Many physiological changes occur with aging. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as "civilization diseases", like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer's disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Incorrect folding of proteins, leading to aggregation and amyloid formation, is associated with a group of highly debilitating medical conditions including Alzheimer's disease and late-onset diabetes. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The glymphatic system is a "pseudo-lymphatic" perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Reduced levels of physical activity in people's daily lives cause the development of metabolic syndromes or age-related disorders. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In this narrative review, a theoretical framework on the crosstalk between physical exercise and blood-brain barrier (BBB) permeability is presented. 5 key findings →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
The multi-site ubiquitination of Tau protein found in Alzheimer's disease filaments hints at the failed attempt of neurons to remove early toxic species. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Two potential disease-modifying approaches for dementia are being vigorously tested: the early targeting of the neuropathology of Alzheimer's disease (AD) and multi-domain lifestyle interventions to promote resilience to neuropathology. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Given the unknown therapeutic value of targeting Alzheimer's disease pathology and the discovery of robust risk factors for dementia, non-pharmacological risk reduction (RR) is increasingly offered as an alternative to targeting Alzheimer's disease pathology. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neuroinflammation is an early detectable marker of mild cognitive impairment, the transition state between normal cognition and dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Resistance exercise is used extensively in athletic and general populations to induce neuromuscular adaptations to increase muscle size and performance. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Since environmental, socioeconomic, and individual risk factors contribute to dementia, we proposed a Comprehensive, Customized, Cost-effective APProach (the CCC-APP) implemented in actionable units with the focus on promoting brain health (eumentia). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The socio-economic and health consequences of our ageing population are well documented, with older adults living in long-term care facilities amongst the frailest possessing specific and significant healthcare and social care needs. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Early-onset dementia (EOD) defines all dementia related conditions with an onset before the age of 65 years. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
Consensus diagnostic criteria for MCI are available, making early recognition and accurate classification of MCI subtypes possible. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
40/100
This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating cognitive decline. 5 key findings →
Participants: 56 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The growing prevalence of dementia emphasizes the need for effective prevention strategies. 4 key findings →
Participants: 289 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The manuscript provides a thorough analysis of the neurovascular and metabolic processes that contribute to cognitive deterioration in patients with Type 2 diabetes (T2D). 5 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42). 5 key findings →
Participants: 42 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Each 10% increase in UPF intake was associated with lower attention scores (-0.05 points) and higher dementia risk (+0.24 points), independent of Mediterranean diet adherence. 2 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
40/100
Dementia affects over 55 million people globally, with early cognitive decline, such as Mild Cognitive Impairment (MCI), often preceding neurodegenerative diseases. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Sample characteristics are shown in Table 1. 5 key findings →
Participants: 1,104 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →