27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
This study provides a systematic review of predictors of NHP in the general population of developed countries. 3 key findings →
Design: systematic review Evidence: high
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Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel disease (SVD). 4 key findings →
Design: cross-sectional Evidence: moderate
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Type 2 diabetes is associated with cognitive dysfunction and structural brain changes. 2 key findings →
Evidence: high
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Compared with controls, patients with idiopathic REM sleep behaviour disorder had decreased colonic 11 C-donepezil uptake (-0·322, 95% CI -0·112 to -0·531; p=0·0020), 123 I-MIBG heart:mediastinum ratio (-0·508, -0·353 to -0·664; p 18 F-DOPA uptake (Ki; -0·0023, -0·0009 to -0·0037; p=0·0013). 3 key findings →
Design: case-control study Participants: 22 Evidence: moderate
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Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease. 2 key findings →
Design: meta-analysis Evidence: high
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Vascular risk factors, such as type 2 diabetes, hypertension, obesity and dyslipidaemia often co-occur. 3 key findings →
Design: longitudinal study Participants: 14 Evidence: moderate
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No systematic review of epidemiological evidence has examined risk factors for sleep disturbances among older adults. 1 key finding →
Design: systematic review Evidence: high
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Overall, 342 recommendations (285 supported by research data and 57 good practice points) and 40 key messages have been formulated. 2 key findings →
Design: systematic review Evidence: high
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Social isolation was significantly associated with reduced cognitive ability (pooled effect = -0.07, 95% CI = -0.08, -0.05), with consistently negative effects across memory, orientation, and executive ability. 4 key findings →
Design: meta-analysis Participants: 101,581 Evidence: high
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After a median follow-up time of 14.3 (7.9-20.0) years, dementia was recorded in 530 (1.2%) individuals with type 1 diabetes and 1,867 (0.9%) age-, sex-, and county-matched control individuals (mean baseline age 33.0 [14.0] years). 4 key findings →
Design: cohort study Participants: 43,440 Evidence: moderate
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Over a mean follow-up of 7.9 years, 694 incident dementia cases occurred. 5 key findings →
Design: cohort study Participants: 82,391 Evidence: moderate
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= 0.009). Significant differences in annualized changes in these FA and MD values were found depending on the presence or absence of type 2 diabetes and smoking. 4 key findings →
Design: longitudinal study Participants: 6,471 Evidence: moderate
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This study classified preclinical Alzheimer's disease (AD) using cognitive screening, neighborhood deprivation via the area deprivation index (ADI), and sociodemographic and genetic risk factors. 2 key findings →
Design: longitudinal study Participants: 2,792 Evidence: moderate
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Mutations in the glucocerebrosidase gene (GBA) are associated with Gaucher's disease, the most common lysosomal storage disorder. 5 key findings →
Participants: 790 Evidence: low
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Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders. 3 key findings →
Design: meta-analysis Evidence: high
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In persons with multimorbidity, there exists co-occurrence of diseases beyond chance, which clinicians need to take into account in their daily practice. 2 key findings →
Design: prospective cohort Participants: 1,099 Evidence: moderate
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Twenty studies met inclusion criteria. 3 key findings →
Design: systematic review Evidence: high
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Increased α-synuclein egress in serum neuronal exosomes precedes the diagnosis of Parkinson's disease, persists with disease progression and in combination with clusterin predicts and differentiates Parkinson's disease from atypical parkinsonism. 2 key findings →
Design: cross-sectional Participants: 314 Evidence: moderate
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The sample consisted of 447 decedents (249 men [56%]; mean [SD] age, 80.3 [9.5] years; median year of death, 2011) spanning 24 years of donation. 5 key findings →
Design: cross-sectional Participants: 24 Evidence: low
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A total of 162 studies were included, with 88 (54.3%) exploring potential risk factors and 74 (45.7%) examining specific risk factors. 5 key findings →
Design: case-control study Participants: 162 Evidence: moderate
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Of 733 participants (mean age 82.5 ± 2.9 years), 164 (22.4%) developed MCI and 93 (12.7%) developed dementia by the follow-up visit. 5 key findings →
Design: longitudinal study Participants: 321 Evidence: moderate
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Sleep is a fundamental biological process with broad implications for physical and mental health, yet its complex relationship with disease remains poorly understood. 5 key findings →
Participants: 65,000 Evidence: low
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NPS were observed to be highly prevalent in AD patients. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Coffee is the leading worldwide beverage after water and its trade exceeds US $10 billion worldwide. 3 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Hearing aids may have a mitigating effect on trajectories of cognitive decline in later life. 2 key findings →
Design: cohort study Participants: 2,040 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →