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CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
Villemagne VL, Leuzy A, Bohorquez SS, Bullich S, Shimada H, Rowe CC, Bourgeat P, Lopresti B et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2023-07-07
Topic: Amyloid, tau and blood-test diagnosis
Introduction Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. Method One thousand forty-five participants underwent tau scans with either 18 F-flortaucipir, 18 F-MK6240, 18 F-PI2620, 18 F-PM-PBB3, 18 F-GTP1, or 18 F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)- subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR z , was constructed. Results None of the regions known to display off-target signal were included in the masks. The CenTauR z allows robust discrimination between low and high levels of tau deposits. Discussion We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.
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APA 7th
Villemagne, V. L., Leuzy, A., Bohorquez, S. S., Bullich, S., Shimada, H., Rowe, C. C., et al. (2023). CenTauR: Toward a universal scale and masks for standardizing tau imaging studies. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12454
Vancouver
Villemagne VL, Leuzy A, Bohorquez SS, Bullich S, Shimada H, Rowe CC, et al. CenTauR: Toward a universal scale and masks for standardizing tau imaging studies. Alzheimer's & dementia (Amsterdam, Netherlands). 2023. doi:10.1002/dad2.12454. PMID: 37424964.
BibTeX
@article{villemagne2023-37424964,
author = {Villemagne, V. L. and Leuzy, A. and Bohorquez, S. S. and Bullich, S. and Shimada, H. and Rowe, C. C. and Bourgeat, P. and Lopresti, B. and others},
title = {{CenTauR: Toward a universal scale and masks for standardizing tau imaging studies}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2023},
doi = {10.1002/dad2.12454},
pmid = {37424964},
url = {https://doi.org/10.1002/dad2.12454}
}
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Key findings
- Results None of the regions known to display off-target signal were included in the masks.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37424964) |
| Free to read | 2 / 2 | Free to read |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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