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Memory-related EEG power and coherence reductions in mild Alzheimer's disease
Hogan MJ, Swanwick GR, Kaiser J, Rowan M, Lawlor B.. International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2003-08-01
Topic: Brain imaging, connectivity and assessment
Objectives To examine memory-related EEG power and coherence over temporal and central recording sites in patients with early Alzheimer's disease (AD) and normal controls. Method EEG was recorded from central (Fz, Cz and Pz) and temporal (T3 and T4) electrodes while ten very mild AD patients and ten controls performed a Sternberg-type memory scanning task with three levels of working memory load. Spectral power in delta (0-3 Hz), theta (3-5 Hz), lower alpha1 (5-7 Hz), lower alpha2 (7-9 Hz), upper alpha (9-11 Hz) and beta (15-30 Hz) was averaged for temporal and central electrodes. Coherence was averaged between central electrodes, between central and right temporal electrodes and between central and left temporal electrodes. Results While behavioral performance of very mild AD patients did not differ significantly from that of normal controls, findings suggest that normal controls but not AD patients respond to memory demands by increasing upper alpha power over temporal cortex. When compared with normal controls, AD patients had reduced upper alpha coherence between central and right temporal cortex. Discussion Results are consistent with previous research on the role of upper alpha in semantic memory and suggest that very mild AD may inhibit selective synchronization of upper alpha in temporal lobes. Reduced coherence between central and temporal cortex is discussed in light of a neurological model of AD that hypothesizes reduced electrocortical efficiency and a breakdown of neural network communication to temporal lobes possibly resulting from temporal lobe atrophy.
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APA 7th
Hogan, M. J., Swanwick, G. R., Kaiser, J., Rowan, M., & Lawlor, B. (2003). Memory-related EEG power and coherence reductions in mild Alzheimer's disease. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. https://doi.org/10.1016/s0167-8760(03)00118-1
Vancouver
Hogan MJ, Swanwick GR, Kaiser J, Rowan M, Lawlor B. Memory-related EEG power and coherence reductions in mild Alzheimer's disease. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 2003. doi:10.1016/s0167-8760(03)00118-1. PMID: 12919717.
BibTeX
@article{hogan2003-12919717,
author = {Hogan, M. J. and Swanwick, G. R. and Kaiser, J. and Rowan, M. and Lawlor, B.},
title = {{Memory-related EEG power and coherence reductions in mild Alzheimer's disease}},
journal = {International journal of psychophysiology : official journal of the International Organization of Psychophysiology},
year = {2003},
doi = {10.1016/s0167-8760(03)00118-1},
pmid = {12919717},
url = {https://doi.org/10.1016/s0167-8760(03)00118-1}
}
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Key findings
- Results While behavioral performance of very mild AD patients did not differ significantly from that of normal controls, findings suggest that normal controls but not AD patients respond to memory demands by increasing upper alpha power over temporal cortex.
- When compared with normal controls, AD patients had reduced upper alpha coherence between central and right temporal cortex.
- Discussion Results are consistent with previous research on the role of upper alpha in semantic memory and suggest that very mild AD may inhibit selective synchronization of upper alpha in temporal lobes.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of psychophysiology : official journal of the International Organization of Psychophysiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2003 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12919717) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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