27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM. 3 key findings →
Participants: 21 Evidence: low
Full summary, score breakdown and related studies → Original source
Aberrations in hippocampal asymmetry and left hippocampal volumes were found for adolescent heavy drinkers. 5 key findings →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
Hypercortisolemia is a frequently observed abnormality in patients with major depression. 2 key findings →
Participants: 30 Evidence: low
Full summary, score breakdown and related studies → Original source
Compared with controls, relatives, particularly from multiplex families, had significantly smaller left hippocampi. 5 key findings →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
The present findings emphasize that patients with reduced hippocampal volumes show more executive dysfunctions than their counterparts. 2 key findings →
Participants: 34 Evidence: low
Full summary, score breakdown and related studies → Original source
Temporal lobe epilepsy (TLE) is considered primarily a limbic disorder. 2 key findings →
Participants: 68 Evidence: low
Full summary, score breakdown and related studies → Original source
Volumetric measures in a group of patients with traumatic brain injury who had received MR imaging 3 months or less after injury were compared with measurements in other patients in the chronic phase of recovery. 5 key findings →
Participants: 94 Evidence: low
Full summary, score breakdown and related studies → Original source
Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume. 2 key findings →
Participants: 27 Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal volume, while disproportionately small for brain size in individuals with Down's syndrome, remains fairly constant through the fifth decade of life in those without dementia. 4 key findings →
Participants: 25 Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal atrophy is not only a characteristic of Alzheimer's disease but also occurs in FTLD. 5 key findings →
Participants: 42 Evidence: low
Full summary, score breakdown and related studies → Original source
This study compared a fornix cross-sectional-area measurement and hippocampal volume in 86 traumatic brain injury (TBI) subjects with 46 normal controls. 3 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Atrophy of the hippocampal formation, a region important for the acquisition of new declarative knowledge, has been well-documented in Alzheimer's disease (AD), although the relation of such atrophy to the extent of memory dysfunction in these patients has been less clear. 1 key finding →
Participants: 18 Evidence: low
Full summary, score breakdown and related studies → Original source
Smaller hippocampal volume is associated with psychiatric disorders. 3 key findings →
Participants: 44 Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. 3 key findings →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
Atrophy of hippocampus and alteration of resting eyes-closed electroencephalographic (EEG) rhythms represent important features of mild cognitive impairment (MCI) and Alzheimer's disease (AD). 4 key findings →
Participants: 40 Evidence: low
Full summary, score breakdown and related studies → Original source
The presence of a single APOE-epsilon4 allele is associated with an increased rate of hippocampal volume loss in healthy women in their sixth decade of life that is not related to any detectable memory changes. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Correction processes can define absolute hippocampal volumes for correlation studies and may enable identification of unsuspected bilateral hippocampal volume loss. 1 key finding →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. 3 key findings →
Participants: 51 Evidence: low
Full summary, score breakdown and related studies → Original source
Measurement of regional abnormalities of HT2 along the length of the hippocampus provides further refinement to the MRI assessment of the hippocampi in patients with temporal lobe epilepsy and is complementary to volumetric and morphological data. 1 key finding →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
The pattern of thinning in TLE-no was different from the pattern in TLE-MTS. 3 key findings →
Participants: 66 Evidence: low
Full summary, score breakdown and related studies → Original source
Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task. 4 key findings →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
Childhood abuse is linked to posttraumatic stress disorder (PTSD), which follows abuse survivors into adulthood. 1 key finding →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. 1 key finding →
Participants: 98 Evidence: low
Full summary, score breakdown and related studies → Original source
Our results demonstrate the striking clinical significance of the brain's intrinsic connectivity in evaluating cognitive capacity and indicating the potential of postsurgical cognitive morbidity in patients with mTLE. 3 key findings →
Participants: 20 Evidence: low
Full summary, score breakdown and related studies → Original source
There is emerging evidence from healthy individuals, as well as direct and indirect evidence from psychiatric and neurological patients with disease-related hippocampal atrophy, linking the cortisol awakening response (CAR) to hippocampal volume. 2 key findings →
Participants: 18 Evidence: low
Full summary, score breakdown and related studies → Original source
9 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →