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Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain
Weller RO, Nicoll JA.. Neurological research, 2003-09-01
Topic: Amyloid, tau and blood-test diagnosis
Cerebral amyloid angiopathy (CAA) is a feature of ageing and Alzheimer's disease (AD); it is also associated with intracerebral hemorrhage and stroke. Here, the pathogenesis of CAA and its effects on the brain are reviewed and the possible effects of CAA on therapies for Alzheimer's disease are evaluated. Tracer experiments in animals and observations on human brains suggest that peptides such as A beta are eliminated along the peri-arterial interstitial fluid drainage pathways that are effectively the lymphatics of the brain.
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APA 7th
Weller, R. O., & Nicoll, J. A. (2003). Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain. Neurological research. https://doi.org/10.1179/016164103101202057
Vancouver
Weller RO, Nicoll JA. Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain. Neurological research. 2003. doi:10.1179/016164103101202057. PMID: 14503015.
BibTeX
@article{weller2003-14503015,
author = {Weller, R. O. and Nicoll, J. A.},
title = {{Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain}},
journal = {Neurological research},
year = {2003},
doi = {10.1179/016164103101202057},
pmid = {14503015},
url = {https://doi.org/10.1179/016164103101202057}
}
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Key findings
- Here, the pathogenesis of CAA and its effects on the brain are reviewed and the possible effects of CAA on therapies for Alzheimer's disease are evaluated.
- Tracer experiments in animals and observations on human brains suggest that peptides such as A beta are eliminated along the peri-arterial interstitial fluid drainage pathways that are effectively the lymphatics of the brain.
- In CAA, A beta becomes entrapped in drainage pathways in the walls of cerebral arteries, reflecting a failure of elimination of A beta from the ageing brain.
- One consequence of failure in clearance of A beta is accumulation of soluble and insoluble A beta associated with cognitive decline in AD.
Why it matters
This review describes how amyloid-beta becomes trapped in the drainage pathways along cerebral arteries in cerebral amyloid angiopathy, a feature of ageing and Alzheimer's disease. It evaluates possible effects of this on Alzheimer's therapies but reports no treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurological research) |
| Journal's citation record | 1 / 4 | Neurological Research: journal h-index 108 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 114 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.6 citations a year over 25 year(s) since 2003 |
| Impact for its field and year | 3 / 6 | Cited 5.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author James A. R. Nicoll: h-index 72 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Southampton: institution h-index 938 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 14503015) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 38 / 100 | — |
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