Home › Research › Cognitive tests and assessment
Smartphone Measurement of Aortic Arch Pulse-Wave Velocity and Total Arterial Compliance: Accessible Local and Global Arterial Stiffness Assessment
Niroumandi S, Rinderknecht D, Bilgi C, Cole S, Ogbonnaya SA, Wolfson AM, Vaidya AS, King KS et al.. Journal of the American Heart Association, 2026-02-11
Topic: Risk, prevention and care in population studies
Plain-language summary
Background Clinical studies have shown that aortic arch pulse-wave velocity (PWV aa ), a measure of local aortic stiffness, is a strong independent predictor of subsequent white matter hyperintensity volume and white matter integrity, both associated with cognitive decline, elevated stroke risk, vascular dementia, and neurodegenerative diseases. Total arterial compliance (TAC), a measure of global arterial stiffness, has been recognized as a marker of preclinical vascular disease. This study introduces a smartphone-based method for the noninvasive measurement of PWV aa and TAC using carotid pressure waveforms acquired via smartphone. Methods This method uses intrinsic frequency analysis of smartphone-acquired (iPhone) carotid pressure waveforms to assess PWV aa and TAC. The method was trained, validated, and blind-tested on a cohort of 132 participants aged 20 to 90 years, including both healthy individuals and those with cardiovascular disease, all of whom underwent cardiac magnetic resonance imaging, tonometry, and iPhone waveform measurements. Results In the blind test set, our method achieved Pearson correlations of 0.81 and 0.80 for PWV aa and TAC, with biases of -0.20 m/s and -0.06 mL/mm Hg and limits of agreement of -4.09 to 3.68 m/s and -0.52 to 0.40 mL/mm Hg, respectively. In the heart failure population, correlations were 0.81 for both, with a PWV aa a bias of -1.07 m/s and TAC bias of -0.06 mL/mm Hg. Conclusions Our smartphone-based method enables accurate assessment of local and global arterial stiffness metrics (PWV aa and TAC). It offers easy-to-use monitoring of vascular aging and arterial health, with important implications for identifying patients at higher risk of neurodegenerative and cardiovascular diseases. Registration URL: clinicaltrials.org; Unique Identifier: NCT02240979.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Niroumandi, S., Rinderknecht, D., Bilgi, C., Cole, S., Ogbonnaya, S. A., Wolfson, A. M., et al. (2026). Smartphone Measurement of Aortic Arch Pulse-Wave Velocity and Total Arterial Compliance: Accessible Local and Global Arterial Stiffness Assessment. Journal of the American Heart Association. https://doi.org/10.1161/jaha.125.043563
Vancouver
Niroumandi S, Rinderknecht D, Bilgi C, Cole S, Ogbonnaya SA, Wolfson AM, et al. Smartphone Measurement of Aortic Arch Pulse-Wave Velocity and Total Arterial Compliance: Accessible Local and Global Arterial Stiffness Assessment. Journal of the American Heart Association. 2026. doi:10.1161/jaha.125.043563. PMID: 41669977.
BibTeX
@article{niroumandi2026-41669977,
author = {Niroumandi, S. and Rinderknecht, D. and Bilgi, C. and Cole, S. and Ogbonnaya, S. A. and Wolfson, A. M. and Vaidya, A. S. and King, K. S. and others},
title = {{Smartphone Measurement of Aortic Arch Pulse-Wave Velocity and Total Arterial Compliance: Accessible Local and Global Arterial Stiffness Assessment}},
journal = {Journal of the American Heart Association},
year = {2026},
doi = {10.1161/jaha.125.043563},
pmid = {41669977},
url = {https://doi.org/10.1161/jaha.125.043563}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Background Clinical studies have shown that aortic arch pulse-wave velocity (PWV aa ), a measure of local aortic stiffness, is a strong independent predictor of subsequent white matter hyperintensity volume and white matter integrity, both associated with cognitive decline, elevated stroke risk, vascular dementia, and neurodegenerative diseases.
- Results In the blind test set, our method achieved Pearson correlations of 0.81 and 0.80 for PWV aa and TAC, with biases of -0.20 m/s and -0.06 mL/mm Hg and limits of agreement of -4.09 to 3.68 m/s and -0.52 to 0.40 mL/mm Hg, respectively.
- It offers easy-to-use monitoring of vascular aging and arterial health, with important implications for identifying patients at higher risk of neurodegenerative and cardiovascular diseases.
Study details
- Participants132
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Heart Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 132 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41669977) |
| Free to read | 2 / 2 | Free to read |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Cognitive tests and assessment from nearby years
Also in Cognitive tests and assessment
99 studies in the library are filed under Cognitive tests and assessment with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Cognitive tests and assessment hub.