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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Cerebral vascular amyloid beta-protein (Abeta) deposition, also known as cerebral amyloid angiopathy, is a common pathological feature of Alzheimer's disease. Additionally, several familial forms of cerebral amyloid angiopathy exist including the Dutch (E22Q) and Iowa (D23N) mutations of Abeta. Increasing evidence has associated cerebral microvascular amyloid deposition with neuroinflammation and dementia in these disorders.

Key findings

Additionally, several familial forms of cerebral amyloid angiopathy exist including the Dutch (E22Q) and Iowa (D23N) mutations of Abeta.
Increasing evidence has associated cerebral microvascular amyloid deposition with neuroinflammation and dementia in these disorders.
We recently established a transgenic mouse model (Tg-SwDI) that expresses human vasculotropic Dutch/Iowa mutant amyloid beta-protein precursor in brain.
Tg-SwDI mice were shown to develop early-onset deposition of Abeta exhibiting high association with cerebral microvessels.

Why it matters

This study used transgenic mice expressing human mutant amyloid beta precursor protein to show that amyloid deposits in brain blood vessels cause vascular degeneration and neuroinflammation. It is an animal study and does not test a treatment or prevention for Alzheimer's disease in humans.

Study details

Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The American journal of pathology)
Journal's citation record	3 / 4	American Journal Of Pathology: journal h-index 328 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “transgenic”) — scores zero
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 199 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.7 citations a year over 23 year(s) since 2005
Impact for its field and year	3 / 6	Cited 6.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 9 other studies in this library
Still being cited	2 / 4	Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author William E. Van Nostrand: h-index 55 (OpenAlex, whole career)
Institution's track record	1 / 3	Radboud University Nijmegen: institution h-index 1,143 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 16049335)
Free to read	0 / 2	Behind a paywall — scores zero
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Miao, J., Xu, F., Davis, J., Otte-Höller, I., Verbeek, M. M., & Van Nostrand, W. E. (2005). Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. The American journal of pathology. https://doi.org/10.1016/s0002-9440(10)62993-8

Vancouver

Miao J, Xu F, Davis J, Otte-Höller I, Verbeek MM, Van Nostrand WE. Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. The American journal of pathology. 2005. doi:10.1016/s0002-9440(10)62993-8. PMID: 16049335.

BibTeX

@article{miao2005-16049335,
  author  = {Miao, J. and Xu, F. and Davis, J. and Otte-Höller, I. and Verbeek, M. M. and Van Nostrand, W. E.},
  title   = {{Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein}},
  journal = {The American journal of pathology},
  year    = {2005},
  doi     = {10.1016/s0002-9440(10)62993-8},
  pmid    = {16049335},
  url     = {https://doi.org/10.1016/s0002-9440(10)62993-8}
}

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