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[Function of intersectin in endocytosis and exocytosis]
Tian CY, Zhang CL, Gu F, Ma YJ.. Sheng li xue bao : [Acta physiologica Sinica], 2012-08-01
Topic: Brain proteins, microglia and lab models
Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains. These domains interact with components of the endocytic and exocytic pathways, such as the clathrin mediating synaptic vesicle recycling, the protein related to endocytosis via caveolae, the with-no-lysine kinases related to the regulation of renal outer medullar potassium, and the Cdc42 mediating exocytic pathway. Recently, the understanding of intersectin function in the pathogenesis of endocrine tumor and many neurodegenerative diseases such as Down syndrome, Alzheimer disease has been deepened. This article reviewed the structure and roles in endocytosis/exocytosis and diseases of intersectin.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tian, C. Y., Zhang, C. L., Gu, F., & Ma, Y. J. (2012). [Function of intersectin in endocytosis and exocytosis]. Sheng li xue bao : [Acta physiologica Sinica].
Vancouver
Tian CY, Zhang CL, Gu F, Ma YJ. [Function of intersectin in endocytosis and exocytosis]. Sheng li xue bao : [Acta physiologica Sinica]. 2012. PMID: 22907312.
BibTeX
@article{tian2012-22907312,
author = {Tian, C. Y. and Zhang, C. L. and Gu, F. and Ma, Y. J.},
title = {{[Function of intersectin in endocytosis and exocytosis]}},
journal = {Sheng li xue bao : [Acta physiologica Sinica]},
year = {2012},
pmid = {22907312}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains.
- These domains interact with components of the endocytic and exocytic pathways, such as the clathrin mediating synaptic vesicle recycling, the protein related to endocytosis via caveolae, the with-no-lysine kinases related to the regulation of renal outer medullar potassium, and the Cdc42 mediating exocytic pathway.
- Recently, the understanding of intersectin function in the pathogenesis of endocrine tumor and many neurodegenerative diseases such as Down syndrome, Alzheimer disease has been deepened.
- This article reviewed the structure and roles in endocytosis/exocytosis and diseases of intersectin.
Why it matters
This review describes the structure and roles of the protein intersectin in endocytosis and exocytosis and its possible links to neurodegenerative diseases. It is a summary of existing knowledge and does not test any treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 24/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 23 of the 96 points we could judge it on, which is 24 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Sheng li xue bao : [Acta physiologica Sinica]) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Yongjie Ma: h-index 8 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Tianjin Medical University: institution h-index 402 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22907312) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 23 of the 96 points we could judge it on is 24 out of 100. |
| Total | 24 / 100 | — |
What each of these 20 components measures, and what this score is not →
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