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Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated
Robinson JL, Xie SX, Baer DR, Suh E, Van Deerlin VM, Loh NJ, Irwin DJ, McMillan CT et al.. Brain : a journal of neurology, 2023-06-01
Topic: Brain proteins, microglia and lab models
The presence of multiple additive pathologies associated with older age, increasing disease duration, APOE e4 allele and presence of dementia across the clinical groups. This observed heterogeneity indicates that the total pathological burden in ND is frequently more than a primary expected clinicopathological correlation with a high frequency of additional disease- or age-associated pathologies.
Key findings
- The presence of multiple additive pathologies associated with older age, increasing disease duration, APOE e4 allele and presence of dementia across the clinical groups.
- This observed heterogeneity indicates that the total pathological burden in ND is frequently more than a primary expected clinicopathological correlation with a high frequency of additional disease- or age-associated pathologies.
Why it matters
This work reports that neurodegenerative disease often involves multiple additive pathologies, associated with older age, longer disease duration, the APOE e4 allele, and dementia. This heterogeneity means the total pathological burden is often more than a single expected clinicopathological correlation, which matters for how disease is classified and studied.
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Study details
- Evidence strengthLow
How this study scored 56/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 179 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 35.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 5 / 6 | Cited 32.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 3 / 4 | Cited 166 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Edward B. Lee: h-index 79 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36864661) |
| Free to read | 2 / 2 | Free to read |
| Total | 56 / 100 | — |
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Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Robinson, J. L., Xie, S. X., Baer, D. R., Suh, E., Van Deerlin, V. M., Loh, N. J., et al. (2023). Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated. Brain : a journal of neurology. https://doi.org/10.1093/brain/awad059
Vancouver
Robinson JL, Xie SX, Baer DR, Suh E, Van Deerlin VM, Loh NJ, et al. Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated. Brain : a journal of neurology. 2023. doi:10.1093/brain/awad059. PMID: 36864661.
BibTeX
@article{robinson2023-36864661,
author = {Robinson, J. L. and Xie, S. X. and Baer, D. R. and Suh, E. and Van Deerlin, V. M. and Loh, N. J. and Irwin, D. J. and McMillan, C. T. and others},
title = {{Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated}},
journal = {Brain : a journal of neurology},
year = {2023},
doi = {10.1093/brain/awad059},
pmid = {36864661},
url = {https://doi.org/10.1093/brain/awad059}
}
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