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Aging Exacerbates Oxidative Stress and Liver Fibrosis in an Ani-Mal Model of Down Syndrome
Giallongo S, Talianova V, Tropea E, Ferrigno J, Caltabiano R, Broggi G, Distefano A, Alanazi A et al.. Aging, 2023-09-04
Topic: Brain proteins, microglia and lab models
Plain-language summary
Abstract: Down Syndrome (DS) is a common genetic disorder characterized by an extra copy of chromosome 21, leading to dysregulation of various metabolic pathways. Oxidative stress in DS is associated with neurodevelopmental defects, neuronal dysfunction, and the onset of dementia re-sembling Alzheimer's disease. Additionally, chronic oxidative stress contributes to cardiovascular diseases and certain cancers prevalent in DS individuals.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Giallongo, S., Talianova, V., Tropea, E., Ferrigno, J., Caltabiano, R., Broggi, G., et al. (2023). Aging Exacerbates Oxidative Stress and Liver Fibrosis in an Ani-Mal Model of Down Syndrome. Aging. https://doi.org/10.20944/preprints202309.0105.v1
Vancouver
Giallongo S, Talianova V, Tropea E, Ferrigno J, Caltabiano R, Broggi G, et al. Aging Exacerbates Oxidative Stress and Liver Fibrosis in an Ani-Mal Model of Down Syndrome. Aging. 2023. doi:10.20944/preprints202309.0105.v1.
BibTeX
@article{giallongo2023-91e8db9c,
author = {Giallongo, S. and Talianova, V. and Tropea, E. and Ferrigno, J. and Caltabiano, R. and Broggi, G. and Distefano, A. and Alanazi, A. and others},
title = {{Aging Exacerbates Oxidative Stress and Liver Fibrosis in an Ani-Mal Model of Down Syndrome}},
journal = {Aging},
year = {2023},
doi = {10.20944/preprints202309.0105.v1},
url = {https://doi.org/10.20944/preprints202309.0105.v1}
}
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Key findings
- Oxidative stress in DS is associated with neurodevelopmental defects, neuronal dysfunction, and the onset of dementia re-sembling Alzheimer's disease.
- Additionally, chronic oxidative stress contributes to cardiovascular diseases and certain cancers prevalent in DS individuals.
- This study investigates the impact of ageing on oxidative stress and liver fibrosis using a DS murine model (Ts2Cje mice).
- The liver in DS mice shows increased oxidative stress and impaired antioxidant defenses, as evidenced by reduced glutathione levels and increased lipid peroxidation.
Why it matters
In a mouse model of Down syndrome, ageing was linked to increased oxidative stress and liver fibrosis. This is animal research and does not test any treatment, cure or prevention for Alzheimer's disease in people.
Study details
- Evidence strengthLow
How this study scored 31/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record and impact for its field and year, so those were left out: it earned 28 of the 90 points we could judge it on, which is 31 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.2 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ignazio Alberto Barbagallo: h-index 37 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Sapienza University of Rome: institution h-index 1,145 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38942607) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 28 / 90 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 28 of the 90 points we could judge it on is 31 out of 100. |
| Total | 31 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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