Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage
Eun Pyo Hong, Seung Hyuk Lim, Dong Hyuk Youn, Sung Woo Han, Harry Jung, Jae Jun Lee, Jin Pyeong Jeon, On Behalf Of The First Korean Stroke Genetics Association Research The FirstKSGAR Study. Biomedicines, 2024-06-22
Topic: Genetics and APOE
Cognitive impairment was observed in 65 patients (42.5%) during a mean follow-up of 37.7 ± 12.4 months. Five genome-wide signals, including rs138753053 (PDCD6IP-LOC101928135, HR = 28.33, p = 3.4 × 10-8), rs56823384 (LINC00499, HR = 12.47, p = 2.8 × 10-9), rs145397166 (CASC15, HR = 11.16, p = 1.7 × 10-8), rs10503670 (LPL-SLC18A1, HR = 2.88, p = 4.0 × 10-8), and rs76507772 (IRS2, HR = 5.99, p = 3.5 × 10-8), were significantly associated with cognitive impairment following SAH. In addition, the well-constructed wPRS containing five markers showed nominal ability to predict cognitive impairment (AUROC = 0.745, 95% CI: 0.667-0.824). Tertile stratification showed a higher effectiveness in predicting cognitive impairment, especially in those with haptoglobin 2-1 (HR = 44.59, 95% CI: 8.61-231.08). Our study revealed novel susceptible loci for cognitive impairment, longitudinally measured in patients with SAH. The clinical utility of these loci will be evaluated in further follow-up studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hong, E. P., Lim, S. H., Youn, D. H., Han, S. W., Jung, H., Lee, J. J., et al. (2024). Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage. Biomedicines. https://doi.org/10.3390/biomedicines12071387
Vancouver
Hong EP, Lim SH, Youn DH, Han SW, Jung H, Lee JJ, et al. Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage. Biomedicines. 2024. doi:10.3390/biomedicines12071387. PMID: 39061961.
BibTeX
@article{hong2024-39061961,
author = {Hong, Eun Pyo and Lim, Seung Hyuk and Youn, Dong Hyuk and Han, Sung Woo and Jung, Harry and Lee, Jae Jun and Jeon, Jin Pyeong and {First Korean Stroke Genetics Association Research The FirstKSGAR Study}},
title = {{Longitudinal Genome-Wide Association Study of Cognitive Impairment after Subarachnoid Hemorrhage}},
journal = {Biomedicines},
year = {2024},
doi = {10.3390/biomedicines12071387},
pmid = {39061961},
url = {https://doi.org/10.3390/biomedicines12071387}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Cognitive impairment was observed in 65 patients (42.5%) during a mean follow-up of 37.7 ± 12.4 months.
- Five genome-wide signals, including rs138753053 (PDCD6IP-LOC101928135, HR = 28.33, p = 3.4 × 10-8), rs56823384 (LINC00499, HR = 12.47, p = 2.8 × 10-9), rs145397166 (CASC15, HR = 11.16, p = 1.7 × 10-8), rs10503670 (LPL-SLC18A1, HR = 2.88, p = 4.0 × 10-8), and rs76507772 (IRS2, HR = 5.99, p = 3.5 × 10-8), were significantly associated with cognitive impairment following SAH.
- In addition, the well-constructed wPRS containing five markers showed nominal ability to predict cognitive impairment (AUROC = 0.745, 95% CI: 0.667-0.824).
- Tertile stratification showed a higher effectiveness in predicting cognitive impairment, especially in those with haptoglobin 2-1 (HR = 44.59, 95% CI: 8.61-231.08).
- Our study revealed novel susceptible loci for cognitive impairment, longitudinally measured in patients with SAH.
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Study details
- Study designcohort study
- Participants153
- Effect size42.5%; HR = 28.33; HR = 12.47
- Evidence strengthModerate
How this study scored 73/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biomedicines) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 153 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39061961) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
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