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Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum
Zhang M, Chen H, Huang W, Guo T, Ma G, Han Y, Shu N.. Human brain mapping, 2024-01-01
Topic: Amyloid, tau and blood-test diagnosis
Our findings suggest that network efficiency mediates the association between plasma biomarkers, specifically GFAP and NfL, and cognitive performance in the context of AD progression, thus highlighting the potential utility of network-plasma approaches for early detection, monitoring, and intervention strategies in the management of AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, M., Chen, H., Huang, W., Guo, T., Ma, G., Han, Y., et al. (2024). Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum. Human brain mapping. https://doi.org/10.1002/hbm.26566
Vancouver
Zhang M, Chen H, Huang W, Guo T, Ma G, Han Y, et al. Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum. Human brain mapping. 2024. doi:10.1002/hbm.26566. PMID: 38224535.
BibTeX
@article{zhang2024-38224535,
author = {Zhang, M. and Chen, H. and Huang, W. and Guo, T. and Ma, G. and Han, Y. and Shu, N.},
title = {{Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum}},
journal = {Human brain mapping},
year = {2024},
doi = {10.1002/hbm.26566},
pmid = {38224535},
url = {https://doi.org/10.1002/hbm.26566}
}
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Key findings
- Our findings suggest that network efficiency mediates the association between plasma biomarkers, specifically GFAP and NfL, and cognitive performance in the context of AD progression, thus highlighting the potential utility of network-plasma approaches for early detection, monitoring, and intervention strategies in the management of AD.
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Study details
- Study designlongitudinal study
- Effect sizeor 3.0
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 37 of the 58 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Human brain mapping) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38224535) |
| Free to read | 2 / 2 | Free to read |
| Points | 37 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 37 of the 58 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Also tagged “continuum”
2 studies in the library carry the topic tag “continuum”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 2 tagged studies.