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neurofilament-light
8 studies tagged neurofilament-light, dated 2007-05-02 to 2022-10-05. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Age- and disease-specific reference values for neurofilament light presented in an online interactive support interface 2022-10-05
- Plasma neurofilament light chain as a biomarker of Alzheimer's disease in Subjective Cognitive Decline and Mild Cognitive Impairment 2022-03-14
- Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau 2021-12-02
Studies
8 studies carry this tag.
Date range
2007 to 2022
Top journals
- Alzheimer's & dementia (Amsterdam, Netherlands) 1
- Alzheimer's & dementia : the journal of the Alzheimer's Association 1
- Alzheimer's research & therapy 1
- Annals of clinical and translational neurology 1
- BMC neurology 1
8 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age-specific and disease-specific reference values.
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Plasma NfL levels might be a promising biomarker for neurodegeneration to discriminate cognitive decline due to AD from other conditions causing cognitive impairment in prodromal stages.
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These results support plasma p-tau 181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
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Comparable performance of CSF and blood NfL in many groups demonstrates the promise of NfL as a noninvasive biomarker of neurodegeneration; however, its utility in clinically meaningful scenarios requires greater scrutiny.
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The diagnostic value of neurofilament light chain protein in neurodegenerative dementia diseases is still controversial.
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The present data indicate that CSF NfL and t-tau levels reflect distinct pathophysiological mechanisms of neurodegeneration and support the clinical use of NfL as a fast screening biomarker for the differential diagnosis of atypical/rapidly progressive NDs.
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40/100
The marked NFL elevation in some but not all FTD cases is likely to reflect the different underlying pathologies.
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The light subunit of neurofilament protein (NFL) is a sensitive indicator of central nervous system axonal injury.