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Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis
Lee J, Jin C, Cho SY, Park SU, Jung WS, Moon SK, Park JM, Ko CN et al.. Medicine, 2020-08-01
Topic: Amyloid, tau and blood-test diagnosis
Background Alzheimer disease (AD) is a leading progressive neurodegenerative disease worldwide, but treating it is challenging in clinical practice. This review is aimed at evaluating the efficacy and safety of herbal medicine for treating AD. Methods and analysis We will search for randomized controlled trials related to the effect and safety of herbal medicine for AD in the following databases: PubMed, Cochrane Central Register of Controlled Trials, Excerpta Medica Database, China National Knowledge Infrastructure database, Oriental Medicine Advanced Searching Integrated system, Korean Traditional Knowledge Portal, and Citation Information by National Institute for Informatics. The risk of bias will be evaluated using the Cochrane risk-of-bias assessment tool. After screening the studies, a meta-analysis will be performed. The primary outcome will be the Mini-Mental State Examination score. Secondary outcomes will consist of other scales for cognitive function and other aspects, such as behavioral and psychological symptoms and plasma levels of amyloid-β. Results This study will provide the current status of evidence for herbal medicine to treat AD. Conclusion The results of this review will determine the efficacy and safety of herbal medicine for AD. Ethics and dissemination Ethical approval is not required, as this study is based on a review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print. Trial registration number Research Registry reviewregistry933.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lee, J., Jin, C., Cho, S. Y., Park, S. U., Jung, W. S., Moon, S. K., et al. (2020). Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis. Medicine. https://doi.org/10.1097/md.0000000000021745
Vancouver
Lee J, Jin C, Cho SY, Park SU, Jung WS, Moon SK, et al. Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis. Medicine. 2020. doi:10.1097/md.0000000000021745. PMID: 32872063.
BibTeX
@article{lee2020-32872063,
author = {Lee, J. and Jin, C. and Cho, S. Y. and Park, S. U. and Jung, W. S. and Moon, S. K. and Park, J. M. and Ko, C. N. and others},
title = {{Herbal medicine treatment for Alzheimer disease: A protocol for a systematic review and meta-analysis}},
journal = {Medicine},
year = {2020},
doi = {10.1097/md.0000000000021745},
pmid = {32872063},
url = {https://doi.org/10.1097/md.0000000000021745}
}
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Key findings
- Results This study will provide the current status of evidence for herbal medicine to treat AD.
- Conclusion The results of this review will determine the efficacy and safety of herbal medicine for AD.
Why it matters
This is a protocol for a planned systematic review and meta-analysis of herbal medicine for Alzheimer's disease, so it reports no results yet. It states only that the review will determine the efficacy and safety of herbal medicine, meaning no conclusion about treatment is available.
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Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 53/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicine) |
| Journal's citation record | 3 / 4 | Medicine: journal h-index 285 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 3 / 7 | Cited 20 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.5 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 3.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Seungwon Kwon: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Kyung Hee University: institution h-index 468 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32872063) |
| Free to read | 2 / 2 | Free to read |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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