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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Drug development

Topic: Brain proteins, microglia and lab models

Plain-language summary

Metabolic dysfunctions are among the best documented hallmarks of ageing. Cardiovascular disease, Alzheimer's disease, cancer, type 2 diabetes mellitus, metabolic-dysfunction-associated steatosis liver disease, and fragility fractures are diseases of hyperinsulinaemia that reduce life and healthspan. We studied the effect of suppressing ketosis in 10 lean (BMI 20.5 kg/m 2 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 ± 8.9 years) maintaining nutritional ketosis (NK) for an average of 3.9 years (± 2.3) who underwent three 21-day phases: nutritional ketosis (NK; P1), suppressed ketosis (SuK; P2), and returned to NK (P3). Ketosis suppression significantly increased insulin, 1.83-fold ( p = 0.0006); glucose, 1.17-fold ( p = 0.0088); homeostasis model assessment for insulin resistance (HOMA-IR), 2.13-fold ( p = 0.0008); leptin, 3.35-fold ( p = 0.0010); total osteocalcin, 1.63-fold ( p = 0.0138); and uncarboxylated osteocalcin, 1.98-fold ( p = 0.0417) and significantly decreased beta-hydroxybutyrate, 13.50-fold ( p = 0.0012) and glucagon-like peptide-1 (GLP-1), 2.40-fold ( p = 0.0209). Sustained NK showed no adverse health effects and may mitigate hyperinsulinemia. All biomarkers returned to basal P1 levels after removing the intervention for SuK, indicating that metabolic flexibility was maintained with long-term euketonaemia.

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APA 7th

Cooper, I. D., Kyriakidou, Y., Petagine, L., Edwards, K., Soto-Mota, A., Brookler, K., et al. (2024). Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females. Biomedicines. https://doi.org/10.3390/biomedicines12071553

Vancouver

Cooper ID, Kyriakidou Y, Petagine L, Edwards K, Soto-Mota A, Brookler K, et al. Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females. Biomedicines. 2024. doi:10.3390/biomedicines12071553. PMID: 39062126.

BibTeX

@article{cooper2024-39062126,
  author  = {Cooper, I. D. and Kyriakidou, Y. and Petagine, L. and Edwards, K. and Soto-Mota, A. and Brookler, K. and Elliott, B. T.},
  title   = {{Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females}},
  journal = {Biomedicines},
  year    = {2024},
  doi     = {10.3390/biomedicines12071553},
  pmid    = {39062126},
  url     = {https://doi.org/10.3390/biomedicines12071553}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Ketosis suppression significantly increased insulin, 1.83-fold ( p = 0.0006); glucose, 1.17-fold ( p = 0.0088); homeostasis model assessment for insulin resistance (HOMA-IR), 2.13-fold ( p = 0.0008); leptin, 3.35-fold ( p = 0.0010); total osteocalcin, 1.63-fold ( p = 0.0138); and uncarboxylated osteocalcin, 1.98-fold ( p = 0.0417) and significantly decreased beta-hydroxybutyrate, 13.50-fold ( p = 0.0012) and glucagon-like peptide-1 (GLP-1), 2.40-fold ( p = 0.0209).

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Study details

Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 26 of the 58 points we could judge it on, which is 45 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Biomedicines)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39062126)
Free to read	2 / 2	Free to read
Points	26 / 58	Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 58 points we could judge it on is 45 out of 100.
Total	45 / 100	—

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