27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Sleep duration had an inverted U-shape relationship with cognitive scores (P <.001); and sleep quality had a positive linear relationship with cognitive scores (P <.001). 5 key findings →
Design: longitudinal study Participants: 10,768 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Of 1,164 participants (mean age 73.5 years, 64% women), 580 (49.8%) had mild hearing impairment and 196 (16.8%) had moderate/severe hearing impairment. 5 key findings →
Design: longitudinal study Participants: 1,164 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The combinations of hearing and proprioceptive impairment and hearing, vision, and proprioceptive impairment, were positively correlated with cDVR (β = 0.087 and p = 0.036, β = 0.110 and p = 0.018, respectively). 3 key findings →
Design: longitudinal study Participants: 174 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Twenty-five meta-analyses published between 2007 and 2021 were included. 5 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
The present study showed that higher educational levels were related to better general cognitive function, executive function, memory, and information processing speed in PD patients, whereas no significant association was showed between educational levels and visuospatial function, language in PD patients. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Alzheimer's disease and related dementias is a major public health burden-compounding over upcoming years due to longevity. 1 key finding →
Design: longitudinal study Participants: 30,097 Evidence: moderate
Full summary, score breakdown and related studies → Original source
We identified 1,041 incident all-cause dementia cases in 4,283 participants over 37,102 person-years of follow-up. 5 key findings →
Design: cohort study Participants: 4,283 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Among 5,699 participants (mean age: 70±8 years), we observed total PM2.5 concentrations ranging from 16 to 206 μg/m3. 5 key findings →
Design: longitudinal study Participants: 5,699 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Evidence on the association between air pollution and dementia is accumulating but still inconclusive, and the potential effect modification by genetics is unclear. 2 key findings →
Design: cohort study Participants: 227,840 Evidence: moderate
Full summary, score breakdown and related studies → Original source
In total, 20 articles were selected for review; 18 included results on the long-term effects of PM2.5 on dementia, 13 on AD, and eight on VaD. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
A high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). 5 key findings →
Design: cohort study Participants: 610 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Emerging evidence of brain injury on risk of neurodegenerative diseases such as Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) have resulted in interest in therapeutic potential of omega-3 fatty acids (n-3FA). 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
The search generated 33 papers, which yielded 11 articles after screening. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients. 2 key findings →
Participants: 21 Evidence: low
Full summary, score breakdown and related studies → Original source
The evolution of the understanding of the intestinal microbiota and its influence on our organism leverages it as a potential protagonist in therapies aimed at diseases that affect not only the intestine but also neural pathways and the central nervous system itself. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. 1 key finding →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
The overall frequency of LATE-NC in Black and White decedents was similar (40.8% vs 45.4%). 5 key findings →
Design: longitudinal study Participants: 76 Evidence: moderate
Full summary, score breakdown and related studies → Original source
We identified 19 studies with primary data. 4 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Eighty-one percent of eligible participants were not aware of a dementia diagnosis. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
General burden is shown to be determined by severity of patient's neuropsychiatric symptoms, caregiver's sense of competence, health-related quality of life. 3 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Further studies are needed to identify modifiable risk factors for FI detection and its symptom management in this patient population. 5 key findings →
Design: cohort study Participants: 4,314 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Three ACP interventions focused on mild dementia and seven on advanced dementia. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Among subjects identified as having dementia by the prediction model, 43.5% to 50.2%, depending on the survey year, reported that they were informed of the dementia status by their physician. 5 key findings →
Design: cohort study Participants: 8,686 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Generally, Blacks and Latinos reported higher prevalence of poor HRQOL compared with whites. 5 key findings →
Design: cohort study Participants: 10,886 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Residents enrolled in managed care (n = 133) were more likely to have do-not-hospitalize orders compared with those in traditional Medicare fee for service (n = 158) (63.7% vs 50.9%; adjusted odds ratio, 1.9; 95% CI, 1.1-3.4), were less likely to be transferred to the hospital for acute illness (3.8% vs 15.7%; adjusted odds ratio, 0.2; 95% CI, 0.1-0.5), had more primary care visits per 90 days (mean [SD], 4.8 [2.6] vs 4.2 [5.0]; adjusted rate ratio, 1.3; 95% CI, 1.1-1.6), and had more nurse practitioner visits (3.0 [2.1] vs 0.8 [2.6]; adjusted rate ratio, 3.0; 95% CI, 2.2-4.1). 3 key findings →
Design: cohort study Participants: 133 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →