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Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review
Mitolo M, Lombardi G, Manca R, Nacmias B, Venneri A.. Journal of neurology, 2024-09-12
Topic: Amyloid, tau and blood-test diagnosis
Blood-based biomarkers (BBM) are becoming easily detectable tools to reveal pathological changes in Alzheimer's disease (AD). A comprehensive and up-to-date overview of the association between BBM and brain MRI parameters is not available. This systematic review aimed to summarize the literature on the associations between the main BBM and MRI markers across the clinical AD continuum. A systematic literature search was carried out on PubMed and Web of Science and a total of 33 articles were included. Hippocampal volume was positively correlated with Aβ42 and Aβ42/Aβ40 and negatively with Aβ40 plasma levels. P-tau181 and p-tau217 concentrations were negatively correlated with temporal grey matter volume and cortical thickness. NfL levels were negatively correlated with white matter microstructural integrity, whereas GFAP levels were positively correlated with myo-inositol values in the posterior cingulate cortex/precuneus. These findings highlight consistent associations between various BBM and brain MRI markers even in the pre-clinical and prodromal stages of AD. This suggests a possible advantage in combining multiple AD-related markers to improve accuracy of early diagnosis, prognosis, progression monitoring and treatment response.
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APA 7th
Mitolo, M., Lombardi, G., Manca, R., Nacmias, B., & Venneri, A. (2024). Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review. Journal of neurology. https://doi.org/10.1007/s00415-024-12674-w
Vancouver
Mitolo M, Lombardi G, Manca R, Nacmias B, Venneri A. Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review. Journal of neurology. 2024. doi:10.1007/s00415-024-12674-w. PMID: 39264441.
BibTeX
@article{mitolo2024-39264441,
author = {Mitolo, M. and Lombardi, G. and Manca, R. and Nacmias, B. and Venneri, A.},
title = {{Association between blood-based protein biomarkers and brain MRI in the Alzheimer's disease continuum: a systematic review}},
journal = {Journal of neurology},
year = {2024},
doi = {10.1007/s00415-024-12674-w},
pmid = {39264441},
url = {https://doi.org/10.1007/s00415-024-12674-w}
}
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Key findings
- These findings highlight consistent associations between various BBM and brain MRI markers even in the pre-clinical and prodromal stages of AD.
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Study details
- Study designsystematic review
- Participants33
- Evidence strengthHigh
How this study scored 79/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 46 of the 58 points we could judge it on, which is 79 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 33 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39264441) |
| Free to read | 2 / 2 | Free to read |
| Points | 46 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 46 of the 58 points we could judge it on is 79 out of 100. |
| Total | 79 / 100 | — |
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