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External Validation of Joint Propagation Model‐Based Tau PET CenTauR units
Alexis Moscoso, Antoine Leuzy, Lars Lau Raket, Victor L. Villemagne, Gregory Klein, Matteo Tonietto, Emily Olafson, Suzanne L. Baker et al.. Alzheimer s & Dementia, 2025-12-01
Topic: Brain proteins, microglia and lab models
Result A cut‐off of 18 CenTauRs was found to optimally classify [ 18 F]flortaucipir PET visual reads (Figure 1B). Conclusion These analyses suggest that CenTauR harmonization increases the comparability of tau‐PET data acquired with different tracers.
Key findings
- Result A cut‐off of 18 CenTauRs was found to optimally classify [ 18 F]flortaucipir PET visual reads (Figure 1B).
- Conclusion These analyses suggest that CenTauR harmonization increases the comparability of tau‐PET data acquired with different tracers.
Why it matters
This analysis suggests that harmonizing tau-PET measurements with CenTauR units makes scans from different tracers more comparable. It does not test any treatment, cure, or prevention, and only addresses how tau-PET images are read and compared.
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Study details
- Study designlongitudinal study
- Participants1,089
- Evidence strengthModerate
How this study scored 51/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,089 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Vincent Doré: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 32 institution(s) in 11 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41434902) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/alz70862_109722
- PubMed: 41434902
- Original source →
- Free full text: Alzheimer s & Dementia →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Moscoso, A., Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., et al. (2025). External Validation of Joint Propagation Model‐Based Tau PET CenTauR units. Alzheimer s & Dementia. https://doi.org/10.1002/alz70862_109722
Vancouver
Moscoso A, Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, et al. External Validation of Joint Propagation Model‐Based Tau PET CenTauR units. Alzheimer s & Dementia. 2025. doi:10.1002/alz70862_109722. PMID: 41434902.
BibTeX
@article{moscoso2025-41434902,
author = {Moscoso, Alexis and Leuzy, Antoine and Raket, Lars Lau and Villemagne, Victor L. and Klein, Gregory and Tonietto, Matteo and Olafson, Emily and Baker, Suzanne L. and others},
title = {{External Validation of Joint Propagation Model‐Based Tau PET CenTauR units}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz70862_109722},
pmid = {41434902},
url = {https://doi.org/10.1002/alz70862_109722}
}