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Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease
Visser D, Wolters EE, Verfaillie SCJ, Coomans EM, Timmers T, Tuncel H, Reimand J, Boellaard R et al.. European journal of nuclear medicine and molecular imaging, 2020-05-27
Topic: Amyloid, tau and blood-test diagnosis
Purpose We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer's disease (AD), by using a single dynamic [ 18 F]flortaucipir positron emission tomography (PET) scan. Methods Seventy-one subjects with AD (66 ± 8 years, mini-mental state examination (MMSE) 23 ± 4) underwent a dynamic 130-min [ 18 F]flortaucipir PET scan. Cognitive assessment consisted of composite scores of four cognitive domains. For tau pathology and rCBF, receptor parametric mapping (cerebellar gray matter reference region) was used to create uncorrected and partial volume-corrected parametric images of non-displaceable binding potential (BP ND ) and R 1 , respectively. (Voxel-wise) linear regressions were used to investigate associations between BP ND and/or R 1 and cognition . RESULTS: Higher [ 18 F]flortaucipir BP ND was associated with lower R 1 in the lateral temporal, parietal and occipital regions. Higher medial temporal BP ND was associated with worse memory, and higher lateral temporal BP ND with worse executive functioning and language. Higher parietal BP ND was associated with worse executive functioning, language and attention, and higher occipital BP ND with lower cognitive scores across all domains. Higher frontal BP ND was associated with worse executive function and attention. For [ 18 F]flortaucipir R 1 , lower values in the lateral temporal and parietal ROIs were associated with worse executive functioning, language and attention, and lower occipital R 1 with lower language and attention scores. When [ 18 F]flortaucipir BP ND and R 1 were modelled simultaneously, associations between lower R 1 in the lateral temporal ROI and worse attention remained, as well as for lower parietal R 1 and worse executive functioning and attention. Conclusion Tau pathology was associated with locally reduced rCBF. Tau pathology and low rCBF were both independently associated with worse cognitive performance. For tau pathology, these associations spanned widespread neocortex, while for rCBF, independent associations were restricted to lateral temporal and parietal regions and the executive functioning and attention domains. These findings indicate that each biomarker may independently contribute to cognitive impairment in AD.
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APA 7th
Visser, D., Wolters, E. E., Verfaillie, S. C. J., Coomans, E. M., Timmers, T., Tuncel, H., et al. (2020). Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. https://doi.org/10.1007/s00259-020-04831-w
Vancouver
Visser D, Wolters EE, Verfaillie SCJ, Coomans EM, Timmers T, Tuncel H, et al. Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2020. doi:10.1007/s00259-020-04831-w. PMID: 32462397.
BibTeX
@article{visser2020-32462397,
author = {Visser, D. and Wolters, E. E. and Verfaillie, S. C. J. and Coomans, E. M. and Timmers, T. and Tuncel, H. and Reimand, J. and Boellaard, R. and others},
title = {{Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease}},
journal = {European journal of nuclear medicine and molecular imaging},
year = {2020},
doi = {10.1007/s00259-020-04831-w},
pmid = {32462397},
url = {https://doi.org/10.1007/s00259-020-04831-w}
}
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Key findings
- RESULTS: Higher [ 18 F]flortaucipir BP ND was associated with lower R 1 in the lateral temporal, parietal and occipital regions.
- Higher medial temporal BP ND was associated with worse memory, and higher lateral temporal BP ND with worse executive functioning and language.
- Higher parietal BP ND was associated with worse executive functioning, language and attention, and higher occipital BP ND with lower cognitive scores across all domains.
- Higher frontal BP ND was associated with worse executive function and attention.
- For [ 18 F]flortaucipir R 1 , lower values in the lateral temporal and parietal ROIs were associated with worse executive functioning, language and attention, and lower occipital R 1 with lower language and attention scores.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nuclear medicine and molecular imaging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32462397) |
| Free to read | 2 / 2 | Free to read |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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