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Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease
Ning A, Cui J, To E, Ashe KH, Matsubara J.. Investigative ophthalmology & visual science, 2008-06-19
Topic: Amyloid, tau and blood-test diagnosis
Purpose To compare the temporal and spatial expression patterns of amyloid precursor protein (APP), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of Alzheimer disease (AD). Methods Retinas of transgenic mice harboring a mutant presenilin (PS1) and a mutant APP gene were processed for TUNEL and immunohistochemistry with antibodies against APP, amyloid-beta, monocyte chemotactic protein (MCP)-1, and F4/80. Comparisons were made between age groups and between transgenic and wild-type congeners.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ning, A., Cui, J., To, E., Ashe, K. H., & Matsubara, J. (2008). Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Investigative ophthalmology & visual science. https://doi.org/10.1167/iovs.08-1849
Vancouver
Ning A, Cui J, To E, Ashe KH, Matsubara J. Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Investigative ophthalmology & visual science. 2008. doi:10.1167/iovs.08-1849. PMID: 18566467.
BibTeX
@article{ning2008-18566467,
author = {Ning, A. and Cui, J. and To, E. and Ashe, K. H. and Matsubara, J.},
title = {{Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease}},
journal = {Investigative ophthalmology \& visual science},
year = {2008},
doi = {10.1167/iovs.08-1849},
pmid = {18566467},
url = {https://doi.org/10.1167/iovs.08-1849}
}
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Key findings
- Methods Retinas of transgenic mice harboring a mutant presenilin (PS1) and a mutant APP gene were processed for TUNEL and immunohistochemistry with antibodies against APP, amyloid-beta, monocyte chemotactic protein (MCP)-1, and F4/80.
- Comparisons were made between age groups and between transgenic and wild-type congeners.
- Results The neuroretina demonstrated age-dependent increases in APP in the ganglion cells (RGCs) and in neurons of the inner nuclear layer (INL).
- Amyloid-beta demonstrated significant age-dependent deposition in the nerve fiber layer (NFL).
Why it matters
In a mouse model of Alzheimer's disease, amyloid-beta deposits in the retina were linked to age-dependent increases in amyloid precursor protein and retinal degeneration. This is an animal study, so it does not yet show whether the same process happens in people or whether it can be treated.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Investigative ophthalmology & visual science) |
| Journal's citation record | 3 / 4 | Investigative Ophthalmology & Visual Science: journal h-index 260 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 303 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.2 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 6.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 2 / 4 | Cited 40 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Joanne Aiko Matsubara: h-index 40 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Minnesota: institution h-index 1,568 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18566467) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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