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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain scans and imaging

Topic: Plasma and spinal-fluid biomarkers

Plain-language summary

There were significant associations (p < 0.05) between the NPI variables (total score, Affective factor) and entorhinal and precuneus tau across all participants. These associations were also significant for the tau-amyloid interaction. These effects were significant in cognitively symptomatic participants (MCI and AD dementia), but not in CN participants. Increased tau burden in the entorhinal and precuneus cortices was modestly associated with greater NPS in MCI and AD dementia. Further evaluation of NPS and their effect on early-stage AD could aid in finding new interventions and slowing disease progression.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Tommasi, N. S., Gonzalez, C., Briggs, D., Properzi, M. J., Gatchel, J. R., Marshall, G. A., et al. (2021). Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease. International journal of geriatric psychiatry. https://doi.org/10.1002/gps.5530

Vancouver

Tommasi NS, Gonzalez C, Briggs D, Properzi MJ, Gatchel JR, Marshall GA, et al. Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease. International journal of geriatric psychiatry. 2021. doi:10.1002/gps.5530. PMID: 33682933.

BibTeX

@article{tommasi2021-33682933,
  author  = {Tommasi, Nicole S and Gonzalez, Christopher and Briggs, Danielle and Properzi, Michael J and Gatchel, Jennifer R and Marshall, Gad A and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease}},
  journal = {International journal of geriatric psychiatry},
  year    = {2021},
  doi     = {10.1002/gps.5530},
  pmid    = {33682933},
  url     = {https://doi.org/10.1002/gps.5530}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: this is a cross-sectional study. Everyone is measured once, so it cannot show which came first. Read it as a snapshot of how two things go together at one moment.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

There were significant associations (p < 0.05) between the NPI variables (total score, Affective factor) and entorhinal and precuneus tau across all participants.
These associations were also significant for the tau-amyloid interaction.
These effects were significant in cognitively symptomatic participants (MCI and AD dementia), but not in CN participants.
Increased tau burden in the entorhinal and precuneus cortices was modestly associated with greater NPS in MCI and AD dementia.
Further evaluation of NPS and their effect on early-stage AD could aid in finding new interventions and slowing disease progression.

New to this subject? Start with our plain-English guide: Brain scans & tests →

Study details

Study designcross-sectional
Evidence strengthLow

How this study scored 48/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2021 — within 6 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 33682933)
Free to read	— / 2	Access not recorded — left out of this score
Points	27 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100.
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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