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Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes
Lisa H. Antoine, Jared J. Tanner, Angela M. Mickle, Cesar E. Gonzalez, Daniel A. Kusko, Kristen Allen-Watts, Deanna Rumble, Taylor Buchanan et al.. Brain and Behavior, 2023-11-20
Topic: Brain proteins, microglia and lab models
Regression analyses showed that with the inclusion of socioenvironmental factors, the model was significant (p < .001), and sociodemographic (ethnic/race) group differences were not significant (p = .118). Additionally, findings revealed an additive stress load pattern indicating thinner temporal lobe cortices with greater socioenvironmental risk and chronic pain severity (p = .048). Although individual socioenvironmental factors were not independent predictors, when collectively combined in models, ethnic/race group differences in bilateral temporal lobe structures were not replicated. Further, combined socioenvironmental risk factors and higher chronic pain severity were associated with thinner bilateral temporal lobes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Antoine, L. H., Tanner, J. J., Mickle, A. M., Gonzalez, C. E., Kusko, D. A., Allen-Watts, K., et al. (2023). Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes. Brain and Behavior. https://doi.org/10.1002/brb3.3330
Vancouver
Antoine LH, Tanner JJ, Mickle AM, Gonzalez CE, Kusko DA, Allen-Watts K, et al. Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes. Brain and Behavior. 2023. doi:10.1002/brb3.3330. PMID: 37984835.
BibTeX
@article{antoine2023-37984835,
author = {Antoine, Lisa H. and Tanner, Jared J. and Mickle, Angela M. and Gonzalez, Cesar E. and Kusko, Daniel A. and Allen-Watts, Kristen and Rumble, Deanna and Buchanan, Taylor and others},
title = {{Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes}},
journal = {Brain and Behavior},
year = {2023},
doi = {10.1002/brb3.3330},
pmid = {37984835},
url = {https://doi.org/10.1002/brb3.3330}
}
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Key findings
- Regression analyses showed that with the inclusion of socioenvironmental factors, the model was significant (p < .001), and sociodemographic (ethnic/race) group differences were not significant (p = .118).
- Additionally, findings revealed an additive stress load pattern indicating thinner temporal lobe cortices with greater socioenvironmental risk and chronic pain severity (p = .048).
- Although individual socioenvironmental factors were not independent predictors, when collectively combined in models, ethnic/race group differences in bilateral temporal lobe structures were not replicated.
- Further, combined socioenvironmental risk factors and higher chronic pain severity were associated with thinner bilateral temporal lobes.
Why it matters
This study found that combined socioenvironmental risk factors and higher chronic pain severity were linked to thinner bilateral temporal lobes. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Participants72
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain and Behavior) |
| Journal's citation record | 1 / 4 | Brain and Behavior: journal h-index 92 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 72 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.6 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Kimberly T. Sibille: h-index 32 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37984835) |
| Free to read | 2 / 2 | Free to read |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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