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Cardiovascular disease and Alzheimer's disease: common links
Stampfer MJ.. Journal of internal medicine, 2006-09-01
Topic: Amyloid, tau and blood-test diagnosis
Growing evidence supports a strong and likely causal association between cardiovascular disease (CVD), and its risk factors, with incidence of cognitive decline and Alzheimer's disease. Individuals with subclinical CVD are at higher risk for dementia and Alzheimer's. Several cardiovascular risk factors are also risk factors for dementia, including hypertension, high LDL cholesterol, low HDL cholesterol and especially diabetes. Moderate alcohol appears to be protective for both CVD and dementia. In contrast, inflammatory markers predict cardiovascular risk, but not dementia, despite biological plausibility for such a link. The substantial overlap in risk factors points to new avenues for research and prevention.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Stampfer, M. J. (2006). Cardiovascular disease and Alzheimer's disease: common links. Journal of internal medicine. https://doi.org/10.1111/j.1365-2796.2006.01687.x
Vancouver
Stampfer MJ. Cardiovascular disease and Alzheimer's disease: common links. Journal of internal medicine. 2006. doi:10.1111/j.1365-2796.2006.01687.x. PMID: 16918818.
BibTeX
@article{stampfer2006-16918818,
author = {Stampfer, M. J.},
title = {{Cardiovascular disease and Alzheimer's disease: common links}},
journal = {Journal of internal medicine},
year = {2006},
doi = {10.1111/j.1365-2796.2006.01687.x},
pmid = {16918818},
url = {https://doi.org/10.1111/j.1365-2796.2006.01687.x}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Individuals with subclinical CVD are at higher risk for dementia and Alzheimer's.
Why it matters
This review reports that cardiovascular disease and its risk factors, such as hypertension and diabetes, are linked to higher risk of cognitive decline and Alzheimer's disease. It suggests that addressing cardiovascular risk factors may be a promising avenue for prevention research.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of internal medicine) |
| Journal's citation record | 2 / 4 | Journal of Internal Medicine: journal h-index 237 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 325 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.8 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 6.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 2 / 4 | Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Meir J. Stampfer: h-index 231 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16918818) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1111/j.1365-2796.2006.01687.x
- PubMed: 16918818
- Original source →
- Free full text: Journal of Internal Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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