title   = {{Pathways to neuronal injury and apoptosis in HIV-associated dementia}},
  journal = {Nature},
  year    = {2001},
  doi     = {10.1038/35073667},
  pmid    = {11309629},
  url     = {https://doi.org/10.1038/35073667}
}

@article{cho2001-11305869,
  author  = {Cho, H. S. and Hyman, B. T. and Greenberg, S. M. and Rebeck, G. W.},
  title   = {{Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.4.342},
  pmid    = {11305869},
  url     = {https://doi.org/10.1093/jnen/60.4.342}
}

@article{borroni2001-11255448,
  author  = {Borroni, B. and Colciaghi, F. and Pastorino, L. and Pettenati, C. and Cottini, E. and Rozzini, L. and Monastero, R. and Lenzi, G. L. and others},
  title   = {{Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment}},
  journal = {Archives of neurology},
  year    = {2001},
  doi     = {10.1001/archneur.58.3.442},
  pmid    = {11255448},
  url     = {https://doi.org/10.1001/archneur.58.3.442}
}

@article{apelt2001-11245811,
  author  = {Apelt, J. and Schliebs, R.},
  title   = {{Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology}},
  journal = {Brain research},
  year    = {2001},
  doi     = {10.1016/s0006-8993(00)03176-0},
  pmid    = {11245811},
  url     = {https://doi.org/10.1016/s0006-8993(00)03176-0}
}

@article{lahoz2001-11257253,
  author  = {Lahoz, C. and Schaefer, E. J. and Cupples, L. A. and Wilson, P. W. and Levy, D. and Osgood, D. and Parpos, S. and Pedro-Botet, J. and others},
  title   = {{Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study}},
  journal = {Atherosclerosis},
  year    = {2001},
  doi     = {10.1016/s0021-9150(00)00570-0},
  pmid    = {11257253},
  url     = {https://doi.org/10.1016/s0021-9150(00)00570-0}
}

@article{levy2001-11202179,
  author  = {Levy, E. and Sastre, M. and Kumar, A. and Gallo, G. and Piccardo, P. and Ghetti, B. and Tagliavini, F.},
  title   = {{Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2001},
  doi     = {10.1093/jnen/60.1.94},
  pmid    = {11202179},
  url     = {https://doi.org/10.1093/jnen/60.1.94}
}

@article{dickson2001-11483304,
  author  = {Dickson, T. C. and Vickers, J. C.},
  title   = {{The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease}},
  journal = {Neuroscience},
  year    = {2001},
  doi     = {10.1016/s0306-4522(01)00169-5},
  pmid    = {11483304},
  url     = {https://doi.org/10.1016/s0306-4522(01)00169-5}
}

@article{collins2000-11121190,
  author  = {Collins, J. S. and Perry, R. T. and Watson, B. and Harrell, L. E. and Acton, R. T. and Blacker, D. and Albert, M. S. and Tanzi, R. E. and others},
  title   = {{Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative}},
  journal = {American journal of medical genetics},
  year    = {2000},
  doi     = {10.1002/1096-8628(20001204)96:6<823::aid-ajmg26>3.0.co;2-i},
  pmid    = {11121190},
  url     = {https://doi.org/10.1002/1096-8628(20001204)96:6<823::aid-ajmg26>3.0.co;2-i}
}

@article{flory2000-11121165,
  author  = {Flory, J. D. and Manuck, S. B. and Ferrell, R. E. and Ryan, C. M. and Muldoon, M. F.},
  title   = {{Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults}},
  journal = {American journal of medical genetics},
  year    = {2000},
  doi     = {10.1002/1096-8628(20001204)96:6<707::aid-ajmg1>3.0.co;2-v},
  pmid    = {11121165},
  url     = {https://doi.org/10.1002/1096-8628(20001204)96:6<707::aid-ajmg1>3.0.co;2-v}
}

@article{finckh2000-11074789,
  author  = {Finckh, U. and von der Kammer, H. and Velden, J. and Michel, T. and Andresen, B. and Deng, A. and Zhang, J. and Müller-Thomsen, T. and others},
  title   = {{Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.11.1579},
  pmid    = {11074789},
  url     = {https://doi.org/10.1001/archneur.57.11.1579}
}

@article{wolozin2000-11030795,
  author  = {Wolozin, Benjamin L.},
  title   = {{Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors}},
  journal = {Archives of Neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.10.1439},
  pmid    = {11030795},
  url     = {https://doi.org/10.1001/archneur.57.10.1439}
}

@article{saunders2000-11005255,
  author  = {Saunders, A. M.},
  title   = {{Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2000},
  doi     = {10.1093/jnen/59.9.751},
  pmid    = {11005255},
  url     = {https://doi.org/10.1093/jnen/59.9.751}
}

@article{bard2000-10932230,
  author  = {Bard, F. and Cannon, C. and Barbour, R. and Burke, R. L. and Games, D. and Grajeda, H. and Guido, T. and Hu, K. and others},
  title   = {{Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease}},
  journal = {Nature medicine},
  year    = {2000},
  doi     = {10.1038/78682},
  pmid    = {10932230},
  url     = {https://doi.org/10.1038/78682}
}

@article{takeuchi2000-10880403,
  author  = {Takeuchi, A. and Irizarry, M. C. and Duff, K. and Saido, T. C. and Hsiao Ashe, K. and Hasegawa, M. and Mann, D. M. and Hyman, B. T. and others},
  title   = {{Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss}},
  journal = {The American journal of pathology},
  year    = {2000},
  doi     = {10.1016/s0002-9440(10)64544-0},
  pmid    = {10880403},
  url     = {https://doi.org/10.1016/s0002-9440(10)64544-0}
}

@article{lee2000-10888876,
  author  = {Lee, C. K. and Weindruch, R. and Prolla, T. A.},
  title   = {{Gene-expression profile of the ageing brain in mice}},
  journal = {Nature genetics},
  year    = {2000},
  doi     = {10.1038/77046},
  pmid    = {10888876},
  url     = {https://doi.org/10.1038/77046}
}

@article{mehlhorn2000-10817926,
  author  = {Mehlhorn, G. and Hollborn, M. and Schliebs, R.},
  title   = {{Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology}},
  journal = {International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year    = {2000},
  doi     = {10.1016/s0736-5748(00)00012-5},
  pmid    = {10817926},
  url     = {https://doi.org/10.1016/s0736-5748(00)00012-5}
}

@article{martin2000-10869235,
  author  = {Martin, E. R. and Lai, E. H. and Gilbert, JR. and Rogala, A. R. and Afshari, A. J. and Riley, J. and Finch, K. L. and Stevens, J. F. and others},
  title   = {{SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {2000},
  doi     = {10.1086/303003},
  pmid    = {10869235},
  url     = {https://doi.org/10.1086/303003}
}

@article{ganguli2000-10867779,
  author  = {Ganguli, M. and Chandra, V. and Kamboh, M. I. and Johnston, J. M. and Dodge, H. H. and Thelma, B. K. and Juyal, R. C. and Pandav, R. and others},
  title   = {{Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study}},
  journal = {Archives of neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.6.824},
  pmid    = {10867779},
  url     = {https://doi.org/10.1001/archneur.57.6.824}
}

@article{olichney2000-10867785,
  author  = {Olichney, J. M. and Hansen, L. A. and Hofstetter, C. R. and Lee, J. H. and Katzman, R. and Thal, L. J.},
  title   = {{Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4}},
  journal = {Archives of neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.6.869},
  pmid    = {10867785},
  url     = {https://doi.org/10.1001/archneur.57.6.869}
}

@article{destrooper2000-10806097,
  author  = {De Strooper, B. and Annaert, W.},
  title   = {{Proteolytic processing and cell biological functions of the amyloid precursor protein}},
  journal = {Journal of cell science},
  year    = {2000},
  doi     = {10.1242/jcs.113.11.1857},
  pmid    = {10806097},
  url     = {https://doi.org/10.1242/jcs.113.11.1857}
}

@article{kane2000-10804202,
  author  = {Kane, M. D. and Lipinski, W. J. and Callahan, M. J. and Bian, F. and Durham, R. A. and Schwarz, R. D. and Roher, A. E. and Walker, L. C.},
  title   = {{Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2000},
  doi     = {10.1523/jneurosci.20-10-03606.2000},
  pmid    = {10804202},
  url     = {https://doi.org/10.1523/jneurosci.20-10-03606.2000}
}

@article{hyman2000-10815129,
  author  = {Hyman, B. T. and Strickland, D. and Rebeck, G. W.},
  title   = {{Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.5.646},
  pmid    = {10815129},
  url     = {https://doi.org/10.1001/archneur.57.5.646}
}

@article{vidal2000-10781099,
  author  = {Vidal, R. and Revesz, T. and Rostagno, A. and Kim, E. and Holton, J. L. and Bek, T. and Bojsen-Møller, M. and Braendgaard, H. and others},
  title   = {{A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2000},
  doi     = {10.1073/pnas.080076097},
  pmid    = {10781099},
  url     = {https://doi.org/10.1073/pnas.080076097}
}

@article{scott2000-10712207,
  author  = {Scott, W. K. and Grubber, J. M. and Conneally, P. M. and Small, G. W. and Hulette, C. M. and Rosenberg, C. K. and Saunders, A. M. and Roses, A. D. and others},
  title   = {{Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity}},
  journal = {American journal of human genetics},
  year    = {2000},
  doi     = {10.1086/302828},
  pmid    = {10712207},
  url     = {https://doi.org/10.1086/302828}
}

@article{holtzman2000-10694577,
  author  = {Holtzman, David M. and Bales, Kelly R. and Tenkova, Tanya and Fagan, Anne M. and Parsadanian, Maia and Sartorius, Leah J. and Mackey, Brian and Olney, John W. and McKeel, Daniel W. and Wozniak, David F. and Paul, Steven M.},
  title   = {{Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2000},
  doi     = {10.1073/pnas.050004797},
  pmid    = {10694577},
  url     = {https://doi.org/10.1073/pnas.050004797}
}

@article{manly2000-10690972,
  author  = {Manly, J. J. and Merchant, C. A. and Jacobs, D. M. and Small, S. A. and Bell, K. and Ferin, M. and Mayeux, R.},
  title   = {{Endogenous estrogen levels and Alzheimer's disease among postmenopausal women}},
  journal = {Neurology},
  year    = {2000},
  doi     = {10.1212/wnl.54.4.833},
  pmid    = {10690972},
  url     = {https://doi.org/10.1212/wnl.54.4.833}
}

@article{maruyama2000-10681083,
  author  = {Maruyama, H. and Toji, H. and Harrington, C. R. and Sasaki, K. and Izumi, Y. and Ohnuma, T. and Arai, H. and Yasuda, M. and others},
  title   = {{Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2000},
  doi     = {10.1001/archneur.57.2.236},
  pmid    = {10681083},
  url     = {https://doi.org/10.1001/archneur.57.2.236}
}

@article{finckh2000-10631141,
  author  = {Finckh, U. and Müller-Thomsen, T. and Mann, U. and Eggers, C. and Marksteiner, J. and Meins, W. and Binetti, G. and Alberici, A. and others},
  title   = {{High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes}},
  journal = {American journal of human genetics},
  year    = {2000},
  doi     = {10.1086/302702},
  pmid    = {10631141},
  url     = {https://doi.org/10.1086/302702}
}

@article{yan1999-10591213,
  author  = {Yan, Riqiang and Bienkowski, Michael J. and Shuck, Mary E. and Miao, Huiyi and Tory, Monica C. and Pauley, Adele M. and Brashler, John R. and Stratman, Nancy C. and Mathews, W. Rodney and Buhl, Allen E. and Carter, Donald B. and Tomasselli, Alfredo G. and Parodi, Luis A. and Heinrikson, Robert L. and Gurney, Mark E.},
  title   = {{Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity}},
  journal = {Nature},
  year    = {1999},
  doi     = {10.1038/990107},
  pmid    = {10591213},
  url     = {https://doi.org/10.1038/990107}
}

@article{sinha1999-10591214,
  author  = {Sinha, Sukanto and Anderson, John P. and Barbour, Robin and Basi, Guriqbal S. and Caccavello, Russell J. and Davis, David L. and Doan, Minhtam and Dovey, Harry F. and Frigon, Normand L. and Hong, Jin and Jacobson-Croak, Kirsten and Jewett, Nancy E. and Keim, Pamela S. and Knops, Jeroen and Lieberburg, Ivan M. and Power, Michael D. and Tan, Hua Tiang and Tatsuno, Gwen P. and Tung, Jay S. and Schenk, Dale and Seubert, Peter A. and Suomensaari, Susanna and Wang, Shuwen and Walker, Donald E. and Zhao, Jun Wei and McConlogue, Lisa and John, Varghese},
  title   = {{Purification and cloning of amyloid precursor protein β-secretase from human brain}},
  journal = {Nature},
  year    = {1999},
  doi     = {10.1038/990114},
  pmid    = {10591214},
  url     = {https://doi.org/10.1038/990114}
}

@article{mclean1999-bc27151b,
  author  = {McLean, Catriona and Cherny, Robert A. and Fraser, Fiona W. and Fuller, Stephanie Jane and Smith, Margaret J. and Vbeyreuther, Konrad and Bush, Ashley Ian and Masters, Colin Louis},
  title   = {{Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease}},
  journal = {Annals of Neurology},
  year    = {1999},
  doi     = {10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m},
  url     = {https://doi.org/10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m}
}

@article{yermakova1999-10560656,
  author  = {Yermakova, A. V. and Rollins, J. and Callahan, L. M. and Rogers, J. and O'Banion, M. K.},
  title   = {{Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1999},
  doi     = {10.1097/00005072-199911000-00003},
  pmid    = {10560656},
  url     = {https://doi.org/10.1097/00005072-199911000-00003}
}

@article{hasel1999-10596928,
  author  = {Hasel, K. M. and Summers, B. A. and De Lahunta, A.},
  title   = {{Encephalopathy with idiopathic hyperammonaemia and Alzheimer type II astrocytes in equidae}},
  journal = {Equine veterinary journal},
  year    = {1999},
  doi     = {10.1111/j.2042-3306.1999.tb03854.x},
  pmid    = {10596928},
  url     = {https://doi.org/10.1111/j.2042-3306.1999.tb03854.x}
}

@article{vassar1999-10531052,
  author  = {Vassar, Robert J. and Bennett, Brian D. and Babu‐Khan, Safura and Kahn, Steve and Mendiaz, Elizabeth A. and Denis, Paul E. and Teplow, David B. and Ross, Sandra L. and others},
  title   = {{β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE}},
  journal = {Science},
  year    = {1999},
  doi     = {10.1126/science.286.5440.735},
  pmid    = {10531052},
  url     = {https://doi.org/10.1126/science.286.5440.735}
}

@article{bretsky1999-10609670,
  author  = {Bretsky, P. M. and Buckwalter, J. G. and Seeman, T. E. and Miller, C. A. and Poirier, J. and Schellenberg, G. D. and Finch, C. E. and Henderson, V. W.},
  title   = {{Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {1999},
  doi     = {10.1097/00002093-199910000-00007},
  pmid    = {10609670},
  url     = {https://doi.org/10.1097/00002093-199910000-00007}
}

@article{smith1999-10499440,
  author  = {Smith, D. H. and Chen, X. H. and Nonaka, M. and Trojanowski, J. Q. and Lee, V. M. and Saatman, K. E. and Leoni, M. J. and Xu, B. N. and others},
  title   = {{Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1999},
  doi     = {10.1097/00005072-199909000-00008},
  pmid    = {10499440},
  url     = {https://doi.org/10.1097/00005072-199909000-00008}
}

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@article{uetsuki1999-10436052,
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@article{breitner1999-10430421,
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  title   = {{APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study}},
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@article{schenk1999-10408445,
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  title   = {{Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse}},
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@article{mccarron1999-10411341,
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  title   = {{The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage}},
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@article{vidal1999-10391242,
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  title   = {{A stop-codon mutation in the BRI gene associated with familial British dementia}},
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@article{rossjohn1999-10201399,
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@article{moir1999-10194381,
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@article{rogers1999-10037734,
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  title   = {{Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences}},
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@article{kehoe1999-10051007,
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  title   = {{Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length}},
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@article{greenfield1999-9892704,
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@article{blasko1999-9872930,
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  title   = {{TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs}},
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@article{buxbaum1998-9822724,
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@article{masliah1998-9825941,
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  title   = {{Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease}},
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@article{lombardi1998-9822164,
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@article{sasaki1998-9777946,
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  title   = {{Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases}},
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@article{corder1998-9771753,
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  title   = {{HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy}},
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@article{blacker1998-9697696,
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  title   = {{Alpha-2 macroglobulin is genetically associated with Alzheimer disease}},
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@article{rogaeva1998-9718052,
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  title   = {{Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity}},
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@article{mcnamara1998-9678319,
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  title   = {{Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease}},
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  year    = {1998},
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@article{egensperger1998-9669695,
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  title   = {{Microglial activation in Alzheimer disease: Association with APOE genotype}},
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  year    = {1998},
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@article{slooter1998-9678314,
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  title   = {{Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study}},
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  year    = {1998},
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  pmid    = {9678314},
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@article{montine1998-9596412,
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  title   = {{Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype}},
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  year    = {1998},
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  pmid    = {9596412},
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@article{nishimura1998-9502800,
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  title   = {{Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1998},
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@article{mclaurin1998-9571042,
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  title   = {{Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest}},
  journal = {Journal of molecular biology},
  year    = {1998},
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@article{jack1998-9506546,
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  title   = {{Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease}},
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@article{tang1998-9508150,
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  title   = {{The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics}},
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@article{mayeux1998-9468467,
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  title   = {{Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease}},
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  year    = {1998},
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@article{holcomb1998-9427614,
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  title   = {{Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes}},
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  year    = {1998},
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  pmid    = {9427614},
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@article{price1998-9530504,
  author  = {Price, D. L. and Sisodia, S. S.},
  title   = {{Mutant genes in familial Alzheimer's disease and transgenic models}},
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  year    = {1998},
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@article{bales1997-9354781,
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  title   = {{Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition}},
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  year    = {1997},
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@article{sturchlerpierrat1997-9371838,
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  title   = {{Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology}},
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@article{borchelt1997-9354339,
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  title   = {{Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins}},
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  year    = {1997},
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@article{pericakvance1997-9333264,
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  title   = {{Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12}},
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  year    = {1997},
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@article{farrer1997-9343467,
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  title   = {{Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium}},
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@article{carlson1997-9302276,
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  title   = {{Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice}},
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  year    = {1997},
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@article{hartmann1997-9288729,
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  title   = {{Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides}},
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  year    = {1997},
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@article{babin1997-9238027,
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  title   = {{Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development}},
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  year    = {1997},
  doi     = {10.1073/pnas.94.16.8622},
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@article{urmoneit1997-9274858,
  author  = {Urmoneit, B. and Prikulis, I. and Wihl, G. and D'Urso, D. and Frank, R. and Heeren, J. and Beisiegel, U. and Prior, R.},
  title   = {{Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy}},
  journal = {Laboratory investigation; a journal of technical methods and pathology},
  year    = {1997},
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@article{li1997-9258260,
  author  = {Li, S. and Mallory, M. and Alford, M. and Tanaka, S. and Masliah, E.},
  title   = {{Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1997},
  doi     = {10.1097/00005072-199708000-00008},
  pmid    = {9258260},
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@article{cataldo1997-9236226,
  author  = {Cataldo, A. M. and Barnett, J. L. and Pieroni, C. and Nixon, R. A.},
  title   = {{Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1997},
  doi     = {10.1523/jneurosci.17-16-06142.1997},
  pmid    = {9236226},
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@article{barger1997-9278049,
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  title   = {{Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E}},
  journal = {Nature},
  year    = {1997},
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@article{xia1997-9223340,
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@article{duyan1997-9144231,
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@article{nalbantoglu1997-9168112,
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  journal = {Nature},
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@article{shao1997-9100668,
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@article{xu1997-9108049,
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@article{tienari1997-9108116,
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@article{davis1997-9114023,
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  title   = {{Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease}},
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@article{davies1997-9258891,
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  title   = {{Activated Alzheimer disease platelets retain more beta amyloid precursor protein}},
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@article{rogaev1997-9073509,
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  title   = {{Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease}},
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  year    = {1997},
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@article{fox1997-9126060,
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  title   = {{Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor}},
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  year    = {1997},
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@article{sheng1997-9056542,
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  year    = {1997},
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@article{racchi1997-9148766,
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  title   = {{Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content}},
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@article{tomita1997-9050898,
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  title   = {{The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue}},
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@article{rosenberg1997-9041854,
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  title   = {{Altered amyloid protein processing in platelets of patients with Alzheimer disease}},
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  title   = {{Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease}},
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  title   = {{Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex}},
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@article{hofman1997-9111537,
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  year    = {1997},
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  year    = {1996},
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  year    = {1996},
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  title   = {{Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia}},
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  year    = {1996},
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  title   = {{In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis}},
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@article{scheuner1996-8705854,
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  title   = {{Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease}},
  journal = {Nature Medicine},
  year    = {1996},
  doi     = {10.1038/nm0896-864},
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  title   = {{Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease}},
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  year    = {1996},
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  title   = {{Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV}},
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  year    = {1996},
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@article{nakai1996-8809843,
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  title   = {{Expression of apolipoprotein E mRNA in rat microglia}},
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@article{payami1996-8644745,
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  title   = {{Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women}},
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  year    = {1996},
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@article{reiman1996-8592548,
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  title   = {{Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E}},
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@article{tang1996-8644717,
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  title   = {{Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City}},
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@article{wragg1996-8596269,
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  title   = {{Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group}},
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  title   = {{Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease}},
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  title   = {{Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults}},
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@article{hsiao1995-7576662,
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  title   = {{Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins}},
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  title   = {{Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample}},
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  year    = {1995},
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  title   = {{Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein}},
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@article{bertrand1995-8774959,
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@article{xu1995-7559474,
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@article{levylahad1995-7638622,
  author  = {Levy‐Lahad, Ephrat and Wasco, Wilma and Poorkaj, Parvoneh and Romano, Donna and Oshima, Junko and Pettingell, Warren H. and Yu, Chang‐En and Jondro, P. D. and Schmidt, Stephen D. and Wang, Kai You and Crowley, Annette C. and Fu, Ying‐Hui and Guénette, Suzanne Y. and Galas, David J. and Nemens, Ellen J. and Wijsman, Ellen Marie and Bird, Thomas D. and Schellenberg, Gerard D. and Tanzi, Rudolph E.},
  title   = {{Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus}},
  journal = {Science},
  year    = {1995},
  doi     = {10.1126/science.7638622},
  pmid    = {7638622},
  url     = {https://doi.org/10.1126/science.7638622}
}

@article{rogaev1995-7651536,
  author  = {Rogaev, Evgeny Ivanovich and Sherrington, Robin P. and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Liang, Yuh‐Jin and Chi, H. and Lin, Chen-Xi and Holman, K. and Tsuda, Takuya and Mar, Lynn and Sorbi, Sandro and Nacmias, Benedetta and Piacentini, Silvia and Amaducci, L. A. and Chumakov, Ilya M. and Cohen, Daniel Blair and Lannfelt, Lars and Fraser, Paul E. and Rommens, Johanna M. and George‐Hyslop, Peter St},
  title   = {{Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/376775a0},
  pmid    = {7651536},
  url     = {https://doi.org/10.1038/376775a0}
}

@article{uchihara1995-7478253,
  author  = {Uchihara, T. and Duyckaerts, C. and He, Y. and Kobayashi, K. and Seilhean, D. and Amouyel, P. and Hauw, J. J.},
  title   = {{ApoE immunoreactivity and microglial cells in Alzheimer's disease brain}},
  journal = {Neuroscience letters},
  year    = {1995},
  doi     = {10.1016/0304-3940(95)11763-m},
  pmid    = {7478253},
  url     = {https://doi.org/10.1016/0304-3940(95)11763-m}
}

@article{moran1995-7777509,
  author  = {Moran, P. M. and Higgins, L. S. and Cordell, B. and Moser, P. C.},
  title   = {{Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.12.5341},
  pmid    = {7777509},
  url     = {https://doi.org/10.1073/pnas.92.12.5341}
}

@article{sherrington1995-7596406,
  author  = {Sherrington, Robin P. and Rogaev, Evgeny Ivanovich and Liang, Yuh‐Jin and Rogaeva, Ekaterina A. and Lévesque, Georges and Ikeda, Masaki and Chi, H. and Lin, Chiao‐Feng and others},
  title   = {{Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/375754a0},
  pmid    = {7596406},
  url     = {https://doi.org/10.1038/375754a0}
}

@article{petersen1995-7646655,
  author  = {Petersen, R. C. and Smith, G. E. and Ivnik, R. J. and Tangalos, E. G. and Schaid, D. J. and Thibodeau, S. N. and Kokmen, E. and Waring, S. C. and others},
  title   = {{Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals}},
  journal = {JAMA},
  year    = {1995},
  doi     = {10.1001/jama.1995.03520400044042},
  pmid    = {7646655},
  url     = {https://doi.org/10.1001/jama.1995.03520400044042}
}

@article{soininen1995-7783963,
  author  = {Soininen, H. and Kosunen, O. and Helisalmi, S. and Mannermaa, A. and Paljärvi, L. and Talasniemi, S. and Ryynänen, M. and Riekkinen, P.},
  title   = {{A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele}},
  journal = {Neuroscience letters},
  year    = {1995},
  doi     = {10.1016/0304-3940(95)11343-6},
  pmid    = {7783963},
  url     = {https://doi.org/10.1016/0304-3940(95)11343-6}
}

@article{small1995-7884953,
  author  = {Small, G. W. and Mazziotta, J. C. and Collins, M. T. and Baxter, L. R. and Phelps, M. E. and Mandelkern, M. A. and Kaplan, A. and La Rue, A. and others},
  title   = {{Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease}},
  journal = {JAMA},
  year    = {1995},
  doi     = {10.1001/jama.1995.03520360056039},
  pmid    = {7884953},
  url     = {https://doi.org/10.1001/jama.1995.03520360056039}
}

@article{wang1995-7876258,
  author  = {Wang, J. Z. and Gong, C. X. and Zaidi, T. and Grundke-Iqbal, I. and Iqbal, K.},
  title   = {{Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B}},
  journal = {The Journal of biological chemistry},
  year    = {1995},
  doi     = {10.1074/jbc.270.9.4854},
  pmid    = {7876258},
  url     = {https://doi.org/10.1074/jbc.270.9.4854}
}

@article{brugg1995-7708769,
  author  = {Brugg, B. and Dubreuil, Y. L. and Huber, G. and Wollman, E. E. and Delhaye-Bouchaud, N. and Mariani, J.},
  title   = {{Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.7.3032},
  pmid    = {7708769},
  url     = {https://doi.org/10.1073/pnas.92.7.3032}
}

@article{wolf1995-7876266,
  author  = {Wolf, B. A. and Wertkin, A. M. and Jolly, Y. C. and Yasuda, R. P. and Wolfe, B. B. and Konrad, R. J. and Manning, D. and Ravi, S. and others},
  title   = {{Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells}},
  journal = {The Journal of biological chemistry},
  year    = {1995},
  doi     = {10.1074/jbc.270.9.4916},
  pmid    = {7876266},
  url     = {https://doi.org/10.1074/jbc.270.9.4916}
}

@article{games1995-7845465,
  author  = {Games, D. and Adams, D. and Alessandrini, R. and Barbour, R. and Berthelette, P. and Blackwell, C. and Carr, T. and Clemens, J. and others},
  title   = {{Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein}},
  journal = {Nature},
  year    = {1995},
  doi     = {10.1038/373523a0},
  pmid    = {7845465},
  url     = {https://doi.org/10.1038/373523a0}
}

@article{evans1995-7846048,
  author  = {Evans, K. C. and Berger, E. P. and Cho, C. G. and Weisgraber, K. H. and Lansbury, P. T.},
  title   = {{Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1995},
  doi     = {10.1073/pnas.92.3.763},
  pmid    = {7846048},
  url     = {https://doi.org/10.1073/pnas.92.3.763}
}

@article{gattaz1995-7893853,
  author  = {Gattaz, W. F. and Maras, A. and Cairns, N. J. and Levy, R. and Förstl, H.},
  title   = {{Decreased phospholipase A2 activity in Alzheimer brains}},
  journal = {Biological psychiatry},
  year    = {1995},
  doi     = {10.1016/0006-3223(94)00123-k},
  pmid    = {7893853},
  url     = {https://doi.org/10.1016/0006-3223(94)00123-k}
}

@article{citron1994-7991571,
  author  = {Citron, M. and Vigo-Pelfrey, C. and Teplow, D. B. and Miller, C. and Schenk, D. and Johnston, J. and Winblad, B. and Venizelos, N. and others},
  title   = {{Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.25.11993},
  pmid    = {7991571},
  url     = {https://doi.org/10.1073/pnas.91.25.11993}
}

@article{reed1994-7986172,
  author  = {Reed, T. and Carmelli, D. and Swan, G. E. and Breitner, J. C. and Welsh, K. A. and Jarvik, G. P. and Deeb, S. and Auwerx, J.},
  title   = {{Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele}},
  journal = {Archives of neurology},
  year    = {1994},
  doi     = {10.1001/archneur.1994.00540240033012},
  pmid    = {7986172},
  url     = {https://doi.org/10.1001/archneur.1994.00540240033012}
}

@article{ma1994-7969426,
  author  = {Ma, J. and Yee, A. and Brewer, H. B. and Das, S. and Potter, H.},
  title   = {{Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments}},
  journal = {Nature},
  year    = {1994},
  doi     = {10.1038/372092a0},
  pmid    = {7969426},
  url     = {https://doi.org/10.1038/372092a0}
}

@article{fraser1994-7966323,
  author  = {Fraser, P. E. and McLachlan, D. R. and Surewicz, W. K. and Mizzen, C. A. and Snow, A. D. and Nguyen, J. T. and Kirschner, D. A.},
  title   = {{Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues}},
  journal = {Journal of molecular biology},
  year    = {1994},
  doi     = {10.1006/jmbi.1994.1704},
  pmid    = {7966323},
  url     = {https://doi.org/10.1006/jmbi.1994.1704}
}

@article{robinson1994-7891822,
  author  = {Robinson, C. A. and Clark, A. W. and Parhad, I. M. and Fung, T. S. and Bou, S. S.},
  title   = {{Gene expression in Alzheimer neocortex as a function of age and pathologic severity}},
  journal = {Neurobiology of aging},
  year    = {1994},
  doi     = {10.1016/0197-4580(94)90049-3},
  pmid    = {7891822},
  url     = {https://doi.org/10.1016/0197-4580(94)90049-3}
}

@article{strittmatter1994-7972031,
  author  = {Strittmatter, W. J. and Saunders, A. M. and Goedert, M. and Weisgraber, K. H. and Dong, L. M. and Jakes, R. and Huang, D. Y. and Pericak-Vance, M. and others},
  title   = {{Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.23.11183},
  pmid    = {7972031},
  url     = {https://doi.org/10.1073/pnas.91.23.11183}
}

@article{frackowiak1994-7964904,
  author  = {Frackowiak, J. and Zoltowska, A. and Wisniewski, H. M.},
  title   = {{Non-fibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {1994},
  doi     = {10.1097/00005072-199411000-00011},
  pmid    = {7964904},
  url     = {https://doi.org/10.1097/00005072-199411000-00011}
}

@article{sheng1994-7884819,
  author  = {Sheng, J. G. and Mrak, R. E. and Griffin, W. S.},
  title   = {{S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques}},
  journal = {Journal of neuroscience research},
  year    = {1994},
  doi     = {10.1002/jnr.490390406},
  pmid    = {7884819},
  url     = {https://doi.org/10.1002/jnr.490390406}
}

@article{frisoni1994-7951679,
  author  = {Frisoni, G. B. and Calabresi, L. and Geroldi, C. and Bianchetti, A. and D'Acquarica, A. L. and Govoni, S. and Sirtori, C. R. and others},
  title   = {{Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia}},
  journal = {Dementia (Basel, Switzerland)},
  year    = {1994},
  doi     = {10.1159/000106730},
  pmid    = {7951679},
  url     = {https://doi.org/10.1159/000106730}
}

@article{saura1994-7816197,
  author  = {Saura, J. and Luque, J. M. and Cesura, A. M. and Da Prada, M. and Chan-Palay, V. and Huber, G. and Löffler, J. and Richards, J. G.},
  title   = {{Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography}},
  journal = {Neuroscience},
  year    = {1994},
  doi     = {10.1016/0306-4522(94)90311-5},
  pmid    = {7816197},
  url     = {https://doi.org/10.1016/0306-4522(94)90311-5}
}

@article{gearing1994-7937774,
  author  = {Gearing, M. and Rebeck, G. W. and Hyman, B. T. and Tigges, J. and Mirra, S. S.},
  title   = {{Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.20.9382},
  pmid    = {7937774},
  url     = {https://doi.org/10.1073/pnas.91.20.9382}
}

@article{naslund1994-8078890,
  author  = {Näslund, J. and Schierhorn, A. and Hellman, U. and Lannfelt, L. and Roses, A. D. and Tjernberg, L. O. and Silberring, J. and Gandy, S. E. and others},
  title   = {{Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.18.8378},
  pmid    = {8078890},
  url     = {https://doi.org/10.1073/pnas.91.18.8378}
}

@article{west1994-7970208,
  author  = {West, H. L. and Rebeck, G. W. and Hyman, B. T.},
  title   = {{Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease}},
  journal = {Neuroscience letters},
  year    = {1994},
  doi     = {10.1016/0304-3940(94)91074-x},
  pmid    = {7970208},
  url     = {https://doi.org/10.1016/0304-3940(94)91074-x}
}

@article{iwatsubo1994-8043280,
  author  = {Iwatsubo, Takeshi and Odaka, Asano and Suzuki, Nobuhiro and Mizusawa, Hidehiro and Nukina, Nobuyuki and Ihara, Yasuo},
  title   = {{Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)}},
  journal = {Neuron},
  year    = {1994},
  doi     = {10.1016/0896-6273(94)90458-8},
  pmid    = {8043280},
  url     = {https://doi.org/10.1016/0896-6273(94)90458-8}
}

@article{corder1994-7920638,
  author  = {Corder, E. H. and Saunders, A. M. and Risch, N. J. and Strittmatter, W. J. and Schmechel, D. E. and Gaskell, P. C. and Rimmler, J. B. and Locke, P. A. and others},
  title   = {{Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease}},
  journal = {Nature genetics},
  year    = {1994},
  doi     = {10.1038/ng0694-180},
  pmid    = {7920638},
  url     = {https://doi.org/10.1038/ng0694-180}
}

@article{suzuki1994-8191290,
  author  = {Suzuki, Nobuhiro and Cheung, Tobun T. and Cai, Xiao-Dan and Odaka, Asano and Ötvös, László and Eckman, Christopher B. and Golde, Todd Eliot and Younkin, Steven G.},
  title   = {{An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants}},
  journal = {Science},
  year    = {1994},
  doi     = {10.1126/science.8191290},
  pmid    = {8191290},
  url     = {https://doi.org/10.1126/science.8191290}
}

@article{vitek1994-8197133,
  author  = {Vitek, M. P. and Bhattacharya, K. and Glendening, J. M. and Stopa, E. and Vlassara, H. and Bucala, R. and Manogue, K. and Cerami, A.},
  title   = {{Advanced glycation end products contribute to amyloidosis in Alzheimer disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1994},
  doi     = {10.1073/pnas.91.11.4766},
  pmid    = {8197133},
  url     = {https://doi.org/10.1073/pnas.91.11.4766}
}

@article{vanduijn1994-8075646,
  author  = {van Duijn, C. M. and de Knijff, P. and Cruts, M. and Wehnert, A. and Havekes, L. M. and Hofman, A. and Van Broeckhoven, C.},
  title   = {{Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {1994},
  doi     = {10.1038/ng0594-74},
  pmid    = {8075646},
  url     = {https://doi.org/10.1038/ng0594-74}
}

@article{jaffe1994-8175728,
  author  = {Jaffe, A. B. and Toran-Allerand, C. D. and Greengard, P. and Gandy, S. E.},
  title   = {{Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {1994},
  doi     = {10.1016/s0021-9258(17)36796-0},
  pmid    = {8175728},
  url     = {https://doi.org/10.1016/s0021-9258(17)36796-0}
}

@article{caporaso1994-8182461,
  author  = {Caporaso, G. L. and Takei, K. and Gandy, S. E. and Matteoli, M. and Mundigl, O. and Greengard, P. and De Camilli, P.},
  title   = {{Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {1994},
  doi     = {10.1523/jneurosci.14-05-03122.1994},
  pmid    = {8182461},
  url     = {https://doi.org/10.1523/jneurosci.14-05-03122.1994}
}

@article{tabaton1994-8185615,
  author  = {Tabaton, M. and Nunzi, M. G. and Xue, R. and Usiak, M. and Autilio-Gambetti, L. and Gambetti, P.},
  title   = {{Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid}},
  journal = {Biochemical and biophysical research communications},
  year    = {1994},
  doi     = {10.1006/bbrc.1994.1634},
  pmid    = {8185615},
  url     = {https://doi.org/10.1006/bbrc.1994.1634}
}

@article{tsai1994-8128961,
  author  = {Tsai, M. S. and Tangalos, E. G. and Petersen, R. C. and Smith, G. E. and Schaid, D. J. and Kokmen, E. and Ivnik, R. J. and Thibodeau, S. N.},
  title   = {{Apolipoprotein E: risk factor for Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {1994},
  pmid    = {8128961}
}

@article{roberts1994-8163989,
  author  = {Roberts, G. W. and Gentleman, S. M. and Lynch, A. and Murray, L. and Landon, M. and Graham, D. I.},
  title   = {{Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {1994},
  doi     = {10.1136/jnnp.57.4.419},
  pmid    = {8163989},
  url     = {https://doi.org/10.1136/jnnp.57.4.419}
}

@article{gowing1994-8157623,
  author  = {Gowing, E. and Roher, A. E. and Woods, A. S. and Cotter, R. J. and Chaney, M. and Little, S. P. and Ball, M. J.},
  title   = {{Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {1994},
  doi     = {10.1016/s0021-9258(19)78080-6},
  pmid    = {8157623},
  url     = {https://doi.org/10.1016/s0021-9258(19)78080-6}
}

@article{suzuki1994-8131745,
  author  = {Suzuki, T. and Oishi, M. and Marshak, D. R. and Czernik, A. J. and Nairn, A. C. and Greengard, P.},
  title   = {{Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein}},
  journal = {The EMBO journal},
  year    = {1994},
  doi     = {10.1002/j.1460-2075.1994.tb06360.x},
  pmid    = {8131745},
  url     = {https://doi.org/10.1002/j.1460-2075.1994.tb06360.x}
}

@article{svennerholm1994-8113790,
  author  = {Svennerholm, L. and Gottfries, C. G.},
  title   = {{Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II)}},
  journal = {Journal of neurochemistry},
  year    = {1994},
  doi     = {10.1046/j.1471-4159.1994.62031039.x},
  pmid    = {8113790},
  url     = {https://doi.org/10.1046/j.1471-4159.1994.62031039.x}
}

@article{strittmatter1994-8313935,
  author  = {Strittmatter, W. J. and Weisgraber, K. H. and Goedert, M. and Saunders, A. M. and Huang, D. and Corder, E. H. and Dong, L. M. and Jakes, R. and others},
  title   = {{Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype}},
  journal = {Experimental neurology},
  year    = {1994},
  doi     = {10.1006/exnr.1994.1019},
  pmid    = {8313935},
  url     = {https://doi.org/10.1006/exnr.1994.1019}
}

@article{daigle1993-8265668,
  author  = {Daigle, I. and Li, C.},
  title   = {{apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
  doi     = {10.1073/pnas.90.24.12045},
  pmid    = {8265668},
  url     = {https://doi.org/10.1073/pnas.90.24.12045}
}

@article{brunden1993-8245966,
  author  = {Brunden, K. R. and Richter-Cook, N. J. and Chaturvedi, N. and Frederickson, R. C.},
  title   = {{pH-dependent binding of synthetic beta-amyloid peptides to glycosaminoglycans}},
  journal = {Journal of neurochemistry},
  year    = {1993},
  doi     = {10.1111/j.1471-4159.1993.tb07453.x},
  pmid    = {8245966},
  url     = {https://doi.org/10.1111/j.1471-4159.1993.tb07453.x}
}

@article{banati1993-7507467,
  author  = {Banati, R. B. and Gehrmann, J. and Czech, C. and Mönning, U. and Jones, L. L. and König, G. and Beyreuther, K. and Kreutzberg, G. W.},
  title   = {{Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia}},
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  year    = {1993},
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  year    = {1993},
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@article{rebeck1993-8398148,
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  title   = {{Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions}},
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  year    = {1993},
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@article{strittmatter1993-8367470,
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  year    = {1993},
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@article{corder1993-8346443,
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  title   = {{Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families}},
  journal = {Science},
  year    = {1993},
  doi     = {10.1126/science.8346443},
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@article{saunders1993-8350998,
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  title   = {{Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease}},
  journal = {Neurology},
  year    = {1993},
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@article{fraser1993-8515277,
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  title   = {{Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro}},
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  year    = {1993},
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  pmid    = {8515277},
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@article{saito1993-8464868,
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  title   = {{Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration}},
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  pmid    = {8464868},
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  title   = {{Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease}},
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  year    = {1993},
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@article{busciglio1993-8446635,
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  title   = {{Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1993},
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  pmid    = {8446635},
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@article{nordstedt1993-8416966,
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  title   = {{Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells}},
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  year    = {1993},
  doi     = {10.1016/s0021-9258(18)54194-6},
  pmid    = {8416966},
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@article{perlmutter1992-1484388,
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  title   = {{MHC class II-positive microglia in human brain: association with Alzheimer lesions}},
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  year    = {1992},
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  pmid    = {1484388},
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@article{citron1992-1465129,
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  title   = {{Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production}},
  journal = {Nature},
  year    = {1992},
  doi     = {10.1038/360672a0},
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@article{kammesheidt1992-1438289,
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  title   = {{Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.22.10857},
  pmid    = {1438289},
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@article{kamino1992-1415269,
  author  = {Kamino, K. and Orr, H. T. and Payami, H. and Wijsman, E. M. and Alonso, M. E. and Pulst, S. M. and Anderson, L. and O'dahl, S. and others},
  title   = {{Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region}},
  journal = {American journal of human genetics},
  year    = {1992},
  pmid    = {1415269}
}

@article{hung1992-1409654,
  author  = {Hung, A. Y. and Koo, E. H. and Haass, C. and Selkoe, D. J.},
  title   = {{Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1992},
  doi     = {10.1073/pnas.89.20.9439},
  pmid    = {1409654},
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@article{nitsch1992-1411529,
  author  = {Nitsch, R. M. and Slack, B. E. and Wurtman, R. J. and Growdon, J. H.},
  title   = {{Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors}},
  journal = {Science (New York, N.Y.)},
  year    = {1992},
  doi     = {10.1126/science.1411529},
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@article{haass1992-1383826,
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  title   = {{Amyloid β-peptide is produced by cultured cells during normal metabolism}},
  journal = {Nature},
  year    = {1992},
  doi     = {10.1038/359322a0},
  pmid    = {1383826},
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@article{mullan1992-1302033,
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  title   = {{A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid}},
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  year    = {1992},
  doi     = {10.1038/ng0892-345},
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@article{knauer1992-1502155,
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  title   = {{Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein}},
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  year    = {1992},
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@article{sisodia1992-1631093,
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  title   = {{Beta-amyloid precursor protein cleavage by a membrane-bound protease}},
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  year    = {1992},
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@article{hendriks1992-1303239,
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  title   = {{Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene}},
  journal = {Nature genetics},
  year    = {1992},
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@article{caporaso1992-1557413,
  author  = {Caporaso, G. L. and Gandy, S. E. and Buxbaum, J. D. and Ramabhadran, T. V. and Greengard, P.},
  title   = {{Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein}},
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  year    = {1992},
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  pmid    = {1557413},
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@article{joachim1992-1605946,
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  title   = {{The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease}},
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  year    = {1992},
  doi     = {10.1097/00002093-199205000-00003},
  pmid    = {1605946},
  url     = {https://doi.org/10.1097/00002093-199205000-00003}
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@article{cataldo1991-1837142,
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  title   = {{Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease}},
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  year    = {1991},
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@article{schubert1991-1786532,
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  title   = {{Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites}},
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  year    = {1991},
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@article{vannostrand1991-1946448,
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  title   = {{The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2}},
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  year    = {1991},
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  pmid    = {1946448},
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@article{terry1991-1789684,
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  title   = {{Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment}},
  journal = {Annals of Neurology},
  year    = {1991},
  doi     = {10.1002/ana.410300410},
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@article{schellenberg1991-1679288,
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  title   = {{APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease}},
  journal = {American journal of human genetics},
  year    = {1991},
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}

@article{cras1991-1652752,
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  title   = {{Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1991},
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  pmid    = {1652752},
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  title   = {{Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage}},
  journal = {American journal of human genetics},
  year    = {1991},
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@article{goate1991-1671712,
  author  = {Goate, Alison and Chartier‐Harlin, Marie‐Christine and Mullan, Mike and Brown, Jeremy and Crawford, Fiona and Fidani, Liana and Giuffra, Luis A. and Haynes, Andrew R. and others},
  title   = {{Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease}},
  journal = {Nature},
  year    = {1991},
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  pmid    = {1671712},
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@article{namba1991-2029618,
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  title   = {{Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease}},
  journal = {Brain Research},
  year    = {1991},
  doi     = {10.1016/0006-8993(91)91092-f},
  pmid    = {2029618},
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  title   = {{The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences}},
  journal = {Brain research. Molecular brain research},
  year    = {1991},
  doi     = {10.1016/0169-328x(91)90009-m},
  pmid    = {1851527},
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  journal = {Alzheimer disease and associated disorders},
  year    = {1991},
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  pmid    = {2025420},
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  year    = {1990},
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  title   = {{Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease}},
  journal = {Neuroscience letters},
  year    = {1990},
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  year    = {1990},
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  year    = {1990},
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@article{tooyama1990-2400911,
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  title   = {{Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease}},
  journal = {Brain research},
  year    = {1990},
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@article{levy1990-2111584,
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  title   = {{Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type}},
  journal = {Science},
  year    = {1990},
  doi     = {10.1126/science.2111584},
  pmid    = {2111584},
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@article{smith1990-2111585,
  author  = {Smith, R. P. and Higuchi, D. A. and Broze, G. J.},
  title   = {{Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein}},
  journal = {Science (New York, N.Y.)},
  year    = {1990},
  doi     = {10.1126/science.2111585},
  pmid    = {2111585},
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@article{cataldo1990-1692625,
  author  = {Cataldo, A. M. and Nixon, R. A.},
  title   = {{Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {1990},
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  pmid    = {1692625},
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  title   = {{Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin}},
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  year    = {1990},
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@article{hixson1990-2341813,
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  year    = {1990},
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@article{oltersdorf1990-1968460,
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  title   = {{The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway}},
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  year    = {1990},
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@article{itagaki1989-2808689,
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@article{ishii1989-2657471,
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  title   = {{The immunohistochemical demonstration of subsequences of the precursor of the amyloid A4 protein in senile plaques in Alzheimer's disease}},
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@article{ozturk1989-2463628,
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  title   = {{Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain}},
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@article{autiliogambetti1988-2904381,
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  title   = {{The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types}},
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  year    = {1988},
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@article{selkoe1988-3140239,
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  title   = {{Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues}},
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  year    = {1988},
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@article{ma1988-3066102,
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  title   = {{Glial fibrillary acidic protein immunohistochemical study of Alzheimer I \& II astrogliosis in Wilson's disease}},
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  year    = {1988},
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@article{itagaki1988-2972943,
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  title   = {{Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue}},
  journal = {Neuroscience letters},
  year    = {1988},
  doi     = {10.1016/0304-3940(88)90690-8},
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@article{mahley1988-3283935,
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  title   = {{Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology}},
  journal = {Science},
  year    = {1988},
  doi     = {10.1126/science.3283935},
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@article{salim1988-3374733,
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  title   = {{Preparation of a recombinant cDNA library from poly(A+) RNA of the Alzheimer brain. Identification and characterization of a cDNA copy encoding a glial-specific protein}},
  journal = {Neurobiology of aging},
  year    = {1988},
  doi     = {10.1016/s0197-4580(88)80046-0},
  pmid    = {3374733},
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@article{tanzi1988-2893290,
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  title   = {{Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease}},
  journal = {Nature},
  year    = {1988},
  doi     = {10.1038/331528a0},
  pmid    = {2893290},
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@article{goldgaber1987-3810169,
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  title   = {{Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease}},
  journal = {Science},
  year    = {1987},
  doi     = {10.1126/science.3810169},
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@article{tanzi1987-2949367,
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  title   = {{Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus}},
  journal = {Science (New York, N.Y.)},
  year    = {1987},
  doi     = {10.1126/science.2949367},
  pmid    = {2949367},
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@article{kang1987-2881207,
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  title   = {{The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor}},
  journal = {Nature},
  year    = {1987},
  doi     = {10.1038/325733a0},
  pmid    = {2881207},
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@article{perl1982-7112111,
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  title   = {{Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam}},
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  year    = {1982},
  doi     = {10.1126/science.7112111},
  pmid    = {7112111},
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}