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Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study
Parbo P, Ismail R, Sommerauer M, Stokholm MG, Hansen AK, Hansen KV, Amidi A, Schaldemose JL et al.. Neurobiology of disease, 2018-06-11
Topic: Amyloid, tau and blood-test diagnosis
Objective Our aim was to assess with positron emission tomography (PET) the temporal and spatial inter-relationships between levels of cortical microglial activation and the aggregated amyloid-β and tau load in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Methods Six clinically probable AD and 20 MCI subjects had inflammation ( 11 C-(R)-PK11195), amyloid ( 11 C-PiB) and tau ( 18 F-flortaucipir) PET, magnetic resonance imaging (MRI) and a neuropsychological assessment. Parametric images of tracer binding were interrogated at a voxel level and by region of interest analyses. Results 55% of MCI and 83% of AD subjects had a high amyloid-β load. We have previously reported that clusters of correlated amyloid and inflammation levels are present in cortex. Here we found no correlation between levels of inflammation ( 11 C-(R)-PK11195 BP ND ) and tau ( 18 F-flortaucipir SUVR) or MMSE scores in high amyloid-β cases. Interpretation While correlated levels of amyloid-β and inflammation can be seen in MCI, we did not detect an association between levels of cortical tau tangles and inflammation in our series of high amyloid-β cases. High levels of inflammation could be seen in amyloid-β positive MCI cases where 18 F-flortaucipir signals were low suggesting microglial activation precedes tau tangle formation. Inflammation levels were higher in high amyloid-β MCI than in early AD cases, compatible with it initially playing a protective role.
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APA 7th
Parbo, P., Ismail, R., Sommerauer, M., Stokholm, M. G., Hansen, A. K., Hansen, K. V., et al. (2018). Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2018.06.004
Vancouver
Parbo P, Ismail R, Sommerauer M, Stokholm MG, Hansen AK, Hansen KV, et al. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiology of disease. 2018. doi:10.1016/j.nbd.2018.06.004. PMID: 29902557.
BibTeX
@article{parbo2018-29902557,
author = {Parbo, P. and Ismail, R. and Sommerauer, M. and Stokholm, M. G. and Hansen, A. K. and Hansen, K. V. and Amidi, A. and Schaldemose, J. L. and others},
title = {{Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study}},
journal = {Neurobiology of disease},
year = {2018},
doi = {10.1016/j.nbd.2018.06.004},
pmid = {29902557},
url = {https://doi.org/10.1016/j.nbd.2018.06.004}
}
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Key findings
- Results 55% of MCI and 83% of AD subjects had a high amyloid-β load.
- Here we found no correlation between levels of inflammation ( 11 C-(R)-PK11195 BP ND ) and tau ( 18 F-flortaucipir SUVR) or MMSE scores in high amyloid-β cases.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 22 of the 58 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of disease) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29902557) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 22 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 22 of the 58 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
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