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Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging
Lekha Yesantharao, Yurun Cai, Jennifer A Schrack, Alden L Gross, Hang Wang, Murat Bilgel, Ryan Dougherty, Eleanor M Simonsick et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2023-04-30
Topic: Brain imaging, connectivity and assessment
The combinations of hearing and proprioceptive impairment and hearing, vision, and proprioceptive impairment, were positively correlated with cDVR (β = 0.087 and p = 0.036, β = 0.110 and p = 0.018, respectively). In stratified analyses of PiB+ participants, combinations of two, three, and four sensory impairments (all involving proprioception) were associated with higher cDVR. Our findings suggest a relationship between multi-sensory impairment (notably proprioceptive impairment) and Aβ deposition, which could reflect sensory impairment as an indicator or potentially a risk factor for Aβ deposition.
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APA 7th
Yesantharao, L., Cai, Y., Schrack, J. A., Gross, A. L., Wang, H., Bilgel, M., et al. (2023). Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12407
Vancouver
Yesantharao L, Cai Y, Schrack JA, Gross AL, Wang H, Bilgel M, et al. Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging. Alzheimer's & dementia (Amsterdam, Netherlands). 2023. doi:10.1002/dad2.12407. PMID: 37139098.
BibTeX
@article{yesantharao2023-37139098,
author = {Yesantharao, Lekha and Cai, Yurun and Schrack, Jennifer A and Gross, Alden L and Wang, Hang and Bilgel, Murat and Dougherty, Ryan and Simonsick, Eleanor M and others},
title = {{Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2023},
doi = {10.1002/dad2.12407},
pmid = {37139098},
url = {https://doi.org/10.1002/dad2.12407}
}
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Key findings
- The combinations of hearing and proprioceptive impairment and hearing, vision, and proprioceptive impairment, were positively correlated with cDVR (β = 0.087 and p = 0.036, β = 0.110 and p = 0.018, respectively).
- In stratified analyses of PiB+ participants, combinations of two, three, and four sensory impairments (all involving proprioception) were associated with higher cDVR.
- Our findings suggest a relationship between multi-sensory impairment (notably proprioceptive impairment) and Aβ deposition, which could reflect sensory impairment as an indicator or potentially a risk factor for Aβ deposition.
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Study details
- Study designlongitudinal study
- Participants174
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 174 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37139098) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
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