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Microglia: biology and pathology
Graeber MB, Streit WJ.. Acta neuropathologica, 2009-12-13
Topic: Brain proteins, microglia and lab models
The past 20 years have seen a gain in knowledge on microglia biology and microglia functions in disease that exceeds the expectations formulated when the microglia "immune network" was introduced. More than 10,000 articles have been published during this time. Important new research avenues of clinical importance have opened up such as the role of microglia in pain and in brain tumors.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Graeber, M. B., & Streit, W. J. (2010). Microglia: biology and pathology. Acta neuropathologica. https://doi.org/10.1007/s00401-009-0622-0
Vancouver
Graeber MB, Streit WJ. Microglia: biology and pathology. Acta neuropathologica. 2010. doi:10.1007/s00401-009-0622-0. PMID: 20012873.
BibTeX
@article{graeber2010-20012873,
author = {Graeber, M. B. and Streit, W. J.},
title = {{Microglia: biology and pathology}},
journal = {Acta neuropathologica},
year = {2010},
doi = {10.1007/s00401-009-0622-0},
pmid = {20012873},
url = {https://doi.org/10.1007/s00401-009-0622-0}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- More than 10,000 articles have been published during this time.
- Important new research avenues of clinical importance have opened up such as the role of microglia in pain and in brain tumors.
- New controversies have also emerged such as the question of whether microglia are active or reactive players in neurodegenerative disease conditions, or whether they may be victims themselves.
- Premature commercial interests may be responsible for some of the confusion that currently surrounds microglia in both the Alzheimer and Parkinson's disease research fields.
Why it matters
This review summarizes two decades of microglia research and notes ongoing controversy over whether microglia are active or reactive players in neurodegenerative disease, or victims themselves. It reports no treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 726 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 40.3 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 5 / 6 | Cited 29.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 3 / 4 | Cited 59 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Wolfgang J. Streit: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florida: institution h-index 1,303 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20012873) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
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