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66/100

✓ Peer-reviewed alzhub usefulness score 66 out of 100. Risk genes beyond APOE

Topic: Amyloid, tau and blood-test diagnosis

Objective To reexamine the association between the neuronal sortilin-related receptor gene (SORL1) and Alzheimer disease (AD). Design Comprehensive and unbiased meta-analysis of all published and unpublished data from case-control studies for the SORL1 single-nucleotide polymorphisms (SNPs) that had been repeatedly assessed across studies. Setting Academic research institutions in the United States, the Netherlands, Canada, Belgium, the United Kingdom, Singapore, Japan, Sweden, Germany, France, and Italy.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Reitz, C., Cheng, R., Rogaeva, E., Lee, J. H., Tokuhiro, S., Zou, F., et al. (2011). Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Archives of neurology. https://doi.org/10.1001/archneurol.2010.346

Vancouver

Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Archives of neurology. 2011. doi:10.1001/archneurol.2010.346. PMID: 21220680.

BibTeX

@article{reitz2011-21220680,
  author  = {Reitz, C. and Cheng, R. and Rogaeva, E. and Lee, J. H. and Tokuhiro, S. and Zou, F. and Bettens, K. and Sleegers, K. and others},
  title   = {{Meta-analysis of the association between variants in SORL1 and Alzheimer disease}},
  journal = {Archives of neurology},
  year    = {2011},
  doi     = {10.1001/archneurol.2010.346},
  pmid    = {21220680},
  url     = {https://doi.org/10.1001/archneurol.2010.346}
}

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Key findings

Design Comprehensive and unbiased meta-analysis of all published and unpublished data from case-control studies for the SORL1 single-nucleotide polymorphisms (SNPs) that had been repeatedly assessed across studies.
Setting Academic research institutions in the United States, the Netherlands, Canada, Belgium, the United Kingdom, Singapore, Japan, Sweden, Germany, France, and Italy.
Participants All published white and Asian case-control data sets, which included a total of 12,464 cases and 17,929 controls.
Main outcome measures Alzheimer disease according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (now known as the Alzheimer's Association).

Why it matters

This meta-analysis reexamined the association between SORL1 variants and Alzheimer's disease across many case-control datasets. It addresses genetic risk association only and does not show that targeting SORL1 treats, cures, or prevents the disease.

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Study details

Study designmeta-analysis
Participants12,464
Evidence strengthHigh

How this study scored 66/100

Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Archives of neurology)
Journal's citation record	3 / 4	Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29)
Study design	12 / 12	A meta-analysis pooling many studies
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2011 — within 20 year(s) of the newest study here
Sample size	4 / 4	12,464 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	5 / 7	Cited 163 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	9.6 citations a year over 17 year(s) since 2011
Impact for its field and year	2 / 6	Cited 2.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 21 other studies in this library
Still being cited	1 / 4	Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Christiane Reitz: h-index 50 (OpenAlex, whole career)
Institution's track record	2 / 3	Columbia University: institution h-index 1,824 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 21220680)
Free to read	0 / 2	Behind a paywall — scores zero
Total	66 / 100	—

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