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Juxtacortical Lesion Precedes Lobar Microbleed During Anti-amyloid β Immunotherapy
Shindo A, Hirata Y, Tomimoto H.. Internal medicine (Tokyo, Japan), 2025-05-15
Topic: Amyloid, tau and blood-test diagnosis
Amyloid-related imaging abnormalities (ARIAs), including edema/effusion (ARIA-E) and hemosiderin deposition (ARIA-H), are complications of anti-amyloid β (Aβ) monoclonal antibody therapy for Alzheimer's disease (AD). A Japanese woman in her 70s with mild cognitive impairment due to AD, confirmed by positive amyloid positron emission tomography, developed a new lobar cerebral microbleed (CMB) after participating in aducanumab clinical trials. Magnetic resonance imaging revealed juxtacortical white matter hyperintensities on fluid-attenuated inversion recovery, which were later resolved as a novel CMB. Juxtacortical white matter hyperintensities may precede ARIA-H and may suggest cerebral amyloid angiopathy-related changes during anti-Aβ therapy. Monitoring of these lesions is essential.
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APA 7th
Shindo, A., Hirata, Y., & Tomimoto, H. (2025). Juxtacortical Lesion Precedes Lobar Microbleed During Anti-amyloid β Immunotherapy. Internal medicine (Tokyo, Japan). https://doi.org/10.2169/internalmedicine.5198-24
Vancouver
Shindo A, Hirata Y, Tomimoto H. Juxtacortical Lesion Precedes Lobar Microbleed During Anti-amyloid β Immunotherapy. Internal medicine (Tokyo, Japan). 2025. doi:10.2169/internalmedicine.5198-24. PMID: 40368787.
BibTeX
@article{shindo2025-40368787,
author = {Shindo, A. and Hirata, Y. and Tomimoto, H.},
title = {{Juxtacortical Lesion Precedes Lobar Microbleed During Anti-amyloid β Immunotherapy}},
journal = {Internal medicine (Tokyo, Japan)},
year = {2025},
doi = {10.2169/internalmedicine.5198-24},
pmid = {40368787},
url = {https://doi.org/10.2169/internalmedicine.5198-24}
}
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Key findings
- Magnetic resonance imaging revealed juxtacortical white matter hyperintensities on fluid-attenuated inversion recovery, which were later resolved as a novel CMB.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 29 of the 58 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Internal medicine (Tokyo, Japan)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40368787) |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 58 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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