This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

ANOVA revealed significant group differences in lateral ventricular SUVR across the Alzheimer, mild cognitive impairment, and healthy control groups ( P = 0.004). Pairwise comparisons revealed significantly lower lateral ventricular SUVR in Alzheimer subjects than in healthy controls ( P P = 0.029). Lateral ventricular SUVR was significantly lower in multiple sclerosis subjects than in healthy controls ( P = 0.008). Compartmental modeling analysis revealed significantly lower uptake rates of 11 C-PiB signal from blood ( P = 0.005) and brain tissue ( P = 0.004) to the lateral ventricles and significantly lower 11 C-PiB signal clearance out of the lateral ventricles ( P = 0.002) in Alzheimer subjects than in healthy controls. These results indicate that dynamic 11 C-PiB PET can be used to observe pathologic changes in CSF dynamics. We have replicated previous work demonstrating CSF clearance deficits in Alzheimer disease associated with amyloid-β deposits and have extended the observations to include ventricular CSF clearance deficits in mild cognitive impairment and multiple sclerosis.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Schubert, J. J., Veronese, M., Marchitelli, L., Bodini, B., Tonietto, M., Stankoff, B., et al. (2019). Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.118.223834

Vancouver

Schubert JJ, Veronese M, Marchitelli L, Bodini B, Tonietto M, Stankoff B, et al. Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019. doi:10.2967/jnumed.118.223834. PMID: 30850505.

BibTeX

@article{schubert2019-30850505,
  author  = {Schubert, J. J. and Veronese, M. and Marchitelli, L. and Bodini, B. and Tonietto, M. and Stankoff, B. and Brooks, D. J. and Bertoldo, A. and others},
  title   = {{Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.223834},
  pmid    = {30850505},
  url     = {https://doi.org/10.2967/jnumed.118.223834}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

ANOVA revealed significant group differences in lateral ventricular SUVR across the Alzheimer, mild cognitive impairment, and healthy control groups ( P = 0.004).
Pairwise comparisons revealed significantly lower lateral ventricular SUVR in Alzheimer subjects than in healthy controls ( P P = 0.029).
Lateral ventricular SUVR was significantly lower in multiple sclerosis subjects than in healthy controls ( P = 0.008).
Compartmental modeling analysis revealed significantly lower uptake rates of 11 C-PiB signal from blood ( P = 0.005) and brain tissue ( P = 0.004) to the lateral ventricles and significantly lower 11 C-PiB signal clearance out of the lateral ventricles ( P = 0.002) in Alzheimer subjects than in healthy controls.
These results indicate that dynamic 11 C-PiB PET can be used to observe pathologic changes in CSF dynamics.

Why it matters

Using dynamic 11C-PiB PET, this study found lower lateral ventricular signal and lower clearance of the tracer out of the lateral ventricles in Alzheimer's patients than in healthy controls, with similar findings in mild cognitive impairment and multiple sclerosis. This suggests a method to observe cerebrospinal fluid flow changes in Alzheimer's, but it does not test treatment, cure or prevention.

New to this subject? Start with our plain-English guide: Brain scans & tests →

Study details

Evidence strengthLow

How this study scored 46/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 119 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	13.2 citations a year over 9 year(s) since 2019
Impact for its field and year	3 / 6	Cited 4.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	3 / 4	Cited 59 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Federico Turkheimer: h-index 81 (OpenAlex, whole career)
Institution's track record	2 / 3	Imperial College London: institution h-index 1,744 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30850505)
Free to read	0 / 2	Behind a paywall — scores zero
Total	46 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 13.

Later studies that cite this one

2 studies in the alzhub library list this one in their references.

Related studies in Brain scans and imaging

Also tagged “small”

900 studies in the library carry the topic tag “small”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Brain scans and imaging

See all studies in Brain scans and imaging →