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Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction
Poosanu Thanapornsangsuth, Tatchaporn Ongphichetmetha, Watayuth Luechaipanit, Pasin Hemachudha, Thiravat Hemachudha. Alzheimer's & dementia (Amsterdam, Netherlands), 2022-09-30
Topic: Plasma and spinal-fluid biomarkers
Among participants enrolled, the median (interquartile range) age was 57 (28.5-75) years and 5.8% had AD. Plasma p-tau181 yielded area under the curve of 0.85 and showed moderate correlation with CSF p-tau181 (Rho = 0.42, P < .001). Using the historical cut-point, many non-AD participants had elevated plasma p-tau181 resulting in a specificity of 0.57. Plasma p-tau181 correlated with the glomerular filtration rate (Rho = -0.52, P < .001). Among A- participants with elevated plasma p-tau181, 42% had kidney dysfunction. Plasma p-tau181 showed inadequate specificity in patients with AOC partially attributable to concomitant kidney dysfunction.
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APA 7th
Thanapornsangsuth, P., Ongphichetmetha, T., Luechaipanit, W., Hemachudha, P., & Hemachudha, T. (2022). Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12358
Vancouver
Thanapornsangsuth P, Ongphichetmetha T, Luechaipanit W, Hemachudha P, Hemachudha T. Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction. Alzheimer's & dementia (Amsterdam, Netherlands). 2022. doi:10.1002/dad2.12358. PMID: 36204656.
BibTeX
@article{thanapornsangsuth2022-36204656,
author = {Thanapornsangsuth, Poosanu and Ongphichetmetha, Tatchaporn and Luechaipanit, Watayuth and Hemachudha, Pasin and Hemachudha, Thiravat},
title = {{Elevation of plasma phosphorylated tau181 during neurological illnesses affecting consciousness and kidney dysfunction}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2022},
doi = {10.1002/dad2.12358},
pmid = {36204656},
url = {https://doi.org/10.1002/dad2.12358}
}
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Key findings
- Among participants enrolled, the median (interquartile range) age was 57 (28.5-75) years and 5.8% had AD.
- Plasma p-tau181 yielded area under the curve of 0.85 and showed moderate correlation with CSF p-tau181 (Rho = 0.42, P < .001).
- Using the historical cut-point, many non-AD participants had elevated plasma p-tau181 resulting in a specificity of 0.57.
- Plasma p-tau181 correlated with the glomerular filtration rate (Rho = -0.52, P < .001).
- Among A- participants with elevated plasma p-tau181, 42% had kidney dysfunction.
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Study details
- Effect size5.8%
- Evidence strengthLow
How this study scored 48/100
Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36204656) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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