Home › Research › Long-term cohort studies
Genome-wide association study of vascular dementia
Schrijvers EM, Schürmann B, Koudstaal PJ, van den Bussche H, Van Duijn CM, Hentschel F, Heun R, Hofman A et al.. Stroke, 2011-11-23
Topic: Risk, prevention and care in population studies
Background and purpose Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Schrijvers, E. M., Schürmann, B., Koudstaal, P. J., van den Bussche, H., Van Duijn, C. M., Hentschel, F., et al. (2012). Genome-wide association study of vascular dementia. Stroke. https://doi.org/10.1161/strokeaha.111.628768
Vancouver
Schrijvers EM, Schürmann B, Koudstaal PJ, van den Bussche H, Van Duijn CM, Hentschel F, et al. Genome-wide association study of vascular dementia. Stroke. 2012. doi:10.1161/strokeaha.111.628768. PMID: 22116812.
BibTeX
@article{schrijvers2012-22116812,
author = {Schrijvers, E. M. and Schürmann, B. and Koudstaal, P. J. and van den Bussche, H. and Van Duijn, C. M. and Hentschel, F. and Heun, R. and Hofman, A. and others},
title = {{Genome-wide association study of vascular dementia}},
journal = {Stroke},
year = {2012},
doi = {10.1161/strokeaha.111.628768},
pmid = {22116812},
url = {https://doi.org/10.1161/strokeaha.111.628768}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The aim of our study was to identify new loci associated with vascular dementia.
- Methods We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands.
- We sought to replicate genome-wide significant loci in 2 independent replication samples.
- Results In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 ± 3.2 years.
Why it matters
This study looked for genes linked to vascular dementia, a form of dementia that has been studied far less than Alzheimer's disease. It identified 67 people who developed vascular dementia among 5700 dementia-free individuals, and the findings are an early step toward understanding whether genes play a role in this condition.
Study details
- Study designcohort study
- Participants67
- Evidence strengthModerate
How this study scored 54/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Stroke) |
| Journal's citation record | 3 / 4 | Stroke: journal h-index 455 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 67 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 61 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.8 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 2 / 6 | Cited 3.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22116812) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
5 studies in the alzhub library list this one in their references.
Related studies in Long-term cohort studies
Also tagged “prevalence”
1,223 studies in the library carry the topic tag “prevalence”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,223 tagged studies.