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Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau
Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari TK et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021-12-02
Topic: Amyloid, tau and blood-test diagnosis
Introduction We examined the ability of plasma hyperphosphorylated tau (p-tau) 181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL). Methods Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables. Results Plasma p-tau 181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau 181 had a direct association with cognitive diagnosis in a bootstrapped GGM. Discussion These results support plasma p-tau 181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
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APA 7th
Frank, B., Ally, M., Brekke, B., Zetterberg, H., Blennow, K., Sugarman, M. A., et al. (2022). Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12508
Vancouver
Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, et al. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. doi:10.1002/alz.12508. PMID: 34854549.
BibTeX
@article{frank2022-34854549,
author = {Frank, B. and Ally, M. and Brekke, B. and Zetterberg, H. and Blennow, K. and Sugarman, M. A. and Ashton, N. J. and Karikari, T. K. and others},
title = {{Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2022},
doi = {10.1002/alz.12508},
pmid = {34854549},
url = {https://doi.org/10.1002/alz.12508}
}
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Key findings
- Results Plasma p-tau 181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance.
- Discussion These results support plasma p-tau 181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
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Study details
- Participants235
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 30 of the 58 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 235 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34854549) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 30 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 30 of the 58 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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