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Research

27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 1,301–1,325 of 2,174 studies in Risk factors (page 53 of 87) · 27,380 in the whole library · How the 0–100 score works

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Other subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 12,859 studies have no institution on record and are not counted here.

What “Risk factors” covers

Risk factors — Conditions, exposures and habits linked to a higher or lower chance of dementia, and how strong each link is.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells

✓ Peer-reviewed alzhub usefulness score 41 out of 100. PLoS ONE 2019-11-07

Succinate dehydrogenase (SDH) inhibitors (SDHIs) are used worldwide to limit the proliferation of molds on plants and plant products. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source

The role of built and social environments in Alzheimer's disease dementia prevalence in the United States: A machine learning approach

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer s Disease 2025-09-01

Significant regional differences in AD dementia prevalence were observed (F = 126.56, p < 0.05). 2 key findings →

Design: cross-sectional Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Geographic variation in shortfalls of dementia specialists in the United States

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Health Affairs Scholar 2024-06-28

Dementia specialists-neurologists, geriatricians, and geriatric psychiatrists-serve a critical clinical function in diagnosing early-stage Alzheimer's disease and determining eligibility for treatment with disease-modifying therapies. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Utilization of home- and community-based services among rural family caregivers of persons with dementia: the role of the area deprivation index

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in Public Health 2025-10-14

About 65% of caregivers used at least one support service, with 52% utilizing home-based services and 52% community-based services. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Association of neighborhood socioeconomic disadvantage and cognitive decline

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2021-12-01

Neighborhood characteristics may play an influential role in SCD regardless of race/ethnicity and thus are likely important risk factors for AD/ADRD. 2 key findings →

Participants: 313 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

The influence of Area Deprivation Index on cognition in cognitively‐normal adults as measured by Principal Component Analysis of Neuropsychological Data

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2023-12-01

Our results suggest that the relationship between greater neighborhood disadvantage and poorer cognitive function are very subtle and may only be present for some, but not all, cognitive domains. 5 key findings →

Design: longitudinal study Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Social determinants of pharmacological dementia management: results from IDEAS

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-12-01

We used multilevel logistic regression with a random site intercept to test whether the probability of change in management associated with social determinants, race/ADI interactions with amyloid‐positivity, comorbidities, and clinical setting, adjusting for demographics. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Geospatial analysis of dementia mortality and its associations with demographic and socioeconomic factors

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer s Disease Reports 2024-01-01

This study highlights diverse links between dementia mortality and demographic and socioeconomic factors at the county level in the United States. 5 key findings →

Participants: 2,019 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Does Medicaid Hcbs Generosity Influence Nursing Home Placement for Dually Eligible Adrd Patients?

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Health Services Research 2020-08-01

After accounting for individual and county level covariates, we found that a 10 percentage‐point increase in HCBS breadth among individuals with ADRD was associated with 1.1 percentage point reduction (P < 0.01) in the likelihood of NH placement. 3 key findings →

Participants: 365 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Community Matters: How Neighborhood Cohesion Buffers Against Cognitive Impairment via Mental Health Pathways in Black Older Adults

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-12-01

The overall sample (N =329) was predominantly female (76.4%) with a mean age of 64.5 (range 45-92) and an average of 14.9 years of education (Table 1). 5 key findings →

Participants: 329 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Hospitalization risk with and without dementia by region and race in the United States

✓ Peer-reviewed alzhub usefulness score 40 out of 100. American Journal of Epidemiology 2026-04-21

Understanding regional and racial variation in the risk of hospitalization with Alzheimer's disease and related dementias (ADRD)-and how it differs from other conditions-is required to inform effective practice and policy. 2 key findings →

Participants: 143 Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Neighborhood Deprivation and Mortality Risk among Medicare Beneficiaries with Alzheimer’s Disease and Related Dementia

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2022-12-01

Our findings suggest neighborhood deprivation is an important risk factor of mortality among older adults with ADRD while accounting for individuals’ demographic and clinical characteristics. 3 key findings →

Participants: 31,218 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death

✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS Genetics 2025-12-29

A key pathological feature of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) is the loss of nuclear localization and accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43). 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-12-01

The table shows a comparative analysis stratified by young-onset AD (YOAD, onset <65 years) and late-onset AD (LOAD, onset ≥65 years). 5 key findings →

Participants: 75 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Mapping spatial hotspots and location specific associated factor of diarrhea-wasting multimorbidity among children aged 6–24 months in East Africa: a geographically weighted regression analysis

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Scientific Reports 2026-04-02

Concurrent diarrhea and wasting (DW) among children aged 6–24 months represents a critical public health threat in East Africa, exacerbating infection susceptibility, stunting, cognitive impairment, and mortality. 2 key findings →

Participants: 1,402 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer s & Dementia 2025-12-01

Among 160 centenarians, 63.7% did not meet the PCFP criteria and were classified as having dementia. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

↑ Change the filters

Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed