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Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography
Bayhan HA, Aslan Bayhan S, Celikbilek A, Tanık N, Gürdal C.. Clinical & experimental ophthalmology, 2014-08-15
Topic: Amyloid, tau and blood-test diagnosis
Background To assess the chorioretinal thickness changes using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the association between these structural changes and cognitive impairment in Alzheimer's disease (AD). Design Prospective, cross-sectional study Participants Thirty-one eyes of 31 consecutive patients with AD and 30 eyes of 30 cognitively healthy age-matched control subjects were recruited Methods SD-OCT (RTVue-100) was used to measure the macular ganglion cell complex thickness (mGCC), outer retinal thickness (ORL), and the choroidal thickness (CT). Cognitive function was evaluated by Mini-Mental State examination (MMSE) on the same day of the optical examination. Main outcome measures Chorioretinal thickness. Results The mGCC average, mGCC superior and mGCC inferior thicknesses of the AD group were significantly thinner than those of the controls (all, P < 0.05). No significant difference was found in the ORL thickness measurements between the two groups. Compared with control subjects, the CT measurements at all regions were significantly thinner in patients with AD than controls except CT measurement at 3.0 mm temporal to the fovea (P = 0.067). Significant correlations between the mGCC thickness measurements of the AD group and MMSE scores were observed. There was no significant correlation between the MMSE scores and the CT measurements (P > 0.05). Conclusions Patients with AD had chorioretinal structural alterations. Retinal structural alterations were seen only in the inner layers. The reduction in mGCC thickness parameters were related to the severity of cognitive impairment in AD.
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APA 7th
Bayhan, H. A., Aslan Bayhan, S., Celikbilek, A., Tanık, N., & Gürdal, C. (2015). Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography. Clinical & experimental ophthalmology. https://doi.org/10.1111/ceo.12386
Vancouver
Bayhan HA, Aslan Bayhan S, Celikbilek A, Tanık N, Gürdal C. Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography. Clinical & experimental ophthalmology. 2015. doi:10.1111/ceo.12386. PMID: 24995484.
BibTeX
@article{bayhan2015-24995484,
author = {Bayhan, H. A. and Aslan Bayhan, S. and Celikbilek, A. and Tanık, N. and Gürdal, C.},
title = {{Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography}},
journal = {Clinical \& experimental ophthalmology},
year = {2015},
doi = {10.1111/ceo.12386},
pmid = {24995484},
url = {https://doi.org/10.1111/ceo.12386}
}
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Key findings
- Results The mGCC average, mGCC superior and mGCC inferior thicknesses of the AD group were significantly thinner than those of the controls (all, P < 0.05).
- No significant difference was found in the ORL thickness measurements between the two groups.
- Compared with control subjects, the CT measurements at all regions were significantly thinner in patients with AD than controls except CT measurement at 3.0 mm temporal to the fovea (P = 0.067).
- Significant correlations between the mGCC thickness measurements of the AD group and MMSE scores were observed.
- There was no significant correlation between the MMSE scores and the CT measurements (P > 0.05).
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Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical & experimental ophthalmology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24995484) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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